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The Skeptics Guide to Emergency Medicine

Dr. Ken Milne
Emergency Medicine
Artificial Intelligence
Evidence-Based Medicine
Pain Management
Ketamine
Pediatric Emergency Medicine
Drug Efficacy
Sepsis
Emergency Department Crowding
Febrile Infants
FDA Approval Process
Covid-19
Acute Aortic Syndrome
Large Language Models
Acute Pain
Critical Thinking
Healthcare
Non-Urgent Patients
Cancer Drugs
Mental Health

Meet 'em, greet 'em, treat 'em and street 'em

PublishesDailyEpisodes300Founded14 years ago
Number of ListenersCategories
EducationHealth & FitnessMedicine

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Artwork for The Skeptics Guide to Emergency Medicine

Latest Episodes

Reference: Huang Y-N, et al. Early Antiviral Therapy in Pediatric Outpatients and Risk of Influenza-Related Hospitalization. Pediatrics. 2026 Date: September 29, 2026 Guest Skeptic: Dr. Gabrielle Jasmine is a pediatric emergency medicine fellow at Ch... more

Date: September 22, 2026 Guest Skeptic: Professor Gordon Guyatt is a physician and Professor of Health Research Methods, Evidence, and Impact at McMaster University, with a joint appointment in Medicine. He coined the term “evidence-based medicine” i... more

Key Facts

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Recent Guests

Ryan Stanton
Emergency physician, creator of the Front Line EM podcast, and president of the American College of Emergency Physicians
American College of Emergency Physicians
Episode: SGEM#524: High, High HOPE for Recovery – Alteplase between 4.5 and 24 hours
Salina Khushal
Pediatric gastroenterologist at Pediatric Specialists of Virginia
Pediatric Specialists of Virginia
Episode: SGEM#523: Everything Grows and Grows…Until it Doesn’t. Clinical Practice Guidelines for Faltering Weight
Aaron Skolnik
Assistant Professor of Emergency Medicine at Mayo Clinic, Alix School of Medicine; Vice Chair of Critical Care Medicine at Mayo Clinic in Arizona
Mayo Clinic
Episode: SGEM#522: Va-so-Pressors – Can You Run Them Peripherally?
Sergey Motov
Emergency physician; researcher on pain management in the ED
Maimonides Medical Center
Episode: SGEM#521: Hit Me with Your Best Shot – IM Ketorolac for Back Pain?
Caitlin Jones
Postdoctoral research associate at Sydney University Institute of Musculoskeletal (paraphrased from intro)
Sydney University Institute of Musculoskeletal
Episode: SGEM#520: It takes my pain away – Morphine, but do I need to add acetaminophen?
Lauren Westafer
Guest skeptic, associate professor in Emergency Medicine
University of Massachusetts Medical School Bay State
Episode: SGEM#519: Don’t Let Pediatric Pulmonary Embolism Leave You Breathless
Roya Caloia
Emergency physician, former EM Program Director, interim associate medical director
Henry Ford Genesys; US Acute Care Solutions
Episode: SGEM#518: What Have You Done for Me Lately – Oseltamivir for Hospitalized Patients?
Carl Heneghan
Professor of Evidence-Based Medicine at the University of Oxford, director of the Centre for Evidence-Based Medicine
University of Oxford, Centre for Evidence-Based Medicine
Episode: SGEM Xtra: Carl Heneghan – Legend of Evidence-Based Medicine
Megan Terle
Orthopedic surgeon, pediatric trauma specialist
UC Davis Health
Episode: SGEM#517 : I Will Try to Fix You. Surgery or Not for Pediatric Displaced Medial Epicondyle Elbow Fractures

Hosts

Ken Milne
Host of The Skeptics Guide to Emergency Medicine
Dennis Wren
Host of SGEM Xtra and co-host in EM skepticism discussions

Reviews

4.6 out of 5 stars from 250 ratings
  • Excited Delirium

    First time listener to the podcast. Like the in depth analysis. E D seems like a very convenient entity/excuse for police to use that in their report (BTW How can a human exhibit “superhuman” qualities?) If that is really a “thing,” if a person were to be exhibiting that behavior, and the police did not intervene (i.e) put a knee on the person’s neck, would the person still have died?

    Apple Podcasts
    5
    Kiddynurse
    United States3 years ago
  • Excellent topics

    Met Dr Milne personally at a conference this week- he is so so personable and intelligent. What a gem and wealth of knowledge!!

    Apple Podcasts
    5
    pinkrunner87
    United States3 years ago
  • Hard to trust

    Muscle relaxants

    A physician that cannot pronounce drug names and thinks people are statistics. No individualized medicine? A study shows if a drug works for a population, not an individual

    You should check the new literature on ‘the placebo effect’ because it turns out not to be what you believe it is.

    P.S. Methocarbamol does a decent job combined with cannabis, especially since nsaids give me mouth ulcers.

    P.P.S. Osteopaths (competent ones) can release that spasm completely at least 7... more

    Apple Podcasts
    3
    Asciguy
    United States4 years ago
  • Political

    I am here to learn about emergency medicine....not to be preached to about race relaions...ughhh.

    Apple Podcasts
    1
    Gorsh
    Canada5 years ago
  • Top drawer

    SGEM is my new fave EM podcast - wish I’d found it earlier! Great work Ken - keep it up!

    Apple Podcasts
    5
    Tombaul
    United Kingdom6 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Some critique pacing or perceived over-enthusiasm, but most impressions are positive on practicality and education.
Listeners appreciate the rigorous, evidence-based lens on EM topics.
Readers note the show as a go-to resource for keeping up with EM research and guidelines.
Fans praise the host for engaging, accessible discussion of complex trials.

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Talking Points

Recent interactions between the hosts and their guests.

SGEM#523: Everything Grows and Grows…Until it Doesn’t. Clinical Practice Guidelines for Faltering Weight
Q: Any guidance on when a kid would need to get admitted versus continuing evaluation and management in the outpatient setting?
Admission is appropriate for acute instability, dehydration or electrolyte problems, severe nutritional compromise, inability to tolerate feeding, a condition requiring inpatient care, or when safe outpatient follow-up cannot be assured. An isolated low percentile or Z score in an otherwise well child without red flags is not by itself a reason to admit.
SGEM#523: Everything Grows and Grows…Until it Doesn’t. Clinical Practice Guidelines for Faltering Weight
Q: How would you recommend that we separate poor weight gain as a non-specific signal from a GI-specific red flag?
Khushal identifies symptoms such as forceful or bilious vomiting, bloody or chronic diarrhea, greasy stools, abdominal distension, swallowing difficulty, feeding refusal, gagging, choking, perianal disease, oral ulcers, and growth deceleration with new gastrointestinal symptoms. Relevant family history and faltering weight despite well-documented caloric intake can also warrant further evaluation.
SGEM#524: High, High HOPE for Recovery – Alteplase between 4.5 and 24 hours
Q: How should clinicians resolve the case of a patient who arrives more than 10 hours after last known well?
Use shared decision-making to discuss the potential functional benefit and increased bleeding risk, then consider the patient's priorities and preferences.
SGEM#524: High, High HOPE for Recovery – Alteplase between 4.5 and 24 hours
Q: Does IV alteplase administered 4.5 to 24 hours after acute ischemic stroke onset improve outcomes in patients with salvageable brain tissue and no initial plan for thrombectomy?
In the HOPE trial, alteplase increased the proportion of patients achieving a modified Rankin Scale score of 0 to 1 at 90 days, but also increased symptomatic intracranial hemorrhage. The evidence came from a highly selected population and does not establish routine treatment through 24 hours.
SGEM#520: It takes my pain away – Morphine, but do I need to add acetaminophen?
Q: What was the design of the OPAL trial and its main result?
A prospective, multicenter, double-blind, placebo-controlled, randomized non-inferiority trial comparing morphine plus placebo versus morphine plus IV acetaminophen in French EDs; it did not establish non-inferiority for morphine alone, suggesting potential additive benefit from acetaminophen but not proving it definitively.

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Frequently Asked Questions About The Skeptics Guide to Emergency Medicine

What is The Skeptics Guide to Emergency Medicine about and what kind of topics does it cover?

A weekly show that rigorously analyzes emergency medicine literature through case-based discussion, trial critique, and practical bedside takeaways. Episodes span topics from pediatric fracture management and prehospital transfusion to antibiotic stewardship and delirium guidelines, all framed around evidence, real-world applicability, and shared decision making with patients and families. A notable strength is the combination of skeptical appraisal with accessible storytelling and humor, helping clinicians translate trials into everyday ED practice.

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Which podcasts are similar to The Skeptics Guide to Emergency Medicine?

These podcasts share a similar audience with The Skeptics Guide to Emergency Medicine:

1. Emergency Medicine Cases
2. EMCrit FOAM Feed
3. Core EM - Emergency Medicine Podcast
4. Critical Care Scenarios
5. Emergency Medicine Board Bombs

How many episodes of The Skeptics Guide to Emergency Medicine are there?

The Skeptics Guide to Emergency Medicine launched 14 years ago and published 300 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on The Skeptics Guide to Emergency Medicine?

Recent guests on The Skeptics Guide to Emergency Medicine include:

1. Ryan Stanton
2. Salina Khushal
3. Aaron Skolnik
4. Sergey Motov
5. Caitlin Jones
6. Lauren Westafer
7. Roya Caloia
8. Carl Heneghan

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