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天方烨谈

基因频道

华大基因专业团队倾情打造,基因科普娓娓道来!

PublishesDailyEpisodes2001Founded10 years ago
Language
Chinese (Simplified)
Number of ListenersCategories
Natural SciencesHealth & FitnessScience

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Artwork for 天方烨谈

Latest Episodes

被账单追着跑,脑子就转不动——反应变慢、记性变差,这不只是错觉。2026年《创新与衰老》追踪英国1946年出生的近3000人,从26岁跟到71岁:成年期持续经济困难的人,53岁处理速度和言语记忆得分就更低,且呈剂量反应——穷得越久,认知越差。69到71岁的脑扫描里,长期低收入者脑室体积平均多出4.67毫升,本质是脑组织在萎缩。

干细胞喊了20年,第一次以药品身份走到床边。本期《天方夜谭》拆解三个关键:原理——帕金森是中脑黑质多巴胺神经元死亡,iPSC让体细胞返老还童,体外分化成神经前体细胞再植入;数据——《自然》24个月随访,细胞长期存活,4例关期评分平均改善20.4%;现实——日本定价238万已进医保,国内仍在临床阶段,价格与支付都没跑通。

人脑可能不是一个器官,而是两个——这不是科幻,是斯坦福医学院发表在《自然·神经科学》的研究:大脑由两套独立系统拼装,后脑管呼吸心跳,前脑管语言、数学和抽象思维。胚胎最早期就各走通路,一个表达OTX2基因,一个表达GBX2,从不重叠,演化上或可追溯到5亿年前。这也解释了后脑神经元为何一直培养不出来:是一直在逼前脑祖细胞干后脑的活。

年纪越大越忘事,认知下滑就真的拦不住吗?哈佛医学院等机构发表在《自然·神经科学》上的研究刷新了认知:海马体里有一种记忆保护蛋白,在年轻人脑中几乎不露面,年纪越大产量反而越高——默默修补神经连接、指挥免疫细胞清理代谢垃圾,拼尽全力守住记忆力。更有意思的是,一些大脑已出现阿尔茨海默病理改变、记性却很好的老人,这种蛋白水平明显更高。动物实验中,补上它,衰老大脑的神经连接和空间记忆力都能稳住。虽然研究尚处基础科研阶段、暂时无法落地,但多学习、均衡饮食、规律运动、睡好觉,就是在给大脑的维稳部队赋能。善待大... more

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Reviews

4.0 out of 5 stars from 123 ratings
  • This episode can't be played on this device.

    "温柔的手木刀"首次出鞘:中国第

    一例BNCT患者順利完成治疔 This episode can't be played on this device.

    Apple Podcasts
    1
    x.com/zhuangyin8
    United States8 months ago
  • 内容不错,但是人声听起来太费劲,音乐声太大,人声有时又太快,听不清楚

    内容不错,但是人声听起来太费劲,音乐声太大,人声有时又太快,听不清楚

    Apple Podcasts
    3
    hope_zhai
    Chinaa year ago
  • 搞成尹烨的个人秀

    没有什么价值

    Apple Podcasts
    1
    出h哈
    China4 years ago
  • 内容倍棒,音质期待改善

    首次评论app,因为很喜欢与感谢尹烨先生这样不遗余力地并且清晰的科普生命科学知识,使我们普通民众从小到老都能听得懂。小建议是:是否可以稍微改善下录音的质量,回音稍大,孩子刚开始听便问是不是在工厂录制的😂(并且尹总语速本身就快,孩子包括妈妈我也有点难跟上如果只是听podcast而非看视频无字幕的情况下)。

    Apple Podcasts
    5
    Qsdrugrttdg
    Australia5 years ago
  • 非常好

    增长了很多知识

    Apple Podcasts
    5
    seyhai
    China9 years ago

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1. 忽左忽右
2. 东腔西调
3. Talk三联
4. 声动早咖啡
5. 知行小酒馆

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天方烨谈 launched 10 years ago and published 2001 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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