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Concentrating on Chromatography

David Oliva
Chromatography
Mass Spectrometry
PFAS
Analytical Chemistry
Gas Chromatography
Sample Preparation
HPLC
Lc-Ms
PFAS Detection
Filtration
Separation Science
Syringe Filters
Labexact
Glp-1 Peptides
Gc-Ms
Comprehensive Two-Dimensional Gas Chromatography
High-Resolution Mass Spectrometry
Complex Chemical Composition Analysis Lab
Liquid Chromatography-Mass Spectrometry
Taste and Odor Analysis

Dive into the frontiers of chromatography, mass spectrometry, and sample preparation with host David Oliva. Each episode features candid conversations with leading researchers, industry innovators, and passionate scientists who are shaping the future of analytical chemistry. From decoding PFAS detection challenges to exploring the latest in AI-assisted liquid chromatography, this show uncovers pra... more

PublishesTwice weeklyEpisodes64Foundeda year ago
Number of ListenersCategories
ScienceChemistry

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Artwork for Concentrating on Chromatography

Latest Episodes

In this episode of @ChromatographyTalk David sits down with Dr. Darshil Patel, Assistant Professor of Forensic Science at the University of North Dakota, to discuss his remarkable journey from dentistry in India to becoming a leading researcher in ... more

In this episode of @ChromatographyTalk , David speaks with Joseph Corstvet from the Fernandez Lab at Georgia Tech about the future of mass spectrometry, LC-MS metabolomics, and the development of low-cost ionization technologies.Joe discusses his wo... more

What happens when you replace just one atom in an amino acid?In this episode of @ChromatographyTalk David sits down with JC Poutsma, Professor of Chemistry at William & Mary, to explore the fascinating world of gas-phase ion chemistry, peptide frag... more

In this episode of @ChromatographyTalk David speaks with Colette Quinn, Senior Director within the Biologics Business at Waters Corporation, about the rapidly evolving world of pharmaceutical and biopharma QA/QC.As biologics become more complex, QA... more

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Recent Guests

Darshil Patel
Assistant Professor of Forensic Science, University of North Dakota
University of North Dakota
Episode: Episode 64: The Chemistry of Human Decomposition: GC×GC, Body Farms, and Forensic Science
Joseph Corstvet
From the Fernandez Lab at Georgia Tech
Fernandez Lab, Georgia Tech
Episode: Episode 63: LC-MS Metabolomics and Next-Generation Ionization Technologies #chromatography #massspectrometry
JC Poutsma
Professor of chemistry at William & Mary, specializes in gas phase ion chemistry and biomolecule behavior in mass spectrometers
William & Mary
Episode: Episode 62: When One Atom Changes Everything | JC Poutsma on Mass Spectrometry, Proteomics & Gas-Phase Chemistry
Colette Quinn
Senior Director within the Biologics business at Waters Corporation
Waters Corporation
Episode: Episode 61: Why Biologics QC Is So Much Harder Than Small Molecule Pharma | Colette Quinn of Waters
Samuel Foster
Industry expert from Axcend
Axcend
Episode: Episode 60: Why Capillary LC Is the Future of LC-MS Sensitivity #chromatography #massspectrometry
Jay Gandhi
Vertical Markets Manager at Metrohm USA
Metrohm USA
Episode: Episode 59: The Future of Ion Chromatography | PFAS Testing, EPA 1621 & AOF Explained #analyticalchemistry
Natasha Le
Chemistry instructor working with general chemistry, organic chemistry, and laboratory education
La Sierra University
Episode: Episode 58: How Separation Science Is Taught vs. How It’s Actually Used #nmrspectroscopy #massspectrometry
Rajas Poorna
PI and collaborator on Evapinator project
Baumler Lab / Frugal Science Academy
Episode: Episode 57: Frugal Science Meets Sample Prep: A Field-Ready Lyophilizer for Biofluids
Charles Anderson
Collaborator on Evapinator project
Georgia Tech / Bauma Lab
Episode: Episode 57: Frugal Science Meets Sample Prep: A Field-Ready Lyophilizer for Biofluids

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Talking Points

Recent interactions between the hosts and their guests.

Episode 63: LC-MS Metabolomics and Next-Generation Ionization Technologies #chromatography #massspectrometry
Q: What are the main challenges you faced in developing the chromatography workflow, and why a C30 column?
Extraction strategies and column choice were critical; lipids are non-polar, so a C30 column improved separation and retention for lipid species compared with C18, enabling better annotation and quantification.
Episode 63: LC-MS Metabolomics and Next-Generation Ionization Technologies #chromatography #massspectrometry
Q: How do you translate a large metabolomics data set into a meaningful biomarker panel for QC?
We annotate a subset of features with MS/MS data, use dimensionality reduction and statistical analyses to identify significant changes, then consult literature to build a coherent story around biomarkers like triglycerides that relate to senescence.
Episode 63: LC-MS Metabolomics and Next-Generation Ionization Technologies #chromatography #massspectrometry
Q: Why did you shift toward ionization technologies and DIY approaches in your lab?
Commercial instruments have become very capable, but there is value in exploring alternative ionization methods to reduce sample prep, improve selectivity, and ultimately lower costs and increase accessibility.
Episode 63: LC-MS Metabolomics and Next-Generation Ionization Technologies #chromatography #massspectrometry
Q: What pulled you into mass spectrometry and analytical chemistry to begin with?
The combination of open access to experimental tools at the CDC and the allure of how MS coupled to chromatography could yield rich data intrigued me, and I enjoyed tinkering with instruments and even taking them apart.
Episode 64: The Chemistry of Human Decomposition: GC×GC, Body Farms, and Forensic Science
Q: What are the biggest challenges facing forensic VOC analysis in decomposition research, and how are you planning to address them at your new lab?
The main challenges are sample variability and environmental factors; he emphasizes the need for multi-donor studies and inter-lab standardization to build a robust, comparable VOC data framework.

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Frequently Asked Questions About Concentrating on Chromatography

What is Concentrating on Chromatography about and what kind of topics does it cover?

This show consistently explores cutting-edge analytical chemistry topics through in-depth conversations with researchers and industry practitioners. Episodes frequently cover chromatography and mass spectrometry workflows, method development strategies, QA/QC in biopharma, PFAS and environmental analysis, and advances in separation science enabled by AI, automation, or novel instrumentation. A standout trait is the broad mix of guests—from leading instrument vendors and wet-lab scientists to educators and field researchers—creating a practical, workflow-centric perspective that helps listeners translate complex techniques into real-world lab improvements. Listeners may find the show's focus on real-time evaluation, method robustness, and su... more

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1. The Ezra Klein Show
2. The Daily

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Concentrating on Chromatography launched a year ago and published 64 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Concentrating on Chromatography?

Recent guests on Concentrating on Chromatography include:

1. Darshil Patel
2. Joseph Corstvet
3. JC Poutsma
4. Colette Quinn
5. Samuel Foster
6. Jay Gandhi
7. Natasha Le
8. Rajas Poorna

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