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UnHack with Drex DeFord

This Week Health
Cybersecurity
Healthcare IT
Healthcare
Imposter Syndrome
Healthcare Technology
Ransomware
Cyber Insurance
Change Healthcare
Data Breaches
The 229 Project
Return To Work Policies
Ascension Hack
Ransomware Attack
SOAR Conference
HHS Cybersecurity Regulations
Generative AI
Patient Engagement
Epic
Rural Hospitals
Cybersecurity Insurance

Cyber-safety is patient-safety. On “UnHack,” Drex DeFord, veteran healthcare CIO and infused strategist, breaks down the biggest cybersecurity and risk challenges facing healthcare today. Drex and expert guests explore what happened, why it matters, and how to build real-world resilience. The show's a mostly plain-English, mostly non-technical discussion that dives into the people, process, and te... more

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Latest Episodes

Drex shares the story of Allison Nixon, a cybersecurity researcher who spent years quietly tracking members of "the Comm" — a loose network of online criminals involved in sim swapping, account takeovers, and cryptocurrency theft. When a hacker known... more

March 9, 2026: What happens when well-meaning clinicians use AI tools that no one approved? Bill Russell and Drex Ford are joined by Dr. Holly Urban, Vice President of Business Development at Wolters Kluwer, to unpack a revealing new survey on shadow... more

A curious engineer in Spain reverse-engineered his robot vacuum to control it with a PlayStation controller, and accidentally gained access to 7,000 vacuums worldwide. No malware, no brute force, just a broken authentication model where one token ope... more

March 2, 2026: Is the CIO role evolving? Or is it quietly being replaced? Bill Russell, Drex DeFord, and Sarah Richardson dig into the emerging CITO trend, the rise of citizen developers, and what AI-powered platforms like Epic's Agent Factory actual... more

Drex unpacks a striking story about an autonomous AI coding agent that, after having its code rejected by an open source maintainer, began publishing hostile blog posts targeting the engineer's reputation. What started as a routine code review turned... more

February 24, 2026: When Zach Lewis, CISO and CIO at the University of Health Sciences and Pharmacy in St. Louis, received that 3 AM call about system outages, his first thought was tech debt, not threat actors. What followed was a masterclass in rans... more

February 23, 2026: Jacob Hansen, Chief Product and Technology Officer at AvaSure, joins Bill, Sarah, and Drex for a critical conversation about healthcare's looming AI battleground. As Epic launches its agent factory and ambient listening wars intens... more

February 16, 2026: Bill, Drex, and Sarah discuss the explosion of autonomous AI agents around moltbook and CommonSpirit's stunning $1.9 billion decision to terminate their revenue cycle partnership. Moltbot (formerly ClaudeBot) has evolved into an un... more

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Recent Guests

Zach Lewis
CIO and CISO at the University of Health Science and Pharmacy
University of Health Science and Pharmacy
Episode: UnHack the Podcast: Inside a Real LockBit Attack - Lessons From Fighting Ransomware with Zach Lewis
Laura O'Toole
CEO of SureTest.
SureTest
Episode: Newsday: CMS ACCESS Model & Tech-Enabled Care with Laura O’Toole
Charles Knight
Founder and Managing Partner at EHC Consulting
EHC Consulting
Episode: Newsday: Preparing for Cloud Outages and Phishing Attacks with Charles Knight
Will Houston
Network Security Manager at Mount Desert Island Hospital.
Mount Desert Island Hospital
Episode: Solution Showcase: Pro Security In Your Pocket With Will Houston, Preston Duren, and Spencer Bales
Preston Duren
Vice President of Threat Services at Fortified Health Security.
Fortified Health Security
Episode: Solution Showcase: Pro Security In Your Pocket With Will Houston, Preston Duren, and Spencer Bales
Spencer Bales
Vice President of Product at Fortified Health Security.
Fortified Health Security
Episode: Solution Showcase: Pro Security In Your Pocket With Will Houston, Preston Duren, and Spencer Bales
Shawna Hofer
CISO at St. Luke's Health System in Boise, Idaho
St. Luke's
Episode: UnHack (the Podcast): Breaking Down Silos and Building Up Culture with Shawna Hofer
Dave Dyell
Principal at Innovative Consulting Group
Innovative Consulting Group
Episode: Newsday: Merger Madness and Why Hospitals are Moving Back to On-Prem Data with Dave Dyell
Kurt Telep
Healthcare Field CTO at Nutanix
Nutanix
Episode: Executive Interview: How Complexity Kills Innovation and Lasting IT Leadership with Kurt Telep

Host

Drex DeFord
A veteran healthcare CIO and infused strategist, Drex DeFord is dedicated to addressing cybersecurity challenges in healthcare. He emphasizes the importance of resilience and the collective effort required across various roles within healthcare organizations to enhance security and patient safety.

Top Technology Podcasts

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AcquiredBen Gilbert and David Rosenthal
Hard Fork
Hard ForkThe New York Times
Tomorrow, Today
Tomorrow, TodayShekhar Natarajan
Technology Now
Technology NowHewlett Packard Enterprise
Dwarkesh Podcast
Dwarkesh PodcastDwarkesh Patel

Talking Points

Recent interactions between the hosts and their guests.

Newsday: Are Health Systems Falling Behind in the Innovation Race? with Jason Rose
Q: Can you say more about the actual execution of ideas from these presentations?
There were less organizations that spoke specifically about results, which raises concerns about the practical execution of visionary ideas presented.
UnHack (the Podcast): Breaking Down Silos and Building Up Culture with Shawna Hofer
Q: What's something about being a health care CISO that most outsiders don't really understand about the job?
Shawna highlights that being a successful health care CISO requires strong relational skills and the ability to work collaboratively with diverse teams, adapting communication to different audiences.
UnHack (the Podcast): Breaking Down Silos and Building Up Culture with Shawna Hofer
Q: How are you all thinking about AI governance and data protection and risks that weren't there six months ago or five or six days ago?
Shawna explains they are embedding new AI governance into existing processes without creating entirely new ones, while also forming an AI governance body to oversee AI initiatives.
UnHack (the Podcast): Breaking Down Silos and Building Up Culture with Shawna Hofer
Q: Tell me about how you have been thinking about the culture built around cybersecurity?
Shawna discusses the importance of making security a shared responsibility through education and initiatives that involve staff at all levels, particularly through community engagement and collaboration.
Executive Interview: How Complexity Kills Innovation and Lasting IT Leadership with Kurt Telep
Q: If you could whisper one piece of advice in a CIO's ear about the future and how they can better engage with it, what would it be?
Focus on simplicity and choose platforms and tools that integrate well, leveraging the resources you already have.

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Frequently Asked Questions About UnHack

What is UnHack about and what kind of topics does it cover?

Focused on the intersection of cybersecurity and healthcare, this series provides insights into the pressing challenges faced by healthcare professionals regarding patient safety and data integrity. Episodes cover a variety of current issues, such as the evolving roles of CISO and CFO in cybersecurity partnerships, innovative technologies like AI, and the implications of insider threats. Engaging discussions often include expert guests who bring a range of perspectives, making the content accessible not only to cyber professionals but also to all healthcare stakeholders, emphasizing the importance of a collective approach to security. Overall, the series is likely to be of interest to those looking to understand how to foster resilience in ... more

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1. The 229 Podcast
2. The AI Daily Brief: Artificial Intelligence News and Analysis
3. Worklife with Adam Grant
4. HBR IdeaCast
5. HBR On Leadership

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UnHack launched 5 years ago and published 222 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on UnHack?

Recent guests on UnHack include:

1. Zach Lewis
2. Laura O'Toole
3. Charles Knight
4. Will Houston
5. Preston Duren
6. Spencer Bales
7. Shawna Hofer
8. Dave Dyell

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