Smart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation

David Brühlmann - CMC Development Leader, Biotech C-level Advisor, Business Strategist

Biotechnology

Stakeholder Management

Impedance Flow Cytometry

Bioprocess Development

Bioprocessing

Biologics

CMC Development

Bead-Based Assays

Biologics Manufacturing

Biopharmaceuticals

Artificial Intelligence

Cell Factories

Synthetic Biology

Regulatory Compliance

Cultivated Meat

High Throughput Screening

Single-Cell Analysis

Cell and Gene Therapies

Quality Control

Cell Culture

The Go-to Podcast for Biotech Scientists Who Want to Master Biopharma CMC Development and Biomanufacturing.

**TOP 10 LIFE SCIENCES PODCAST**

Are you ready to simplify bioprocess development and scale with confidence to reduce time to market?

Are you feeling overwhelmed by the complexity and guesswork of biologics development and biomanufacturing?

Do you wish you had more time to enjoy the beauty o... more

29 ratings

Publishes	Daily	Episodes	217	Founded	2 years ago
Number of Listeners		Categories	Life SciencesScience

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Guests Host Reviews Charts Talking Points

Latest Episodes

216: From Data Silos to Autonomous Biomanufacturing: Digital Twins and AI-Driven Scale-Up with Ilya Burkov - Part 2

Biomanufacturing has always dealt with the challenge of turning vast, complex datasets and intricate production steps into life-changing therapies. But when batch records multiply and process deviations loom, how do biotech teams make sense of it all... more

18 Dec 2025 • 18 min

215: From Data Silos to Autonomous Biomanufacturing: Digital Twins and AI-Driven Scale-Up with Ilya Burkov - Part 1

Across biotech labs, researchers swim in oceans of process data: sensor streams, run records, engineering logs, and still, crucial decisions get stuck in spreadsheets or scribbled into fading notebooks. The challenge isn’t having enough information, ... more

16 Dec 2025 • 21 min

214: From Developability to Formulation: How In Silico Methods Predict Stability Issues Before the Lab with Giuseppe Licari - Part 2

Computational methods can predict stability issues before the lab. But how do you actually implement these approaches in your formulation workflow? From excipient selection to long-term stability prediction, in silico tools are transforming how biote... more

11 Dec 2025 • 14 min

213: From Developability to Formulation: How In Silico Methods Predict Stability Issues Before the Lab with Giuseppe Licari - Part 1

What if you could predict formulation failures before ever touching a pipette? Computational approaches are revolutionizing biologics development, replacing trial-and-error experimentation with predictive intelligence that catches stability issues ea... more

9 Dec 2025 • 25 min

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Recent Guests

Giuseppe Licari

Principal Scientist in Computational Structural Biology

Merck KGaA

Episode: 213: From Developability to Formulation: How In Silico Methods Predict Stability Issues Before the Lab with Giuseppe Licari - Part 1

Jesús Zurdo

A veteran in drug discovery and technology development, and a leukemia survivor

Episode: 211: When the Innovator Becomes the Patient: Manufacturing Reality vs. Patient Urgency with Jesús Zurdo - Part 1

Irina Ramos

A downstream processing powerhouse with extensive experience in CMC projects and was involved in the transfer of the AstraZeneca COVID vaccine globally.

AstraZeneca

Episode: 209: From Batch to Continuous: Building Innovation Culture in Conservative Biotech Environments with Irina Ramos - Part 1

Tom Rizzo

Former Dean of the School of Basic Sciences at EPFL, Chief Scientific Officer at Isospec Analytics

Isospec Analytics

Episode: 207: Cryogenic Infrared Ion Spectroscopy: From Mass Spec Limitations to Molecular Precision with Tom Rizzo - Part 1

Niklas Jungnelius

Process modeling expert at Cytiva

Cytiva

Episode: 206: Process Economics Decoded: How to Model Biomanufacturing Costs From Clinical to Commercial Scale with Niklas Jungnelius - Part 2

Daniel Galbraith

Chief Scientific Officer at Solvias with nearly three decades of experience guiding analytical development

Solvias

Episode: 203: Mastering CRO Selection: Essential Questions for CMC Analytical Development with Daniel Galbraith - Part 1

Amanda Hoertz

Expert in ADC development and project management

KBI Biopharma

Episode: 198: Mastering ADC Development: CDMO Strategies for Analytics and Scale-Up with Amanda Hoertz - Part 2

Alois Jungbauer

Professor emeritus of downstream processing at the Institute of Bioprocessed Science at Technology at BOKU University in Vienna

BioChromatographix International

Episode: 196: Monolithic Chromatography Innovations: Solving High-Capacity Purification for Gene Therapy Vectors with Alois Jungbauer - Part 2

Lucas Chan

A molecular and cell biologist with over 20 years in cell and gene therapy development.

CellVec, APAC's first GMP certified specialist CDMO for viral vectors

Episode: 193: Viral Vector CDMO Mastery: Singapore's Answer to Cell and Gene Therapy Supply Shortages with Lucas Chan - Part 1

Host

David Brühlmann

Host of the podcast and a biotech entrepreneur and strategic advisor who collaborates with C-level biopharma leaders to tackle major challenges in biomanufacturing, especially relating to reducing costs and improving accessibility of therapies.

Reviews

4.9 out of 5 stars from 29 ratings

Good stuff !
I am enjoying this podcast and always learn a thing or two! Thanks David!
Apple Podcasts
5
Rob78_13
United Statesa year ago
Insightful!
I love my weekly dose of the Smart Biotech Scientist podcast! I enjoy hearing and learning from my peers in the biopharmaceutical development field, gaining new insights and perspectives on CMC development challenges, tech, and strategies. The host is knowledgeable and engaging, bringing expert guests who share their cutting-edge strategies and real-world experiences. Whether you’re a seasoned professional or new to the field, this podcast offers practical advice and innovative solutions that c... more
Apple Podcasts
5
Giulia Lambiase
United Kingdoma year ago
Great interviews, good format
David delivers a great podcasts: I like the depth of the conversations and also that the episodes have the perfect length for my commute to work👍
Apple Podcasts
5
pilldipp
Germany2 years ago
Deeply Refreshing Perspective
I am really a fan of David’s content and his approach to intriguing subjects.
Apple Podcasts
5
Stem Cell Guy
United States2 years ago
Fantastic content!
Great podcast! Highly recommend that anybody working in biotech listen to this podcast. David, the host, is very knowledgeable in the bio tech space. I have enjoyed the insights from the guests.
Apple Podcasts
5
MatthiasV1976
United States2 years ago

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Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Many reviewers have recommended it as an essential resource for anyone in the biomanufacturing field, emphasizing its relevance and insights.

Listeners appreciate the knowledge and engaging nature of the host and guests, highlighting valuable insights into complex biopharmaceutical topics.

The podcast is praised for its practical advice and ability to distill complex concepts in bioprocess development into understandable information.

Audiences enjoy the discussions that reflect real-world challenges faced in biomanufacturing and CMC development.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Apple Podcasts	#215	United States/Science/Life Sciences
Apple Podcasts	#185	United Kingdom/Science/Life Sciences
Apple Podcasts	#34	Germany/Science/Life Sciences
Apple Podcasts	#70	Italy/Science/Life Sciences
Apple Podcasts	#226	Australia/Science/Life Sciences
Apple Podcasts	#13	Finland/Science/Life Sciences

Talking Points

Recent interactions between the hosts and their guests.

212: When the Innovator Becomes the Patient: Manufacturing Reality vs. Patient Urgency with Jesús Zurdo - Part 2

Q: What are the trends you see with respect to new manufacturing technologies?

While automation can enhance manufacturing consistency, the over-engineering of technologies may lead to unnecessary complexities without addressing real issues.

212: When the Innovator Becomes the Patient: Manufacturing Reality vs. Patient Urgency with Jesús Zurdo - Part 2

Q: What is your perspective on point of care manufacturing?

Point of care manufacturing can streamline processes by using fresh cells and minimizing traditional testing, thus enhancing accessibility and efficiency.

214: From Developability to Formulation: How In Silico Methods Predict Stability Issues Before the Lab with Giuseppe Licari - Part 2

Q: What comes next then in this field?

I see new machines and computational power increasing, which will enable us to simulate bigger systems for a longer time.

214: From Developability to Formulation: How In Silico Methods Predict Stability Issues Before the Lab with Giuseppe Licari - Part 2

Q: What would be your advice to still be able to leverage some of the potential of these in silico approaches?

Consider doing a small feasibility with an external provider to test the approaches, as in silico methods are generally not expensive from the computational side.

213: From Developability to Formulation: How In Silico Methods Predict Stability Issues Before the Lab with Giuseppe Licari - Part 1

Q: Can you explain how in silico approaches are used to help in the development process?

In silico methods are utilized to assess drug candidates' properties and ensure they are feasible for formulation, thus aiding in developability assessments.

Audience Metrics

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Frequently Asked Questions About Smart Biotech Scientist

What is Smart Biotech Scientist about and what kind of topics does it cover?

This podcast provides valuable insights tailored for biotechnology professionals, particularly those focused on bioprocess development and manufacturing. It actively addresses the complexities faced in the biopharmaceutical sector, offering listeners practical strategies to streamline processes in biologics manufacturing and reduce time to market for innovative therapies. The conversations feature industry experts sharing their knowledge and experiences, focusing primarily on key areas such as cell culture, CMC development, and the use of AI in bioprocessing. This engaging format encourages both seasoned and newcomer professionals to optimize their practices and embrace new technologies that can advance their work in the biotechnology field... more

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Which podcasts are similar to Smart Biotech Scientist?

These podcasts share a similar audience with Smart Biotech Scientist:

1. The Intelligence from The Economist
2. The Rest Is Politics
3. BioCentury This Week

How many episodes of Smart Biotech Scientist are there?

Smart Biotech Scientist launched 2 years ago and published 217 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Smart Biotech Scientist?

Recent guests on Smart Biotech Scientist include:

1. Giuseppe Licari
2. Jesús Zurdo
3. Irina Ramos
4. Tom Rizzo
5. Niklas Jungnelius
6. Daniel Galbraith
7. Amanda Hoertz
8. Alois Jungbauer

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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