
Your daily pharmaceutical news briefing — FDA decisions, clinical trial results, biotech M&A, and drug pipeline updates in under 15 minutes, every weekday. Hosted by Alex Mercer and Maya Patel. Plus a Week in Review every Sunday synthesizing the week's biggest moves in pharma and biotech. Covering drug approvals, licensing and M&A deals, biopharma investing, and healthcare market intelligence. Sma... more
| Publishes | Daily | Episodes | 152 | Founded | 6 months ago |
|---|---|---|---|---|---|
| Number of Listeners | Categories | Life SciencesScience | |||

AstraZeneca's broader-use trial of Etcamah (camizestrant)missed its primary goal in advanced breast cancer, while the existing approval stands. Scholar Rock's ISEMBYLD (apitegromab) adds a muscle-directed option inspinal muscular atrophy, while Roiva... more
FDA extended its review of Exelixis's zanzalintinib-Tecentriq combination for metastatic colorectal cancer to March 3, 2027, after classifying updated data as a major amendment. Karyopharm missed a $15.8 million loan payment and secured a creditor st... more
Biohaven's FDA partial hold pauses new epilepsy-trialenrollment; the company still expects RISE-3 results this year. AbbVie reports LUNA menstrual-migraine results for oral Qulipta (atogepant), while Shionogi misses a stroke endpoint and Disc Medicin... more
Bayer's Hyrnuo (sevabertinib) gains first-line accelerated approval in HER2-mutant lung cancer, joining an established rival. Permanent FDA center leaders follow repeated turnover, while Structure's experimental obesity pill aleniglipron adds 72-week... more
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- A rapid-fire briefing on the pharma and biotech landscape, with a steady focus on regulatory decisions, FDA/EMA actions, pivotal trial readouts, and major deals. Across episodes, listeners get concise breakdowns of committee votes, data interpretability concerns, and how briefing documents shape market expectations and strategic decisions for developers, investors, and strategists. Notable threads include the regulatory risk around single pivotal readouts, the impact of M&A and deal re-structuring on portfolio strategy, and how market reactions, earnings, and guidance moves drive valuation and messaging in biotech and pharma.
- The show frequently ties regulatory and clinical momentum to near-term business implications, such as launch tim... more
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Recent guests on The Pharma Closeout include:
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2. Nana Loonborg
3. Marcus Webb
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