Rephonic
Artwork for Approved
Amylin Pharmaceuticals
Eli Lilly
Glp-1
GERON Corporation
Byetta
Telomerase
Imetelstat
Embryonic Stem Cells
Merck
Pd-1

Life sciences, under the hood. Deep dives into the patent filings, regulatory gauntlets, and capital-risks that shape the business of biology.

PublishesInfrequentlyEpisodes4Founded7 months ago
Number of ListenersCategories
Life SciencesBusinessEntrepreneurshipScience

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Artwork for Approved

Latest Episodes

Blueprint Medicines was built to find the next Gleevec-style cancer drug. It ended up pivoting to allergic disease instead, and selling to Sanofi for $9B. This is the platform, the pivot, and who got paid.

Blueprint Medicines set out to be the natur... more

Keytruda is Merck's $31 billion a year PD-1 inhibitor and the best-selling cancer drug of all time. In Episode 3 of Approved, Alex Kesin and Matthew Pech trace the development of pembrolizumab , featuring interviews the scientists who drove the progr... more

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TABLE OF CONTENTS

(00:00:00) - Introduction 

(00:01:19) - Hayflick Limit 

(00:08:30) - Michael West & Founding of Geron 

(00:15:16) - Early Science & IP Strategy 

(00:27:25) - Cloni... more

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TABLE OF CONTENTS

(00:00:00) - Introduction

(00:04:40) - $50 of Dried Lizard Venom

(00:29:17) - Fax of Death

(00:43:04) - Sleeping Beauty Awakens

(00:52:07) - Carl Icahn Sends a Let... more

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Recent Guests

Mariana Castells
Clinician researcher, Mastocytosis Center, Brigham and Women's Hospital
Brigham and Women's Hospital
Episode: Blueprint Medicines: Chasing Gleevec to a $9B Allergy Drug
Tim Guzi
Head of Medicinal Chemistry (Blueprint at the time)
Blueprint Medicines
Episode: Blueprint Medicines: Chasing Gleevec to a $9B Allergy Drug
Erika Evans
Former VP of Biology at Blueprint
Blueprint Medicines / Curie Bio
Episode: Blueprint Medicines: Chasing Gleevec to a $9B Allergy Drug
Christoph Lengauer
Founding CSO, Blueprint Medicines
Blueprint Medicines
Episode: Blueprint Medicines: Chasing Gleevec to a $9B Allergy Drug
Jeff Albers
Former CEO, Blueprint Medicines
Blueprint Medicines
Episode: Blueprint Medicines: Chasing Gleevec to a $9B Allergy Drug
Alexis Borisy
Founding partner at Third Rock; founder of Curie Bio
Third Rock Ventures / Curie Bio
Episode: Blueprint Medicines: Chasing Gleevec to a $9B Allergy Drug
Greg Carven
Organon inventor on Keytruda patent
Organon (Netherlands)
Episode: Keytruda: How Merck's Pembrolizumab Became the Best-Selling Cancer Drug of All Time
Michel Streuli
Immunology and tumor immunology leader at Organon Cambridge site
Organon Cambridge / Organon (Netherlands)
Episode: Keytruda: How Merck's Pembrolizumab Became the Best-Selling Cancer Drug of All Time
Roy Baynes
Former Chief Medical Officer, Merck Research Laboratories
Merck
Episode: Keytruda: How Merck's Pembrolizumab Became the Best-Selling Cancer Drug of All Time

Reviews

4.7 out of 5 stars from 44 ratings
  • Best Biotech Podcast

    Where others interview today's CEO about tomorrow's pipeline, they examine what actually happened and why it mattered. They go back to primary sources — patents, SEC filings, clinical records — to reconstruct the origin story and the critical decisions that shaped it.

    Best Biotech Podcast to learn the ins and outs of the industry. Highly recommend it.

    Apple Podcasts
    5
    mevesavard
    United States4 months ago
  • Aquired for life sciences

    That’s it

    Apple Podcasts
    5
    4k4m41
    Sweden5 months ago
  • Fantastic work

    This was fantastically interesting! Thank you

    Apple Podcasts
    5
    Jk,:
    United States5 months ago
  • Great start!

    Really appreciate you doing this! Re: Donald Rumsfeld, beyond serving as Secretary of Defense for two Presidents, he was also CEO of GD Searle.

    Apple Podcasts
    5
    Aidan Finley
    United States7 months ago

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Apple Podcasts
#20
United States/Science/Life Sciences
Apple Podcasts
#192
United States/Science
Apple Podcasts
#17
United Kingdom/Science/Life Sciences
Apple Podcasts
#17
Canada/Science/Life Sciences
Apple Podcasts
#169
Canada/Science
Apple Podcasts
#212
United Kingdom/Science

Audience Metrics

Listeners, social reach, demographics and more for this podcast.

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Household IncomeSocial Media Reach

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Which podcasts are similar to Approved?

These podcasts share a similar audience with Approved:

1. The Readout Loud
2. BioCentury This Week
3. Biotech Hangout
4. Dwarkesh Podcast
5. The a16z Show

How many episodes of Approved are there?

Approved launched 7 months ago and published 4 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Approved?

Recent guests on Approved include:

1. Mariana Castells
2. Tim Guzi
3. Erika Evans
4. Christoph Lengauer
5. Jeff Albers
6. Alexis Borisy
7. Greg Carven
8. Michel Streuli

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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