Clinical Chemistry Podcast

Association for Diagnostics and Laboratory Medicine

Alzheimer's Disease

Machine Learning

Laboratory Medicine

Clinical Chemistry

Biomarkers

Myocardial Infarction

Clinical Laboratories

Chronic Kidney Disease

Cardiovascular Disease

Pregnancy

Cardiovascular Events

FDA

Cardiac Troponin

Proteomics

Tuberculosis

Covid-19

Clinical Trials

Mass Spectrometry

Digital PCR

Vitamin D

This free monthly podcast is offered by Clinical Chemistry. Clinical Chemistry is the leading forum for peer-reviewed, original research on innovative practices in today's clinical laboratory.

60 ratings

Publishes	Weekly	Episodes	1122	Founded	15 years ago
Number of Listeners		Categories	ChemistryHealth & FitnessMedicineScience

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Latest Episodes

Genetic Investigation of X-Linked Defects with Optimized Targeted Long-Read Sequencing

Jia Zheng, Keying Li, Jin Han, Chi Chun Chan, Huilin Wang, Jasmine Yan Tung Law, Lin Chen, Fan Jiang, Rui Zhang, Hailei Liang, Xiaofang Chen, Mengmeng Shi, Matthew Hoi Kin Chau, Ye Cao, Yvonne K Kwok, Yuanfang Zhu, Tak Yeung Leung, Kwong Wai Choy, Zi... more

9 Nov 2026 • 10 min

Accuracy-Based Proficiency Testing Surveys for Testosterone Provide Important Information About Measurement Accuracy and Its Impact on Patient Care

Joely A Straseski, Hubert W Vesper, Thomas A Long, Gary L Horowitz. Accuracy-Based Proficiency Testing Surveys for Testosterone Provide Important Information About Measurement Accuracy and Its Impact on Patient Care. Clinical Chemistry, Volume 72, I... more

28 Oct 2026 • 12 min • Most popular

TSH Pediatric Reference Intervals: Lack of CALIPER Applicability to US-Based Populations

Jillian Kodger, Joe M El-Khoury. TSH Pediatric Reference Intervals: Lack of CALIPER Applicability to US-Based Populations. Clinical Chemistry, Volume 72, Issue 9, September 2026, Pages 1003–1004. doi.org/10.1093/clinchem/hvag075

28 Oct 2026 • 12 min

Audio Summary November2026

27 Oct 2026 • 4 min

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Recent Guests

Joely A Straseski

Professor of pathology at the University of Utah School of Medicine and head of clinical operations for clinical chemistry, toxicology and biochemical genetics

University of Utah School of Medicine

Episode: Accuracy-Based Proficiency Testing Surveys for Testosterone Provide Important Information About Measurement Accuracy and Its Impact on Patient Care

Gary L Horowitz

Professor of pathology at Tufts University School of Medicine and chief of clinical pathology at Tufts Medical Center

Tufts Medical Center

Episode: Accuracy-Based Proficiency Testing Surveys for Testosterone Provide Important Information About Measurement Accuracy and Its Impact on Patient Care

Joe El-Khoury

Professor of laboratory medicine and director of the Clinical Chemistry Laboratory at Yale New Haven Hospital

Yale School of Medicine

Episode: TSH Pediatric Reference Intervals: Lack of CALIPER Applicability to US-Based Populations

Tianyu Cao

PhD student in epidemiology researching diabetes and cardiovascular epidemiology

Johns Hopkins Bloomberg School of Public Health

Episode: Patterns of One-Year Change in HbA1c and Continuous Glucose Monitoring (CGM) Metrics in Older Adults with Type 2 Diabetes

Yifei Yang

Clinical chemist and clinical laboratory consultant in laboratory medicine and pathology

Mayo Clinic

Episode: Mining and Refining Elusive Microproteins from Noncanonical Open Reading Frames

Peter Kavsak

Professor in the Department of Pathology and Molecular Medicine at McMaster University; clinical chemist for hospitals affiliated with the Hamilton Regional Laboratory Medicine Program

McMaster University; Hamilton Regional Laboratory Medicine Program

Episode: Point of Concern for Troponin Testing with High-Sensitivity Assays in the Near Patient Setting

Melissa Ix

Lead author of the review on alpha-synuclein RT-QUIC; medical physicist and doctoral researcher

University Hospital Essen, Germany

Episode: Alpha-Synuclein-Specific RT-QuIC As a Tool for the Differential Diagnosis of Neurodegenerative Diseases Using Peripheral Tissues

Mitchell von Itzstein

Assistant professor, Division of Hematology and Oncology, UT Southwestern

University of Texas Southwestern Medical Center

Episode: Predictive Biomarkers for Immune Checkpoint Inhibitor Efficacy: Challenges, Innovations, and a Pathway to Precision Medicine in the Era of Cancer Immunotherapy

Shengjie Li

Lead author of the study; professor and vice chair for academic affairs in the Department of Clinical Laboratory at the I&ENT Hospital of Fudan University

Fudan University, Shanghai, China

Episode: Tumor-Derived HAVCR1 As a Reliable Fluid Biomarker for the Diagnosis of CNS Lymphoma

Host

Bob Barrett

Reviews

4.3 out of 5 stars from 60 ratings

Clinical chem
Amazing podcast on biochemistry...great for physicians and graduate students!
Apple Podcasts
5
The-Thingi
United States11 years ago

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Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

One reviewer praises the biochemistry coverage and says it is useful for physicians and graduate students.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Apple Podcasts	#15	United States/Science/Chemistry
Apple Podcasts	#16	Canada/Science/Chemistry
Apple Podcasts	#23	United Kingdom/Science/Chemistry
Apple Podcasts	#6	Australia/Science/Chemistry
Apple Podcasts	#19	Italy/Science/Chemistry
Apple Podcasts	#41	Germany/Science/Chemistry

Talking Points

Recent interactions between the hosts and their guests.

TSH Pediatric Reference Intervals: Lack of CALIPER Applicability to US-Based Populations

Q: Given what you report in your study and the difficulty of developing pediatric reference intervals, what do you recommend laboratories do when implementing pediatric reference intervals?

He recommends locally verifying published intervals with existing outpatient data, using a tool such as RefineR, before implementation. He cautions that the approach is most useful for commonly ordered tests with many normal results.

TSH Pediatric Reference Intervals: Lack of CALIPER Applicability to US-Based Populations

Q: What is CALIPR?

Joe El-Khoury describes CALIPR as the Canadian Laboratory Initiative for Pediatric Reference Intervals, a large prospective study that established pediatric intervals using samples from more than 14,000 healthy children and multiple commercial assay platforms.

Accuracy-Based Proficiency Testing Surveys for Testosterone Provide Important Information About Measurement Accuracy and Its Impact on Patient Care

Q: What was the most important finding from the study?

Average performance across laboratories was excellent, with less than 2% bias overall, but individual method groups ranged from 16% negative bias to 15% positive bias. At the clinical threshold, this could produce substantially different results and affect patient management.

Accuracy-Based Proficiency Testing Surveys for Testosterone Provide Important Information About Measurement Accuracy and Its Impact on Patient Care

Q: How is accuracy-based proficiency testing different from traditional proficiency testing?

Traditional testing uses highly processed, non-commutable materials to compare laboratories with peers using the same methods. Accuracy-based testing uses commutable human serum samples with reference values, allowing assessment of accuracy on patient-like specimens.

Patterns of One-Year Change in HbA1c and Continuous Glucose Monitoring (CGM) Metrics in Older Adults with Type 2 Diabetes

Q: When hemoglobin A1C and CGM metrics show discordant or even opposite changes which one should people trust and what would you suggest doing next?

Cao advises consulting a healthcare provider and not assuming either result is more accurate. Check CGM data integrity and conditions that may affect either measure; repeat testing if appropriate, and consider an alternative glycemia measure such as fructosamine if the discordance persists.

Audience Metrics

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Frequently Asked Questions About Clinical Chemistry Podcast

What is Clinical Chemistry Podcast about and what kind of topics does it cover?

Monthly conversations connect clinical chemistry research with decisions made in diagnostic laboratories and patient care. Regular host Bob Barrett interviews researchers, laboratory medicine leaders and clinicians about their studies, explaining the methods, findings and practical implications. Topics range from assay accuracy, reference intervals and proficiency testing to biomarkers, mass spectrometry, genomic screening and point-of-care diagnostics. Brief audio-summary episodes also synthesize several studies from recent issues.

The focus is technical but clinically grounded: discussions consider how results are measured, validated and interpreted, and what is needed before emerging tests can be used in routine practice. It is a strong... more

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Which podcasts are similar to Clinical Chemistry Podcast?

These podcasts share a similar audience with Clinical Chemistry Podcast:

1. JAMA Editors' Summary
2. JAMA Clinical Reviews
3. Annals On Call Podcast
4. Medicine and Science from The BMJ
5. Science Magazine Podcast

How many episodes of Clinical Chemistry Podcast are there?

Clinical Chemistry Podcast launched 15 years ago and published 1122 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Clinical Chemistry Podcast?

Recent guests on Clinical Chemistry Podcast include:

1. Joely A Straseski
2. Gary L Horowitz
3. Joe El-Khoury
4. Tianyu Cao
5. Yifei Yang
6. Peter Kavsak
7. Melissa Ix
8. Mitchell von Itzstein

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