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The Pharma Closeout | Daily Pharmaceutical & Biotech News in 15 Minutes

BZ Group
Merck & Co.
Lilly
Novo Nordisk
Gilead Sciences
FDA
Pfizer
Eli Lilly
Astrazeneca
Bristol Myers Squibb
Glp-1
Regeneron
GSK
Artificial Intelligence In Pharma
Capricor Therapeutics
Moderna
Gilead
Abbvie
Replimune
Uniqure
Sun Pharmaceutical Industries

Your daily pharmaceutical news briefing — FDA decisions, clinical trial results, biotech M&A, and drug pipeline updates in under 15 minutes, every weekday. Hosted by Alex Mercer and Maya Patel. Plus a Week in Review every Sunday synthesizing the week's biggest moves in pharma and biotech. Covering drug approvals, pharma industry deals, biopharma investing, and healthcare market intelligence. Smart... more

PublishesDailyEpisodes114Founded5 months ago
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Life SciencesScience

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Latest Episodes

An FDA advisory panel backed Replimune's RP1 by 10 to 3, overriding agency reviewers, with an approval decision due August 2nd. Also: the same-day panel voted Capricor's Duchenne cell therapy deramiocel down 9 to 3, Johnson & Johnson took a $2.58 bil... more

FDA advisers recommended against Capricor's deramiocel — and the stock had already lost up to 60% before the vote. Also: Replimune falls nearly 40% as FDA reviewers call RP1's melanoma survival data uninterpretable ahead of Thursday's panel; Biogen p... more

FDA reviewers say Replimune's IGNYTE overall survival analysis is "not interpretable" days before Thursday's advisory committee — shares fell more than 32% to $5.78. We break down what it means for RP1, Opdivo combination therapy, and accelerated app... more

Capricor fell roughly 67% after FDA briefing documentsquestioned deramiocel's efficacy days before its advisory committee — and the company's rebuttal is a fight over which statistical analysis plan governs. Webreak down what that means for cell ther... more

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Recent Guests

Marcus Webb
Market commentator invited for expert analysis on deal structure and regulatory dynamics
Independent analyst
Episode: Daily Roundup | FDA Halts Drug Rejection Letters — What It Means for Competitive Intel
Nana Loonborg
Forbeon's analyst/commentator referenced in discussion
Forbeon
Episode: Jun 04, 2026 | SCOTUS Backs Hikma Skinny-Label Win on Vascepa; ADC Therapeutics Crashes 50% on Death

Hosts

Alex Mercer
Host of The Pharma Closeout; primary anchor across editions; frequently presents market and deal analysis.
Maya Patel
Co-host across editions; provides strategic and market-context commentary.

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Talking Points

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Mar 31, 2026 | Lilly's $7.8B Centessa Deal; Biogen Buys Apellis for $5.6B; FDA Flags Tavneos Deaths | Mar 31, 2026
Q: What does the CVR signal tell you about Lilly's deal structure?
It signals that Lilly is pricing in clinical uncertainty and tying part of the economics to milestones, effectively sharing downside risk with the seller while keeping upside tied to future performance.

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Frequently Asked Questions About The Pharma Closeout

What is The Pharma Closeout about and what kind of topics does it cover?

This briefing delivers fast, executive-focused coverage of pharma and biotech news, with a strong emphasis on drug approvals, clinical readouts, and M&A activity. Across episodes, listeners see concise synthesis of regulatory moves, deal dynamics, and pipeline updates, translated into practical implications for strategy, pitching, and investor positioning. Notable is the cadence: weekday fast briefs plus a Sunday wrap that ties together the week's biggest moves, helping professionals stay informed without sifting through lengthy reports. The format tends to feature real-time interpretation from two steady hosts, focusing on how data, policy, and market moves interact to shape competition, launches, and lifecycle decisions in cardiology, onc... more

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Which podcasts are similar to The Pharma Closeout?

These podcasts share a similar audience with The Pharma Closeout:

1. Biotech Hangout
2. BioCentury This Week
3. The Readout Loud
4. Science Vs
5. Value Hive Podcast

How many episodes of The Pharma Closeout are there?

The Pharma Closeout launched 5 months ago and published 114 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on The Pharma Closeout?

Recent guests on The Pharma Closeout include:

1. Marcus Webb
2. Nana Loonborg

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