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Artwork for Breast Cancer Update

Breast Cancer Update

Dr. Neil Love
Breast Cancer
Antibody-Drug Conjugates
Clinical Trials
Triple Negative Breast Cancer
Metastatic Breast Cancer
Triple-Negative Breast Cancer
Metastatic Triple-Negative Breast Cancer
Her2-Positive Breast Cancer
ESR1 Mutations
Chemotherapy
Quality Of Life
Er-Positive Metastatic Breast Cancer
Tdxd
Endocrine Therapy
Cdk4-6 Inhibitors
CDK4/6 Inhibitors
Her2-Low Breast Cancer
Hormone Receptor-Positive Breast Cancer
Selective Estrogen Receptor Degraders
HER2 Positive Breast Cancer

Featuring one-on-one interviews conducted by Dr Neil Love, this series bridges the gap between research and patient care by providing medical oncologists, hematologists and hematology-oncology fellows ongoing access to the perspectives and opinions of national and international breast cancer clinical investigators.

PublishesTwice weeklyEpisodes499Founded20 years ago
Number of ListenersCategories
ScienceHealth & FitnessMedicine

Listen to this Podcast

Artwork for Breast Cancer Update

Latest Episodes

Featuring perspectives from Dr David W Cescon, including the following topics:

• Clinical treatment of BRCA-mutated metastatic triple-negative breast cancer (0:00)

• CNS activity of TROP2-directed antibody-drug conjugates (5:36)

• Autoimmune conside... more

YouTube

Featuring perspectives from Dr David W Cescon, including the following topics:

• First-line treatment of metastatic triple-negative breast cancer (mTNBC) in patients not eligible for immunotherapy (0:00)

• First-line treatment of mTNBC in patients e... more

YouTube

Featuring perspectives from Dr Aditya Bardia, Dr Kevin Kalinsky and Dr Joyce O'Shaughnessy, including the following topics:

• Introduction (0:00)

• Hormone Receptor-Positive Breast Cancer — Dr Kalinsky (1:18)

• HER2-Positive Breast Cancer — Dr Bardi... more

YouTube

Featuring perspectives from Dr Lisa A Carey and Dr Maha Hussain, including the following topics:

• Introduction (0:00)

• HER2 History (1:32)

• Cases from the GMO Survey (7:06)

• Biology and Selection of First-Line Therapy for HR-Positive, HER2-Posit... more

YouTube

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Recent Guests

David Cescon
Dr. David Cescon, Princess Margaret Cancer Centre/U of Toronto clinician
Princess Margaret Cancer Centre, University of Toronto
Episode: Metastatic Triple-Negative Breast Cancer — 5-Minute Journal Club Activity 2 with Dr David W Cescon
Kevin Kalinsky
Medical Oncologist, Winship Cancer Institute of Emory University
Emory University
Episode: Breast Cancer — Reviewing Key Presentations from the 2026 ASCO Annual Meeting
Rashma Mataani
Oncologist at Miami Cancer Institute and Baptist Health South Florida
Miami Cancer Institute, Baptist Health South Florida
Episode: ER-Positive, HER2-Positive Metastatic Breast Cancer — Patterns of Care Among Community Oncologists
Lisa Carey
Oncologist at UNC Health and affiliated centers
UNC Health, Chapel Hill
Episode: ER-Positive, HER2-Positive Metastatic Breast Cancer — Patterns of Care Among Community Oncologists
Peter Schmid
Professor, Barts Cancer Institute, London
Barts Cancer Institute, London
Episode: Metastatic Triple-Negative Breast Cancer — Patterns of Care
Melinda Telli
Physician, Stanford Cancer Institute
Stanford Cancer Institute
Episode: Metastatic Triple-Negative Breast Cancer — Patterns of Care
Ruth O'Regan
Professor and expert in breast cancer biology and therapies
University of Rochester
Episode: For Oncology Nurses: Oral Selective Estrogen Receptor Degraders in Breast Cancer — Proceedings from the 2026 Annual ONS Congress
Blanca Ledezma
Clinical expert in breast cancer care
University of California, Los Angeles
Episode: For Oncology Nurses: Oral Selective Estrogen Receptor Degraders in Breast Cancer — Proceedings from the 2026 Annual ONS Congress
Marissa Marti-Smith
Oncologist specializing in breast cancer treatment
Texas Oncology
Episode: For Oncology Nurses: Oral Selective Estrogen Receptor Degraders in Breast Cancer — Proceedings from the 2026 Annual ONS Congress

Hosts

Neil Love
Host providing interview facilitation and overview context across episodes.
Sara Tolaney
Host and moderator with clinical perspective in breast cancer.
Erica Mayer
Faculty guest, oncologist; provides clinical trial experience and ESR1 mutation perspective.

Reviews

4.5 out of 5 stars from 87 ratings
  • Misc

    Overall wonderful updates. Listen to these while driving. Would however appreciate if the Oncology nursing series was on a separate platform or podcasts. When one is driving the podcasts roll on and I don’t want to hear the nursing discussions .It is somewhat dangerous to be messing with the podcasts while driving. (With all due respect to nursing collegues). Also in areas where there is no reception, manually skipping a talk often just causes the connection to drop.

    Apple Podcasts
    5
    worldhobo
    United States5 years ago
  • Hem/onc fellow

    I’m very grateful for these podcasts and educational videos and definitely owe majority of my hem/onc knowledge to Dr. Love! Looking forward to many more episodes across different disease sites!

    Apple Podcasts
    5
    hem/onc fellow
    United States7 years ago
  • Hemonc fellow

    Outstanding discussions! I especially like the fact they those are patient centered and touch upon some ethical/personal dilemmas! I really hope to hear annual update, thank you Dr. Love!

    Apple Podcasts
    5
    kdarbin
    United States7 years ago
  • Hem/Onc fellow

    Because of this podcast my knowledge in this field has grown substantially. It has helped me to keep up with the new data to deliver the best care to my patients. Thank you Dr. Love

    Apple Podcasts
    5
    John.KH
    United States7 years ago
  • The best

    Simply one of the best most complete and informative podcasts in any medical topic ever made. I am a pediatrician and do not treat cancer. Yet I listen to every new episode. Outstanding.

    Apple Podcasts
    5
    Bob a la sob mob
    United States7 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Guests provide robust data-driven discussions with real-world applicability.
The host consistently delivers precise questions that extract practical clinical insights.
Audience notes driving-related navigation issues but overall high quality.
Content is patient-centered and ethically mindful, offering thoughtful perspectives on dilemmas.
Listeners praise breadth of topics from ADCs to SERDs and trial interpretations.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Apple Podcasts
#123
Saudi Arabia/Science
Apple Podcasts
#179
Singapore/Science
Apple Podcasts
#190
Israel/Science
Apple Podcasts
#195
United Arab Emirates/Science
Apple Podcasts
#229
New Zealand/Science

Talking Points

Recent interactions between the hosts and their guests.

Metastatic Triple-Negative Breast Cancer — 5-Minute Journal Club Activity 1 with Dr David W Cescon
Q: What is the impact of PD-L1 status and immunotherapy combinations on first-line treatment in this context, particularly with ASCENT-04 and KENO-355 like regimens?
Immunotherapy combinations can yield deep, durable responses in PD-L1 positive patients, but benefits depend on patient selection and trial design; ongoing data suggest potential new standard-of-care options, though longer follow-up is needed to confirm overall survival advantages and to define which patients benefit most.
Metastatic Triple-Negative Breast Cancer — 5-Minute Journal Club Activity 1 with Dr David W Cescon
Q: With no head-to-head trials, how should clinicians think about choosing between ASCENT-03 and Tropion Breast O2 in first-line, PD-L1 negative, immunotherapy-ineligible patients?
Clinicians should consider crossover design, local drug availability, toxicity management needs (e.g., myelosuppression for SG vs stomatitis/ocular toxicity for datapodumab), and patient-specific factors such as prior exposure and comprehensive risk assessment rather than assuming one agent is universally superior.
Metastatic Triple-Negative Breast Cancer — 5-Minute Journal Club Activity 1 with Dr David W Cescon
Q: Do you prefer one of the Trope II ADCs in any situation, for example in rapid relapsers where data exist for one agent but not the other?
In practice, availability and patient-specific factors such as prior therapies and disease biology drive choice; while both agents show superior activity to chemotherapy, differences in toxicity profiles and approval status influence sequencing, with a leaning toward using the agent that best aligns with a patient's risk profile and access at the time.
Breast Cancer — Reviewing Key Presentations from the 2026 ASCO Annual Meeting
Q: What are your thoughts on using ESR1 mutation testing in routine practice, given Serena 6 results and FDA ODAC concerns?
ESR1 mutation testing can guide decisions in patients on AI therapy; Serena 6 provides a rationale for switching to a CDK4-6 inhibitor plus a PI3K-targeted or SERD option in ESR1-mutant cases, but clinicians should weigh the absence of US approval for some strategies and consider patient-specific factors and biomarker dynamics.
Breast Cancer — Reviewing Key Presentations from the 2026 ASCO Annual Meeting
Q: Aditya, how do you see the Elegant Study (L-acestrin) fitting with Lidera and MAMA-Print data in the adjuvant setting?
Elegant is an adjuvant CERD trial comparing an oral CERD switch strategy versus continuing endocrine therapy, and it mirrors the Lidera concept but with a different design; the data will help clarify whether a switch strategy can be beneficial in partially endocrine-sensitive populations, though direct comparisons to MAMA-Print or Oncotype are not straightforward.

Audience Metrics

Listeners, social reach, demographics and more for this podcast.

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Frequently Asked Questions About Breast Cancer Update

What is Breast Cancer Update about and what kind of topics does it cover?

This program features expert clinicians and researchers sharing in-depth discussions on breast cancer, with a strong emphasis on HR-positive, HER2-negative and HER2-positive disease, PI3K/AKT/mTOR pathway inhibitors, SERDs, CDK4/6 inhibitors, ADCs, and emerging targeted therapies. Episodes often center on clinical trial data, sequencing of therapies, toxicity management, real-world practice, and nuanced decision-making across adjuvant, neoadjuvant, and metastatic settings. The format typically uses one-on-one or panel-driven conversations with renowned investigators, offering practical insights for treating physicians, fellows, and advanced practitioners while highlighting patient-centered considerations and real-world challenges in toxicit... more

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Which podcasts are similar to Breast Cancer Update?

These podcasts share a similar audience with Breast Cancer Update:

1. Two Onc Docs
2. Gastrointestinal Cancer Update
3. Oncology Today with Dr Neil Love
4. Lung Cancer Update
5. Research To Practice | Oncology Videos

How many episodes of Breast Cancer Update are there?

Breast Cancer Update launched 20 years ago and published 499 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

How do I contact Breast Cancer Update?

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What guests have appeared on Breast Cancer Update?

Recent guests on Breast Cancer Update include:

1. David Cescon
2. Kevin Kalinsky
3. Rashma Mataani
4. Lisa Carey
5. Peter Schmid
6. Melinda Telli
7. Ruth O'Regan
8. Blanca Ledezma

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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