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Smart Biotech Scientist | The CMC and Biomanufacturing Podcast for Bioprocess Development and Manufacturing Leaders

David Brühlmann - CMC Development Leader, Bioprocess Expert, Business Strategist
Biotechnology
Stakeholder Management
Impedance Flow Cytometry
Bioprocess Development
Bioprocessing
Biologics
CMC Development
Bead-Based Assays
Biologics Manufacturing
Biopharmaceuticals
Artificial Intelligence
Cell Factories
Synthetic Biology
Regulatory Compliance
Cultivated Meat
High Throughput Screening
Single-Cell Analysis
Cell and Gene Therapies
Quality Control
Cell Culture

The go-to CMC and bioprocessing podcast for process development scientists and CMC leaders scaling biologics into regulatory-ready therapies with less trial and error.

Practical, execution-focused guidance on CMC development, tech transfer, scale-up, GMP readiness, CDMO partnerships, and manufacturing economics.

Hosted by Dr. David Brühlmann, CMC strategist, former Bioprocess Innovation Manager ... more

PublishesTwice weeklyEpisodes242Founded2 years ago
Number of ListenersCategories
Life SciencesScience

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Artwork for Smart Biotech Scientist

Latest Episodes

Arctic fish survive in waters that would freeze most life solid. Not because they tolerate ice, but because their biology prevents crystals from forming in the first place. That same principle, translated into synthetic peptide chemistry, is now show... more

Why do CDMOs keep building bigger stainless-steel facilities while their margins erode and Asian competitors undercut them on price? And what happens when big pharma decides to stop outsourcing altogether? The business model that sustained the indust... more

What if continuous microbial manufacturing wasn't a pipe dream, but a reality quietly reshaping the foundations of bioprocessing?

Meet Juergen Mairhofer, CEO of enGenes Biotech GmbH and a scientist with a rare dual fluency in molecular biology and b... more

YouTube

For many biotech innovators, high-throughput screening platforms promise faster discoveries and streamlined workflows. Yet beneath the surface, the reality is more demanding, requiring hands-on expertise, careful assay design, and a sharp understandi... more

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Recent Guests

Juergen Mairhofer
CEO of Engenes Biotech, engineer focused on continuous microbial manufacturing
Engenes Biotech
Episode: 239: Continuous Microbial Manufacturing: From Genetic Instability to 40-Day E. coli Processes with Juergen Mairhofer - Part 1
Sebastian Blum
Microbiologist and market development manager at Beckman Coulter
Beckman Coulter
Episode: 237: High-Throughput Microbial Screening: Avoiding Early Mistakes That Derail Scale-Up with Sebastian Blum - Part 1
Waranyoo Phoolcharoen
Professor and Co-founder of Baiya Phytopharm
Baiya Phytopharm
Episode: 235: Plant-Based Biomanufacturing: How Molecular Farming Produces Biopharmaceuticals in Weeks, Not Months with Waranyoo Phoolcharoen - Part 1
Anthony Catacchio
Guest expert on robotics and automation for bioprocessing
Product Insight
Episode: 234: Why Most Bioprocess Automation Projects Fail Before the Robot Is Even Ordered with Anthony Catacchio - Part 2
Henri Kornmann
Biotech industry veteran with experience at Merck, Biogen, and Ferring; led CMC development for biologics and gene therapy
Ferring (former), Merck (former), Biogen (former)
Episode: 231: From IND to BLA: The Biologics CMC Decisions That Determine Regulatory Success with Henri Kornmann - Part 1
Tim Corcoran
CEO of Deep Blue Biotech
Deep Blue Biotech
Episode: 229: Cyanobacteria Biomanufacturing: Achieving Carbon-Neutral Production at Lower Cost Than Fermentation with Tim Corcoran - Part 1
Bryan Miller
Director of Scientific and Technical Operations at Crown Bioscience UK
Crown Bioscience
Episode: 225: Mastering Radiopharmaceutical Development: Preclinical Model Selection for Clinical Success with Bryan Miller - Part 1
Steven Lang
Expert in cellular agriculture and plant cell culture
California Culture
Episode: 224: From Cultivated Meat to Chocolate: Rethinking Cellular Agriculture Scale-Up with Steven Lang - Part 2
Catarina Brito
Expert in advanced cell models and their applications in biopharmaceutical research
iBET
Episode: 222: From 2D Cultures to Advanced 3D Cell Models for Preclinical Research with Catarina Brito - Part 2

Host

David Brühlmann
Host of Smart Biotech Scientist; CMC strategist; former Bioprocess Innovation Manager at Merck; PhD in glycoengineering; close to 20 years in biomanufacturing.

Reviews

4.9 out of 5 stars from 30 ratings
  • Good stuff !

    I am enjoying this podcast and always learn a thing or two! Thanks David!

    Apple Podcasts
    5
    Rob78_13
    United Statesa year ago
  • Insightful!

    I love my weekly dose of the Smart Biotech Scientist podcast! I enjoy hearing and learning from my peers in the biopharmaceutical development field, gaining new insights and perspectives on CMC development challenges, tech, and strategies. The host is knowledgeable and engaging, bringing expert guests who share their cutting-edge strategies and real-world experiences. Whether you’re a seasoned professional or new to the field, this podcast offers practical advice and innovative solutions that c... more

    Apple Podcasts
    5
    Giulia Lambiase
    United Kingdom2 years ago
  • Great interviews, good format

    David delivers a great podcasts: I like the depth of the conversations and also that the episodes have the perfect length for my commute to work👍

    Apple Podcasts
    5
    pilldipp
    Germany2 years ago
  • Deeply Refreshing Perspective

    I am really a fan of David’s content and his approach to intriguing subjects.

    Apple Podcasts
    5
    Stem Cell Guy
    United States2 years ago
  • Fantastic content!

    Great podcast! Highly recommend that anybody working in biotech listen to this podcast. David, the host, is very knowledgeable in the bio tech space. I have enjoyed the insights from the guests.

    Apple Podcasts
    5
    MatthiasV1976
    United States2 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Clear, practical guidance for bioprocess development teams.
Concise episodes with in-depth technical discussions.
High-quality guests share real-world CMC insights.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Talking Points

Recent interactions between the hosts and their guests.

238: High-Throughput Microbial Screening: Avoiding Early Mistakes That Derail Scale-Up with Sebastian Blum - Part 2
Q: How do you see early stage bioprocess development evolving with automation and AI?
Automation and miniaturization will continue to dominate, enabling higher throughput and more sophisticated micro bioreactor systems. AI and machine learning will increasingly analyze the large data sets from screening to predict optimal conditions, while digital twins will let researchers simulate thousands of scenarios virtually before running physical experiments.
237: High-Throughput Microbial Screening: Avoiding Early Mistakes That Derail Scale-Up with Sebastian Blum - Part 1
Q: What is the main difference between small and large companies in their approach to development?
Smaller startups prioritize speed and lower costs, often using simpler, lower-throughput solutions; large pharmaceutical companies invest in robust, data-rich early-stage development with automation and high-throughput systems to de-risk processes and ensure scalability, with CDMOs occupying a flexible middle ground.
237: High-Throughput Microbial Screening: Avoiding Early Mistakes That Derail Scale-Up with Sebastian Blum - Part 1
Q: Paint us a picture of the various small-scale systems available and when to use them.
Smaller systems like shake flasks are cheap but offer limited control; benchtop 1–10 L systems provide better process control and scalability; high-throughput platforms enable dozens of parallel experiments with rich data, suitable for rapid screening and early-stage DOE, with the caveat of higher upfront cost and the need for good experimental design.
236: Plant-Based Biomanufacturing: How Molecular Farming Produces Biopharmaceuticals in Weeks, Not Months with Waranyoo Phoolcharoen - Part 2
Q: How does your platform speed up process development?
By using transient expression in plants, there is no need to generate stable cell lines; once the gene is available, production starts quickly and expression happens in days, with harvest in about a week from gene to product.
233: Why Most Bioprocess Automation Projects Fail Before the Robot Is Even Ordered with Anthony Catacchio - Part 1
Q: How do you decide when automation is the right solution versus using human labor?
The answer centers on rigorous problem definition, ROI analysis, and the concept phase, emphasizing that many problems can be solved more cheaply and effectively with people or simpler setups, rather than jumping straight to complex robotic systems.

Audience Metrics

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Frequently Asked Questions About Smart Biotech Scientist

What is Smart Biotech Scientist about and what kind of topics does it cover?

This show targets senior practitioners in bioprocess development and CMC, offering execution-focused guidance for scaling biologics from lab to regulatory-ready manufacturing. Episodes frequently cover CMC strategy, process development, scale-up, tech transfer, GMP readiness, and CDMO partnerships, often weaving in regulatory considerations, lifecycle management, and manufacturing economics. A notable strength is the hands-on, house-style analogy approach to complex topics, plus a steady stream of practitioner guests who share practical lessons from industry leaders and innovators. The format tends to favor concise, implementation-ready takeaways, making it a valuable resource for teams preparing INDs, optimizing manufacturing workflows, or... more

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Which podcasts are similar to Smart Biotech Scientist?

These podcasts share a similar audience with Smart Biotech Scientist:

1. BioCentury This Week
2. Biotech Hangout
3. Gemischtes Hack
4. The Mel Robbins Podcast
5. Cell & Gene: The Podcast

How many episodes of Smart Biotech Scientist are there?

Smart Biotech Scientist launched 2 years ago and published 242 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Smart Biotech Scientist?

Recent guests on Smart Biotech Scientist include:

1. Juergen Mairhofer
2. Sebastian Blum
3. Waranyoo Phoolcharoen
4. Anthony Catacchio
5. Henri Kornmann
6. Tim Corcoran
7. Bryan Miller
8. Steven Lang

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