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Artwork for Gastrointestinal Cancer Update

Gastrointestinal Cancer Update

Dr. Neil Love
Colorectal Cancer
Immunotherapy
Gastroesophageal Cancer
Biliary Tract Cancers
Circulating Tumor DNA
Gastroesophageal Cancers
Clinical Trials
Hepatocellular Carcinoma
Hepatobiliary Cancers
HER2
Desmoid Tumors
Immune Checkpoint Inhibitors
Targeted Therapy
Adjuvant Chemotherapy
Cholangiocarcinoma
Biliary Tract Cancer
Pancreatic Cancer
Adjuvant Therapy
Neuroendocrine Tumors
Neuroendocrine Carcinoma

This series bridges the gap between research and patient care by providing medical oncologists and hematologists with ongoing access to the perspectives and opinions of national and international clinical investigators with expertise in gastrointestinal cancers.

PublishesWeeklyEpisodes322Founded20 years ago
Number of ListenersCategories
ScienceHealth & FitnessMedicine

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Artwork for Gastrointestinal Cancer Update

Latest Episodes

Featuring perspectives from Ms Caroline Kuhlman, Dr Eileen M O'Reilly, Dr Philip A Philip and Ms Amanda K Wagner, moderated by Dr O'Reilly, including the following topics:

• Introduction (0:00)

• Clinical Presentation and Prognosis of Pancreatic Ade... more

Featuring perspectives from Dr David H Ilson and Dr Kohei Shitara, including the following topics:

• Introduction (0:00)

• Biomarker Evaluation in Localized and Metastatic Disease (1:49)

• Role of Immune Checkpoint Inhibitors in the Management of Ga... more

Featuring perspectives from Dr Yelena Y Janjigian, Dr Manish A Shah and Prof Eric Van Cutsem, moderated by Dr Janjigian, including the following topics:

• Introduction (0:00)

• HER2-Targeted Approaches in Advanced Gastroesophageal Cancers — Prof Van... more

Featuring perspectives from Dr Tanios Bekaii-Saab, Dr Stacey A Cohen and Dr Arvind Dasari, moderated by Dr Bekaii-Saab, including the following topics:

• Introduction (0:00)

• Current and Future Role of Immune Checkpoint Inhibition in the Management... more

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Recent Guests

Caroline Kuhlman
GI oncologist faculty presenter
Mass General Brigham
Episode: For Oncology Nurses: Pancreatic Cancer — Proceedings from the 2026 Annual ONS Congress
Amanda Wagner
GI oncologist faculty presenter
The James Cancer Hospital at Ohio State University
Episode: For Oncology Nurses: Pancreatic Cancer — Proceedings from the 2026 Annual ONS Congress
Philip Philip
GI medical oncologist
Wayne State University
Episode: For Oncology Nurses: Pancreatic Cancer — Proceedings from the 2026 Annual ONS Congress
David Ilson
Dr. David Ilson, Memorial Sloan Kettering Cancer Center
Memorial Sloan Kettering Cancer Center
Episode: Gastroesophageal Cancers — Year in Review Series on Relevant New Datasets and Advances
Kohei Shitara
Dr. Kohei Shitara, National Cancer Center Hospital East
National Cancer Center Hospital East
Episode: Gastroesophageal Cancers — Year in Review Series on Relevant New Datasets and Advances
Dr. Fakih
Contributing clinical investigator
Episode: Colorectal Cancer — Proceedings from a Session Held in Conjunction with the 2026 ASCO Annual Meeting
Dr. Lu
Contributing clinical investigator
Episode: Colorectal Cancer — Proceedings from a Session Held in Conjunction with the 2026 ASCO Annual Meeting
Dr. Said
Contributing clinical investigator
Episode: Colorectal Cancer — Proceedings from a Session Held in Conjunction with the 2026 ASCO Annual Meeting
Kristen Ciombor
Oncologist from Vanderbilt Ingram Cancer Center
Vanderbilt Ingram Cancer Center
Episode: Colorectal Cancer — Fifth Annual National General Medical Oncology Summit

Hosts

Dr. Neal Love
Host of Expert's Second Opinion / Expert Second Opinion / CME host; multiple mentions across episodes
Michael Nakazawa
Doctor presenting case studies from MD Anderson Cancer Center

Reviews

4.3 out of 5 stars from 23 ratings
  • Gastrointestinal Cancers

    Podcast Addict
    5
    Donald Gravenor
    6 years ago

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Apple Podcasts
#79
Philippines/Science

Talking Points

Recent interactions between the hosts and their guests.

Gastroesophageal Cancers — Year in Review Series on Relevant New Datasets and Advances
Q: What did the Matterhorn and Keynote 585 trials teach us about adjuvant immunotherapy vs perioperative strategies in gastric cancer?
Matterhorn showed strong long-term event-free survival benefits with triplet chemotherapy plus durvalumab, supporting aggressive perioperative approaches in patients who can tolerate it. Keynote 585, by contrast, did not demonstrate a PATH-CR benefit in the adjuvant setting, prompting caution about extrapolating immunotherapy benefits to all perioperative contexts and highlighting the importance of backbone chemotherapy choice and timing.
Gastroesophageal Cancers — Year in Review Series on Relevant New Datasets and Advances
Q: Can you walk through the key biomarkers and how you prioritize testing in the first-line metastatic setting if a patient is very ill?
The four key biomarkers—mismatch repair status/MSI, HER2, PD-L1, and CLDN (CLAWD) testing—are prioritized because they drive eligibility for checkpoint inhibitors, HER2-targeted therapy, and chemosensitive regimens. If results are delayed in a very sick patient, start chemotherapy (e.g., Fulfox) and obtain tissue as quickly as possible; in MSI-H patients, checkpoint inhibitors may be particularly beneficial, and testing for DPD deficiency is considered to tailor regimens.
Gastroesophageal Cancers — Proceedings from a Session Held in Conjunction with the 2026 ASCO Annual Meeting
Q: How do you prioritize anti-PD-1/PD-L1 agents when adding them to HER2-directed therapy in first-line treatment?
Most agree there is no definitive superior anti-PD-1/PD-L1 antibody; choices often depend on label, formulation, and local formulary availability, with a tendency to favor agents that balance efficacy with manageable toxicity and practical administration schedules.
Gastroesophageal Cancers — Proceedings from a Session Held in Conjunction with the 2026 ASCO Annual Meeting
Q: What first-line treatment would you recommend for a 65-year-old HER2-positive, PD-L1 CPS zero gastric/gastroesophageal junction cancer?
The panel generally favors HER2-targeted therapy in combination with chemotherapy as a first-line approach, with considerations for anti-PD-1/PD-L1 therapy in selected contexts based on toxicity, accessibility, and patient fitness; however, when Zanidatumab (Zan) is not approved in that setting, full Fox with Trastuzumab remains a common choice.
HER2-Positive Gastrointestinal Cancers — Microlearning Activity 3: Proceedings from a Session Held Adjunct to the 2026 ASCO GI Cancers Symposium
Q: Would you consider TDXD in the second line for a patient with 2+ HER2 status or who has a 2+ISH- or similar discordance?
If the tumor shows strong HER2 amplification and the disease biology supports HER2 targeting, TDXD is favored in appropriate contexts; there is caution about lower copy number or ambiguous HER2 IHC status.

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Frequently Asked Questions About Gastrointestinal Cancer Update

What is Gastrointestinal Cancer Update about and what kind of topics does it cover?

This program focuses on gastrointestinal cancer in a practical, clinically oriented way, often bringing together leading oncologists, surgical and medical specialists, and disease-area experts to discuss the latest trials, biomarkers, and treatment sequencing. Episodes frequently center on immunotherapy and targeted therapies in colorectal and gastroesophageal cancers, MRD/ctDNA-guided decision making, and evolving perioperative and adjuvant strategies, with particular attention to MSI-H/dMMR disease, HER2-altered tumors, and desmoid tumors. Real-world case discussions, practical management tips, and updates from major cancer centers drive conversations, making it useful for practitioners seeking to translate research into patient care and ... more

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Which podcasts are similar to Gastrointestinal Cancer Update?

These podcasts share a similar audience with Gastrointestinal Cancer Update:

1. Lung Cancer Update
2. Two Onc Docs
3. Prostate Cancer Update
4. Breast Cancer Update
5. Hematologic Oncology Update

How many episodes of Gastrointestinal Cancer Update are there?

Gastrointestinal Cancer Update launched 20 years ago and published 322 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Gastrointestinal Cancer Update?

Recent guests on Gastrointestinal Cancer Update include:

1. Caroline Kuhlman
2. Amanda Wagner
3. Philip Philip
4. David Ilson
5. Kohei Shitara
6. Dr. Fakih
7. Dr. Lu
8. Dr. Said

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