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Smart Biotech Scientist | The CMC and Biomanufacturing Podcast for Bioprocess Development and Manufacturing Leaders

David Brühlmann - CMC Development Leader, Bioprocess Expert, Business Strategist
Biotechnology
Stakeholder Management
Impedance Flow Cytometry
Bioprocess Development
Bioprocessing
Biologics
CMC Development
Bead-Based Assays
Biologics Manufacturing
Biopharmaceuticals
Artificial Intelligence
Synthetic Biology
Cell Factories
Regulatory Compliance
Cultivated Meat
High Throughput Screening
Single-Cell Analysis
Cell and Gene Therapies
Quality Control
Cell Culture

The go-to CMC and bioprocessing podcast for process development scientists and CMC leaders scaling biologics into regulatory-ready therapies with less trial and error.

Practical, execution-focused guidance on CMC development, tech transfer, scale-up, GMP readiness, CDMO partnerships, and manufacturing economics.

Hosted by Dr. David Brühlmann, CMC strategist, former Bioprocess Innovation Manager ... more

PublishesTwice weeklyEpisodes237Founded2 years ago
Number of ListenersCategories
ScienceLife Sciences

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Artwork for Smart Biotech Scientist

Latest Episodes

For years, mammalian cells and microbial systems have dominated the biotech landscape, shaping the economics and access to life-saving biologics. Yet, in countries where capital and infrastructure are limited, those gold-standard systems bring hefty ... more

Imagine producing life-saving antibodies or vaccines not in sprawling stainless steel facilities, but in sunlit greenhouses, inside living, breathing plants.

Waranyoo Phoolcharoen, Co-Founder and CTO of Baiya Phytopharm and Professor at Chulalongkor... more

YouTube

Picture a new bioprocess automation project: ambitious, expensive, and packed with promise. But after months of development, your team discovers a flaw that could have been caught with a simple mockup and a few sticky notes on a whiteboard. This epis... more

YouTube

Many bioprocess automation projects fail, not because the technology is wrong, but because no one clearly defined the problem before buying the robot.

In this episode, David Brühlmann sits down with Anthony Catacchio, CEO of Product Insight, to expl... more

YouTube

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Recent Guests

Waranyoo Phoolcharoen
Professor and Co-founder of Baiya Phytopharm
Baiya Phytopharm
Episode: 235: Plant-Based Biomanufacturing: How Molecular Farming Produces Biopharmaceuticals in Weeks, Not Months with Waranyoo Phoolcharoen - Part 1
Anthony Catacchio
CEO of Product Insight
Product Insight
Episode: 233: Why Most Bioprocess Automation Projects Fail Before the Robot Is Even Ordered with Anthony Catacchio - Part 1
Henri Kornmann
Biotech industry veteran with experience at Merck, Biogen, and Ferring; led CMC development for biologics and gene therapy
Ferring (former), Merck (former), Biogen (former)
Episode: 231: From IND to BLA: The Biologics CMC Decisions That Determine Regulatory Success with Henri Kornmann - Part 1
Tim Corcoran
Founder, Deep Blue Biotech
Deep Blue Biotech
Episode: 230: Cyanobacteria Biomanufacturing: Achieving Carbon-Neutral Production at Lower Cost Than Fermentation with Tim Corcoran - Part 2
Bryan Miller
Director of Scientific and Technical Operations at Crown Bioscience UK
Crown Bioscience
Episode: 225: Mastering Radiopharmaceutical Development: Preclinical Model Selection for Clinical Success with Bryan Miller - Part 1
Steven Lang
Expert in cellular agriculture and plant cell culture
California Culture
Episode: 224: From Cultivated Meat to Chocolate: Rethinking Cellular Agriculture Scale-Up with Steven Lang - Part 2
Catarina Brito
Expert in advanced cell models and their applications in biopharmaceutical research
iBET
Episode: 222: From 2D Cultures to Advanced 3D Cell Models for Preclinical Research with Catarina Brito - Part 2
Troy Lionberger
Chief Business Officer at A-Alpha Bio
A-Alpha Bio
Episode: 219: From 10,000 Structures to 1.8 Billion Interactions: Breaking the Data Bottleneck to Engineer Efficacious Therapeutics with Troy Lionberger - Part 1
Masafumi Osawa
Pioneering biomanufacturing expert at KAICO
KAICO
Episode: 217: Silkworm Biomanufacturing: From Ancient Silk Production to Phase I Vaccine Trials with Masafumi Osawa - Part 1

Host

David Brühlmann
Host of Smart Biotech Scientist; CMC strategist; former Bioprocess Innovation Manager at Merck; PhD in glycoengineering; close to 20 years in biomanufacturing.

Reviews

4.9 out of 5 stars from 30 ratings
  • Good stuff !

    I am enjoying this podcast and always learn a thing or two! Thanks David!

    Apple Podcasts
    5
    Rob78_13
    United Statesa year ago
  • Insightful!

    I love my weekly dose of the Smart Biotech Scientist podcast! I enjoy hearing and learning from my peers in the biopharmaceutical development field, gaining new insights and perspectives on CMC development challenges, tech, and strategies. The host is knowledgeable and engaging, bringing expert guests who share their cutting-edge strategies and real-world experiences. Whether you’re a seasoned professional or new to the field, this podcast offers practical advice and innovative solutions that c... more

    Apple Podcasts
    5
    Giulia Lambiase
    United Kingdom2 years ago
  • Great interviews, good format

    David delivers a great podcasts: I like the depth of the conversations and also that the episodes have the perfect length for my commute to work👍

    Apple Podcasts
    5
    pilldipp
    Germany2 years ago
  • Deeply Refreshing Perspective

    I am really a fan of David’s content and his approach to intriguing subjects.

    Apple Podcasts
    5
    Stem Cell Guy
    United States2 years ago
  • Fantastic content!

    Great podcast! Highly recommend that anybody working in biotech listen to this podcast. David, the host, is very knowledgeable in the bio tech space. I have enjoyed the insights from the guests.

    Apple Podcasts
    5
    MatthiasV1976
    United States2 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Clear, practical guidance for bioprocess development teams.
Concise episodes with in-depth technical discussions.
High-quality guests share real-world CMC insights.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Talking Points

Recent interactions between the hosts and their guests.

233: Why Most Bioprocess Automation Projects Fail Before the Robot Is Even Ordered with Anthony Catacchio - Part 1
Q: How do you decide when automation is the right solution versus using human labor?
The answer centers on rigorous problem definition, ROI analysis, and the concept phase, emphasizing that many problems can be solved more cheaply and effectively with people or simpler setups, rather than jumping straight to complex robotic systems.
233: Why Most Bioprocess Automation Projects Fail Before the Robot Is Even Ordered with Anthony Catacchio - Part 1
Q: What got you started in robotics, automation, and what were some interesting pit stops along the way?
Anthony explains his background in mechanical engineering, initial work in surgical positioning devices, and how a career path through medical devices and consulting led him to industrial robotics and warehouse automation, shaping his views on how to apply robotics to bioprocessing.
231: From IND to BLA: The Biologics CMC Decisions That Determine Regulatory Success with Henri Kornmann - Part 1
Q: Henri, share something that you believe about bioprocess development that most people disagree with.
The core premise is that CMC is not just a back-office requirement but the architectural foundation of a successful biologics program; start with a rock-solid phase-one supply, proper cell bank clonality, and rigorous characterization to prevent costly late-stage gaps.
230: Cyanobacteria Biomanufacturing: Achieving Carbon-Neutral Production at Lower Cost Than Fermentation with Tim Corcoran - Part 2
Q: What's a critical takeaway about commercialization versus lab success?
Breakthrough science requires disciplined commercialization; the best path is to build one scalable factory, prove its profitability, and then license the technology to reach broader markets efficiently.
230: Cyanobacteria Biomanufacturing: Achieving Carbon-Neutral Production at Lower Cost Than Fermentation with Tim Corcoran - Part 2
Q: What is the best path for a novel biomanufacturing technology to reach scale and revenue quickly?
Start with proof of concept at small scale, engage CMOs for growth and processing steps, secure pre-sales from big customers to de-risk investment, and then consider licensing the technology to accelerate market reach while maintaining ongoing process refinement.

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Frequently Asked Questions About Smart Biotech Scientist

What is Smart Biotech Scientist about and what kind of topics does it cover?

This show targets senior practitioners in bioprocess development and CMC, offering execution-focused guidance for scaling biologics from lab to regulatory-ready manufacturing. Episodes frequently cover CMC strategy, process development, scale-up, tech transfer, GMP readiness, and CDMO partnerships, often weaving in regulatory considerations, lifecycle management, and manufacturing economics. A notable strength is the hands-on, house-style analogy approach to complex topics, plus a steady stream of practitioner guests who share practical lessons from industry leaders and innovators. The format tends to favor concise, implementation-ready takeaways, making it a valuable resource for teams preparing INDs, optimizing manufacturing workflows, or... more

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These podcasts share a similar audience with Smart Biotech Scientist:

1. Gemischtes Hack
2. The Joe Rogan Experience

How many episodes of Smart Biotech Scientist are there?

Smart Biotech Scientist launched 2 years ago and published 237 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Smart Biotech Scientist?

Recent guests on Smart Biotech Scientist include:

1. Waranyoo Phoolcharoen
2. Anthony Catacchio
3. Henri Kornmann
4. Tim Corcoran
5. Bryan Miller
6. Steven Lang
7. Catarina Brito
8. Troy Lionberger

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