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Artwork for Pharm to Table
Merck
Biocatalysis
Process Chemistry
Thiophene
Antibody-Drug Conjugates
Chemistry
Peptide Synthesis
Organic Chemistry
Drug Discovery
Catalysis
Pharmaceutical Industry
Podcasting
Cyrene
C-N Cross Coupling
Job Talks
On-Site Interviews
Merck Chemistry
Pharmaceuticals
Liquid-Liquid Extraction
Automation Technologies

A podcast hosted by L.-C. Campeau and Dani Schultz that dives into the stories about the people behind the chemistry and science that happens at #MerckChemistry. Follow us on X (formerly Twitter) at @PharmToTablePod, @DrLCSquare, @danithechemist Email us comments and suggestions at pharmtotablepod@gmail.com

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Artwork for Pharm to Table

Latest Episodes

What happens when the textbook SAR playbook stops working? On this episode of Pharm to Table, Rob Garbaccio joins Dani and LC to share the discovery story behind enlicitide (MK-0616), a journey filled with unusual SAR, creative problem-solving, and p... more

To kick off Season 5, Dani and LC discuss a recent perspective published in the Journal of Organic Chemistry that highlights innovations in synthetic chemistry which trace their origins to the work of discovering, developing and commercializing novel... more

In Part 2 of our Pharm to Table deep dive on MK‑7845, Dani and LC shift from invention to implementation, welcoming process chemists Nastaran Salehi Marzijarani and Ben Turnbull to the pod. We explore how the team re‑imagined the synthesis to enable ... more

In this first installment of our two‑part Pharm to Table special on MK‑7845, Dani and LC sit down with medicinal chemist Valerie Shurtleff to unpack the discovery journey behind this 3CL protease inhibitor—from early structural insights to an unexpec... more

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Recent Guests

Rob Garbaccio
Head of Medicinal Chemistry at Merck
Merck & Co.
Episode: SE5:E2: The Macrocyclic Mullet
Nastaran Salehi Marzijarani
Process Chemistry Lead at Merck, discussed as the guest who led the Oogie route preparation and de-risking
Merck
Episode: SE4:E8: From Discovery to Process, Part 2: Getting Ugi with it - scaling a 3CL protease inhibitor
Ben Turnbull
Process Chemistry Group member at Merck, discussed Yugi reaction optimization and endgame strategy
Merck
Episode: SE4:E8: From Discovery to Process, Part 2: Getting Ugi with it - scaling a 3CL protease inhibitor
Valerie Shurtleff
Medicinal chemist at Merck
Merck
Episode: SE4:E7: From Discovery to Process, Part 1: Building a 3CL Protease Inhibitor Through Smart Fluorine Placement and Design Intuition
Yining Ji Chen
Principal Scientist at Merck and recipient of the ACS Rising Star Award
Merck
Episode: SE4:E6 - Mechanism-Driven Innovation in Process Research: Yining Ji Chen’s Road as a Rising Star
Jeff Moore
Recipient of ACS Affordable Green Chemistry Award and Enzyme Engineering Award, recognized for his innovation in biocatalysis.
Merck
Episode: SE4:E5 - Evolution of a Green Chemistry Trailblazer
Petr Vachal
Leading teams in discovery chemistry at Merck with over 20 years of experience.
Merck
Episode: SE4:E4 - MedChem Masters: Molecules, Mentors and Mindsets
Shane Krska
Discovery chemist with nearly 26 years at Merck, with a focus on catalysis.
Merck
Episode: SE4:E4 - MedChem Masters: Molecules, Mentors and Mindsets
Damien Valette
Associate Principal Scientist at MSD, specializing in Discovery Processed Chemistry
Merck
Episode: S4:E3 - London Calling ... Spirocycles

Hosts

Dani Schultz
Co-host of the show, provides guidance and hosts conversations; frequently discusses Merck's chemistry and industry insights
L.-C. Campeau
Host, storyteller, and chemist with a focus on Merck's chemistry journey and peptide modalities

Reviews

4.7 out of 5 stars from 38 ratings
  • I am lesser for having known this existed

    Corporate so called scientists raving about the chemical research capabilities of a publicly traded entity that only cares about profit and raising shareholder value as the bottom line. I cannot imagine using your own time to parrot such candy coated drivel while dragging in unwilling colleagues and academics desperate for industrial funding to repeat the party lines like some Soviet era propaganda piece. My heart goes out to the victims of this blatant self congratulatory affair. I can only ima... more

    Apple Podcasts
    1
    Unhook it
    United Statesa month ago

Listeners Say

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Listeners may perceive the show as strongly industry-aligned and promotional in a corporate context.
Some critics feel discussions promote corporate narratives over independent perspectives.

Chart Rankings

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Talking Points

Recent interactions between the hosts and their guests.

SE4:E7: From Discovery to Process, Part 1: Building a 3CL Protease Inhibitor Through Smart Fluorine Placement and Design Intuition
Q: Why did you pick the 3CL protease as a potential target for drug discovery?
Valerie explained that the protease is critical to the viral replication cycle, highly conserved across coronaviruses, and its recognition sequence is distinct from human proteases, allowing for selectivity.
SE4:E7: From Discovery to Process, Part 1: Building a 3CL Protease Inhibitor Through Smart Fluorine Placement and Design Intuition
Q: What would you say you underestimated the most coming out of grad school that ultimately helped you the most in your current role?
Valerie pointed out that non-synthesis skills such as problem solving, teamwork, and asking the right questions were just as crucial as her technical skills in her career as a medicinal chemist.
SE4:E6 - Mechanism-Driven Innovation in Process Research: Yining Ji Chen’s Road as a Rising Star
Q: What motivated you to take on this rotation and maybe help our listeners understand what is LED NMR?
Yining shared that she sought a rotation in the NMR group to address a gap in photochemical reaction study tools and that LED NMR integrates LED technology in NMR tubes for real-time monitoring.
SE4:E6 - Mechanism-Driven Innovation in Process Research: Yining Ji Chen’s Road as a Rising Star
Q: Yining, can you give our listeners a sense of what this transformation was and what challenges you were faced with when you studied this reaction?
Yining explained that her first project involved developing a palladium-catalyzed C-N coupling for an HIV drug, facing issues like robustness and catalyst loading.
SE4:E5 - Evolution of a Green Chemistry Trailblazer
Q: What makes an IRED different from a transaminase and what are the motivations to pursue this platform?
IREDs allow for the incorporation of functional amines directly, simplifying routes and allowing for more complex molecular synthesis.

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Frequently Asked Questions About Pharm to Table

What is Pharm to Table about and what kind of topics does it cover?

The show centers on the people and stories behind chemistry and drug discovery in a major pharmaceutical company. Episodes highlight how process chemistry, biocatalysis, and innovative bond-forming technologies scale from lab to manufacturing, with deep dives into topics like peptide modalities, green chemistry, and the development of SARS-CoV-2 inhibitors. Noteworthy is a consistent emphasis on teamwork, practical route design, and real-world manufacturing considerations, often illustrated through case studies and insider perspectives from Merck scientists. This combination of technical depth, practical scale-up insights, and guest expertise is likely to appeal to industry professionals, researchers, and chemists seeking actionable takeawa... more

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1. Freakonomics Radio
2. The Ezra Klein Show
3. Huberman Lab
4. 99% Invisible
5. The Happiness Lab with Dr. Laurie Santos

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Pharm to Table launched 5 years ago and published 54 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Pharm to Table?

Recent guests on Pharm to Table include:

1. Rob Garbaccio
2. Nastaran Salehi Marzijarani
3. Ben Turnbull
4. Valerie Shurtleff
5. Yining Ji Chen
6. Jeff Moore
7. Petr Vachal
8. Shane Krska

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