Breast Cancer Update

Dr. Neil Love

Breast Cancer

Antibody-Drug Conjugates

Clinical Trials

Metastatic Breast Cancer

Triple Negative Breast Cancer

Triple-Negative Breast Cancer

Metastatic Triple-Negative Breast Cancer

Her2-Positive Breast Cancer

ESR1 Mutations

Quality Of Life

Chemotherapy

Er-Positive Metastatic Breast Cancer

TDXD

Endocrine Therapy

CDK4/6 Inhibitors

Cdk4-6 Inhibitors

Her2-Low Breast Cancer

Hormone Receptor-Positive Breast Cancer

Selective Estrogen Receptor Degraders

HER2 Positive Breast Cancer

Featuring one-on-one interviews conducted by Dr Neil Love, this series bridges the gap between research and patient care by providing medical oncologists, hematologists and hematology-oncology fellows ongoing access to the perspectives and opinions of national and international breast cancer clinical investigators.

97 ratings

Publishes	Weekly	Episodes	499	Founded	20 years ago
Number of Listeners		Categories	ScienceHealth & FitnessMedicine

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Guests Hosts Reviews Charts Talking Points

Latest Episodes

ER-Positive, HER2-Positive Metastatic Breast Cancer — Patterns of Care Among Community Oncologists

Featuring perspectives from Dr Lisa A Carey and Dr Maha Hussain, including the following topics:

• Introduction (0:00)

• HER2 History (1:32)

• Cases from the GMO Survey (7:06)

• Biology and Selection of First-Line Therapy for HR-Positive, HER2-Posit... more

3 Sep 2026 • 58 min

YouTube

Metastatic Triple-Negative Breast Cancer — Patterns of Care

Featuring perspectives from Prof Peter Schmid and Dr Melinda Telli, including the following topics:

• Introduction: TROP2-Targeting Antibody-Drug Conjugates (ADCs) for Metastatic Triple-Negative Breast Cancer (0:00)

• First-Line Therapy (PD-L1 Negat... more

28 Aug 2026 • 1 hr 2 min

YouTube

HR-Positive Metastatic Breast Cancer — Year in Review Series on Relevant New Datasets and Advances in the PI3K/AKT/mTOR Pathway

Featuring perspectives from Dr Virginia Kaklamani and Dr Hope S Rugo, including the following topics:

• Introduction: San Antonio Memories (0:00)

• PI3K/AKT/PTEN Alterations and Therapies (7:18)

• Capivasertib (20:22)

• Gedatolisib (34:08)

• Inavoli... more

24 Aug 2026 • 58 min • Most popular

For Oncology Nurses: Oral Selective Estrogen Receptor Degraders in Breast Cancer — Proceedings from the 2026 Annual ONS Congress

Featuring perspectives from Ms Blanca Ledezma, Dr Marissa Marti-Smith, Dr Heather McArthur and Dr Ruth M O'Regan, moderated by Dr McArthur, including the following topics:

• Introduction (0:00)

• Current Clinical Role of Oral Selective Estrogen Rece... more

18 Aug 2026 • 1 hr 27 min

YouTube

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Recent Guests

Rashma Mataani

Oncologist at Miami Cancer Institute and Baptist Health South Florida

Miami Cancer Institute, Baptist Health South Florida

Episode: ER-Positive, HER2-Positive Metastatic Breast Cancer — Patterns of Care Among Community Oncologists

Lisa Carey

Oncologist at UNC Health and affiliated centers

UNC Health, Chapel Hill

Episode: ER-Positive, HER2-Positive Metastatic Breast Cancer — Patterns of Care Among Community Oncologists

Peter Schmid

Professor, Barts Cancer Institute, London

Barts Cancer Institute, London

Episode: Metastatic Triple-Negative Breast Cancer — Patterns of Care

Melinda Telli

Physician, Stanford Cancer Institute

Stanford Cancer Institute

Episode: Metastatic Triple-Negative Breast Cancer — Patterns of Care

Ruth O'Regan

Professor and expert in breast cancer biology and therapies

University of Rochester

Episode: For Oncology Nurses: Oral Selective Estrogen Receptor Degraders in Breast Cancer — Proceedings from the 2026 Annual ONS Congress

Blanca Ledezma

Clinical expert in breast cancer care

University of California, Los Angeles

Episode: For Oncology Nurses: Oral Selective Estrogen Receptor Degraders in Breast Cancer — Proceedings from the 2026 Annual ONS Congress

Marissa Marti-Smith

Oncologist specializing in breast cancer treatment

Texas Oncology

Episode: For Oncology Nurses: Oral Selective Estrogen Receptor Degraders in Breast Cancer — Proceedings from the 2026 Annual ONS Congress

Reva Basho

Oncologist discussing PI3K pathway and mutations

Los Angeles, CA, United States

Episode: For Oncology Nurses: Targeting the PI3K/AKT/mTOR Pathway in HR-Positive Metastatic Breast Cancer — Proceedings from the 2026 Annual ONS Congress

Kelly Fischer

Clinician sharing practical management and patient counseling

Boston, MA, United States

Episode: For Oncology Nurses: Targeting the PI3K/AKT/mTOR Pathway in HR-Positive Metastatic Breast Cancer — Proceedings from the 2026 Annual ONS Congress

Hosts

Neil Love

Host providing interview facilitation and overview context across episodes.

Sara Tolaney

Host and moderator with clinical perspective in breast cancer.

Erica Mayer

Faculty guest, oncologist; provides clinical trial experience and ESR1 mutation perspective.

Reviews

4.5 out of 5 stars from 97 ratings

Misc
Overall wonderful updates. Listen to these while driving. Would however appreciate if the Oncology nursing series was on a separate platform or podcasts. When one is driving the podcasts roll on and I don’t want to hear the nursing discussions .It is somewhat dangerous to be messing with the podcasts while driving. (With all due respect to nursing collegues). Also in areas where there is no reception, manually skipping a talk often just causes the connection to drop.
Apple Podcasts
5
worldhobo
United States5 years ago
Hem/onc fellow
I’m very grateful for these podcasts and educational videos and definitely owe majority of my hem/onc knowledge to Dr. Love! Looking forward to many more episodes across different disease sites!
Apple Podcasts
5
hem/onc fellow
United States7 years ago
Hemonc fellow
Outstanding discussions! I especially like the fact they those are patient centered and touch upon some ethical/personal dilemmas! I really hope to hear annual update, thank you Dr. Love!
Apple Podcasts
5
kdarbin
United States7 years ago
Hem/Onc fellow
Because of this podcast my knowledge in this field has grown substantially. It has helped me to keep up with the new data to deliver the best care to my patients. Thank you Dr. Love
Apple Podcasts
5
John.KH
United States7 years ago
The best
Simply one of the best most complete and informative podcasts in any medical topic ever made. I am a pediatrician and do not treat cancer. Yet I listen to every new episode. Outstanding.
Apple Podcasts
5
Bob a la sob mob
United States7 years ago

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Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Guests provide robust data-driven discussions with real-world applicability.

The host consistently delivers precise questions that extract practical clinical insights.

Audience notes driving-related navigation issues but overall high quality.

Content is patient-centered and ethically mindful, offering thoughtful perspectives on dilemmas.

Listeners praise breadth of topics from ADCs to SERDs and trial interpretations.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Apple Podcasts	#125	South Korea/Science
Apple Podcasts	#189	Argentina/Science
Apple Podcasts	#194	India/Science

Talking Points

Recent interactions between the hosts and their guests.

HER2-Positive Metastatic Breast Cancer — An Interview with Prof Dr Sibylle Loibl on First-Line and Maintenance Therapy

Q: How long should maintenance continue after six cycles of T-DXd, and is there randomized data to guide stopping points?

Maintenance decisions should be made with patients, as no randomized data clearly define stopping after six cycles; some centers consider continuing while tolerating, and future maintenance studies may guide a switch to other regimens, but current practice varies and centers tailor to patient tolerance and preferences.

HER2-Positive Metastatic Breast Cancer — An Interview with Prof Dr Sibylle Loibl on First-Line and Maintenance Therapy

Q: In what situations would you not use T-DXd in first-line therapy?

The main limiting factors are frailty, age-related considerations, and significant preexisting pulmonary disease; otherwise, many patients without severe comorbidities were included in trials, favoring broader use with careful monitoring.

Breast Cancer — Proceedings from a Session Held in Conjunction with the 2026 ASCO Annual Meeting on the Use of Oral SERDs and Agents Targeting the PI3K/AKT/mTOR Pathway

Q: What is your view on using gerodestrant in adjuvant settings if approved, and how would you sequence it with CDK4/6 inhibitors in higher-risk patients?

The consensus acknowledged gerodestrant's potential, particularly in intolerant patients or those needing long-term endocrine therapy alternatives, but emphasized that sequencing with CDK4/6 inhibitors would be tailored to risk level and tolerability, with a preference to defer until CDK4/6 inhibitors have been used in higher-risk patients unless data strongly support earlier use.

Breast Cancer — Proceedings from a Session Held in Conjunction with the 2026 ASCO Annual Meeting on the Use of Oral SERDs and Agents Targeting the PI3K/AKT/mTOR Pathway

Q: Would you use a CERD monotherapy or a CERD plus targeted agent in ESR1-mutant patients who progressed after CDK4-6 inhibitors?

Many panelists favored a CERD-containing combination in ESR1-mutant patients with prior CDK4/6 inhibitors to address cross-resistance, though some remained cautious about monotherapy in certain contexts; the discussion highlighted ebalance between efficacy and toxicity, and the potential sequencing of CERDs with mTOR/PI3K inhibitors.

Breast Cancer — Proceedings from a Session Held in Conjunction with the 2026 ASCO Annual Meeting on the Use of Oral SERDs and Agents Targeting the PI3K/AKT/mTOR Pathway

Q: What first-line treatment would you recommend for a 65-year-old woman with HR-positive HER2-low metastatic breast cancer who develops metastatic disease after AI therapy and has a PI3K mutation?

The panel favored a combination approach in many scenarios, often preferring triplets or CERD-containing regimens in endocrine-resistant settings, especially if there is a PI3K mutation; however, decisions were individualized based on mutation status, prior therapies, and tolerability, with some favoring triplets like fulvestrant plus CDK4/6 inhibitors with a PI3K inhibitor when feasible.

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Frequently Asked Questions About Breast Cancer Update

What is Breast Cancer Update about and what kind of topics does it cover?

This program features expert clinicians and researchers sharing in-depth discussions on breast cancer, with a strong emphasis on HR-positive, HER2-negative and HER2-positive disease, PI3K/AKT/mTOR pathway inhibitors, SERDs, CDK4/6 inhibitors, ADCs, and emerging targeted therapies. Episodes often center on clinical trial data, sequencing of therapies, toxicity management, real-world practice, and nuanced decision-making across adjuvant, neoadjuvant, and metastatic settings. The format typically uses one-on-one or panel-driven conversations with renowned investigators, offering practical insights for treating physicians, fellows, and advanced practitioners while highlighting patient-centered considerations and real-world challenges in toxicit... more

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Which podcasts are similar to Breast Cancer Update?

These podcasts share a similar audience with Breast Cancer Update:

1. Two Onc Docs
2. Gastrointestinal Cancer Update
3. Oncology Today with Dr Neil Love
4. Lung Cancer Update
5. Research To Practice | Oncology Videos

How many episodes of Breast Cancer Update are there?

Breast Cancer Update launched 20 years ago and published 499 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Breast Cancer Update?

Recent guests on Breast Cancer Update include:

1. Rashma Mataani
2. Lisa Carey
3. Peter Schmid
4. Melinda Telli
5. Ruth O'Regan
6. Blanca Ledezma
7. Marissa Marti-Smith
8. Reva Basho

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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