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BioVenture VoiCes with Chris Garabedian

BiotechTV
Venture Capital
Biotechnology
Drug Development
Biotech
Biotech Venture Capital
Clinical Trials
Life Sciences
Novartis
Venrock
Entrepreneurship
Rare Diseases
Harvard University
Canaan Partners
Genentech
MIT
Pillar VC
Aditum Bio
Health Tech
Therapeutics
Pharmaceuticals

Hosted by Chris Garabedian, meet the leading Voices in the BioVenture community and hear their insights and perspectives on the challenges and successes with VC investing.

PublishesTwice monthlyEpisodes36Foundeda year ago
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Life SciencesScience

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Latest Episodes

Simeon George discusses his early days at SR One while it was part of GSK, and the transition to making the firm independent in 2020. Plus, the importance of peer-to-peer collaboration, and his how he thinks about investing in different indications a... more

He discusses learnings from his decades in venture at Sofinnova Investments including 'products vs platform', therapeutics areas of interest, modalities, and how he utilizes board seats and thinks about management teams.

Jessica Owens discusses the many experiences she has had in her career, including working on the venture side at Kleiner Perkins and Versant Ventures and on the operating side at Genomic Health and Grail. She highlights the value of VCs being able to... more

Brett Zbar describes his early career, including working at Aisling Capital and Foresight Capital, and now managing the healthcare strategy at General Atlantic. He describes how he sees the difference between private equity and venture capital, and d... more

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Recent Guests

Simeon George
CEO and co-founder of SR One
SR One
Episode: Episode 37: SR One's Simeon George
Jim Healy
Managing Partner and Chairman
Sofinnova Investments
Episode: Episode 36: Sofinnova Invetments' Jim Healy
Brett Zbar
Managing Director and Head of Global Life Sciences at General Atlantic
General Atlantic
Episode: Episode 34: General Atlantic's Brett Zbar
Art Pappas
Founder and managing partner of Pappas Capital
Pappas Capital
Episode: Episode 33: Pappas Capital's Art Pappas
Bob Nelsen
Managing Director and Co-Founder of ARCH Venture Partners
ARCH Venture Partners
Episode: Episode 32: ARCH Venture Partners' Bob Nelsen
David Berry
Managing Partner at Averin Capital
Averin Capital
Episode: Episode 29: Averin Managing Partner David Berry
Srini Akkaraju
Founder and Managing General Partner of Samsara Biocapital
Samsara Biocapital
Episode: Episode 24: Samsara Biocapital's Srini Akkaraju
Vineeta Agarwala
General Partner at A16Z and physician-scientist
A16Z
Episode: Episode 23: a16z's Vineeta Agarwala
Glenn Rockman
Managing Partner at Adjuvant Capital with experience in the venture capital space focused on public health.
Adjuvant Capital
Episode: Episode 22: Adjuvant Capital's Glenn Rockman

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Talking Points

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Episode 37: SR One's Simeon George
Q: What guidance can you share about building a successful biotech investment firm post-independence?
Key lessons include focusing on people as the core determinant of success, maintaining strong external relationships with pharma and other investors, and balancing risk with strategic, disciplined capital deployment. He also notes the importance of patient capital, portfolio construction driven by power laws, and being willing to back founders with conviction even in high-risk space.
Episode 37: SR One's Simeon George
Q: How did SR One evolve from a GSK venture arm to an independent firm?
Initial acquisitions of independence began with leadership changes, expanded geographic hubs, and a strategic shift to larger checks and early/late-stage investments, all while maintaining GSK as an anchor LP. The guest emphasizes a firewall between corporate and investment activities to ensure fiduciary duty to portfolio companies, and highlights the importance of trust and alignment with senior stakeholders.
Episode 37: SR One's Simeon George
Q: What were you thinking when you pursued an MD/MBA and considered how to apply those degrees beyond practicing medicine?
The guest explains that the combination opened doors to broader opportunities at the intersection of science and business, with a focus on enabling founders to realize the potential in biotech, rather than a traditional clinical path. He experimented through internships and found venture capital to be a compelling way to leverage scientific insight to help companies grow and bring medicines to patients.
Episode 36: Sofinnova Invetments' Jim Healy
Q: How do you balance staying on boards for value creation versus exiting to redeploy capital?
We stay on boards for as long as there's meaningful upside and ongoing data that could improve returns; we tend to hold for late-stage value creation when the incremental data justifies it, but we also monitor liquidity and opportunity costs carefully.
Episode 36: Sofinnova Invetments' Jim Healy
Q: What is Sofinnova's core investment strategy and how has it evolved?
We focus on de-risked clinical-stage investments with four pillars: high medical need, high likelihood of success, clear value-creation paths, and IPO/M&A optionality. Over time we've shifted to predominantly clinical-stage work and refined our portfolio with a two-tier approach that balances risk and potential liquidity.

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Frequently Asked Questions About BioVenture VoiCes

What is BioVenture VoiCes about and what kind of topics does it cover?

Biotech venture-focused conversations that center on how leading venture firms source, evaluate, and scale breakthrough therapies. Episodes profile fund strategies, portfolio construction, and governance, with deep dives into early-stage risk, platform vs. single-product approaches, regulatory dynamics, and the evolving role of AI and data in drug discovery. Across interviews, listeners get practical takeaways on due diligence, founder support, and navigating financing cycles, as guests reveal lessons from building independent biotech platforms, managing portfolios through downturns, and balancing pharma relationships with independent capital.

Noteworthy angles include insider perspectives on portfolio bets, exits, and strategic partnershi... more

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Which podcasts are similar to BioVenture VoiCes?

These podcasts share a similar audience with BioVenture VoiCes:

1. Biotech Hangout
2. The Long Run with Luke Timmerman
3. BioCentury This Week
4. BiotechTV - News
5. The Readout Loud

How many episodes of BioVenture VoiCes are there?

BioVenture VoiCes launched a year ago and published 36 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on BioVenture VoiCes?

Recent guests on BioVenture VoiCes include:

1. Simeon George
2. Jim Healy
3. Brett Zbar
4. Art Pappas
5. Bob Nelsen
6. David Berry
7. Srini Akkaraju
8. Vineeta Agarwala

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