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Smart Biotech Scientist | The CMC and Bioprocessing Podcast for Process Development and Manufacturing Leaders

David Brühlmann - CMC Development Leader, Bioprocess Expert, Business Strategist
Biotechnology
Bioprocess Development
Bioprocessing
Biomanufacturing
Artificial Intelligence
Cell Therapy
Biologics Manufacturing
Cell and Gene Therapy
Gene Therapy
Cell Culture
Biologics
Drug Development
Continuous Manufacturing
Regulatory Compliance
Clinical Trials
Process Development
Biopharmaceutical Manufacturing
CMC Development
Biotech
Biopharmaceuticals

The go-to CMC and biomanufacturing podcast for bioprocess development scientists and CMC leaders scaling biologics into regulatory-ready therapies with less trial and error.

Practical, execution-focused, and strategic guidance on CMC development, tech transfer, scale-up, GMP readiness, CDMO partnerships, and manufacturing economics for biologics, cell and gene therapies, cultivated meat, and biom... more

PublishesTwice weeklyEpisodes271Founded3 years ago
Number of ListenersCategories
Life SciencesScience

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Artwork for Smart Biotech Scientist

Latest Episodes

In the biotech industry, advancing cell-based therapies is not just about innovation. It's about solving real gaps where conventional treatments fall short, especially against complex, aggressive tumors.

In this episode of the Smart Biotech Scientis... more

What if the answer to solid tumor therapy isn’t about making immune cells smarter—but about rethinking what a therapeutic cell can do For years, mesenchymal stem cells (MSCs) have turned heads for their ability to home in on damaged tissue, yet their... more

Why does life-saving insulin cost hundreds of dollars a month for patients, when manufacturing costs are just a fraction of that price? What if the nonprofit model could change everything for affordable access?

In the pharmaceutical industry, afford... more

YouTube

Insulin was first discovered over a century ago—yet in the United States, 1 in 5 insulin-dependent patients still ration their lifesaving supply. Why is a molecule so essential, and so well understood, still so out of reach for so many?

Eric Moyal, ... more

YouTube

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Recent Guests

Farlan Veraitch
Founder and Chief Scientific Officer, Ori Biotech
Ori Biotech
Episode: 265: From Human Variability to Automated Precision: Accelerating Cell and Gene Therapy Manufacturing Scale-Out with Farlan Veraitch - Part 1
David Hardy
Market and Innovation Strategist at Thermo Fisher Scientific
Thermo Fisher Scientific
Episode: 263: Why AI and Automation Tools Won't Deliver Until Your Lab's Data Is Connected with David Hardy - Part 1
Michael Rome
Investor at Foresite Capital
Foresite Capital
Episode: 260: Why Strong Science Isn't Enough to Get Funded: What Investors Actually Look For with Michael Rome - Part 2
Milan Tomic
Founder/CEO of Albrem; experienced bioprocess developer and manufacturing leader
Albrem
Episode: 257: Why Regulatory Affairs Belongs in Drug Design: 30 Years of CMC Lessons from Discovery to GMP Manufacturing with Milan Tomic - Part 1
Steffen Kreye
Professor of industrial biotechnology
Berliner Hochschule für Technik (Berlin University of Applied Sciences)
Episode: 255: Is Bioprocess Education Keeping Up With New Tech? The Training Gap Industry Cannot Afford to Ignore with Steffen Kreye - Part 1
Yuta Lee
CEO of Accelerated Bio
Accelerated Bio
Episode: 254: How to Source, Manufacture, and Scale the Earliest Stem Cells for Allogeneic Cell Therapy Without Ethical Barriers with Yuta Lee - Part 2
Chantale Bernatchez
Head of process development at CTMC (Resilience and MD Anderson joint venture)
CTMC (Resilience + MD Anderson)
Episode: 249: How T Cell Activation Redefines TIL and CAR-T Manufacturing (Boosting Success Rates to 95%) with Chantale Bernatchez - Part 1
Ron Najafi
Founder/CEO with decades in chemistry and biopharma
Emery Pharma (CRO) and NovaBay Pharmaceuticals
Episode: 247: Nitrosamine Risk Assessment and CRO Selection: The $6 Million Mistake CMC Teams Must Avoid with Ron Najafi - Part 1
Tibor Anderlei
Pioneered online monitoring and shake flasks; co-founded AC Biotech; leads customer success at Kühner Shaker
Kühner Shaker; AC Biotech
Episode: 245: Why Your Shake Flask Culture Doesn't Scale: OTR, Shaking Diameter, and How to Fix It with Tibor Anderlei - Part 1

Host

David Brühlmann
Host of Smart Biotech Scientist; CMC strategist and bioprocessing expert

Reviews

4.9 out of 5 stars from 31 ratings
  • Good stuff !

    I am enjoying this podcast and always learn a thing or two! Thanks David!

    Apple Podcasts
    5
    Rob78_13
    United States2 years ago
  • Insightful!

    I love my weekly dose of the Smart Biotech Scientist podcast! I enjoy hearing and learning from my peers in the biopharmaceutical development field, gaining new insights and perspectives on CMC development challenges, tech, and strategies. The host is knowledgeable and engaging, bringing expert guests who share their cutting-edge strategies and real-world experiences. Whether you’re a seasoned professional or new to the field, this podcast offers practical advice and innovative solutions that c... more

    Apple Podcasts
    5
    Giulia Lambiase
    United Kingdom2 years ago
  • Great interviews, good format

    David delivers a great podcasts: I like the depth of the conversations and also that the episodes have the perfect length for my commute to work👍

    Apple Podcasts
    5
    pilldipp
    Germany2 years ago
  • Deeply Refreshing Perspective

    I am really a fan of David’s content and his approach to intriguing subjects.

    Apple Podcasts
    5
    Stem Cell Guy
    United States3 years ago
  • Fantastic content!

    Great podcast! Highly recommend that anybody working in biotech listen to this podcast. David, the host, is very knowledgeable in the bio tech space. I have enjoyed the insights from the guests.

    Apple Podcasts
    5
    MatthiasV1976
    United States3 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Listeners praise deep, practical discussions and knowledgeable hosts.
Guests are high-caliber with actionable insights for biotech manufacturing and CMC.
The show consistently delivers engaging interviews with a clear focus on bioprocessing challenges and solutions.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Talking Points

Recent interactions between the hosts and their guests.

260: Why Strong Science Isn't Enough to Get Funded: What Investors Actually Look For with Michael Rome - Part 2
Q: What should a startup founder do today to prepare for the next funding round?
Start by articulating a clear unmet medical need, a credible pathway to an approved drug, and a realistic development plan that shows how they will reach that goal, including CMC readiness and a scalable manufacturing strategy as risk-reduction signals for investors.
259: Why Strong Science Isn't Enough to Get Funded: What Investors Actually Look For with Michael Rome - Part 1
Q: What do you actually do on a daily basis as an investor and what does Foresite Capital look for when deploying capital?
The firm continually scans biotech ideas and companies across stages, maintains a broad portfolio to understand multiple perspectives, and prioritizes product-market fit, strong leadership, and scalable assets, rather than focusing solely on the science. They also pursue partnerships and asset-in-licensing to build clinical-stage opportunities.
264: Why AI and Automation Tools Won't Deliver Until Your Lab's Data Is Connected with David Hardy - Part 2
Q: Where can listeners connect with you to learn more about connected labs and AI in bioprocessing?
Listeners can reach me on LinkedIn for follow-up questions and discussion.
264: Why AI and Automation Tools Won't Deliver Until Your Lab's Data Is Connected with David Hardy - Part 2
Q: What additional questions should we be asking as we wrap up this topic?
Ask how data standardization and governance will scale across the organization, what the ROI timeline looks like, and how to balance democratizing data with security and IP protection to sustain long-term progress.
264: Why AI and Automation Tools Won't Deliver Until Your Lab's Data Is Connected with David Hardy - Part 2
Q: What is the right approach to adopting AI in bioprocessing given the evolving landscape and uncertain paths forward?
Start with ensuring data quality and governance, differentiate between predictive AI and generative AI, and implement a clear, end-to-end workflow that can be piloted at scale. Focus on data standardization and incremental, measurable improvements rather than chasing speculative capabilities.

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Frequently Asked Questions About Smart Biotech Scientist

What is Smart Biotech Scientist about and what kind of topics does it cover?

The show targets process development scientists and CMC leaders driving biologics into regulatory-ready therapies, with a practical, execution-focused angle on scale-up, tech transfer, GMP readiness, CDMO partnerships, and manufacturing economics. Episodes feature deep dives into cell therapy, bioprocess optimization, analytics, and regulatory strategy, often weaving in real-world practicalities, vendor and partner perspectives, and forward-looking tech like continuous manufacturing and digital twins. A standout aspect is the guest mix: senior industry practitioners and established biotech leaders share actionable frameworks, from SHAKe-scale decisions to complex CMC programs, making it a valuable resource for both hands-on engineers and bi... more

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Which podcasts are similar to Smart Biotech Scientist?

These podcasts share a similar audience with Smart Biotech Scientist:

1. BioCentury This Week
2. Biotech Hangout
3. The Readout Loud
4. Nature Podcast
5. All-In with Chamath, Jason, Sacks & Friedberg

How many episodes of Smart Biotech Scientist are there?

Smart Biotech Scientist launched 3 years ago and published 271 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Smart Biotech Scientist?

Recent guests on Smart Biotech Scientist include:

1. Farlan Veraitch
2. David Hardy
3. Michael Rome
4. Milan Tomic
5. Steffen Kreye
6. Yuta Lee
7. Chantale Bernatchez
8. Ron Najafi

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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