Psychopharmacology and Psychiatry Updates

Psychopharmacology Institute

Bipolar Disorder

Lithium

ADHD

Depression

Clozapine

Schizophrenia

Olanzapine

Lamotrigine

Pregnancy

Major Depressive Disorder

Benzodiazepines

Child and Adolescent Psychiatry

Psychopharmacology

Ssris

Weight Gain

Cognitive Behavioral Therapy

Antipsychotics

Opioid Use Disorder

Anxiety Disorders

Antidepressants

Practical psychopharmacology updates for mental health clinicians. Useful for psychiatry / mental health professionals. Expert interviews and soundbites from CME presentations. Practical and free of commercial bias. Not sponsored by any pharmaceutical company.

526 ratings

Publishes	Twice weekly	Episodes	405	Founded	8 years ago
Number of Listeners		Categories	MedicineHealth & Fitness

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Guests Host Reviews Charts Talking Points

Latest Episodes

EPA vs. DHA: Fish Oil and Treatment-Resistant Depression

In this episode, we explore whether EPA, a specific omega-3 fatty acid, can help patients with treatment-resistant depression. Dr. Derick Vergne breaks down the clinical evidence, dosing, and the anti-inflammatory mechanisms that may explain why EPA ... more

8 Sep 2026 • 12 min

AUD Medications and Hepatic Safety

In this episode, we explore how liver status shapes medication choice for alcohol use disorder. Dr. Kevin Sevarino breaks down a practical algorithm for selecting between naltrexone, acamprosate, disulfiram, and other options, tailored to hepatic fun... more

3 Sep 2026 • 10 min

GLP-1 Agonists in Serious Mental Illness: Current Evidence

In this episode, we explore whether GLP-1 agonists like semaglutide can tackle the metabolic toll of antipsychotics in schizophrenia. Can a drug famous for celebrity weight loss actually protect our most vulnerable psychiatric patients from diabetes ... more

29 Aug 2026 • 15 min • Popular

Gabapentin, Topiramate & Baclofen in AUD

In this episode, we explore three off-label but evidence-supported medications — gabapentin, topiramate, and baclofen — for alcohol use disorder, examining their mechanisms, dosing strategies, tolerability challenges, and which patients are most like... more

24 Aug 2026 • 17 min • Most popular

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Recent Guests

Dr. Kevin A. Sevarino

psychiatrist and addiction medicine specialist; medical director for the American Academy of Addiction Psychiatry; past president of that organization

American Academy of Addiction Psychiatry

Episode: Disulfiram Unpacked: Efficacy, Risks, and Liver Safety

Paul Zarkowski

Clinical associate professor in the Department of Psychiatry and Behavioral Sciences at the University of Washington

University of Washington

Episode: GLP-1s and Lithium: What Clinicians Need to Know

Kevin Sevarino

Addiction psychiatrist, medical director of the American Academy of Addiction Psychiatry

American Academy of Addiction Psychiatry

Episode: Naltrexone for Alcohol Use Disorder: What You Should Know

Dr. Sagar Parikh

John F. Gredden Professor of Depression and Clinical Neuroscience, Michigan Medicine; Professor of Health Management and Policy, University of Michigan School of Public Health

University of Michigan / Michigan Medicine

Episode: Difficult-to-Treat Depression: First, Second, and Third-Line Strategies

Sagar V. Parikh

Dr. Sagar V. Parikh, John F. Greiden Professor of Depression and Clinical Neuroscience at Michigan Medicine; Professor of Health Management and Policy at the University of Michigan School of Public Health

Michigan Medicine; University of Michigan School of Public Health

Episode: CANMAT Guidelines: Herbs, Supplements, and Depression

David Gorelick

Clinical professor of psychiatry; long-time addiction psychiatrist and clinical psychopharmacologist

University of Maryland School of Medicine, Baltimore, MD

Episode: Xylazine in the ED: Managing Toxicity

Brian Miller

Tenured professor in the Department of Psychiatry and Health Behavior at Augusta University

Augusta University

Episode: Preventing Relapse: The Role of LAIs in Schizophrenia

Scott Beach

Associate Professor of Psychiatry at Harvard Medical School; former Program Director for the MGH and McLean Hospital Adult Psychiatry Residency Program

Harvard Medical School, Massachusetts General Hospital, McLean Hospital

Episode: Could Lithium Play a Role in Preventing Alzheimer's Disease?

Amanda Koire

Attending psychiatrist in the Division of Women's Mental Health and Reproductive Psychiatry at Brigham and Women's Hospital; instructor of psychiatry at Harvard Medical School

Brigham and Women's Hospital; Harvard Medical School

Episode: Bipolar Disorder, Lithium, and Pregnancy: What the Evidence Says

Host

Dr. Richard Seeber

Host of the Psychopharmacology Institute podcast

Reviews

4.7 out of 5 stars from 526 ratings

Solid, straightforward psychopharmacology
So good. I love that the episodes are full of good useful tips to prescribe and manage psych meds.
Apple Podcasts
5
GIProphet
United States6 months ago
Great but please stop using AI
The podcast is a great quick knowledge refresher or a way to stay up to date. I’ve not listened for a while due to being on Mat Leave, but now the podcast is read by an AI voice and it is so difficult to listen to and actually understand due to the unnatural voice tone and breaks. Please go back to a human reading.
Apple Podcasts
3
Skinnybones94
United Kingdom10 months ago
This commitment to providing reliable information is commendable!
I highly recommend this podcast's episode titled Antidepressants and Mood Stabilizers for Managing Explosive Behavior. As a health clinician, I found this episode to be an invaluable resource! What sets this podcast apart is its focus on serving psychiatry and mental health professionals. It offers unbiased content, free from commercial influence and sponsorship by pharmaceutical companies. This commitment to providing reliable information is commendable.Kudos to the Psychopharmacology and Psych... more
Apple Podcasts
5
Sabrina Runbeck, MPH, MHS, PA-
Philippines3 years ago
Smita Varshney MD
Love to listen to daily pearls!
Apple Podcasts
5
Tavar1234
United States4 years ago
DocGermosen
Is a wonderful way to end the day by listening to current and relevant treatment information, base on different reviews of RCT’s.
Apple Podcasts
5
DEG1966
United States4 years ago

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Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Listeners appreciate concise, credible updates for busy clinicians

Clinically practical and evidence-based pharmacology tips

Praise for unbiased, sponsor-free educational content

Some prefer human narration over AI voices for clarity

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Apple Podcasts	#88	United States/Health & Fitness/Medicine
Apple Podcasts	#193	United Kingdom/Health & Fitness/Medicine
Apple Podcasts	#237	Australia/Health & Fitness/Medicine
Apple Podcasts	#3	United Arab Emirates/Health & Fitness/Medicine
Apple Podcasts	#22	Sweden/Health & Fitness/Medicine
Apple Podcasts	#47	China/Health & Fitness/Medicine

Talking Points

Recent interactions between the hosts and their guests.

Difficult-to-Treat Depression: First, Second, and Third-Line Strategies

Q: What can we do for the pharmacologic management of difficult to treat depression?

Begin with a diagnostic recheck, assess adherence and interactions, then optimize the current antidepressant dose and consider augmentation with first-line agents like aripiprazole or brexpiprazole, while also incorporating psychological treatments; if needed, move to adjuncts or third-line options with careful attention to side effects and functioning.

Xylazine in the ED: Managing Toxicity

Q: In such a scenario, do you have xylazine intoxication or a mixed xylazine opioid intoxication on your differential?

Dr. Gorelick explains that many cases involve a co-intoxicant like fentanyl, so treating the opioid component with naloxone is reasonable, but the management must be tailored to supportive care since xylazine itself is not an opioid.

Could Lithium Play a Role in Preventing Alzheimer's Disease?

Q: So, what is lithium orotate?

Dr. Beach explains that lithium orotate is different from the lithium forms used for mood disorders, potentially avoiding sequestration by amyloid plaques and thereby staying in the brain where it's needed; however, human trials are not yet completed and regulation of supplements is a concern.

Predicting Lithium Response in Bipolar Disorder

Q: What does the latest precision medicine work suggest about predicting who will respond to which bipolar treatments?

It shows that beyond traditional guidelines, individual clinical features and family history can guide choices, and that non-drug strategies or different augmentations may outperform simply increasing antidepressant doses, though differences in efficacy across strategies were not always statistically large.

Preventing Relapse: The Role of LAIs in Schizophrenia

Q: What about our 28-year-old patient who struggles with adherence and relapses?

Based on the evidence and the patient profile, this case meets multiple criteria for LAI candidacy, reinforcing the need to discuss LAIs with patients.

Audience Metrics

Listeners, social reach, demographics and more for this podcast.

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Frequently Asked Questions About This Podcast

What is This Podcast about and what kind of topics does it cover?

This show delivers concise, clinically focused updates on psychopharmacology for mental health professionals, often featuring expert guests who interpret current research, guidelines, and practical treatment strategies. Recent episodes cover topics such as high-dose olanzapine versus clozapine in treatment-resistant schizophrenia, CANMAT-guided use of herbs and supplements for depression, and the expanding role of long-acting injectable antipsychotics. Practical takeaways include dosing ranges, deprescribing strategies after delirium, and real-world considerations for safety and implementation. The format tends to blend literature reviews with case-based guidance, emphasizing evidence-based, unbiased information free from industry sponsorsh... more

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Which podcasts are similar to this podcast?

These podcasts share a similar audience with this podcast:

1. The Carlat Psychiatry Podcast
2. PsychRounds: The Psychiatry Podcast
3. NEI Podcast
4. Psychiatry Boot Camp
5. Psychiatry & Psychotherapy Podcast

How many episodes of this podcast are there?

this podcast launched 8 years ago and published 405 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on this podcast?

Recent guests on this podcast include:

1. Dr. Kevin A. Sevarino
2. Paul Zarkowski
3. Kevin Sevarino
4. Dr. Sagar Parikh
5. Sagar V. Parikh
6. David Gorelick
7. Brian Miller
8. Scott Beach

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