Rephonic
Artwork for Approved
Amylin Pharmaceuticals
Biotech Industry
Botox
FDA
Eli Lilly
Glp-1
GERON Corporation
Allergan
Byetta
Telomerase
Imetelstat
Embryonic Stem Cells
Merck
Pd-1

Life sciences, under the hood. Deep dives into the patent filings, regulatory gauntlets, and capital-risks that shape the business of biology.

PublishesMonthlyEpisodes6Founded8 months ago
Number of ListenersCategories
Life SciencesBusinessEntrepreneurshipScience

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Artwork for Approved

Latest Episodes

The wild story of how a Cold War bioweapon became Botox — and how Allergan turned a sleepy ophthalmology drug into an enduring aesthetic franchise.

Every part of this story looks nothing like your normal blockbuster drug. Botox started its developme... more

Approved tells the definitive stories behind the world's most interesting biotech ventures. 

Most people learn about the industry in a fragmented, ad hoc way-- an industry article here, a clinical trial readout there, some science twitter.  In contr... more

Blueprint Medicines was built to find the next Gleevec-style cancer drug. It ended up pivoting to allergic disease instead, and selling to Sanofi for $9B. This is the platform, the pivot, and who got paid.

Blueprint Medicines set out to be the natur... more

Keytruda is Merck's $31 billion a year PD-1 inhibitor and the best-selling cancer drug of all time. In Episode 3 of Approved, Alex Kesin and Matthew Pech trace the development of pembrolizumab , featuring interviews the scientists who drove the progr... more

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Recent Guests

Gavin Herbert Jr.
Founder of Allergan, early sales leader
Allergan
Episode: Allergan: Botox, Rogue Scientists, and the Ultimate Beauty Franchise
Eric Johnson
Professor who helped manufacture the clinical toxin
University of Wisconsin
Episode: Allergan: Botox, Rogue Scientists, and the Ultimate Beauty Franchise
Eric Finzi
Dermatologist researching depression treatment with Botox
Episode: Allergan: Botox, Rogue Scientists, and the Ultimate Beauty Franchise
Alan Scott
Eye surgeon who pioneered Botox clinical use
Smith-Kettlewell Eye Research Institute
Episode: Allergan: Botox, Rogue Scientists, and the Ultimate Beauty Franchise
Brent Saunders
CEO of Allergan during late 2000s-2010s
Allergan/AbbVie
Episode: Allergan: Botox, Rogue Scientists, and the Ultimate Beauty Franchise
Carl Lamina
FDA insider formerly at Camp Dietrich/bioweapons program
FDA
Episode: Allergan: Botox, Rogue Scientists, and the Ultimate Beauty Franchise
Mariana Castells
Clinician researcher, Mastocytosis Center, Brigham and Women's Hospital
Brigham and Women's Hospital
Episode: Blueprint Medicines: Chasing Gleevec to a $9B Allergy Drug
Tim Guzi
Head of Medicinal Chemistry (Blueprint at the time)
Blueprint Medicines
Episode: Blueprint Medicines: Chasing Gleevec to a $9B Allergy Drug
Erika Evans
Former VP of Biology at Blueprint
Blueprint Medicines / Curie Bio
Episode: Blueprint Medicines: Chasing Gleevec to a $9B Allergy Drug

Hosts

Matthew Pech
Cancer biologist and drug hunter; host/co-host of the show
Alex Kesin
Biotech writer and co-host; known for deep-dive industry context

Reviews

4.9 out of 5 stars from 101 ratings
  • Please stop ad reads

    Brothers, your ad reads are comically bad. I’m not asking you to channel Daniel Day Lewis during them but rn they’ve got the jilted cadence of a porn actor. Figure it out. Otherwise, good pod.

    Apple Podcasts
    5
    Stevie_Spielberg
    United States2 months ago
  • Best Biotech Podcast

    Where others interview today's CEO about tomorrow's pipeline, they examine what actually happened and why it mattered. They go back to primary sources — patents, SEC filings, clinical records — to reconstruct the origin story and the critical decisions that shaped it.

    Best Biotech Podcast to learn the ins and outs of the industry. Highly recommend it.

    Apple Podcasts
    5
    mevesavard
    United States5 months ago
  • Aquired for life sciences

    That’s it

    Apple Podcasts
    5
    4k4m41
    Sweden6 months ago
  • Fantastic work

    This was fantastically interesting! Thank you

    Apple Podcasts
    5
    Jk,:
    United States7 months ago
  • Great start!

    Really appreciate you doing this! Re: Donald Rumsfeld, beyond serving as Secretary of Defense for two Presidents, he was also CEO of GD Searle.

    Apple Podcasts
    5
    Aidan Finley
    United States8 months ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

The focus on primary sources and patents makes the content uniquely rigorous.
Great way to understand the real-world decisions behind drug development and financing.
Excellent bioscience storytelling with deep dives into origin stories and regulatory hurdles.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Audience Metrics

Listeners, social reach, demographics and more for this podcast.

Listeners per EpisodeGender SkewLocation
InterestsProfessionsAge Range
Household IncomeSocial Media Reach

Frequently Asked Questions About Approved

What is Approved about and what kind of topics does it cover?

A reporting-style show that blends science, business strategy, and dealmaking in biopharma. Episodes often trace a biotech venture from discovery through funding, regulatory hurdles, and clinical milestones, with deep dives into platform biology, pivotal drug candidates, and the capital dynamics shaping outcomes. Listeners get practical takes on market timing, strategic pivots, and the stories behind blockbuster therapies, including how teams navigate IPOs, licensing, acquisitions, and evolving scientific paradigms. A standout aspect is the willingness to reconstruct origin stories from primary sources, patent histories, and trial data, offering a rare blend of technical detail and business context that's valuable for founders, investors, a... more

Where can I find podcast stats for Approved?

Rephonic provides a wide range of podcast stats for Approved. We scanned the web and collated all of the information that we could find in our comprehensive podcast database. See how many people listen to Approved and access YouTube viewership numbers, download stats, audience demographics, chart rankings, ratings, reviews and more.

How many listeners does Approved get?

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What are the audience demographics for Approved?

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How many subscribers and views does Approved have?

To see how many followers or subscribers Approved has on Spotify and other platforms such as Castbox and Podcast Addict, simply upgrade your account. You'll also find viewership figures for their YouTube channel if they have one.

Which podcasts are similar to Approved?

These podcasts share a similar audience with Approved:

1. The Long Run with Luke Timmerman
2. The Readout Loud
3. Biotech Hangout
4. BioCentury This Week
5. Odd Lots

How many episodes of Approved are there?

Approved launched 8 months ago and published 6 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

How do I contact Approved?

Our systems regularly scour the web to find email addresses and social media links for this podcast. We scanned the web and collated all of the contact information that we could find in our podcast database. But in the unlikely event that you can't find what you're looking for, our concierge service lets you request our research team to source better contacts for you.

Where can I see ratings and reviews for Approved?

Rephonic pulls ratings and reviews for Approved from multiple sources, including Spotify, Apple Podcasts, Castbox, and Podcast Addict.

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What guests have appeared on Approved?

Recent guests on Approved include:

1. Gavin Herbert Jr.
2. Eric Johnson
3. Eric Finzi
4. Alan Scott
5. Brent Saunders
6. Carl Lamina
7. Mariana Castells
8. Tim Guzi

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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