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The Pharma Closeout | Daily Pharmaceutical & Biotech News in 15 minus

BZ Group
Lilly
Novo Nordisk
Gilead Sciences
Merck & Co.
FDA
Pfizer
Bristol Myers Squibb
Glp-1
Regeneron
GSK
Artificial Intelligence In Pharma
Moderna
Gilead
Abbvie
Eli Lilly
Uniqure
Sun Pharmaceutical Industries
Organon
Apogee Therapeutics
J&J Icotyde

Your daily pharmaceutical news briefing — FDA decisions, clinical trial results, biotech M&A, and drug pipeline updates in under 15 minutes, every weekday. Hosted by Alex Mercer and Maya Patel. Plus a Weekend Edition every Sunday synthesizing the week's biggest moves in pharma and biotech. Covering drug approvals, pharma industry deals, biopharma investing, and healthcare market intelligence. Smar... more

PublishesDailyEpisodes99Founded4 months ago
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Artwork for The Pharma Closeout

Latest Episodes

AstraZeneca's Wainua missed in cardiomyopathy — one of three clinical setbacks in five days even as pharma dealmaking stayed red-hot with Vertex's ~$10B Crinetics buy and GSK's biggest oncology bet in a decade. Webreak down what the Wainua miss means... more

GSK walked away from its $2.2 billion Alector alliance,ending its neuroscience re-entry as clinical setbacks piled up. Plus: the FDA resumes releasing rejection letters with fourteen new CRLs, Hengrui and Elevar's PD-1 liver cancer combo is rejected ... more

AstraZeneca and Ionis's Wainua missed its Phase 3 ATTR-CMendpoint — Ionis fell ~20% while BridgeBio surged ~17%. We break down the CARDIO-T Transform failure and what it means for Alnylam's Amvuttra and BridgeBio's Attruby, plus Roche scrapping tomin... more

The FDA quietly paused publishing complete response letters after a citizen petition — reversing the Makary-era transparency push and closing a live window into rival drug failures. Plus: Sino Biopharmaceutical's dual respiratory deals with AstraZene... more

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Recent Guests

Nana Loonborg
Forbeon's analyst/commentator referenced in discussion
Forbeon
Episode: Jun 04, 2026 | SCOTUS Backs Hikma Skinny-Label Win on Vascepa; ADC Therapeutics Crashes 50% on Death
Marcus Webb
Industry analyst invited for commentary on the Otsuka Transcend Transaction
Otsuka Pharmaceutical
Episode: Mar 27, 2026 | Novo Nordisk's Once-Weekly Insulin Awiqli Wins FDA Approval; $15B+ in Pharma Deals

Hosts

Alex Mercer
Host of The Pharma Closeout; primary anchor across editions; frequently presents market and deal analysis.
Maya Patel
Co-host across editions; provides strategic and market-context commentary.

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Talking Points

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Mar 31, 2026 | Lilly's $7.8B Centessa Deal; Biogen Buys Apellis for $5.6B; FDA Flags Tavneos Deaths | Mar 31, 2026
Q: What does the CVR signal tell you about Lilly's deal structure?
It signals that Lilly is pricing in clinical uncertainty and tying part of the economics to milestones, effectively sharing downside risk with the seller while keeping upside tied to future performance.

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Frequently Asked Questions About The Pharma Closeout

What is The Pharma Closeout about and what kind of topics does it cover?

This briefing delivers fast, executive-focused coverage of pharma and biotech news, with a strong emphasis on drug approvals, clinical readouts, and M&A activity. Across episodes, listeners see concise synthesis of regulatory moves, deal dynamics, and pipeline updates, translated into practical implications for strategy, pitching, and investor positioning. Notable is the cadence: weekday fast briefs plus a Sunday wrap that ties together the week's biggest moves, helping professionals stay informed without sifting through lengthy reports. The format tends to feature real-time interpretation from two steady hosts, focusing on how data, policy, and market moves interact to shape competition, launches, and lifecycle decisions in cardiology, onc... more

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Which podcasts are similar to The Pharma Closeout?

These podcasts share a similar audience with The Pharma Closeout:

1. Biotech Hangout
2. The Readout Loud
3. ASCO Daily News
4. Empire: World History
5. Oncology On The Go

How many episodes of The Pharma Closeout are there?

The Pharma Closeout launched 4 months ago and published 99 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on The Pharma Closeout?

Recent guests on The Pharma Closeout include:

1. Nana Loonborg
2. Marcus Webb

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