Rephonic
Artwork for BIOACTIVE
Cannabis
Cannabinoid Hyperemesis Syndrome
Cannabis Cultivation
Endocannabinoid System
Cannabis Education
Cannabis Industry
Terpenes
Mental Health
Cheese Making
Dry Herb Vaping
Psychedelics
Natural Products
Nausea
Vomiting
Medical Cannabis
Exercise
Consumer Safety
Cannabinoids
THCA
Anxiety

Dr. Riley Kirk is a cannabis research scientist and educator. She obtained her Ph.D. in pharmaceutical sciences, specializing in natural product chemistry, studying the traditional and contemporary uses of hundreds of medicinal plants. She is currently an assistant associate professor at the University of Rhode Island, has worked as an immunology scientist in the biotech industry, and works in the... more

PublishesTwice monthlyEpisodes98Founded3 years ago
Number of ListenersCategories
NatureScience

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Artwork for BIOACTIVE

Latest Episodes

What is living soil cannabis cultivation, and how do soil microbes, mineral balancing, and growing environments influence cannabis plants? On this episode of the Bioactive Podcast, Dr. Riley Kirk sits down with Luna Whitcomb, an organic cannabis cult... more

YouTube

What are cannabis terpenes, how do they influence aroma and consumer experiences, and what do we know about their safety? On this episode of the Bioactive Podcast, Dr. Riley Kirk sits down with Dr. Shawna Vreeke, PhD, DABT, Head of Toxicology at True... more

YouTube

Dr. Riley Kirk welcomes Dr. Miyabe Shields for a deep dive into cannabis real-world data, cannabis consumption patterns, dosing, neurodivergent cannabis use, and the Endocannabinoid System (ECS). As co-founders of the Network of Applied Pharmacognosy... more

YouTube

What if carbon is one of the most overlooked inputs in plant nutrition? In this episode of the Bioactive Podcast, Dr. Riley Kirk sits down with Nik Nikolayev, CEO of Rooted Leaf Agritech, to explore the science of carbon-based fertilizers, plant nutr... more

YouTube

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Recent Guests

Luna Whitcomb
Organic cannabis cultivator, consultant, writer, and breeder with more than 18 years of experience
Moon Grown Botanicals
Episode: Organic Cannabis Cultivation: Living Soil, Microbes & Terpenes with Luna Whitcomb
Shawna Vreeke
PhD chemist and toxicologist specializing in vaping chemistry, aerosol safety and risk assessment
True Terpenes
Episode: The Science of Terpenes with Dr. Shawna Vreeke
Miyabe Shields
Co-founder of NAP; researcher focusing on real-world cannabis data
Network of Applied Pharmacognosy (NAP)
Episode: Cannabis and Real World Data with Dr. Miyabe Shields
Nick Nikolaev
Owner of Rooted Leaf Agritech
Rooted Leaf Agritech
Episode: Unlocking Plant Potential: The Science of Carbon and Natural Fertilizers with Nik Nikolayev
Dr. Denise Valenti
Cannabis impairment researcher and optometry/retina expert
Episode: Cannabis and Driving with Dr. Denise Valenti
Dr. Rick Pescatore
Emergency physician; BellyMD founder focusing on gut-brain interaction disorders
BellyMD
Episode: The Gut-Brain Axis with Dr. Rick Pescatore
Max Jackson
Founder of Cannabis Wise Guys, policy translator and advocate
Cannabis Wise Guys
Episode: What went down at the Cannabis Rescheduling Hearing with Max Jackson
Ben Cleary
Research scientist, Village Farms International (formerly Pure Sun Farms)
Village Farms International
Episode: Should THC Be a Range Instead of One Number? with guest Ben Cleary
Jim Riddle
Seed breeder and seed company owner; advocate for seed freedom in hemp and cannabis
Seed breeder; American Seed Innovation and Growth Alliance (SIGA)
Episode: Stop the Seed Ban! with Jim Riddle

Host

Dr. Riley Kirk
Cannabis research scientist and educator; co-founder of the Network of Applied Pharmacognosy (NAP); focuses on chemistry and pharmacology of natural products and cannabis.

Reviews

5.0 out of 5 stars from 350 ratings
  • Effects of CBD vs THC

    There were a few episodes that alluded to the effects of Cannabis on the heart. As I understand, CBD doesn’t affect the heart the same way THC does, and when people refer to this effect, there is no distinction between the two. It would be great to hear an episode about the differences and the benefits/side effects of one vs the other and the differentiation.

    Apple Podcasts
    5
    Bunneh🐰🐇
    Canada2 months ago
  • Great show

    Great show. I always learn something new.

    Apple Podcasts
    5
    Thegoodtwin1994
    United Statesa year ago
  • Great podcast for the info you seek

    I’m learning a lot of solid info and expanding my knowledge about medicinal plants.

    Apple Podcasts
    5
    ilikecool
    United Statesa year ago
  • Love it, great for weed nerds

    Love Riley and Miyabee both amazingly talented people with a gift for making cannabis and personal well being exciting, empowering and fun. If your looking for insight into your own personal well being you might find this to be the insight you need. Cheers fellow nerds!

    Apple Podcasts
    5
    JP From NB
    Canada3 years ago
  • Best Podcast 🙌🏼👏🏼

    As a cannabis biology and chemistry student attending university this podcast is extremely inspiring. Hearing what Dr. Kirk has done and continues to do gives me hope that cannabis will become more widely accepted and appreciated for its medicinal values. In addition how she is able to describe everything is chefs kiss, personally i am able to grasp the concepts that she explains… where as in lecture i have to go back watch videos and take extra notes. Plus the other natural products this podcas... more

    Apple Podcasts
    5
    🧪🥼🧫
    United States3 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Positive: episodes are seen as informative for cannabis biology, regulation, and health topics.
Positive: guests are described as knowledgeable and credible, with a strong emphasis on education.
Positive: listeners praise accessible science communication and practical insights for growers and patients.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Apple Podcasts
#51
United States/Science/Nature
Apple Podcasts
#153
Canada/Science/Nature
Apple Podcasts
#229
United Kingdom/Science/Nature
Apple Podcasts
#39
Australia/Science/Nature
Apple Podcasts
#193
Germany/Science/Nature
Apple Podcasts
#230
Australia/Science

Talking Points

Recent interactions between the hosts and their guests.

Organic Cannabis Cultivation: Living Soil, Microbes & Terpenes with Luna Whitcomb
Q: Do you think you can tell by just rolling or smoking or smelling something, whether it's living soil or not?
Whitcomb can often distinguish sun-grown from indoor cannabis, but says she would not reliably identify every living-soil sample in a blind test. Living soil may support greater aroma-compound diversity, but that depends on the cultivation and environment.
Organic Cannabis Cultivation: Living Soil, Microbes & Terpenes with Luna Whitcomb
Q: If somebody wanted to get into this, say they want to grow at home using living soil, is the first thing to get a soil test or is the first thing to do kind of trial and error with different nutrients or like, what is the stepping point to get into this type of cultivation?
Whitcomb recommends starting with living soil already prepared and balanced by knowledgeable growers, then watering it. Those who want to learn the underlying science can study soil mineral balancing theory and get soil tested to guide amendments.
The Science of Terpenes with Dr. Shawna Vreeke
Q: What is happening to terpenes when we take them in edible form? Do we know what's happening? Is this entourage effect that you've been talking about, is that still present if we are ingesting our terpenes in edible form compared to inhaling them?
Vreeke says oral terpene effects are supported by animal studies, but oral dosing may need to be higher because absorption and metabolism differ from inhalation. The role of emulsions and carrier oils remains an important research question.
The Science of Terpenes with Dr. Shawna Vreeke
Q: Can we make any claims based on the science that's been published about terpene profiles being related to specific effects on the consumer when they're consuming that product?
Vreeke says research and consumer reports indicate terpene profiles can affect experience, including in combination with cannabinoids, but researchers still need to establish meaningful doses, ratios and differences by route of exposure.
Cannabis and Driving with Dr. Denise Valenti
Q: What is the current best practice for evaluating cannabis impairment at roadside?
There is no single perfect biomarker; a combination of tests (eye movement, pupil responses, balance/sway, and possibly saliva tests) is considered more informative, but courtroom acceptance and standardization across jurisdictions remain major challenges.

Audience Metrics

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Frequently Asked Questions About BIOACTIVE

What is BIOACTIVE about and what kind of topics does it cover?

Across episodes, the show centers on cannabis science, policy, and practical application, with frequent deep dives into how biology, chemistry, and regulation shape real-world use. Listeners get tightly argued perspectives on topics like regulatory changes, cannabinoid chemistry, plant genetics, tissue culture, soil science, and medical contexts such as CHS and TBI, all framed by a science-forward host who connects academia, industry, and consumers. A standout aspect is the blend of rigorous scientific discussion with accessible storytelling and concrete takeaways for growers, patients, and professionals, plus guests ranging from researchers and clinicians to policy advocates and industry practitioners. This makes it a compelling pick for l... more

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1. The Joe Rogan Experience
2. The MeatEater Podcast
3. Radio Rental
4. SmartLess
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BIOACTIVE launched 3 years ago and published 98 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on BIOACTIVE?

Recent guests on BIOACTIVE include:

1. Luna Whitcomb
2. Shawna Vreeke
3. Miyabe Shields
4. Nick Nikolaev
5. Dr. Denise Valenti
6. Dr. Rick Pescatore
7. Max Jackson
8. Ben Cleary

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