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What's it Worth? A Journal Club Podcast

Diana Langworthy
Autism Spectrum Disorder
Attention-Deficit/hyperactivity Disorder
Staphylococcus Aureus
Migraine
Obesity
Evidence-Based Healthcare
Clinical Trials
Tylenol
Intellectual Disability
Acetaminophen (tylenol)
Evidence
Vaccines
OPAT
Oral Switch
Non-Inferiority Trial
Staphylococcus Aureus Bacteremia
Sglt-2 Inhibitors
Glp-1 Receptor Agonists
Dpp-4 Inhibitors
COPD

Get into the weeds with us as we take deep dives into clinical trials and build the essential skills of evidence critique! This podcast is a tool for healthcare professions students and practitioners to sharpen their science sleuth skills, learn key concepts about study design, biostatistics, and application of evidence to clinical practice.

PublishesTwice monthlyEpisodes39Founded3 years ago
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MedicineHealth & Fitness

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Artwork for What's it Worth? A Journal Club Podcast

Latest Episodes

In this What's It Worth? For Everyone episode, we're talking about AFib, blood thinners, and liver disease.

AFib stands for atrial fibrillation. It is a common heart rhythm problem that can increase the risk of stroke. Because of that stroke risk, ... more

For patients with atrial fibrillation and chronic liver disease, the "correct" anticoagulation strategy has long been a clinical catch-22. Balancing the high risk of stroke against the elevated risk of catastrophic bleeding—all while navigating a lac... more

Welcome to What's It Worth? For Everyone — a shorter, everyone-friendly version of What's It Worth? focused on making health evidence clearer, calmer, and easier to use.

In this episode, Dr. Diana Langworthy revisits the recent What's It Worth? lon... more

Welcome back to What's it Worth! Join your host, Dr. Diana Langworthy, and guests Dr. Alexis Quade and Dr. Tory Pressman, as they break down a 2026 systematic review and meta-analysis evaluating prenatal paracetamol exposure and child neurodevelopmen... more

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Recent Guests

Dr. Tory Pressman
Pediatrician
Unspecified in transcript
Episode: S4E6.5 - What's It Worth? For Everyone: Does Tylenol Cause Autism? What Studies Can and Can't Tell Us
Dr. Alexis Quade
Internal Medicine Pediatrics hospitalist
Unspecified in transcript
Episode: S4E6.5 - What's It Worth? For Everyone: Does Tylenol Cause Autism? What Studies Can and Can't Tell Us
Alexis Quade
Board-certified internal medicine pediatrics hospitalist
University of Minnesota
Episode: S4E6 - Tylenol and Neurodevelopmental Disorders: Reassurance from a 2026 Systematic Review
Tory Pressman
Board-certified pediatrician
M Health Fairview Rosemount Clinic
Episode: S4E6 - Tylenol and Neurodevelopmental Disorders: Reassurance from a 2026 Systematic Review
Alexandra Rola
Clinical Assistant Professor focusing in ambulatory care and psychiatry
Binghamton University College of Pharmacy
Episode: S4E4 - Beyond Dopamine: Xanomeline-Trospium in Acute Schizophrenia
Mia Lussier
Clinical Assistant Professor at Binghamton University School of Pharmacy and Pharmaceutical Sciences; practices in primary care
Binghamton University; United Health Services
Episode: S4E3 - The GLP-1 Battle: Cardiovascular outcomes of Tirzepatide vs. Dulaglutide in the SURPASS-CVOT Trial
Dr. Rachel Khan
Associate professor at VCU School of Pharmacy; nephrology clinical pharmacist
Virginia Commonwealth University (VCU)
Episode: S4E2 - The Kidney Formula Conundrum: Navigating eCrCl vs. eGFR in DOAC Dosing
Ben Webber
Hospitalist and Senior Medical Director for the Adult Wards on the East Bank campus
University of Minnesota Medical Center
Episode: S3E13 | Secondary SBP Prophylaxis — Asking Better Questions of Retrospective Data
Kylee Funk
Associate professor at the University of Minnesota College of Pharmacy; clinical pharmacist in ambulatory care
University of Minnesota
Episode: S3E12 | Tirzepatide vs Semaglutide for Obesity — What Did SURMOUNT-5 Teach Us?

Host

Dr. Diana Langworthy
Host of What's it Worth?For Everyone; primary presenter

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S3E8 | SABATO Trial - Oral vs IV Antibiotics for Uncomplicated MSSA Bacteremia
Q: What practical factors affect implementing an oral switch in SAB?
Adherence, pharmacokinetics and bioavailability of oral agents (especially for MSSA), potential adverse events, and the need to rule out deeper infection sources with appropriate imaging and follow-up, all influence whether an oral switch is appropriate.
S3E8 | SABATO Trial - Oral vs IV Antibiotics for Uncomplicated MSSA Bacteremia
Q: What were the primary outcomes and how were they defined?
The primary outcome was a composite of relapse of SAB, deep-seated infection with SAB, or death attributable to SAB, measured from end of therapy to 90 days after first positive culture, with an emphasis on attribution to SAB rather than all-cause mortality.
S3E8 | SABATO Trial - Oral vs IV Antibiotics for Uncomplicated MSSA Bacteremia
Q: Why is the non-inferiority margin a point of contention?
The trial started with a 5% margin but widened to 10% due to slow recruitment; this wider margin increases the chance of declaring non-inferiority even if clinically meaningful differences exist, which raises concerns about statistical and clinical significance.
S3E8 | SABATO Trial - Oral vs IV Antibiotics for Uncomplicated MSSA Bacteremia
Q: What were the main treatment comparisons in the Sabato trial?
Patients were randomized to continue IV antibiotics for the full course or switch to an oral regimen after an initial period of IV therapy, with five to seven days of IV antibiotics required before switching, provided the infection was deemed low-risk and appropriate therapy had begun within 72 hours.
S4E2 - The Kidney Formula Conundrum: Navigating eCrCl vs. eGFR in DOAC Dosing
Q: What are the practical implications of adopting race-free eGFR equations for dosing in clinics?
Clinics should consider standardizing to race-free eGFR for drug dosing, account for body surface area adjustments when using these equations for medications, and involve patients in shared decision-making given the nuances of dosing across kidney function estimates.

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Frequently Asked Questions About What's it Worth? A Journal Club Podcast

What is What's it Worth? A Journal Club Podcast about and what kind of topics does it cover?

This show acts as a practical journal club for healthcare professionals, focusing on in-depth evaluations of clinical trials, study design, and evidence interpretation. Episodes cover topics from trial methodologies and statistical concepts to real-world clinical decision-making across therapeutic areas such as anticoagulation, GLP-1 therapies, migraine management, obesity treatments, COPD, schizophrenia, and vaccine safety. A distinctive strength is the emphasis on critical thinking, uncertainty, and clear communication with patients and clinicians, often featuring subject-matter experts who translate complex trial design into actionable clinical guidance. The format is brisk and data-driven, with episodes frequently unpacking trial design... more

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What guests have appeared on What's it Worth? A Journal Club Podcast?

Recent guests on What's it Worth? A Journal Club Podcast include:

1. Dr. Tory Pressman
2. Dr. Alexis Quade
3. Alexis Quade
4. Tory Pressman
5. Alexandra Rola
6. Mia Lussier
7. Dr. Rachel Khan
8. Ben Webber

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