Rephonic
Artwork for GU Cast
Prostate Cancer
Bladder Cancer
Robotic Surgery
GU Oncology
Clinical Trials
KEYNOTE 564
PSMA PET CT
EAU Prostate Cancer Guidelines
Urology
Androgen Deprivation Therapy
Pelvic Lymph Node Dissection
Hormone-Sensitive Prostate Cancer
Biochemical Recurrence
TRANSLATE Trial
Active Surveillance
Metastatic Hormone-Sensitive Prostate Cancer
Theranostics
PSMA Imaging
Docetaxel
PSA Testing

A urology podcast, focussing on prostate cancer, kidney cancer, bladder cancer, testis and penile cancer. Join Professor Declan Murphy and Dr Renu Eapen from Peter MacCallum Cancer Centre in Melbourne for this regular dive into the world of genitourinary (GU) Oncology and Urology. Regular guests from all over the world, from every walk of life. Find out more gucast.org

PublishesWeeklyEpisodes234Founded6 years ago
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MedicineScienceHealth & Fitness

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Artwork for GU Cast

Latest Episodes

Welcome to Episode 8 of our monthly GU Cast Journal Club! Today we focus on two very important papers in localised prostate cancer and metastatic bladder cancer. The landmark 15 year update of the PROTECT trial, published in NEJM in 2023, and the bre... more

Renu had been to an excellent Bayer Apex meeting in Europe in the past, so was very happy to hear Apex was coming to us for its first Asia-Pacific outing! A wonderful prostate cancer Faculty headlined by Neal Shore, Dan George, Derya Tilki, Fred Saad... more

Breaking News podcast just after the long-awaited PROTEUS trial reads out at the ASCO Plenary in Chicago! Plus a simultaneous NEJM paper! Huge day for prostate cancer surgery. 

Declan and Renu are joined by lead author Dr Mary-Ellen Taplin (Dana Farb... more

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Two interesting papers caught the eye of our GU Cast China team this week; the first is the ARASEC trial which Dr Rana McKay read out in the Practice-Changing Plenary at the AUA Annual Meeting in Washington. This is an interesting comparison of ADT +... more

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Recent Guests

Mary-Ellen Taplin
Professor of Medicine at Harvard University and the Dana-Farber Cancer Centre
Harvard Medical School / Dana-Farber Cancer Institute
Episode: Did PROTEUS just change Urology??
Chuguan Yang
Professor, Tonji Hospital
Tonji Hospital, Wuhan
Episode: ARASEC and Lead-in ADT - China focus
Yige Bau
GU Cast China editor, surgeon
China editorial team
Episode: ARASEC and Lead-in ADT - China focus
Matt Roberts
Urologist from Brisbane, co-author
Brisbane, Australia
Episode: Is Copper the new Gold??! Co-PSMA trial in European Urology
Derya Tilki
Deputy Chair, EAU Prostate Cancer Guidelines; expert on guideline updates
Martini Clinic
Episode: EAU Prostate Cancer Guideline Update
Gianluca Giannarini
Chair of the EAU Guideline Dissemination Committee
Udine, Italy
Episode: EAU Prostate Cancer Guideline Update
Deepak Kilari
GU Medical Oncologist
The Medical College of Wisconsin
Episode: ASPIRE-ing to answer the Triplet question! With Rana McKay and Deepak Kilari
Daria Tilkey
Deputy Chair of the EAU Prostate Cancer Guidelines Committee; Chair of the Dissemination Committee
EAU Prostate Cancer Guidelines
Episode: From Studio to Stage: GU Cast Live at EAU in London!
Gianluca Gianarini
Chair of Dissemination Committee of EAU Guidelines; Prostate Cancer Guidelines Committee member
EAU Guidelines
Episode: From Studio to Stage: GU Cast Live at EAU in London!

Hosts

Declan Murphy
Host of GU Cast; clinician and researcher with Peter MacCallum Cancer Centre, Melbourne; long-running presence coordinating GU Cast discussions and live events.
Renu Eapen
Co-host of GU Cast; clinician and researcher focusing on guideline updates, journal clubs, and dissemination.

Reviews

4.7 out of 5 stars from 67 ratings
  • Basically, an advertising platform for pharmaceutical companies

    Disbalanced presentation of pharmaceutical data. Guests can claim anything without critics by the creators. Seems commentators don‘t know anything about the presented trials. Best example Freedland claiming Enza Mono is better tolerated than ADT. Poor performance of Declan Murphy and Renu Eapen. Did you look at the data?

    Apple Podcasts
    2
    DocyG
    Switzerlanda year ago
  • To infinity and beyond

    This is a fantastic way to disseminate urological knowledge and to touch all generations of urologists. Congrats. Morgan Roupret

    Apple Podcasts
    5
    @MRoupret
    France3 years ago
  • Patting the shark

    As a pharma industry colleague we claim to be patient focussed, but do we really know how the patients on our treatments are feeling and thinking? Unless you have walked in someone else’s shoes, you really don’t know. I thought this podcast was excellent! I loved the acronym MEDS, so important for people living with a range of cancers. Thank you Tim Baker for sharing your story. I’m going to buy the book!

    Apple Podcasts
    5
    JenShan28
    Australia3 years ago
  • Great podcast to help keep up to date

    Really enjoy GU casts! Recommended by my consultant and now listen regularly on my commutes. Really up to date with interesting topics. Informal format that makes sometimes complex discussion easier to follow. Would highly recommend for anyone interested in urology

    Apple Podcasts
    5
    Naomi Drye
    United Kingdom4 years ago
  • Definitely worth adding to your favourites if you are interested in GU Oncology

    Declan and Renu do such an amazing job at providing informative, engaging and also entertaining discussion on the important and sometimes controversial topics in GU oncology!

    Apple Podcasts
    5
    meisbac
    Australia4 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Listeners appreciate accessible explainers of complex trials and guidelines.
Feedback notes strong engagement and high-quality guest lineups, with some negative remarks about data critique.
Varied reception with praise for practical clinical insights, though some critiques view promotional bias in trial discussions.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Talking Points

Recent interactions between the hosts and their guests.

Did PROTEUS just change Urology??
Q: How might these results influence clinical practice and future trials?
Given the positive endpoints and the integration of PSMA-PET into endpoints, there is potential for adoption of intensified hormonal therapy in select high-risk patients, with careful consideration of control arms in studies and the possibility of future adjuvant strategies guided by tissue biomarkers like residual cancer burden. Regulatory and guideline bodies will determine adoption timelines, and there is expectation of more phase 3 studies exploring similar approaches and combinations.
Did PROTEUS just change Urology??
Q: First of all, what was Proteus, and what were the primary endpoints?
Proteus was a randomized, blinded phase 3-like trial in high-risk localized prostate cancer comparing intensified androgen pathway inhibition plus ADT versus ADT alone, with six months of preoperative therapy and six months post-prostatectomy. The co-primary endpoints were major pathologic response (PCR MRD) and metastasis-free survival (MFS), using both PSMA-PET and conventional imaging in the assessment.
From Studio to Stage: GU Cast Live at EAU in London!
Q: What are the big changes in the 2026 EAU Prostate Cancer Guidelines?
There were no major changes to the guidelines themselves this year; updates focused on refining risk classifications to align with Cambridge risk groups and clarifying recommendations such as Enzalutamide plus ADT for high-risk biochemical recurrence in MBARC-like patients, while noting data like Micro-ultrasound and NeuroSafe as topics of ongoing discussion.
ASPIRE-ing to answer the Triplet question! With Rana McKay and Deepak Kilari
Q: What exactly is the ASPIRE trial trying to determine?
ASPIRE is testing whether adding docetaxel to the ADT plus ARPI backbone improves outcomes for metastatic hormone-sensitive prostate cancer, compared with the standard ADT plus ARPI without chemotherapy, across a broad patient population with stratification by tumor suppressor gene alterations and disease volume.
Is high-risk BCR really mHSPC?? Live webinar replay
Q: What are the indications for systemic therapy in patients with high-risk BCR?
Jeff indicated that patients with a rapid PSA doubling time and positive PSMA PET findings would generally necessitate systemic options.

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Frequently Asked Questions About GU Cast

What is GU Cast about and what kind of topics does it cover?

Two experienced hosts explore genitourinary oncology through timely trials, guideline updates, journal clubs, and live events. Episodes often center on prostate cancer, PSMA imaging, trial design, and dissemination of research findings across global medical communities, with a mix of clinical, imaging, surgical, and policy perspectives. A standout feature is the guest roster, which frequently includes leading researchers, guideline authors, and international collaborators, creating a broad, practical view of how new evidence translates into practice. Potential listeners include clinicians, researchers, residents, and medical communicators seeking accessible, expert dialogue on evolving GU oncology topics, practical trial takeaways, and stra... more

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How many subscribers and views does GU Cast have?

To see how many followers or subscribers GU Cast has on Spotify and other platforms such as Castbox and Podcast Addict, simply upgrade your account. You'll also find viewership figures for their YouTube channel if they have one.

Which podcasts are similar to GU Cast?

These podcasts share a similar audience with GU Cast:

1. The Uromigos
2. EAU Podcasts
3. Two Onc Docs
4. AUAUniversity
5. BackTable Urology

How many episodes of GU Cast are there?

GU Cast launched 6 years ago and published 234 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on GU Cast?

Recent guests on GU Cast include:

1. Mary-Ellen Taplin
2. Chuguan Yang
3. Yige Bau
4. Matt Roberts
5. Derya Tilki
6. Gianluca Giannarini
7. Deepak Kilari
8. Daria Tilkey

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