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Artwork for The New Biology

The New Biology

Niko McCarty
Magnetogenetics
Hyperspectral Biology
Innovate Animal Ag
Chickens
Terraforming Mars
Plasmidsaurus
Spudcell
Mars
Rna-Seq
Toxic Substances Control Act
Hyperspectral Cameras
Regulatory Policy
Agriculture
Bioremediation
Synthetic Cells
TEA Analysis

The New Biology features long-form discussions with historians, technologists, and scientists who are working on some of the biggest ideas in biotechnology, from magnet-controlled medicines to virtual cells. Supported by Astera Institute.

PublishesMonthlyEpisodes7Founded5 months ago
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Life SciencesScienceTechnology

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Artwork for The New Biology

Latest Episodes

Pioneer Labs, a nonprofit research group, has engineered a microbe that eats Martian dirt and excretes bioplastic. It is the first step of their "five organism" plan to terraform Mars and make the planet habitable. This interview is with Erika DeBene... more

Chemists at the University of Minnesota, led by Kate Adamala, recently built a synthetic cell that eats, grows, and divides; purely by putting together molecules in the laboratory. Their creation, called SpudCell, can only divide for five generations... more

A dairy cow is worth $1,000 to $2,000 to a farmer, whereas a broiler chicken, raised for meat, generates just $4 of profit. Quantifying animals this way may feel uncomfortable, but those $4 are all a farmer can spend to keep a chicken healthy. And th... more

Scientists have studied bacteria under microscopes for 400 years. But Yonatan Chemla, a postdoctoral fellow at MIT, has developed a technology that lets us see microbes from a drone 100 meters in the air.

In this episode, we discuss the emerging fie... more

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Recent Guests

Erika DeBenedictis
Co-founder and CEO of Pioneer Labs, a non-profit research group engineering microbes to terraforming Mars
Pioneer Labs
Episode: How to Terraform Mars – Erika DeBenedictis
Kate Adamala
A researcher whose group built the synthetic cell platform SpudCell that eats, grows, and divides
University of Minnesota (interview subject)
Episode: SpudCell will replicate continuously by 2030 | Kate Adamala
Robert Yaman
Founder and CEO, Innovate Animal Ag
Innovate Animal Ag
Episode: Biotech for Chickens — Robert Yaman
Yonatan Chemla
Biotechnologist and researcher known for hyperspectral biology work in MIT labs (Field: hyperspectral reporters, sensing in soil, drones)
Massachusetts Institute of Technology
Episode: Engineered Microbes Seen from the Sky — Yonatan Chemla on Hyperspectral Biology
Adam Green
Founder of Markov Biosciences
Markov Biosciences
Episode: The Bitter Lesson for Biology — Adam Green on Virtual Cells and Scaling Laws
Maria Ingaramo
Biochemist, protein engineer; co-founder of Nonfiction Labs
Nonfiction Laboratories
Episode: Magnet-Controlled Medicines — Andrew York & Maria Ingaramo
Andrew York
Physicist, entrepreneur; co-founder of Nonfiction Labs
Nonfiction Laboratories
Episode: Magnet-Controlled Medicines — Andrew York & Maria Ingaramo
Mark Budde
CEO of Plasmidsaurus
Plasmidsaurus
Episode: Mark Budde - How to speed up wet-lab biology

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Talking Points

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SpudCell will replicate continuously by 2030 | Kate Adamala
Q: Why did SpudCell stop dividing after five generations, and can this be overcome?
The five-generation stopping point is due to accumulation of non-degradable waste and lack of protein/RNA recycling, leading to degraded components and reduced yields. Overcoming this requires implementing waste recognition and recycling pathways, improving ribosome turnover, and possibly introducing a simple cytoskeleton to help partition genomes more reliably, with ongoing work to test and optimize these strategies.
SpudCell will replicate continuously by 2030 | Kate Adamala
Q: What is SpudCell and what are its key components?
SpudCell is a synthetic liposome-based cell with a two-component membrane housing a multipartite genome that is transcribed and translated to produce proteins, including a pore-forming protein that enables nutrient uptake and waste removal. Its division and growth are controlled by surface-tagged membrane proteins that regulate feeding and division, with growth rate depending on expression levels and environmental resources.
The Bitter Lesson for Biology — Adam Green on Virtual Cells and Scaling Laws
Q: What is the thesis behind training virtual cell models on perturbation data versus observational data?
The guest argues that while perturbation data are valuable, the most scalable and robust path is to pre-train on large observational single-cell RNA-seq data and then fine-tune with a small amount of perturbational data, leveraging a loss function that emphasizes ordinal ranking to handle zeros and measurement noise.
Mark Budde - How to speed up wet-lab biology
Q: How do you view data ownership and partnerships with AI labs or frontier models?
Customer data is theirs; Plasmidsaurus does not sell data and supports partnerships that enable data to flow into AI systems with explicit customer control. The goal is to empower researchers and frontier labs to leverage models without compromising data ownership or privacy.
Mark Budde - How to speed up wet-lab biology
Q: What differentiates Plasmidsaurus from traditional CROs in terms of execution and product vision?
We focus on speed, end-to-end automation, a superior UI, and a standardization of analyses so scientists can get high-quality data with minimal effort. This lets researchers focus on interpretation rather than data wrangling, enabling broader and faster scientific progress.

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Frequently Asked Questions About The New Biology

What is The New Biology about and what kind of topics does it cover?

Tapping into cutting-edge biotech, the show features deep-dive conversations with researchers, founders, and engineers who are building and testing transformative technologies. Episodes center on practical advances like magnetogenetics, virtual cell models, rapid plasmid sequencing, hyperspectral sensing, and AI-driven biology, often balancing technical detail with real-world implications such as regulation, clinical translation, manufacturing scale, and market adoption. A recurring strength is grounding speculative ideas in measurable progress, field experiments, and entrepreneurship stories that illuminate how science moves from concept to impact while navigating ethical, regulatory, and funding landscapes. Listeners likely gain a clear s... more

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These podcasts share a similar audience with The New Biology:

1. The Rest Is History
2. Dwarkesh Podcast
3. The Ezra Klein Show
4. All-In with Chamath, Jason, Sacks & Friedberg
5. The Twenty Minute VC (20VC): Venture Capital | Startup Funding | The Pitch

How many episodes of The New Biology are there?

The New Biology launched 5 months ago and published 7 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on The New Biology?

Recent guests on The New Biology include:

1. Erika DeBenedictis
2. Kate Adamala
3. Robert Yaman
4. Yonatan Chemla
5. Adam Green
6. Maria Ingaramo
7. Andrew York
8. Mark Budde

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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