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Merck
Biocatalysis
Thiophene
Antibody-Drug Conjugates
Chemistry
Process Chemistry
Peptide Synthesis
Organic Chemistry
Drug Discovery
Catalysis
Pharmaceutical Industry
Podcasting
Cyrene
C-N Cross Coupling
Job Talks
On-Site Interviews
Merck Chemistry
Pharmaceuticals
Liquid-Liquid Extraction
Automation Technologies

A podcast hosted by L.-C. Campeau and Dani Schultz that dives into the stories about the people behind the chemistry and science that happens at #MerckChemistry. Follow us on X (formerly Twitter) at @PharmToTablePod, @DrLCSquare, @danithechemist Email us comments and suggestions at pharmtotablepod@gmail.com

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Artwork for Pharm to Table

Latest Episodes

In this first installment of our two‑part Pharm to Table special on MK‑7845, Dani and LC sit down with medicinal chemist Valerie Shurtleff to unpack the discovery journey behind this 3CL protease inhibitor—from early structural insights to an unexpec... more

Join us for a conversation with Yining Ji Chen, recipient of the 2025 ACS Rising Star Award, on how mechanistic insight powers innovation in pharmaceutical process research. We dive into her career journey and standout projects—from Pd-catalyzed C–N ... more

In this episode, Dani and LC welcome Jeff Moore, recipient of the 2025 ACS Affordable Green Chemistry Award, to discuss his pioneering work in biocatalysis at Merck. The conversation explores the evolution (pun intended) of biocatalytic processes in ... more

In this episode, Dani and LC interview Dr. Shane Krska, recipient of the ACS Arthur C. Cope Award, and Dr. Petr Vachal, recipient of the ACS Earle B. Barnes Award for Leadership in Chemical Research Management. Shane shares his pioneering work in cat... more

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Recent Guests

Valerie Shurtleff
Medicinal chemist at Merck
Merck
Episode: SE4:E7: From Discovery to Process, Part 1: Building a 3CL Protease Inhibitor Through Smart Fluorine Placement and Design Intuition
Yining Ji Chen
Principal Scientist at Merck and recipient of the ACS Rising Star Award
Merck
Episode: SE4:E6 - Mechanism-Driven Innovation in Process Research: Yining Ji Chen’s Road as a Rising Star
Jeff Moore
Recipient of ACS Affordable Green Chemistry Award and Enzyme Engineering Award, recognized for his innovation in biocatalysis.
Merck
Episode: SE4:E5 - Evolution of a Green Chemistry Trailblazer
Petr Vachal
Leading teams in discovery chemistry at Merck with over 20 years of experience.
Merck
Episode: SE4:E4 - MedChem Masters: Molecules, Mentors and Mindsets
Shane Krska
Discovery chemist with nearly 26 years at Merck, with a focus on catalysis.
Merck
Episode: SE4:E4 - MedChem Masters: Molecules, Mentors and Mindsets
Damien Valette
Associate Principal Scientist at MSD, specializing in Discovery Processed Chemistry
Merck
Episode: S4:E3 - London Calling ... Spirocycles
David Petrone
Senior Scientist in the Discovery Process Chemistry group at Merck
Merck
Episode: S4:E3 - London Calling ... Spirocycles
Olivia Boyd
Senior Scientist in the Discovery Chemistry Team at MSD
Merck
Episode: S4:E3 - London Calling ... Spirocycles
Ethan Wappes
Chemist in the Discovery Process Chemistry group
Merck
Episode: S4:E2 - Making Sulfur Smell like Success!

Hosts

L.-C. Campeau
Host and storyteller, passionate chemist
Dani Schultz
Spirited chemistry co-host

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Talking Points

Recent interactions between the hosts and their guests.

SE4:E7: From Discovery to Process, Part 1: Building a 3CL Protease Inhibitor Through Smart Fluorine Placement and Design Intuition
Q: Why did you pick the 3CL protease as a potential target for drug discovery?
Valerie explained that the protease is critical to the viral replication cycle, highly conserved across coronaviruses, and its recognition sequence is distinct from human proteases, allowing for selectivity.
SE4:E7: From Discovery to Process, Part 1: Building a 3CL Protease Inhibitor Through Smart Fluorine Placement and Design Intuition
Q: What would you say you underestimated the most coming out of grad school that ultimately helped you the most in your current role?
Valerie pointed out that non-synthesis skills such as problem solving, teamwork, and asking the right questions were just as crucial as her technical skills in her career as a medicinal chemist.
SE4:E6 - Mechanism-Driven Innovation in Process Research: Yining Ji Chen’s Road as a Rising Star
Q: What motivated you to take on this rotation and maybe help our listeners understand what is LED NMR?
Yining shared that she sought a rotation in the NMR group to address a gap in photochemical reaction study tools and that LED NMR integrates LED technology in NMR tubes for real-time monitoring.
SE4:E6 - Mechanism-Driven Innovation in Process Research: Yining Ji Chen’s Road as a Rising Star
Q: Yining, can you give our listeners a sense of what this transformation was and what challenges you were faced with when you studied this reaction?
Yining explained that her first project involved developing a palladium-catalyzed C-N coupling for an HIV drug, facing issues like robustness and catalyst loading.
SE4:E5 - Evolution of a Green Chemistry Trailblazer
Q: What makes an IRED different from a transaminase and what are the motivations to pursue this platform?
IREDs allow for the incorporation of functional amines directly, simplifying routes and allowing for more complex molecular synthesis.

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Frequently Asked Questions About Pharm to Table

What is Pharm to Table about and what kind of topics does it cover?

This podcast focuses on the personal journeys and impactful work of scientists within the pharmaceutical industry, primarily highlighting their contributions to chemistry and drug development. Episodes often feature in-depth discussions with experts from Merck, exploring topics such as mechanistic studies, biocatalysis, and advancements in synthesis methods. The hosts engage with guests who are recognized leaders in their fields, providing insights into their scientific research, challenges they face, and the innovative solutions they have developed. Unique to this podcast is its ability to blend personal stories with complex scientific discussions, appealing to both professionals in the field and those interested in the human element behin... more

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Which podcasts are similar to Pharm to Table?

These podcasts share a similar audience with Pharm to Table:

1. Stereo Chemistry

How many episodes of Pharm to Table are there?

Pharm to Table launched 5 years ago and published 51 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Pharm to Table?

Recent guests on Pharm to Table include:

1. Valerie Shurtleff
2. Yining Ji Chen
3. Jeff Moore
4. Petr Vachal
5. Shane Krska
6. Damien Valette
7. David Petrone
8. Olivia Boyd

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