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Artwork for Note to File: A Clinical Research Podcast

Note to File: A Clinical Research Podcast

Brad Hightower
Clinical Trials
Clinical Research
Patient Recruitment
Private Equity
FDA
Artificial Intelligence
Cros
AI In Clinical Research
AI In Clinical Trials
Innovation Network Gathering
Electronic Data Capture
Predictive Analytics
FDA Guidance
Oncology
Operational Success
Enrollment Rates
Protocol Design
Technology In Healthcare
Clinical Research Sites
Patient Engagement

Note to File is a podcast for clinical research sites - interviews, best practices, and candid commentary from Brad Hightower, founder of Hightower Clinical and clinical research professional.

PublishesDailyEpisodes130Founded6 years ago
Number of ListenersCategories
ManagementBusinessHealth & FitnessMedicine

Listen to this Podcast

Artwork for Note to File: A Clinical Research Podcast

Latest Episodes

What happens when DC policy, FDA buzzwords, and real-world site pain all collide? In this episode, Brad and Denali sit down with Anthony Corso, VP of Public Policy at Veeva, to unpack the chaos and opportunity in today's "clinical research renaissanc... more

YouTube

From National Mac & Cheese Day to the broken economics of centralized recruitment… this Sticky Notes episode goes from nonsense to nuclear takes on how sites really handle patient recruitment.

Denali and Brad dig into why so many sites are drowning... more

YouTube

Clinical research sites are *quietly holding all the cards*—so why are they still struggling for support, fair budgets, and real partnership?

In this episode of **Note to File**, Brad and Denali sit down with **Maria P. Ladd**, self-declared **Clin... more

YouTube

In this episode of **Note to File**, Brad and Denali dig into:

- **Why independent sites get boxed out** of imaging, colonoscopy suites, and other hospital-owned services - How **legal, IRB, compliance, and procurement** teams quietly kill otherwi... more

YouTube

Key Facts

Accepts Guests
Accepts Sponsors
Contact Information
Podcast Host
Number of Listeners
Find out how many people listen to this podcast per episode and each month.

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Recent Guests

Oliver Keh
CEO of Gleam (data-entry automation for clinical research)
Gleam
Episode: eSource, Paper, and AI Slop: A Site-First Reality Check with Oliver Keh
Joe O'Rourke
Executive involved in IRB/IBC and retail pharmacy research initiatives
Former Walgreens leadership; currently with WCG (as described)
Episode: Joe O'Rourke: Private Equity, Retail Pharmacies & The Future of Research Sites
Jonathan (guest)
LinkedIn commenter and industry participant
Healthcare/Clinical Research
Episode: Who owns eSource?
Marta (guest)
Participant contributing site-centric viewpoints
Healthcare/Clinical Research
Episode: Who owns eSource?
Bill Trembly (guest)
Commenter referenced in the discussion
Healthcare/Clinical Research
Episode: Who owns eSource?
Christopher Brightfly
Guest referenced in closing shout-out
IRO/industry figure
Episode: Tarantulas, Raccoons & $3.5B Drug Plants
Dr. Brad Hall
Founder of Senge, a clinical research organization specializing in investigator-initiated trials in eye care.
Senge
Episode: Investigator-Initiated Trials in Eye Care with Dr Brad Hall
Dr. Les Enterline
Physician Assistant with experience in medical and surgical hematology and oncology
Thermo Fisher
Episode: Dr. Les Enterline on CRO Partnerships, FSP Models, and Industry Innovation
Susannah Fox
Internet Geologist and advocate for patient-led research
Episode: Patient-Led Revolution: Susannah Fox on Rare Disease, Peer Networks & Rethinking Clinical Trials

Hosts

Brad Hightower
Founder of Hightower Clinical; long-standing clinical research professional providing industry leadership and interview presence.
Denali
Co-host providing continuity and additional perspective on site operations and industry trends.

Reviews

4.8 out of 5 stars from 42 ratings
  • Eavesdropping on Coworkers in a Remote World

    I am a HUGE fan of this podcast. A great mix of humor, humility, without the hubris that infects many other podcasts. The tone, content, and cadence made it seem like I was hanging around the coffee pot too long to eavesdrop on coworkers.

    Apple Podcasts
    5
    Paju0101
    United States7 months ago
  • Tells it like it is

    I am a huge fan of Brad’s perspective on Clinical Research and life in the trench’s of getting the job done to help get get new medicines to market. Brad’s approach to podcasting is very refreshing and something our industry does not have. It’s nice to have a resource to goto in the clinical trials industry. Love Brad’s content and the guests he has on are fantastic!

    Apple Podcasts
    5
    Joedustin
    United States4 years ago
  • Brads daughter

    It is a great platform to learn about clinical research even for kids like me. Please give a five star review.

    Apple Podcasts
    5
    brads daughter
    United States4 years ago
  • Great discussions!

    Thank you for this latest episode on recruitment. I especially appreciated the discussion about educating the public on the importance of clinical trials. Overall, I like listening to this podcast for the honest & necessary discussions. Keep them coming!

    Apple Podcasts
    5
    atp3d
    United States5 years ago
  • Note to file is a must listen!

    Thank you for making this podcast, I love it!

    Apple Podcasts
    5
    🛹🍗🥩🏀
    United States5 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Many appreciate the host's industry familiarity and ability to translate complex topics into actionable tips.
Listeners praise the practical insights and candid tone, especially on recruitment and site operations.
The show is seen as a valuable resource for CRAs, coordinators, and site staff seeking real-world context.
Some episodes are noted for balancing humor with serious industry discussions, making it engaging.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Talking Points

Recent interactions between the hosts and their guests.

eSource, Paper, and AI Slop: A Site-First Reality Check with Oliver Keh
Q: What's next for Gleam after expanding into paper support and continuing e-source usage?
Next is expanding quality-control capabilities and widening how Gleam interfaces with different trial workflows, continuing to emphasize ease of use, and maintaining the human-in-the-loop approach to AI. The goal is to help sites perform better and win more studies without forcing a one-size-fits-all solution.
eSource, Paper, and AI Slop: A Site-First Reality Check with Oliver Keh
Q: Do you think sites are more or less quick to adopt new technology?
Adoption varies by site; some are early adopters when clear benefits are shown, but many require hands-on onboarding, training, and evidence that the tool truly saves time and reduces errors. The key is avoiding heavy-handed sales and focusing on user-centric development and ongoing support.
Patient-Led Revolution: Susannah Fox on Rare Disease, Peer Networks & Rethinking Clinical Trials
Q: Are we seeing engagement with patients in clinical trials more widely?
There is more awareness and need for patient involvement in clinical research.
Patient-Led Revolution: Susannah Fox on Rare Disease, Peer Networks & Rethinking Clinical Trials
Q: Is there a bridge between Rebel Health and clinical trials?
Yes, we can bring ideas from patient experiences into clinical trial design.
Patient-Led Revolution: Susannah Fox on Rare Disease, Peer Networks & Rethinking Clinical Trials
Q: How did you get plugged into ING?
It was because of Rare Disease Day, where I connected with Lindsay from Ron is Fun Lab and got invited to speak.

Audience Metrics

Listeners, social reach, demographics and more for this podcast.

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Frequently Asked Questions About This Podcast

What is This Podcast about and what kind of topics does it cover?

This show centers on practical realities of clinical research for sites, CROs, and sponsors. Episodes frequently tackle recruitment, branding and patient outreach, data integrity, vendor dynamics, and the evolving role of technology and AI in trials. Expect candid conversations about site staffing, enrollment strategies, and governance, with real-world anecdotes from industry practitioners. The format blends actionable tips with thoughtful critique of industry norms, making it a valuable listen for professionals seeking to improve study operations and participant engagement.

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Which podcasts are similar to this podcast?

These podcasts share a similar audience with this podcast:

1. Random Musings From The Clinical Trials Guru
2. SCRS Talks
3. Up First from NPR
4. Planet Money
5. The Daily

How many episodes of this podcast are there?

this podcast launched 6 years ago and published 130 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on this podcast?

Recent guests on this podcast include:

1. Oliver Keh
2. Joe O'Rourke
3. Jonathan (guest)
4. Marta (guest)
5. Bill Trembly (guest)
6. Christopher Brightfly
7. Dr. Brad Hall
8. Dr. Les Enterline

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