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Mendelspod Podcast

Theral Timpson
Genomics
Precision Medicine
Proteomics
Illumina
Genomic Medicine
Artificial Intelligence
Genetic Testing
Drug Development
Oncology
Cancer
Liquid Biopsy
Synthetic Biology
Biotechnology
Single-Cell Genomics
Aging
Rare Diseases
CRISPR
Cancer Treatment
Iconpcr
Epigenetics

Offering a front row seat to the Century of Biology, veteran podcast host Theral Timpson interviews the who's who in genomics and genomic medicine. www.mendelspod.com

PublishesTwice weeklyEpisodes552Founded11 years ago
Number of ListenersCategories
NewsTech NewsScienceNatural Sciences

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Artwork for Mendelspod Podcast

Latest Episodes

For years, precision oncology has largely been discussed through the lens of breakthrough drugs. But there’s another story running underneath modern cancer care: the quiet rise of companion diagnostics. These tests are increasingly deciding who recei... more

Dr. Eric Green returns to Mendelspod in a new role: Chief Medical Officer of Illumina. After more than three decades at the National Human Genome Research Institute, where he helped guide genomics from research initiatives to clinical reality, he now... more

This is a free preview of a paid episode. To hear more, visit www.mendelspod.com

For years, proteomics was described as the missing layer of biology. Why missing? Because measuring proteins at scale turned out to be vastly harder than sequencing DNA... more

We’ve gotten very good at reading DNA. We’re just beginning to understand how to read its state.

On today’s show, Rob Osborne, Senior Vice President of R&D at Biomodal, discusses new evidence that separating two epigenetic marks—5-methylcytosine and... more

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Recent Guests

Eric Green
Chief Medical Officer at Illumina
Illumina
Episode: Mapping the Multi-Omic Era with Eric Green of Illumina
Yan Zhang
President of Proteomic Sciences at Thermo Fisher Scientific
Thermo Fisher Scientific
Episode: Inside Proteomics at Thermo Fisher with Yan Zhang
Rob Osborne
Senior Vice President of R&D at Biomodal
Biomodal
Episode: Separating Epigenetic Signals Improves Early Cancer Detection with Rob Osborne, Biomodal
Irina Babina
CEO of Concr
Concr
Episode: Digital Controls for Cancer Drug Trials? Irina Babina, Concr
Sir Shankar Balasubramanian
Herschel Smith Professor of Medicinal Chemistry, University of Cambridge; co-inventor of Solexa sequencing; founder of Biomodal
University of Cambridge; Biomodal
Episode: Solexa Co-Inventor Shankar Balasubramanian on Six-Base Sequencing and What's Next in Genomics
Erdinc Sezgin
Associate Professor at Karolinska Institute
Karolinska Institute
Episode: The Next Frontier in Biology: Physics? Erdinc Sezgin of the Karolinska Institute
Peter Fromen
CEO of Biomodal
Biomodal
Episode: The Case for a 6-Base Genome with Peter Fromen, CEO of Biomodal
Damon Hostin
Head of Market Access for Clinical Solutions at Illumina
Illumina
Episode: The Eligible But Under-Tested: Genomic Medicine in 2026 with Damon Hostin, Illumina
Fei Chen
Core Institute member at the Broad Institute and associate professor at Harvard University
Broad Institute, Harvard University
Episode: Spatial Transcriptomics Is Changing How We Do Biology: Fei Chen, The Broad Institute

Host

Theral Timpson
Host of Mendelspod Podcast

Reviews

4.5 out of 5 stars from 55 ratings
  • Great views into high science

    As a fractional CFO at BluePrint CPAs, I find the technical aspects of the shows help me dive into the fast-paced world of life sciences.

    Apple Podcasts
    5
    BluePrint CPAs
    Canada4 years ago
  • Fascinating content!

    No matter the subject, you’re guaranteed to learn something from every episode - can’t recommend Mendelspod enough! 🙌

    Apple Podcasts
    5
    Arlie K
    United States5 years ago
  • Great podcast if you’re into life science

    Great interviews and panelists. In depth and entertaining.

    Apple Podcasts
    5
    111CooperDale
    United States6 years ago
  • Informative Listen

    Informative, up-to-date commentary and interviews delivered by a knowledgable, engaging and entertaining host.

    Apple Podcasts
    5
    B-111
    United Kingdom7 years ago
  • Interesting subject, bad interviewer

    There are some great guests but Theral interrupts them often to put in his own 'two cents'. Let your guests tell their story!

    Apple Podcasts
    2
    smlmbrt
    Canada9 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Mix of praise for depth and some critique of host pacing or interruptions
Content is up-to-date and practically informative for biotech strategy
Guests are often top-tier, with rigorous questions from the host
Insightful discussions pairing high science with industry context
Some listeners wish for smoother moderation and more guest-led dialogue

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Talking Points

Recent interactions between the hosts and their guests.

The Case for a 6-Base Genome with Peter Fromen, CEO of Biomodal
Q: What makes Biomodal's six-base genome different from previous epigenetic approaches?
It reads three layers of information directly from each cytosine base—unmethylated, 5-methylcytosine, and 5-hydroxymethylcytosine—within a single workflow, avoiding the noise and imputation issues of bisulfite-based methods and enabling more precise, early-disease detection.
Beyond GLP-1: Why Peptides Are Back at the Center of Drug Discovery with Charlie Johannes and Tomi Sawyer
Q: What has driven peptide drug discovery back into the limelight?
It's the combination of longer-acting peptides enabled by lipid modifications, improved oral delivery approaches, and new tools that let us engineer properties directly into peptides, expanding the feasible pharmacology beyond what was possible a decade ago.
Illumina's New Mapped Read Technology Provides Insights into Rare Disease: Stephen Kingsmore, Olivia Kim-McManus and Ali Crawford
Q: What impact does this technology have on designing therapeutics?
It allows for targeted therapies to be developed based on precise genomic information, tailored to individual patient needs.
Illumina's New Mapped Read Technology Provides Insights into Rare Disease: Stephen Kingsmore, Olivia Kim-McManus and Ali Crawford
Q: What biological problems are you addressing with proximity-mapped read technology?
This technology resolves complex genome structures, previously difficult to interpret with short read sequencing, particularly for identifying elusive genetic variants.
From Hereditary Risk to Residual Disease: Natera’s Integrated Vision for Precision Oncology with Adam ElNaggar, MD
Q: What are the core clinical needs that Natera is satisfying for oncologists?
Establishing risk is a significant core need for oncologists, enhanced by CT DNA testing to better inform treatment decisions.

Audience Metrics

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Frequently Asked Questions About Mendelspod Podcast

What is Mendelspod Podcast about and what kind of topics does it cover?

The show consistently centers on cutting-edge biology, genomics, and biomedical innovation, with episodes spanning Bayesian modeling in oncology, six-base genomics, spatial transcriptomics, MRD and genomic medicine adoption, aging biology, and peptide therapeutics. Guests include lab scientists, biotech founders, and industry leaders, often pairing deep technical explanations with practical implications for clinical practice, drug development, and health systems. A notable strength is bridging laboratory advances with real-world applications, from diagnostics and therapy design to regulatory and reimbursement considerations, making it a strong resource for researchers, investors, and decision-makers seeking the latest in genomic medicine an... more

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1. Prof G Markets
2. The a16z Show
3. The Prof G Pod with Scott Galloway
4. Naval
5. The Readout Loud

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Mendelspod Podcast launched 11 years ago and published 552 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Mendelspod Podcast?

Recent guests on Mendelspod Podcast include:

1. Eric Green
2. Yan Zhang
3. Rob Osborne
4. Irina Babina
5. Sir Shankar Balasubramanian
6. Erdinc Sezgin
7. Peter Fromen
8. Damon Hostin

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