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Smart Biotech Scientist | The CMC and Bioprocessing Podcast for Process Development and Manufacturing Leaders

David Brühlmann - CMC Development Leader, Bioprocess Expert, Business Strategist
Biotechnology
Bioprocess Development
Biomanufacturing
Bioprocessing
Artificial Intelligence
Cell Therapy
Biologics Manufacturing
Cell and Gene Therapy
Gene Therapy
Cell Culture
Biologics
Drug Development
Regulatory Compliance
Continuous Manufacturing
Clinical Trials
Process Development
Biopharmaceutical Manufacturing
CMC Development
Biotech
Biopharmaceuticals

The go-to CMC and biomanufacturing podcast for bioprocess development scientists and CMC leaders scaling biologics into regulatory-ready therapies with less trial and error.

Practical, execution-focused, and strategic guidance on CMC development, tech transfer, scale-up, GMP readiness, CDMO partnerships, and manufacturing economics for biologics, cell and gene therapies, cultivated meat, and biom... more

PublishesTwice weeklyEpisodes248Founded2 years ago
Number of ListenersCategories
Life SciencesScience

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Artwork for Smart Biotech Scientist

Latest Episodes

When drug safety fails, patients and entire markets pay the price. Understanding your CMC isn't just compliance — it's the line between therapeutic promise and product recall.

Ron Najafi has lived that reality firsthand. As founder of NovaBay Pharma... more

Shear sensitivity is the silent challenge behind many advanced biomanufacturing modalities. Orbital-shaken bioreactors—often underestimated—may be a key enabler your CMC development is missing.

Tibor Anderlei, CSO at Kühner Shaker, joined David Brüh... more

Why do small-scale bioprocess experiments often fail to translate in scale-up despite “perfect” results on paper?

Tibor Anderlei, Chief Scientific Officer and leader of customer support at Kühner Shaker, has spent three decades solving an issue that... more

When a single mismanaged tech transfer threatens an entire development program, pressure on CMC leaders and bioprocess teams is intense. The truth? Tech transfers aren’t a black box. They’re complex, but solvable with the right mindset and playbook. more

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Recent Guests

Steve Oh
Leader in stem cell bioprocessing solutions, previously at ASTAR
ASTAR (Singapore)
Episode: 241: DMSO in Cell Therapy: Why Viability Scores Hide the Real Toxicity with Steve Oh - Part 1
Juergen Mairhofer
CEO of Engenes Biotech, engineer focused on continuous microbial manufacturing
Engenes Biotech
Episode: 239: Continuous Microbial Manufacturing: From Genetic Instability to 40-Day E. coli Processes with Juergen Mairhofer - Part 1
Sebastian Blum
Microbiologist and market development manager at Beckman Coulter
Beckman Coulter
Episode: 237: High-Throughput Microbial Screening: Avoiding Early Mistakes That Derail Scale-Up with Sebastian Blum - Part 1
Waranyoo Phoolcharoen
Professor and Co-founder of Baiya Phytopharm
Baiya Phytopharm
Episode: 235: Plant-Based Biomanufacturing: How Molecular Farming Produces Biopharmaceuticals in Weeks, Not Months with Waranyoo Phoolcharoen - Part 1
Anthony Catacchio
CEO of Product Insight
Product Insight
Episode: 233: Why Most Bioprocess Automation Projects Fail Before the Robot Is Even Ordered with Anthony Catacchio - Part 1
Henri Kornmann
CMC strategist and expert discussing lifecycle CMC strategy
Episode: 232: From IND to BLA: The Biologics CMC Decisions That Determine Regulatory Success with Henri Kornmann - Part 2
Tim Corcoran
Founder, Deep Blue Biotech
Deep Blue Biotech
Episode: 230: Cyanobacteria Biomanufacturing: Achieving Carbon-Neutral Production at Lower Cost Than Fermentation with Tim Corcoran - Part 2
Bryan Miller
Director of Scientific and Technical Operations at Crown Bioscience UK
Crown Bioscience
Episode: 225: Mastering Radiopharmaceutical Development: Preclinical Model Selection for Clinical Success with Bryan Miller - Part 1
Steven Lang
Expert in cellular agriculture and plant cell culture
California Culture
Episode: 224: From Cultivated Meat to Chocolate: Rethinking Cellular Agriculture Scale-Up with Steven Lang - Part 2

Host

David Brühlmann
Host of Smart Biotech Scientist; CMC strategist; former Bioprocess Innovation Manager at Merck; PhD in glycoengineering; close to 20 years in biomanufacturing.

Reviews

4.9 out of 5 stars from 30 ratings
  • Good stuff !

    I am enjoying this podcast and always learn a thing or two! Thanks David!

    Apple Podcasts
    5
    Rob78_13
    United States2 years ago
  • Insightful!

    I love my weekly dose of the Smart Biotech Scientist podcast! I enjoy hearing and learning from my peers in the biopharmaceutical development field, gaining new insights and perspectives on CMC development challenges, tech, and strategies. The host is knowledgeable and engaging, bringing expert guests who share their cutting-edge strategies and real-world experiences. Whether you’re a seasoned professional or new to the field, this podcast offers practical advice and innovative solutions that c... more

    Apple Podcasts
    5
    Giulia Lambiase
    United Kingdom2 years ago
  • Great interviews, good format

    David delivers a great podcasts: I like the depth of the conversations and also that the episodes have the perfect length for my commute to work👍

    Apple Podcasts
    5
    pilldipp
    Germany2 years ago
  • Deeply Refreshing Perspective

    I am really a fan of David’s content and his approach to intriguing subjects.

    Apple Podcasts
    5
    Stem Cell Guy
    United States2 years ago
  • Fantastic content!

    Great podcast! Highly recommend that anybody working in biotech listen to this podcast. David, the host, is very knowledgeable in the bio tech space. I have enjoyed the insights from the guests.

    Apple Podcasts
    5
    MatthiasV1976
    United States2 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Clear, practical guidance for bioprocess development teams.
Concise episodes with in-depth technical discussions.
High-quality guests share real-world CMC insights.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Talking Points

Recent interactions between the hosts and their guests.

242: DMSO in Cell Therapy: Why Viability Scores Hide the Real Toxicity with Steve Oh - Part 2
Q: What are the practical workflow implications for labs using XT Thrive compared to DMSO?
XT Thrive allows longer processing windows (up to 24 hours) without the need for rapid, post-thaw washing, reducing bottlenecks in large-volume operations and improving overall logistics and safety.
242: DMSO in Cell Therapy: Why Viability Scores Hide the Real Toxicity with Steve Oh - Part 2
Q: How easily can teams switch from DMSO to XT Thrive in an existing process?
The transition is described as plug-and-play; teams can adopt XT Thrive at the same concentrations and integrate it with existing manufacturing workflows with minimal disruption, aided by GMP-grade validation and drug master files.
241: DMSO in Cell Therapy: Why Viability Scores Hide the Real Toxicity with Steve Oh - Part 1
Q: What are the fundamental challenges in preserving cells beyond viability, and why has DMSO remained the standard despite its limitations?
The host and guest discuss how viability alone is not enough; thawed cells must retain function, genetic stability, and potency, and how historical regulatory concerns and practical benefits kept DMSO in use even as new toxicities and regulatory weariness emerged.
241: DMSO in Cell Therapy: Why Viability Scores Hide the Real Toxicity with Steve Oh - Part 1
Q: Take us back to the beginning. What sparked your passion for biotech and cell therapy, and what pivotal moments shaped your path?
Steve describes early breakthroughs with microcarriers for stem cells, shifts in how cells could be grown at scale, and the challenging yet pivotal move from traditional fermentation for bacteria to scalable mammalian cell culture, which laid the groundwork for his leadership in cryopreservation solutions.
238: High-Throughput Microbial Screening: Avoiding Early Mistakes That Derail Scale-Up with Sebastian Blum - Part 2
Q: How do you see early stage bioprocess development evolving with automation and AI?
Automation and miniaturization will continue to dominate, enabling higher throughput and more sophisticated micro bioreactor systems. AI and machine learning will increasingly analyze the large data sets from screening to predict optimal conditions, while digital twins will let researchers simulate thousands of scenarios virtually before running physical experiments.

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Frequently Asked Questions About Smart Biotech Scientist

What is Smart Biotech Scientist about and what kind of topics does it cover?

This show targets senior practitioners in bioprocess development and CMC, offering execution-focused guidance for scaling biologics from lab to regulatory-ready manufacturing. Episodes frequently cover CMC strategy, process development, scale-up, tech transfer, GMP readiness, and CDMO partnerships, often weaving in regulatory considerations, lifecycle management, and manufacturing economics. A notable strength is the hands-on, house-style analogy approach to complex topics, plus a steady stream of practitioner guests who share practical lessons from industry leaders and innovators. The format tends to favor concise, implementation-ready takeaways, making it a valuable resource for teams preparing INDs, optimizing manufacturing workflows, or... more

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Which podcasts are similar to Smart Biotech Scientist?

These podcasts share a similar audience with Smart Biotech Scientist:

1. Biotech Hangout
2. Huberman Lab
3. BioCentury This Week
4. The Daily
5. The Mel Robbins Podcast

How many episodes of Smart Biotech Scientist are there?

Smart Biotech Scientist launched 2 years ago and published 248 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Smart Biotech Scientist?

Recent guests on Smart Biotech Scientist include:

1. Steve Oh
2. Juergen Mairhofer
3. Sebastian Blum
4. Waranyoo Phoolcharoen
5. Anthony Catacchio
6. Henri Kornmann
7. Tim Corcoran
8. Bryan Miller

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