The Lung Science Podcast: An AJRCMB Podcast

American Thoracic Society

Asthma

Alveolar Macrophages

Sex-Biased Gene Expression

National Institutes Of Health

Ozone

Early Career Reviewer Program

Efferocytosis

Neutrophil Degranulation

Airway Smooth Muscle

Goblet Cell Metaplasia

Five Core Review Criteria

Training Grants (F32, K Awards)

Diversity In Peer Review

Junctional Epidermolysis Bullosa (JEB)

Mertk

Sepsis

COPD

Single-Cell RNA Sequencing

Rhoa Signaling

Genomics

The American Journal of Respiratory Cell and Molecular Biology (AJRCMB) is proud to present the Lung Science Podcast series! Featuring engaging interviews and commentaries with luminaries in pulmonary and critical care basic investigation.

5 ratings

Publishes	Twice monthly	Episodes	50	Founded	10 years ago
Number of Listeners		Categories	Health & FitnessMedicine

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Latest Episodes

19(S)-Hydroxyeicosatetraenoic Acid Promotes Airway Smooth Muscle Relaxation and Decreases DNA Synthesis Through the Prostacyclin Receptor

Dr. Ajay Nayak interviews Dr. Christopher Pascoe about his article, "19(S)-Hydroxyeicosatetraenoic Acid Promotes Airway Smooth Muscle Relaxation and Decreases DNA Synthesis Through the Prostacyclin Receptor."

Yesterday • 20 min

Protocadherin-1 Deficiency Increases Baseline and Allergen-Induced Airway Hyperresponsiveness in Mice

Dr. Nilesh Ambhore interviews Dr. Gerard H. Koppelman about his article, "Protocadherin-1 Deficiency Increases Baseline and Allergen-Induced Airway Hyperresponsiveness in Mice."

23 Jul 2026 • 16 min

Pirfenidone and its Derivative: Novel Bronchodilators and Leukocyte Airway Inflammation Inhibitors

Dr. Niyati A. Borkar speaks with Dr. Yaping Tu and Dr. Thomas B. Casale about their article, "Pirfenidone and its Derivative: Novel Bronchodilators and Leukocyte Airway Inflammation Inhibitors."

16 Jul 2026 • 49 min

Airway Goblet Metaplasia Resulting from YAP/TAZ Deletion Drives Pulmonary Inflammatory Responses

Dr. Marija Gredic chats with Dr. Bob Varelas about his article, "Airway Goblet Metaplasia Resulting from YAP/TAZ Deletion Drives Pulmonary Inflammatory Responses."

19 Mar 2026 • 17 min

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Recent Guests

Yaping Tu

Interim Chair and Professor, Creighton University School of Medicine, Department of Pharmacology and Neuroscience

Creighton University

Episode: Pirfenidone and its Derivative: Novel Bronchodilators and Leukocyte Airway Inflammation Inhibitors

Thomas Casale

Professor of Medicine, University of South Florida; clinician-scientist in allergy, immunology and asthma

University of South Florida

Episode: Pirfenidone and its Derivative: Novel Bronchodilators and Leukocyte Airway Inflammation Inhibitors

Bob Varelas

Professor, affiliation with Boston University and Chobanian and Ovidian School of Medicine

Boston University; Chobanian and Ovidian School of Medicine

Episode: Airway Goblet Metaplasia Resulting from YAP/TAZ Deletion Drives Pulmonary Inflammatory Responses

Heather Giannini

Physician researcher studying immune dynamics in sepsis

University of Pennsylvania

Episode: Whole Blood Transcriptomics Reveals Sepsis Mortality-associated Changes in Neutrophil Degranulation

Mengyuan Kan

Research associate specializing in genetics and bioinformatics

University of Pennsylvania

Episode: Whole Blood Transcriptomics Reveals Sepsis Mortality-associated Changes in Neutrophil Degranulation

Nuala Meyer

Professor directing the SMESI cohort

University of Pennsylvania

Episode: Whole Blood Transcriptomics Reveals Sepsis Mortality-associated Changes in Neutrophil Degranulation

Marissa Guttenberg

Postdoctoral researcher discussing tissue-resident alveolar macrophages and ozone-induced inflammation

Research Institute for Fragrance Materials

Episode: Tissue-Resident Alveolar Macrophages Reduce Ozone-induced Inflammation via MerTK-mediated Efferocytosis

Shannon Kay

Assistant professor in the Division of Pulmonary Critical Care and Sleep Medicine

AL School of Medicine

Episode: Sex-biased Gene Expression Underlies Immune Dysfunction in Asthma

Sally Kim

Lecturer in Respiratory Drug Delivery, King's College London

Institute of Pharmaceutical Science, King's College London

Episode: Interviews with Authors Selected for the Outstanding Abstract Presentation Award

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Apple Podcasts	#73	Argentina/Health & Fitness/Medicine
Apple Podcasts	#170	Norway/Health & Fitness/Medicine
Apple Podcasts	#190	Russia/Health & Fitness/Medicine
Apple Podcasts	#225	Singapore/Health & Fitness/Medicine

Talking Points

Recent interactions between the hosts and their guests.

Airway Goblet Metaplasia Resulting from YAP/TAZ Deletion Drives Pulmonary Inflammatory Responses

Q: What first sparked the idea that goblet cells might actively drive inflammation rather than merely respond to it?

The researchers describe that inactivating the lung epithelium leads to transdifferentiation into goblet cells and mucus production, which remodels the microenvironment and triggers immune changes—shifting the view from epithelial passivity to active inflammatory signaling.

Whole Blood Transcriptomics Reveals Sepsis Mortality-associated Changes in Neutrophil Degranulation

Q: What are the future directions for this line of work?

Plans include integrating multi-omic profiling (mRNA, plasma proteins, genotype, and flow cytometry) across acute and recovery phases, tying molecular phenotypes to clinical phenotypes, and building larger biorepositories to enable rigorous hypothesis testing.

Whole Blood Transcriptomics Reveals Sepsis Mortality-associated Changes in Neutrophil Degranulation

Q: How do you see these findings impacting clinical care for sepsis in the near term?

While not immediately changing practice, the results strengthen the rationale for exploring targeted therapies and biomarker-guided strategies, using blood as a surrogate to guide therapeutic decisions and to prioritize targets for future trials.

Whole Blood Transcriptomics Reveals Sepsis Mortality-associated Changes in Neutrophil Degranulation

Q: Could you briefly describe your study's main findings?

In a comprehensive transcriptomic analysis of sepsis patients in the MESI cohort, they found significant dysregulation of neutrophil marker genes and pathways related to neutrophil degranulation, suggesting linkages between transcriptomic changes and mortality risk.

Whole Blood Transcriptomics Reveals Sepsis Mortality-associated Changes in Neutrophil Degranulation

Q: From your perspective, what are the biggest barriers to developing new sepsis therapies and how did this shape your study?

The group emphasizes sepsis heterogeneity as a core barrier, the lack of clear causal links between bloodstream abnormalities and tissue injury, and the need for discovery-driven approaches using accessible tissues like blood to identify mechanisms and potential targets.

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Frequently Asked Questions About This Podcast

What is This Podcast about and what kind of topics does it cover?

This program centers on cutting-edge pulmonary and critical care research, translating basic science findings into clinical context. Across recent episodes, guests explore asthma biology, airway signaling, sepsis transcriptomics, lung injury and repair, and the molecular underpinnings of respiratory diseases. The discussions frequently emphasize translational potential, methodological rigor, and how complex mechanisms—such as neutrophil function, macrophage-driven resolution, and sex-biased gene expression—could inform new therapies, diagnostics, and precision medicine. A notable strength is the blend of clinical insight with foundational science, offering listeners actionable perspectives on how laboratory discoveries may reach patients. T... more

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1. ATS Breathe Easy
2. ERS Publications Podcasts
3. CHEST Journal Podcasts
4. CHEST Pulse
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this podcast launched 10 years ago and published 50 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on this podcast?

Recent guests on this podcast include:

1. Yaping Tu
2. Thomas Casale
3. Bob Varelas
4. Heather Giannini
5. Mengyuan Kan
6. Nuala Meyer
7. Marissa Guttenberg
8. Shannon Kay

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