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Smart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation

David Brühlmann - CMC Development Leader, Biotech C-level Advisor, Business Strategist
Biotechnology
Stakeholder Management
Impedance Flow Cytometry
Bioprocess Development
Bioprocessing
Biologics
CMC Development
Bead-Based Assays
Biologics Manufacturing
Biopharmaceuticals
Artificial Intelligence
Synthetic Biology
Cell Factories
Regulatory Compliance
Cultivated Meat
High Throughput Screening
Single-Cell Analysis
Cell and Gene Therapies
Quality Control
Cell Culture

The Go-to Podcast for Biotech Scientists Who Want to Master Biopharma CMC Development and Biomanufacturing.

**TOP 10 LIFE SCIENCES PODCAST**

Are you ready to simplify bioprocess development and scale with confidence to reduce time to market?

Are you feeling overwhelmed by the complexity and guesswork of biologics development and biomanufacturing?

Do you wish you had more time to enjoy the beauty o... more

PublishesTwice weeklyEpisodes200Founded2 years ago
Number of ListenersCategories
Life SciencesScience

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Artwork for Smart Biotech Scientist

Latest Episodes

Over 40% of biotherapeutic failures during clinical development stem from stability problems—and most trace back to protein aggregation that could have been prevented. In this episode of the Smart Biotech Scientist Podcast, David Brühlmann exposes th... more

What happens when the most complex molecules in biotech meet the organizational challenge of managing 300+ analytical scientists? The answer lies not just in the science, but in building systems that turn technical complexity into reliable delivery. more

What if the key to unlocking ADC manufacturing success lies in abandoning the platform mindset entirely?

Antibody-drug conjugates represent biotech's most promising weapon against cancer: precision-targeted therapeutics that deliver cytotoxic payloa... more

What if solving tomorrow’s bioprocessing challenges meant questioning the very physics of chromatography and reimagining downstream processing from the ground up?

For years, large biomolecules like viral vectors and exosomes have squeezed through th... more

Key Facts

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Recent Guests

Amanda Hoertz
Expert in ADC development and project management
KBI Biopharma
Episode: 198: Mastering ADC Development: CDMO Strategies for Analytics and Scale-Up with Amanda Hoertz - Part 2
Alois Jungbauer
Professor emeritus of downstream processing at the Institute of Bioprocessed Science at Technology at BOKU University in Vienna
BioChromatographix International
Episode: 196: Monolithic Chromatography Innovations: Solving High-Capacity Purification for Gene Therapy Vectors with Alois Jungbauer - Part 2
Lucas Chan
Fellow of the Royal Society of Biology and a viral vector manufacturing pioneer.
National University of Singapore
Episode: 194: Viral Vector CDMO Mastery: Singapore's Answer to Cell and Gene Therapy Supply Shortages with Lucas Chan - Part 2
Andreas Castan
A 25-year industry veteran who provides leadership and support to Cytiva's bioprocess business.
Cytiva
Episode: 191: Process Intensification Secrets: A Process Engineer's Decision Framework with Andreas Castan - Part 1
Carmen Jungo Rhême
Professor at the University of Applied Sciences and Director of the Biofactory Competence Center
University of Applied Sciences, Freiburg, Switzerland
Episode: 187: From Biology Is Messy to Designable: The Smart Bioprocessing Transformation with Carmen Jungo Rhême - Part 1
Elise de Reus
AI and protein design expert at Cradle
Cradle
Episode: 186: How Generative AI Accelerates Protein Design for Biotech Discovery with Elise de Reus - Part 2
Jarno Robin
Expert with over 20 years in upstream continuous processes at industry giants and now at Sani Membranes
Sani Membranes
Episode: 181: Innovating Continuous Bioprocessing with Vibrating Membrane Filtration with Jarno Robin - Part 1
Lindsay Davies
Chief Scientific Officer at NextCell Pharma and Consultant at CellTherEx
NextCell Pharma
Episode: 179: How Mesenchymal Stromal Cells Are Transforming Care for Diabetes and Autoimmune Diseases with Lindsay Davies - Part 1
Richard Alldread
Chief Technology Officer at The Cultured Hub
The Cultured Hub
Episode: 177: Rethinking Cultivated Meat Production: Scale and Media Optimization Strategies Slashing Manufacturing Costs with Richard Alldread - Part 1

Host

David Brühlmann
Host with extensive experience in biopharma CMC development and biomanufacturing, known for engaging conversations with industry experts.

Reviews

4.9 out of 5 stars from 27 ratings
  • Good stuff !

    I am enjoying this podcast and always learn a thing or two! Thanks David!

    Apple Podcasts
    5
    Rob78_13
    United Statesa year ago
  • Insightful!

    I love my weekly dose of the Smart Biotech Scientist podcast! I enjoy hearing and learning from my peers in the biopharmaceutical development field, gaining new insights and perspectives on CMC development challenges, tech, and strategies. The host is knowledgeable and engaging, bringing expert guests who share their cutting-edge strategies and real-world experiences. Whether you’re a seasoned professional or new to the field, this podcast offers practical advice and innovative solutions that c... more

    Apple Podcasts
    5
    Giulia Lambiase
    United Kingdoma year ago
  • Great interviews, good format

    David delivers a great podcasts: I like the depth of the conversations and also that the episodes have the perfect length for my commute to work👍

    Apple Podcasts
    5
    pilldipp
    Germany2 years ago
  • Deeply Refreshing Perspective

    I am really a fan of David’s content and his approach to intriguing subjects.

    Apple Podcasts
    5
    Stem Cell Guy
    United States2 years ago
  • Fantastic content!

    Great podcast! Highly recommend that anybody working in biotech listen to this podcast. David, the host, is very knowledgeable in the bio tech space. I have enjoyed the insights from the guests.

    Apple Podcasts
    5
    MatthiasV1976
    United States2 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

The host is praised for his engaging style and ability to simplify complex topics, making them accessible to a wider audience.
Listeners find the content insightful and informative, often mentioning the depth of discussions and actionable insights.
Many appreciate the high-quality guests and relevant industry topics, showcasing the podcast's value in the biotech community.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Talking Points

Recent interactions between the hosts and their guests.

198: Mastering ADC Development: CDMO Strategies for Analytics and Scale-Up with Amanda Hoertz - Part 2
Q: How has digital transformation changed the way you operate?
We've implemented systems like LIMS and ELN to enhance data tracking and operational efficiency.
198: Mastering ADC Development: CDMO Strategies for Analytics and Scale-Up with Amanda Hoertz - Part 2
Q: What best practices do you follow to accelerate the path of ADC development?
We look at each molecule individually, leveraging our experience and remembering similar molecules to accelerate development.
195: Monolithic Chromatography Innovations: Solving High-Capacity Purification for Gene Therapy Vectors with Alois Jungbauer - Part 1
Q: What were the major inflection points during your long career?
There were a couple of really radical changes, one being the transition from soft chromatography materials to more rigid ones that allowed for improved speed and throughput.
195: Monolithic Chromatography Innovations: Solving High-Capacity Purification for Gene Therapy Vectors with Alois Jungbauer - Part 1
Q: Share something that you believe about bioprocess development that most people disagree with.
A lot of people in the field think that especially the recovery of the biological product has been well established and there is no need for further development, research and innovation.
193: Viral Vector CDMO Mastery: Singapore's Answer to Cell and Gene Therapy Supply Shortages with Lucas Chan - Part 1
Q: Lucas, share something that you believe about bioprocess development that most people disagree with.
It's challenging to define the differences between viral vectors and traditional viruses, as many confuse them.

Audience Metrics

Listeners, social reach, demographics and more for this podcast.

Listeners per Episode
Gender Skew
Location
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Social Media Reach

Frequently Asked Questions About Smart Biotech Scientist

What is Smart Biotech Scientist about and what kind of topics does it cover?

This podcast serves as a valuable resource for biotech professionals, particularly those involved in biopharma CMC (Chemistry, Manufacturing, and Controls) development and biomanufacturing. Engaging conversations with industry experts provide practical insights into overcoming challenges within bioprocess development and scaling up the manufacturing of biologics. Topics such as strategizing for faster market delivery, optimizing manufacturing costs, and utilizing innovative techniques in cell culture and gene therapies are frequently explored, making the content highly relevant and actionable for listeners in the biotechnology space. The host combines expert perspectives with real-world experiences, encouraging aspiring biochemists and inno... more

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How many listeners does Smart Biotech Scientist get?

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Which podcasts are similar to Smart Biotech Scientist?

These podcasts share a similar audience with Smart Biotech Scientist:

1. BioCentury This Week
2. The Life Stylist
3. Business Of Biotech
4. Beyond Biotech - the podcast from Labiotech
5. The Biotech Startups Podcast

How many episodes of Smart Biotech Scientist are there?

Smart Biotech Scientist launched 2 years ago and published 200 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Smart Biotech Scientist?

Recent guests on Smart Biotech Scientist include:

1. Amanda Hoertz
2. Alois Jungbauer
3. Lucas Chan
4. Andreas Castan
5. Carmen Jungo Rhême
6. Elise de Reus
7. Jarno Robin
8. Lindsay Davies

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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