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NEJM AI Grand Rounds

NEJM Group
Artificial Intelligence
AI In Medicine
Healthcare
Machine Learning
Large Language Models
Natural Language Processing
Gpt-4
AI In Healthcare
AI In Cardiology
Patient Care
Computational Biology
Openai
Healthcare Biases
Healthcare Innovation
Drug Repurposing
Medical Education
Radical Abundance
Economics
Productivity
Human Wellbeing

NEJM AI Grand Rounds, hosted by Arjun (Raj) Manrai, Ph.D. and Andrew Beam, Ph.D., features informal conversations with a variety of unique experts exploring the deep issues at the intersection of artificial intelligence, machine learning, and medicine. You’ll learn how AI will change clinical practice and healthcare, how it will impact the patient experience, and about the people who are pushing f... more

PublishesMonthlyEpisodes46Founded4 years ago
Number of ListenersCategories
TechnologyHealth & FitnessMedicine

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Artwork for NEJM AI Grand Rounds

Latest Episodes

A patient can deteriorate while the warning signs remain buried in a noisy electronic record. Dr. Suchi Saria, Founder and CEO of Bayesian Health and a faculty member at Johns Hopkins University, has spent her career trying to surface those signals s... more

Brandon Rice believes that improving health care sometimes means improving the systems behind it. Through his work at Weave, he focuses on modernizing the regulatory infrastructure that helps bring new medicines to market. He discusses the challenge ... more

YouTube

Medical expertise has always been scarce. Dr. Karan Singal believes AI can help change that. Drawing on his work at OpenAI and earlier efforts behind Med‑PaLM, he discusses how clinicians and patients are already using AI to answer questions, support... more

YouTube

Dr. Travis Zack, Chief Medical Officer of OpenEvidence, takes us behind the scenes of the start and growth of the company, and brings a clinician’s perspective to one of medicine’s hardest questions: how should artificial intelligence support decisio... more

YouTube

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Recent Guests

Suchi Saria
CEO of Bayesian Health; Professor of Computer Science
Bayesian Health
Episode: Dr. Suchi Saria on Building AI That Changes Care
Brandon Rice
CEO of Weave Bio
Weave Bio
Episode: Weave’s Brandon Rice on Rebuilding Drug Regulation with AI
Karan Singhal
Leads Health AI at OpenAI
OpenAI
Episode: OpenAI’s Karan Singal on HealthBench and the Future of Medical AI
Travis Zack
Chief Medical Officer, OpenEvidence
OpenEvidence
Episode: The OpenEvidence Episode: Dr. Travis Zack on the Future of Clinical Evidence
Byron Crowe
Chief Medical Officer at Doctronic
Doctronic
Episode: Doctronic’s Autonomous AI with Dr. Byron Crowe
Kyunghyun Cho
Glen de Vries Professor of Health Statistics and Professor of Computer Science and Data Science at New York University
New York University
Episode: AI’s Next Frontier with Dr. Kyunghyun Cho
Seth Hain
SVP of R&D at Epic
Epic
Episode: Epic’s Approach to AI with Seth Hain
Dr. Marinka Zitnik
Associate professor of biomedical informatics at Harvard Medical School, known for her work on AI in drug discovery.
Harvard Medical School
Episode: Bridging AI and Biology to Tackle Medicine’s Hardest Problems with Dr. Marinka Zitnik
Dr. Laura Zwaan
Associate professor at Erasmus University, expert in cognitive psychology and epidemiology
Erasmus University
Episode: From Hindsight Bias to Machine Bias: Dr. Laura Zwaan on Learning from Mistakes

Hosts

Arjun (Raj) Manrai
Co-host and host of the series, affiliated with NEJM Group / NYU, frequently drives discussions on AI in medicine and regulatory implications.
Andrew Beam
Co-host with deep ties to NEJM AI Grand Rounds; leads conversations on AI applications in healthcare, policy, and clinical practice.

Reviews

4.8 out of 5 stars from 121 ratings
  • Fantastic

    Inside scoop on cutting edge thinking in medical AI. You feel like you’re sitting having a coffee with some of the world thought leaders in medical AI. Tends to be a bit more on the ‘computational’ end rather than the clinical, but exactly what I need as a clinical informaticist facing the torrential onslaught of AI. Highly recommended. Thanks guys!!

    Apple Podcasts
    5
    DocDenver
    United States9 months ago
  • Great show, 1 improvement

    Would love to have the links to papers referenced on a show in the show description to save going searching for them. Given it is run by. Medical journal would have expected this :-)

    Apple Podcasts
    5
    rich2011apps
    Australia3 years ago
  • Good show but please use AI to filter out “fillers”

    Enjoyed the podcasts, but in the most recent episode (#13), the interviewee begins with “AND” in nearly every sentence! This really impacted my focusing on the content. I have to skip this episode. This is a podcast on AI. Suggest you make some investments and demonstrate how AI can filter out fillers (AND, LIKE, …) and improve the listener experience of your podcasts! Reputable podcasts or broadcasts do this step to improve listener’s experience.

    Apple Podcasts
    4
    Phan-
    United States3 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Some wish for more direct paper references or links in show notes.
Friction noted with guests' filler speech impacting focus in one episode.
Listeners praise accessible, insightful conversations with world-leading experts in medical AI.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Apple Podcasts
#186
United States/Technology
Apple Podcasts
#220
Canada/Technology
Apple Podcasts
#224
United Kingdom/Technology
Apple Podcasts
#69
Italy/Technology
Apple Podcasts
#148
Australia/Technology
Apple Podcasts
#25
South Korea/Technology

Talking Points

Recent interactions between the hosts and their guests.

Dr. Suchi Saria on Building AI That Changes Care
Q: What prompted the origin of Bayesian Health and your shift from professor to CEO?
After demonstrating that AI could detect sepsis earlier (e.g., median 5.5 hours sooner), the need to translate research into scalable, real-world tools became clear. This led to founding Bayesian Health to translate and scale AI across health systems with rigorous validation and partnerships.
Dr. Suchi Saria on Building AI That Changes Care
Q: What surprised you when moving from retrospective analyses to prospective, multi-site validation of your sepsis risk score?
The biggest surprise was how much more complex real-world evaluation is compared to retrospective metrics; you must define clear ground truth, ensure the signal can actually change care, integrate with workflows, and maintain performance across sites with proper governance and monitoring.
Doctronic’s Autonomous AI with Dr. Byron Crowe
Q: Do you think autonomous AI in medicine will eventually do everything a clinician does?
Crowe argues no; cognitive systems will not fully replace humans due to the unique context and moral agency of clinicians. He envisions AI augmenting clinicians, with humans handling nuanced judgments and values-centered decisions.
Doctronic’s Autonomous AI with Dr. Byron Crowe
Q: What is the Doctronic Utah pilot and how is eligibility determined for patients?
The Utah pilot operates under a state sandbox with physician supervision; patients on existing prescriptions are enrolled by verifying identity and medication history, then undergoing a medical interview to determine eligibility. High-risk/controlled substances and de novo prescriptions are excluded in this phase.
OpenAI’s Karan Singal on HealthBench and the Future of Medical AI
Q: How does a harness affect model performance, and how general is a harness across model generations?
A harness enhances inputs/outputs around the model using domain-specific prompts, tools, and resources; it is designed to be general rather than bespoke to a single model generation, maintaining usefulness as models evolve.

Audience Metrics

Listeners, social reach, demographics and more for this podcast.

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Frequently Asked Questions About NEJM AI Grand Rounds

What is NEJM AI Grand Rounds about and what kind of topics does it cover?

This show features in-depth conversations with leading researchers, clinicians, and industry leaders who are applying artificial intelligence to medicine. Episodes commonly explore how AI can transform regulatory work, clinical decision support, data infrastructure, and the deployment of AI in real-world health systems. Listeners can expect practical discussions about safety, governance, and trust, along with visions for future AI-enabled workflows in healthcare and medicine. A notable strength is bringing senior clinicians and researchers together to bridge theory and implementation, often with concrete examples from startups, hospitals, and large health organizations. This mix makes it useful for audiences evaluating how AI innovations tr... more

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1. JAMA Medical News
2. JAMA Editors' Summary
3. NEJM This Week
4. Ground Truths
5. JAMA Clinical Reviews

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NEJM AI Grand Rounds launched 4 years ago and published 46 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on NEJM AI Grand Rounds?

Recent guests on NEJM AI Grand Rounds include:

1. Suchi Saria
2. Brandon Rice
3. Karan Singhal
4. Travis Zack
5. Byron Crowe
6. Kyunghyun Cho
7. Seth Hain
8. Dr. Marinka Zitnik

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