
Your daily pharmaceutical news briefing — FDA decisions, clinical trial results, biotech M&A, and drug pipeline updates in under 15 minutes, every weekday. Hosted by Alex Mercer and Maya Patel. Plus a Week in Review every Sunday synthesizing the week's biggest moves in pharma and biotech. Covering drug approvals, pharma industry deals, biopharma investing, and healthcare market intelligence. Smart... more
| Publishes | Daily | Episodes | 133 | Founded | 5 months ago |
|---|---|---|---|---|---|
| Number of Listeners | Categories | Life SciencesScience | |||

AstraZeneca pulled its Phase 3 volrustomig lung trial at interim review — and released no efficacy data at all. The eVOLVE-Lung02 study tested the PD-1 by CTLA-4 bispecific plus chemotherapy against pembrolizumab plus chemo in first-line PD-L1-low no... more
Akeso cleared AK157D1, a B7-H3 antibody-drug conjugate, into Phase 1 in solid tumors — its third differentiated ADC, and a late entry into an already crowded target. Alex and Maya argue whether three assets from one engine is platform depth or correl... more
Intismeran autogene plus KEYTRUDA met its primary and key secondary endpoints in the 1,137-patient Phase 3 INTerpath-001 melanoma trial — the first Phase 3 win for a neoantigen mRNA cancer therapy — as Moderna added roughly $44 billion in market valu... more
Trump names Heidi Overton to lead the FDA — and a Republican senator calls part of her record almost disqualifying on day one. We break down the confirmation fight, the regulatory risk to mRNA programs in oncology and immunology, Regeneron's Pasatru ... more
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- A rapid-fire briefing on the pharma and biotech landscape, with a steady focus on regulatory decisions, FDA/EMA actions, pivotal trial readouts, and major deals. Across episodes, listeners get concise breakdowns of committee votes, data interpretability concerns, and how briefing documents shape market expectations and strategic decisions for developers, investors, and strategists. Notable threads include the regulatory risk around single pivotal readouts, the impact of M&A and deal re-structuring on portfolio strategy, and how market reactions, earnings, and guidance moves drive valuation and messaging in biotech and pharma.
- The show frequently ties regulatory and clinical momentum to near-term business implications, such as launch tim... more
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The Pharma Closeout launched 5 months ago and published 133 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.
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Recent guests on The Pharma Closeout include:
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2. Marcus Webb
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