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Smart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation

David Brühlmann - CMC Development Leader, Biotech C-level Advisor, Business Strategist
Biotechnology
Stakeholder Management
Impedance Flow Cytometry
Bioprocess Development
Bioprocessing
Biologics
CMC Development
Bead-Based Assays
Biologics Manufacturing
Biopharmaceuticals
Artificial Intelligence
Cell Factories
Synthetic Biology
Regulatory Compliance
Cultivated Meat
High Throughput Screening
Single-Cell Analysis
Cell and Gene Therapies
Quality Control
Cell Culture

The Go-to Podcast for Biotech Scientists Who Want to Master Biopharma CMC Development and Biomanufacturing.

**TOP 10 LIFE SCIENCES PODCAST**

Are you ready to simplify bioprocess development and scale with confidence to reduce time to market?

Are you feeling overwhelmed by the complexity and guesswork of biologics development and biomanufacturing?

Do you wish you had more time to enjoy the beauty o... more

PublishesDailyEpisodes220Founded2 years ago
Number of ListenersCategories
Life SciencesScience

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Artwork for Smart Biotech Scientist

Latest Episodes

Antibody therapeutics have transformed modern medicine, but for many scientists, developing new candidates still feels like searching for a needle in a haystack—a slow, expensive, and unpredictable process. Structural biology and high-throughput data... more

For generations, silkworm pupae were discarded as waste from silk production. Now, KAICO is proving these organisms can function as highly efficient protein factories—producing complex vaccine antigens at yields and costs that challenge conventional ... more

For over 4,000 years, silkworms have connected civilizations through ancient trade routes. Now, KAICO Ltd., a Japanese biotech spin-off from Kyushu University, is transforming these creatures into living bioreactors capable of producing complex recom... more

Biomanufacturing has always dealt with the challenge of turning vast, complex datasets and intricate production steps into life-changing therapies. But when batch records multiply and process deviations loom, how do biotech teams make sense of it all... more

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Recent Guests

Masafumi Osawa
Pioneering biomanufacturing expert at KAICO
KAICO
Episode: 217: Silkworm Biomanufacturing: From Ancient Silk Production to Phase I Vaccine Trials with Masafumi Osawa - Part 1
Ilya Burkov
AI expert and member of Nebius AI
Nebius AI
Episode: 216: From Data Silos to Autonomous Biomanufacturing: Digital Twins and AI-Driven Scale-Up with Ilya Burkov - Part 2
Giuseppe Licari
Principal Scientist in Computational Structural Biology
Merck KGaA
Episode: 213: From Developability to Formulation: How In Silico Methods Predict Stability Issues Before the Lab with Giuseppe Licari - Part 1
Jesús Zurdo
A veteran in drug discovery and technology development, and a leukemia survivor
Episode: 211: When the Innovator Becomes the Patient: Manufacturing Reality vs. Patient Urgency with Jesús Zurdo - Part 1
Irina Ramos
A downstream processing powerhouse with extensive experience in CMC projects and was involved in the transfer of the AstraZeneca COVID vaccine globally.
AstraZeneca
Episode: 209: From Batch to Continuous: Building Innovation Culture in Conservative Biotech Environments with Irina Ramos - Part 1
Tom Rizzo
Former Dean of the School of Basic Sciences at EPFL, Chief Scientific Officer at Isospec Analytics
Isospec Analytics
Episode: 207: Cryogenic Infrared Ion Spectroscopy: From Mass Spec Limitations to Molecular Precision with Tom Rizzo - Part 1
Niklas Jungnelius
Process modeling expert at Cytiva
Cytiva
Episode: 206: Process Economics Decoded: How to Model Biomanufacturing Costs From Clinical to Commercial Scale with Niklas Jungnelius - Part 2
Daniel Galbraith
Chief Scientific Officer at Solvias with nearly three decades of experience guiding analytical development
Solvias
Episode: 203: Mastering CRO Selection: Essential Questions for CMC Analytical Development with Daniel Galbraith - Part 1
Amanda Hoertz
Vice President of Analytical and Formulation Sciences at KBI Biopharma
KBI Biopharma
Episode: 197: Mastering ADC Development: CDMO Strategies for Analytics and Scale-Up with Amanda Hoertz - Part 1

Host

David Brühlmann
Host of the podcast and a biotech entrepreneur and strategic advisor who collaborates with C-level biopharma leaders to tackle major challenges in biomanufacturing, especially relating to reducing costs and improving accessibility of therapies.

Reviews

4.9 out of 5 stars from 30 ratings
  • Good stuff !

    I am enjoying this podcast and always learn a thing or two! Thanks David!

    Apple Podcasts
    5
    Rob78_13
    United Statesa year ago
  • Insightful!

    I love my weekly dose of the Smart Biotech Scientist podcast! I enjoy hearing and learning from my peers in the biopharmaceutical development field, gaining new insights and perspectives on CMC development challenges, tech, and strategies. The host is knowledgeable and engaging, bringing expert guests who share their cutting-edge strategies and real-world experiences. Whether you’re a seasoned professional or new to the field, this podcast offers practical advice and innovative solutions that c... more

    Apple Podcasts
    5
    Giulia Lambiase
    United Kingdoma year ago
  • Great interviews, good format

    David delivers a great podcasts: I like the depth of the conversations and also that the episodes have the perfect length for my commute to work👍

    Apple Podcasts
    5
    pilldipp
    Germany2 years ago
  • Deeply Refreshing Perspective

    I am really a fan of David’s content and his approach to intriguing subjects.

    Apple Podcasts
    5
    Stem Cell Guy
    United States2 years ago
  • Fantastic content!

    Great podcast! Highly recommend that anybody working in biotech listen to this podcast. David, the host, is very knowledgeable in the bio tech space. I have enjoyed the insights from the guests.

    Apple Podcasts
    5
    MatthiasV1976
    United States2 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Many reviewers have recommended it as an essential resource for anyone in the biomanufacturing field, emphasizing its relevance and insights.
Listeners appreciate the knowledge and engaging nature of the host and guests, highlighting valuable insights into complex biopharmaceutical topics.
The podcast is praised for its practical advice and ability to distill complex concepts in bioprocess development into understandable information.
Audiences enjoy the discussions that reflect real-world challenges faced in biomanufacturing and CMC development.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Talking Points

Recent interactions between the hosts and their guests.

218: Silkworm Biomanufacturing: From Ancient Silk Production to Phase I Vaccine Trials with Masafumi Osawa - Part 2
Q: How fast can you develop a new vaccine with the Silkworm platform?
As long as the DNA sequence is known, any protein can be produced quickly, exemplified by producing the SARS-CoV-2 spike protein just three months after the outbreak.
218: Silkworm Biomanufacturing: From Ancient Silk Production to Phase I Vaccine Trials with Masafumi Osawa - Part 2
Q: Can you just give us the two-minute version of the differences between human and animal health?
Regulatory pathways for silkworm-derived products vary greatly between human and animal health domains. Human vaccines follow globally harmonized standards, while animal health regulations differ by country, allowing for rapid marketing entry in some cases.
215: From Data Silos to Autonomous Biomanufacturing: Digital Twins and AI-Driven Scale-Up with Ilya Burkov - Part 1
Q: What do you see happening in drug discovery in relation to AI?
AI-driven lab automation is allowing processes that took months to be done in weeks, compressing timelines dramatically.
215: From Data Silos to Autonomous Biomanufacturing: Digital Twins and AI-Driven Scale-Up with Ilya Burkov - Part 1
Q: Can AI actually help us scale faster and smarter or is it just a hype?
AI helps by identifying scale ups that are at risk before they're expensive.
216: From Data Silos to Autonomous Biomanufacturing: Digital Twins and AI-Driven Scale-Up with Ilya Burkov - Part 2
Q: What is the most important takeaway?
AI transforms bioprocessing, enhances human capabilities, and is crucial for competitive manufacturing.

Audience Metrics

Listeners, social reach, demographics and more for this podcast.

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Frequently Asked Questions About Smart Biotech Scientist

What is Smart Biotech Scientist about and what kind of topics does it cover?

This podcast provides valuable insights tailored for biotechnology professionals, particularly those focused on bioprocess development and manufacturing. It actively addresses the complexities faced in the biopharmaceutical sector, offering listeners practical strategies to streamline processes in biologics manufacturing and reduce time to market for innovative therapies. The conversations feature industry experts sharing their knowledge and experiences, focusing primarily on key areas such as cell culture, CMC development, and the use of AI in bioprocessing. This engaging format encourages both seasoned and newcomer professionals to optimize their practices and embrace new technologies that can advance their work in the biotechnology field... more

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Which podcasts are similar to Smart Biotech Scientist?

These podcasts share a similar audience with Smart Biotech Scientist:

1. Cold War Conversations Podcast
2. Huberman Lab
3. Business Of Biotech
4. The Diary Of A CEO with Steven Bartlett
5. BioCentury This Week

How many episodes of Smart Biotech Scientist are there?

Smart Biotech Scientist launched 2 years ago and published 220 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Smart Biotech Scientist?

Recent guests on Smart Biotech Scientist include:

1. Masafumi Osawa
2. Ilya Burkov
3. Giuseppe Licari
4. Jesús Zurdo
5. Irina Ramos
6. Tom Rizzo
7. Niklas Jungnelius
8. Daniel Galbraith

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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