
是由两位生物医药领域的科研工作者发起的聊天类播客。我们关注生命如何走到今天,以及如何让ta更好。 商务合作:zyx3200@163.com
| Publishes | Monthly | Episodes | 65 | Founded | 4 years ago |
|---|---|---|---|---|---|
| Language | Number of Listeners | Categories | ScienceLeisure |

「安慰剂」在新药研发过程中处处可见,amylose 和 amylopectin是安慰剂糖丸的主要成分,其实就是淀粉(标题注释)。
安慰剂效应究竟是应该被消除的统计噪声,还是一种被低估的真实治疗机制?当一针生理盐水能让帕金森患者的大脑释放出与真药相当的多巴胺,当假手术的疗效与真手术完全持平。我们要回答的问题是:如果安慰剂这么强,新药研发的投入还有意义吗?如果安慰剂能治病,我们可以只给病人吃糖丸吗?这期节目我们一起聊聊安慰剂效应在大脑中究竟通过哪些神经通路起效;它为什么越来越强以至于成为新药研发的障... more
2026 年 5 月底,一项名为 RESolute 302 的三期临床试验结果登上了 ASCO 压轴场。10 多年来,胰腺癌的中位总生存期,都卡在 6 个月出头,而一款叫做 Daraxonrasib 的新药,把这个数字拉到了 13.2 个月——死亡风险下降了 60%。
为什么这件事如此震撼?因为它攻克的靶点叫做 KRAS——一个 1982 年就已被发现、与三成人类癌症相关、在胰腺癌中突变率接近 95%,却被整个科学界宣判了近 40 年"不可成药"的基因。这期节目里,我们聊了聊 RAS 蛋白到底是... more
SSRI,全称 selective serotonin reuptake inhibitor,中文叫做选择性血清素再摄取抑制剂,是目前全球使用最广泛的抗抑郁药物。百忧解、左洛复、来士普,这些名字你可能不陌生。仅在美国,2023年就有约11.4%的成年人在服用抗抑郁药物处方。在全球抗抑郁药市场中,SSRI 占据了超过55%的份额,市场规模在2024年达到187亿美元,而且还在持续增长。
这类药物之所以能走到今天的位置,背后有一个支撑它的理论——「血清素假说」,也就是抑郁症是因为大脑里的血清素不足。... more
这期节目的起点是人类学家 Helen Fisher 的著作《我们为什么相爱》,我们打开大脑,问一个更底层的问题:当我们爱上一个人,神经里究竟发生了什么?
原来,浪漫爱的底层驱动不是快乐,而是渴望——多巴胺的工作是让你"想要",而不是让你"享受"。分手时经历的不只是情绪,而是真实的戒断反应,包括身体上的疼痛。
你会在这期听到:草原田鼠和山地田鼠为什么是动物界的"模范夫妻"和"渣男"?间歇性随机奖励为什么比稳定的爱更容易上瘾?以及失恋后为什么"越想停止反思、越停不下来"?
【时间轴】
[02:45]... more
我与科研也快谈了6年了,主持人所谈的顾虑与选择都是我当下的迷茫点,然而主持人好的一点。起码有个喜好种子,然而我还没有找到这个种子
生物狗每期必听
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Apple Podcasts | #72 |
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