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The Optimized Women

Orshi McNaughton
Women's Health
Nutrition
Biohacking
Hormone Replacement Therapy
Menopause
Thyroid Health
Testosterone
Stress Management
Gut Health
Hormones
Seed Oils
Women's Health Research
Glp-1
Chronic Insomnia
Chronic Inflammation
Functional Medicine
Breathwork
Vision Training
Hormonal Imbalance
Hair Loss

The Optimized Women explores the frontier of longevity medicine through conversations with the physicians, scientists, founders, and innovators building the future of human health. Hosted by Orshi McNaughton, each episode explores emerging interventions, breakthrough research, and the strategies shaping the future of healthspan, performance, and healthy aging. Topics include gene therapies, regene... more

PublishesWeeklyEpisodes24Founded2 years ago
Number of ListenersCategories
Health & FitnessSelf-ImprovementEducationAlternative Health

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Latest Episodes

Microdosing GLP-1s is quickly becoming one of the most talked-about topics in obesity medicine, but can taking less actually produce better long-term results for some people?

In this episode, Dr. Karen Mann shares how personalized GLP-1 dosing, food... more

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Methylene blue is one of the most talked-about tools in biohacking for mitochondrial function, brain fog, and energy—and the nuance is in dosing, quality, and context. In this episode, Dr. Scott Sherr explains how chronic stress and hormone shifts ca... more

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If you’re strength training, eating “clean,” and still gaining fat or losing muscle after 40, it’s not just willpower—it’s physiology. In this episode we break down what actually changes during perimenopause and menopause (lean mass, central fat gain... more

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This episode explores how women’s hormones, aging, regenerative therapies, and technology are shaping the next era of longevity medicine. Dr. Amy Killen shares her evolution from ER doctor to multi-company entrepreneur, her work in stem cells and ful... more

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Recent Guests

Karen Mann
Obesity medicine physician, gynecologist; advocate for personalized GLP-1 therapies
Noom (clinical partner discussions); Obesity medicine physician
Episode: Microdosing GLP-1s: Can Less Actually Work Better? | Dr. Karen Mann
Dr. Scott Sherr
Physician specializing in health optimization medicine
One Base Health, TROscription
Episode: Methylene Blue for Brain Fog, Anxiety and Low Energy | Dr. Scott Sherr, MD
Bill Campbell
Leading researcher in physique optimization; Director of Performance and Physique Enhancement Lab, USF
University of South Florida
Episode: Weight Loss Resistance in Midlife: What the Research Reveals I Dr. Bill Campbell, PhD
Amy Killen
Co-founder and Chief Medical Officer of Humanát Health; hormone and longevity physician
Humanát Health
Episode: Women’s Hormones & the Future of Longevity Medicine | Dr. Amy Killen
Carol Covino
Female bodybuilder, fitness coach, and author
Carol Covino Fitness
Episode: A Female Bodybuilder’s Guide to Muscle & Metabolism Over 50 I Carol Covino
Jim Donnelly
Founder and CEO of Humanot Health
Humanot Health
Episode: How AI Is Revolutionizing Longevity Medicine | Jim Donnelly
Faraz Khan
Longevity educator, speaker, biohacker
Anti-Aging Hacks Podcast
Episode: Hormonal Imbalances & Hair Thinning: What Every Woman Should Know | Faraz Khan
Ryan Monahan
Functional diagnostic nutrition practitioner
Episode: Reverse Hashimoto’s and Autoimmunity Naturally | Ryan Monahan
Dr. Salome Masghati
Gynecologist and expert in women's hormones
Episode: Real Talk on Perimenopause, Hormones, and HRT I Dr. Salome Masghati

Reviews

5.0 out of 5 stars from 11 ratings
  • Amazing content

    Thank you for bringing Nathalie Niddam to the show! Excellent episode on peptides and bioregulators.

    Apple Podcasts
    5
    Shy Logan’s Mom
    United Statesa year ago
  • Love this topic!

    I think this is a great topic and can’t wait to hear more about women’s health especially as I’m getting to the “older” age

    Apple Podcasts
    5
    jess8844
    United States2 years ago
  • Orshi & This Podcast

    Excited to learn from a knowledgeable and loving human like Orshi! Let’s Go!

    Apple Podcasts
    5
    Surfawaveeee
    United States2 years ago
  • Yeessss! Can’t wait to hear more!

    I cannot wait to listen to more. This is fire! It is so important and needed for us women. It’s time to take “power over our bodies”. The part about muscle being our “metabolic currency” and how muscle disposes 80% of our glucose really motivates me to get to the gym. And learning about how certain foods can cause inflammation in our bodies and how to try different diets for better health. Yes, more please! As a post menopausal woman, I can’t wait to hear and learn more. And this would’ve been ... more

    Apple Podcasts
    5
    LisaLee in Cali
    United States2 years ago
  • A Must-Listen for Women Seeking to Thrive

    My goal is to bring insightful, empowering conversations with top experts in wellness, nutrition, and performance—tailored specifically for women. I hope the podcast provides valuable, actionable advice that helps you unlock your full potential. Looking forward to hearing your thoughts and feedback!

    Apple Podcasts
    5
    Orshi McNaughton
    United States2 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Listeners appreciate expert guests and actionable takeaways for longevity.
Strong positive feedback on the host's depth and empathy.
Audiences value the focus on women's health and aging with evidence-based insights.
Engaging discussions that blend science and practical health tips.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Talking Points

Recent interactions between the hosts and their guests.

Microdosing GLP-1s: Can Less Actually Work Better? | Dr. Karen Mann
Q: How does oral GLP-1 therapy compare to injectables in terms of results and practicality?
Oral GLP-1 therapies show similar effectiveness and side-effect profiles to injectables, with advantages in convenience for some patients, though titration dynamics can be different and adherence to dosing timing is important.
Microdosing GLP-1s: Can Less Actually Work Better? | Dr. Karen Mann
Q: What is microdosing in GLP-1 therapies and how does it differ from standard dosing?
Microdosing lacks a fixed definition; it generally means using a smaller dose than the max therapeutic dose, sometimes with longer intervals between doses, while aiming to maintain steady-state effects and reduce side effects.
How AI Is Revolutionizing Longevity Medicine | Jim Donnelly
Q: How will AI transform the operations and patient care at Humanot, and where should clinicians still maintain the lead?
AI is envisioned as a tool to digest and organize thousands of data points from diagnostics to generate preliminary care plans quickly. The doctor remains essential as the overlay—interpreting AI outputs, fine-tuning plans, and maintaining the human connection with patients. The goal is to let AI handle data-heavy tasks while clinicians focus on empathy, nuanced judgment, and in-person interventions when needed.
How AI Is Revolutionizing Longevity Medicine | Jim Donnelly
Q: What was the primary problem Restore Hyper Wellness was solving, and how did the model evolve beyond cryotherapy?
The biggest surprise was that recovery appeals to athletes but the much larger impact came from addressing chronic conditions through a multi-modality approach. By layering IV therapies, hyperbaric oxygen, red light, and other modalities under a cohesive brand and scalable franchise model, they created a real, difficult-to-replicate business that could reach many people and deliver measurable health improvements.
Weight Loss Resistance in Midlife: What the Research Reveals I Dr. Bill Campbell, PhD
Q: How does estrogen replacement therapy affect muscle and fat in this population?
Estrogen replacement therapy tends to support muscle mass gains in many cases, but its impact on fat loss is highly variable across individuals and studies; the overall effect depends on hormone balance, training, and other factors.

Audience Metrics

Listeners, social reach, demographics and more for this podcast.

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Frequently Asked Questions About The Optimized Women

What is The Optimized Women about and what kind of topics does it cover?

This program centers on longevity medicine, with conversations featuring physicians, scientists, founders, and biohacking innovators who are shaping healthspan, performance, and healthy aging. Episodes cover hormone optimization, metabolic health, regenerative approaches, diagnostics, and emerging technologies, often weaving in practitioner insights, personal experimentation, and data-driven strategies. Listeners are likely drawn to evidence-based wellness, practical health optimization, and the intersection of science and everyday living, with a strong emphasis on women's health and aging. A notable strength is the blend of expert interviews and first-person experimentation that translates complex research into actionable takeaways.

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How many listeners does The Optimized Women get?

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What are the audience demographics for The Optimized Women?

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How many subscribers and views does The Optimized Women have?

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How many episodes of The Optimized Women are there?

The Optimized Women launched 2 years ago and published 24 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

How do I contact The Optimized Women?

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What guests have appeared on The Optimized Women?

Recent guests on The Optimized Women include:

1. Karen Mann
2. Dr. Scott Sherr
3. Bill Campbell
4. Amy Killen
5. Carol Covino
6. Jim Donnelly
7. Faraz Khan
8. Ryan Monahan

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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