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The Uromigos

The Uromigos
Prostate Cancer
Bladder Cancer
Kidney Cancer
Clinical Trials
Pembrolizumab
Immunotherapy
Renal Cell Carcinoma
Non-Muscle Invasive Bladder Cancer
Belzutifan
Muscle-Invasive Bladder Cancer
Renal Cancer
Urothelial Cancer
Overall Survival
Adjuvant Therapy
Enzalutamide
Biomarkers
Abiraterone
PARP Inhibitors
Chemotherapy
Tar-200

Broadcasting the latest developments in GU cancer Hosted by Brian Rini and Tom Powles Brian Rini MD is an Ingram Professor of Medicine (Hematology/Oncology), Vanderbilt-Ingram Cancer Center Tom Powles is the Director of Barts Cancer Centre, St Bartholomew's Hospital and Professor of Genitourinary Oncology, Queen Mary University of London

PublishesDailyEpisodes501Founded6 years ago
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Latest Episodes

In our final episode recorded at APCCC, Louise Emmett joins us to discuss clinical results and mechanisms of PSMA upregulation by enzalutamide.

Tanya Dorff joins Tom and Brian to discuss her ASCO 2026 data on a novel dual targeting ADC in prostate cancer. The broader scope of ADC development in prostate cancer is discussed with a focus on cytopenia toxicity and future direcctions.

This comprehensive podcast covers the latest advances in prostate, bladder, and kidney cancers from ASCO 2026, including new therapies, trial data, and practice-changing insights. Brian, Tom and Silke analyze recent studies, controversies, and future... more

Mary Ellen Taplin joins us on the heels of her ASCO 2026 Plenary presentation with this exciting phase 3 data certain to generate discussion about the landscape of high risk prostate cancer.

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Recent Guests

Mary Ellen Taplin
Guest, presented the Proteus data in the Ask-O-Plenary session
Dana-Farber Cancer Institute
Episode: Episode 508: ASCO 2026 Plenary - PROTEUS: ADT +/- Apalutamide in high-risk Localized Prostate Cancer
Neeraj Aggarwal
Presented TALAPRO-3 data and discussed trial design
Cancer Center / academic research (inferred)
Episode: Episode 507: ASCO 2026 - TALAPRO-3
Peter O'Donnell
University of Chicago clinician-scientist; presented Kino 905 QoL data
University of Chicago
Episode: Episode 506: ASCO 2026 - How do we measure quality of life in GU patients?
Beth Nally
Clinical research fellow at Barts Cancer Institute; presented QoL work in adjuvant kidney cancer setting
Barts Cancer Institute
Episode: Episode 506: ASCO 2026 - How do we measure quality of life in GU patients?
James Larkin
Presenter of Rampart data and trial contributor
Institute/organization not explicitly stated in transcript
Episode: Episode 505 : ASCO 2026 - RAMPART
Ashish Kamat
Urologic oncologist
MD Anderson Cancer Center; President and Founder of the International Bladder Cancer Group
Episode: Episode 502: AUA 2026 and FDA bladder cancer meeting
Chuck Ryan
Friend of the show and guest on the episode
The Good News About Cancer podcast
Episode: Episode 501: APCCC 2026 - Biochemically-relapsed Prostate cancer
Filippo Pietrantonio
GI Medical Oncologist at the National Cancer Institute of Milan
National Cancer Institute of Milan
Episode: Episode 500: RAS Inhibition in Pancreatic Cancer (yes this is the Uromigos podcast..)
Mike Morris
Radioligand therapy expert
Episode: Episode 499: APCCC 2026 - Radioligands

Hosts

Brian Rini
Host of the show, focusing on GU cancer updates; Ingram Professor of Medicine (Hematology/Oncology)
Tom Powles
Co-host and host, discussing GU oncology data and updates; Director of Barts Cancer Centre

Reviews

4.8 out of 5 stars from 174 ratings
  • Excellent resource for patients anddocs

    The Uromigos keep patients and doctors informed with the very latest studies and research in urogenital cancer. I appreciate their hopeful, upbeat and revealing interviews with cutting edge researchers.

    Apple Podcasts
    5
    Tea Green
    United States9 months ago
  • Informative podcast

    This podcast is a one-stop shop for all things GU oncology. The information is balanced, up to date and relevant for anyone in this field

    Apple Podcasts
    5
    F93111111
    United Kingdom2 years ago
  • Great for staying up on GU oncology

    Drs. Powles and Rini are some of the most eminent current leaders in GU oncology. In this podcast, they discuss recent key studies in the field and really break down the key questions clinicians and patients want to know — are they clinically significant, will they change practice, and what are the next steps? Also, there are a lot of cheesy jokes which this humble listener somehow enjoys.

    Apple Podcasts
    5
    Attentive listener 12345
    United States2 years ago
  • Topical and interesting

    Great discussion of topical issues within the urology space from a engaging, experienced and knowledgeable group of oncologists.

    Apple Podcasts
    5
    Antman1805
    Australia3 years ago
  • Fantastic podcast

    This is a fantastic podcast! Great insight with provocative discussions (while keeping it lighthearted at the same time).... Thank you guys. Keep them coming....

    Apple Podcasts
    5
    Jacky4911
    United States5 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Guests are consistently described as experts who illuminate data without oversimplifying.
Listeners praise clear data interpretation and accessible breakdowns of complex trials.
Audience appreciates a balance of rigor and approachable discussion with practical takeaways.

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Talking Points

Recent interactions between the hosts and their guests.

Episode 510: ADCs in Prostate Cancer
Q: Do the early results justify moving directly to a randomized phase 3, and what factors could influence that decision?
The high PSA50 and objective responses are encouraging, but decisions will hinge on confirming durability, managing hematologic toxicity across broader populations, and ensuring appropriate comparator arms (likely vs. docetaxel) to demonstrate a meaningful advantage.
Episode 510: ADCs in Prostate Cancer
Q: What were the key safety observations in the ABBV969 study, and how might they influence future trial design?
The main safety signal was neutropenia, which was dose-dependent but not associated with febrile neutropenia deaths in the presented data; prophylactic G-CSF and careful dose selection will likely shape phase 3 trial designs.
Episode 510: ADCs in Prostate Cancer
Q: What is the mechanism and potential advantage of ABBV969 compared with earlier PSMA-targeted ADCs?
ABBV969 is dual-targeted, binding both PSMA and STEAP1 to broaden target expression within tumors, which may translate into higher response rates and more durable responses by addressing heterogeneity.
Episode 504: ASCO 2026 - ADC Drug Development in Urothelial Cancer
Q: What other ADCs and targets look promising, and how might we see a diversification of payloads and targets affecting the field in the next few years?
There will likely be a diversification of targets (TROP2, NECTIN-4, FGFR, EGFR-HER3) and payloads (Topo-1, MMAE) with bispecifics and combinations with PD-1/PD-L1 inhibitors; triplet regimens and biomarker-guided selection could become standard, potentially moving some therapies earlier in disease.
Episode 504: ASCO 2026 - ADC Drug Development in Urothelial Cancer
Q: What do you think is the realistic path for novel ADCs? Could we see front-line trials against EVP or move into perioperative space given the transformative 302 data?
A practical path may involve positioning new ADCs in the post-EVP frontline setting and exploring perioperative use, with the possibility of triplet strategies and varied payloads to expand activity; front-line EVP against EV PEMBRO might be feasible in a subset, but many programs will focus on earlier disease where the impact could be greatest.

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Frequently Asked Questions About The Uromigos

What is The Uromigos about and what kind of topics does it cover?

GU cancer-focused discussions featuring in-depth analysis of the latest clinical trial data, real-world practice implications, and trial design nuances. Coverage spans bladder, kidney, and prostate cancer with emphasis on targeted therapies (ADCs, radioligand therapy), sequencing, biomarkers, and quality-of-life considerations in perioperative and metastatic settings. Noteworthy is the consistent emphasis on translating ASCO- and conference-derived findings into clinical decision-making, practical dosing/tolerability strategies, and a transparent critique of study design trade-offs. The show often features expert guests who provide data interpretation, regulatory context, and clinician-oriented insights, making it valuable for oncologists, ... more

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Which podcasts are similar to The Uromigos?

These podcasts share a similar audience with The Uromigos:

1. GU Cast | Urology Podcast
2. ASCO Daily News
3. Two Onc Docs
4. The Daily
5. The Headlines

How many episodes of The Uromigos are there?

The Uromigos launched 6 years ago and published 501 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on The Uromigos?

Recent guests on The Uromigos include:

1. Mary Ellen Taplin
2. Neeraj Aggarwal
3. Peter O'Donnell
4. Beth Nally
5. James Larkin
6. Ashish Kamat
7. Chuck Ryan
8. Filippo Pietrantonio

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