The Lancet Respiratory Medicine in conversation with

The Lancet Group

Bronchiectasis

Chronic Obstructive Pulmonary Disease

Pleural Mesothelioma

Asthma

Clinical Trials

Lymphangioleiomyomatosis

Extended Peritoneal Cordication

Sepsis

Chemotherapy

Pulmonary Embolism

Children and Adolescents

Epidemiological Study

Pulmonary Arterial Hypertension

Acute Respiratory Distress Syndrome

European Respiratory Society

Leicester

Corticosteroids

Health Systems

Phenotyping

Exacerbations

Editors at The Lancet Respiratory Medicine, in conversation with the journal’s authors, explore their latest research and its impact on people’s health, healthcare, and health policy.A monthly audio companion to the journal, this podcast covers a broad range of topics, from long COVID outcomes to tobacco control, the management of uncontrolled asthma to intensive care medicine, and more.

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Publishes	Infrequently	Episodes	163	Founded	6 years ago
Number of Listeners		Categories	Health & FitnessMedicine

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Latest Episodes

Andrew Bush, Heather Zar, Fernando de Benedictis on how inhaled corticosteroids have changed the treatment of asthma

Andrew Bush, Heather Zar, Fernando de Benedictis talk about their recent personal view piece where they summarise and discuss the 50-year journey and evolution of inhaled corticosteroids (ICS) in asthma treatment.

Click here to read the full article... more

15 Jun 2026 • 13 min

Anne-Marie Dingemans; Isabelle Opiz; Corinne Faivre-Finn on a consensus definition of stage III Non-Small Cell Lung Cancer technical resectability

Anne-Marie Dingemans, Isabelle Opiz, and Corinne Faivre-Finn talk about their multidisciplinary efforts to develop a consensus definition of stage III Non-Small Cell Lung Cancer technical resectability.

www.thelancet.com/journals/lanres/arti... more

26 Mar 2026 • 28 min

Anne Holland and Christine McDonald

Anne Holland and Christine McDonald join Diana Stanley to discuss ambulatory oxygen for treatment of exertional hypoxaemia in pulmonary fibrosis.

Click here to read the full article, Ambulatory oxygen for treatment of exertional hypoxaemia in pulmon... more

2 Mar 2026 • 12 min

Marion Moseby-Knappe on Blood biomarkers for the prediction of outcome after cardiac arrest

Marion Moseby-Knappe talks about a prospective, international, observational biomarker study, within the Targeted Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial, to compare four markers of brain injury for the predi... more

22 Dec 2025 • 7 min

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Recent Guests

Anne-Marie Dingemans

Pulmonologist and professor of thoracic oncology

Erasmus University Medical Center; past chair EORTC Lung Cancer Group

Episode: Anne-Marie Dingemans; Isabelle Opiz; Corinne Faivre-Finn on a consensus definition of stage III Non-Small Cell Lung Cancer technical resectability

Isabelle Opiz

Thoracic surgeon

University Hospital Zurich; chair/professor at University of Zurich; former president of European Society of Thoracic Surgery

Episode: Anne-Marie Dingemans; Isabelle Opiz; Corinne Faivre-Finn on a consensus definition of stage III Non-Small Cell Lung Cancer technical resectability

Corinne Faivre-Finn

Radiation oncologist

The Christie; University of Manchester; involved in EORTC

Episode: Anne-Marie Dingemans; Isabelle Opiz; Corinne Faivre-Finn on a consensus definition of stage III Non-Small Cell Lung Cancer technical resectability

Anne Holland

Professor of Physiotherapy and Head of Respiratory Research

Monash University, Melbourne, Australia

Episode: Anne Holland and Christine McDonald

Christine McDonald

Director of Respiratory and Sleep Medicine

Austin Health and University of Melbourne, Australia

Episode: Anne Holland and Christine McDonald

Dr. Marion Moseby-Knappe

Clinical neurologist and researcher at Lund University

Lund University and the Skein University Hospital in Lund, Sweden

Episode: Marion Moseby-Knappe on Blood biomarkers for the prediction of outcome after cardiac arrest

Sailesh Kotecha

Head and Professor of Child Health at Cardiff University

Cardiff University

Episode: Sailesh Kotecha on Prematurity-associated lung disease

Toby Maher

Professor of Clinical Medicine and Director of Interstitial Lung Disease at the University of Southern California.

University of Southern California

Episode: Toby Maher on ENV-101 in patients with idiopathic pulmonary fibrosis

Lorenzo Guglielmetti

Reader at Medicisensa Frontiere and lead researcher of the NTBQ trial

Medicisensa Frontiere

Episode: Lorenzo Guglielmetti parla del trial clinico ENDTB-Q (in Italian)

Host

Ari

APT editor and curator at The Lancet Respiratory Medicine; appears across several episodes.

Chart Rankings

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Apple Podcasts	#204	United Kingdom/Health & Fitness/Medicine
Apple Podcasts	#49	Brazil/Health & Fitness/Medicine
Apple Podcasts	#192	Brazil/Health & Fitness

Talking Points

Recent interactions between the hosts and their guests.

Andrew Bush, Heather Zar, Fernando de Benedictis on how inhaled corticosteroids have changed the treatment of asthma

Q: What challenges exist in global access to inhaled corticosteroids, especially in LMICs?

Access remains limited due to cost, availability, and infrastructure. In many LMICs, only a minority of pharmacies carry inhaled corticosteroids, and spacers are often unavailable. This inequity contributes to higher asthma morbidity and mortality in children, despite affordable options in high-income settings.

Andrew Bush, Heather Zar, Fernando de Benedictis on how inhaled corticosteroids have changed the treatment of asthma

Q: What were the key milestones in the evolution of inhaled corticosteroids for asthma?

The introduction of inhaled corticosteroids into clinical practice, followed by landmark studies showing dose-dependent reductions in mortality and improvements in control, established them as the bedrock of therapy. Over time, data confirmed long-term benefits, including fewer exacerbations and better lung function, creating a paradigm shift toward regular, maintained treatment.

Anne Holland and Christine McDonald

Q: What should future research focus on, and are there ongoing studies that might shed more light on patient management?

Future work should prioritize device innovation to deliver sufficient oxygen during exertion while remaining comfortable and manageable for patients, enabling longer-term and more frequent use. Shared decision making remains crucial, and there is a need for longer, well-powered trials with improved devices before broader adoption.

Anne Holland and Christine McDonald

Q: What do you think are the most important findings from this study, and what limitations should be considered when interpreting the results?

The primary outcome showed no meaningful difference in daily-life physical activity between the portable oxygen and sham, and secondary outcomes mirrored this lack of benefit. Limitations include the COVID-affected recruitment leading to a smaller sample size and the use of current-generation portable concentrators with limited oxygen flow, which may not fully address exertional desaturation in ILD.

Sailesh Kotecha on Prematurity-associated lung disease

Q: What further research is needed to accurately improve outcomes and what needs to change?

We need a form of diagnosing, as early as we can, follow-up and monitoring, and the institutes and treatments that we got existing.

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Frequently Asked Questions About This Podcast

What is This Podcast about and what kind of topics does it cover?

The show concentrates on cutting-edge respiratory health research, translating new findings into implications for patient care, health systems, and policy. Recent episodes spotlight blood biomarkers for cardiac arrest prognosis, lung disease in preterm infants, multidimensional risk stratification in COPD, and novel therapies for asthma and pulmonary fibrosis, including monoclonal antibodies and experimental oral inhibitors. A notable pattern is international collaboration and clinical trial-focused discussions, often featuring researchers and clinicians who contextualize results within real-world care, diagnostics, and long-term outcomes. A distinctive strength is connecting biomarker work, pediatric and adult respiratory conditions, and t... more

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this podcast launched 6 years ago and published 163 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on this podcast?

Recent guests on this podcast include:

1. Anne-Marie Dingemans
2. Isabelle Opiz
3. Corinne Faivre-Finn
4. Anne Holland
5. Christine McDonald
6. Dr. Marion Moseby-Knappe
7. Sailesh Kotecha
8. Toby Maher

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