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The Pharma Closeout | Daily Pharmaceutical & Biotech News in 15 Minutes

BZ Group
Novo Nordisk
Merck & Co.
Lilly
Gilead Sciences
FDA
Bristol Myers Squibb
Astrazeneca
Pfizer
Replimune
Regeneron
Eli Lilly
Abbvie
Glp-1
GSK
Artificial Intelligence In Pharma
Capricor Therapeutics
Moderna
Gilead
Uniqure
Sun Pharmaceutical Industries

Your daily pharmaceutical news briefing — FDA decisions, clinical trial results, biotech M&A, and drug pipeline updates in under 15 minutes, every weekday. Hosted by Alex Mercer and Maya Patel. Plus a Week in Review every Sunday synthesizing the week's biggest moves in pharma and biotech. Covering drug approvals, pharma industry deals, biopharma investing, and healthcare market intelligence. Smart... more

PublishesDailyEpisodes133Founded5 months ago
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Latest Episodes

AstraZeneca pulled its Phase 3 volrustomig lung trial at interim review — and released no efficacy data at all. The eVOLVE-Lung02 study tested the PD-1 by CTLA-4 bispecific plus chemotherapy against pembrolizumab plus chemo in first-line PD-L1-low no... more

Akeso cleared AK157D1, a B7-H3 antibody-drug conjugate, into Phase 1 in solid tumors — its third differentiated ADC, and a late entry into an already crowded target. Alex and Maya argue whether three assets from one engine is platform depth or correl... more

Intismeran autogene plus KEYTRUDA met its primary and key secondary endpoints in the 1,137-patient Phase 3 INTerpath-001 melanoma trial — the first Phase 3 win for a neoantigen mRNA cancer therapy — as Moderna added roughly $44 billion in market valu... more

Trump names Heidi Overton to lead the FDA — and a Republican senator calls part of her record almost disqualifying on day one. We break down the confirmation fight, the regulatory risk to mRNA programs in oncology and immunology, Regeneron's Pasatru ... more

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Recent Guests

Nana Loonborg
Forbeon's analyst/commentator referenced in discussion
Forbeon
Episode: Jun 04, 2026 | SCOTUS Backs Hikma Skinny-Label Win on Vascepa; ADC Therapeutics Crashes 50% on Death
Marcus Webb
Anchor/industry analyst brought in for expert perspective on deals and market strategy
Unnamed brokerage/firm mentioned as anchor by host
Episode: Mar 1, 2026 | CagriSema Week of Reckoning: Analysts Revise, Novo Regroups | YUVIWEL Approved + PRV Voucher | Weekend Edition

Hosts

Alex Mercer
Host of The Pharma Closeout; generally leads coverage of regulatory and market-moving biotech and pharma news; affiliation: The Pharma Closeout
Maya Patel
Co-host of The Pharma Closeout; provides market-forward synthesis and daily pharma/biotech headlines; affiliation: The Pharma Closeout

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Talking Points

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Mar 31, 2026 | Lilly's $7.8B Centessa Deal; Biogen Buys Apellis for $5.6B; FDA Flags Tavneos Deaths | Mar 31, 2026
Q: What does the CVR signal tell you about Lilly's deal structure?
It signals that Lilly is pricing in clinical uncertainty and tying part of the economics to milestones, effectively sharing downside risk with the seller while keeping upside tied to future performance.

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Frequently Asked Questions About The Pharma Closeout

What is The Pharma Closeout about and what kind of topics does it cover?

- A rapid-fire briefing on the pharma and biotech landscape, with a steady focus on regulatory decisions, FDA/EMA actions, pivotal trial readouts, and major deals. Across episodes, listeners get concise breakdowns of committee votes, data interpretability concerns, and how briefing documents shape market expectations and strategic decisions for developers, investors, and strategists. Notable threads include the regulatory risk around single pivotal readouts, the impact of M&A and deal re-structuring on portfolio strategy, and how market reactions, earnings, and guidance moves drive valuation and messaging in biotech and pharma.

- The show frequently ties regulatory and clinical momentum to near-term business implications, such as launch tim... more

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Which podcasts are similar to The Pharma Closeout?

These podcasts share a similar audience with The Pharma Closeout:

1. Biotech Hangout
2. The Readout Loud
3. BioCentury This Week
4. Pharma and BioTech Daily
5. The Diary Of A CEO with Steven Bartlett

How many episodes of The Pharma Closeout are there?

The Pharma Closeout launched 5 months ago and published 133 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on The Pharma Closeout?

Recent guests on The Pharma Closeout include:

1. Nana Loonborg
2. Marcus Webb

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