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Artwork for Let's Talk Alzheimer's

Let's Talk Alzheimer's

BrightFocus Foundation
Alzheimer's Disease
Clinical Trials
Pointer Study
Brightfocus Foundation
Porphyromonas Gingivalis
Gut Microbiome
Multidomain Lifestyle Intervention
Biomarkers
Amyloid
Gingivalis / Oral Bacteria
Finger Study
Tau
Spring Clinical Trial
Apoe4
Mediterranean Diet
Probiotics

Welcome to Let’s Talk Alzheimer’s, your place to go for trusted insights from leading scientists and medical experts. Get the latest information on diagnosis, risk reduction, clinical trials, and the latest treatments. Presented by BrightFocus Foundation's Alzheimer's Disease Research program.

PublishesWeeklyEpisodes6Founded3 months ago
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Health & FitnessMedicineScience

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Artwork for Let's Talk Alzheimer's

Latest Episodes

Could the trillions of bacteria in your gut affect your brain health and risk for Alzheimer’s disease? Emerging research suggests the gut microbiome may play an important role in inflammation and brain function. In this episode, Dr. Beau Ances of Was... more

Could bacteria linked to gum disease play a role in Alzheimer’s disease? Emerging science suggests that P. gingivalis, a bacterium associated with gum disease, may contribute to inflammation and brain damage linked to Alzheimer’s disease. In this epi... more

Exciting advances in understanding Alzheimer’s biology, genetics, and biomarkers are driving new medicines, devices, and prevention strategies. In 2025 alone, 182 clinical trials evaluated 138 novel drugs for Alzheimer’s disease. In this episode, lea... more

Can everyday lifestyle choices really protect your memory? Dr. Laura Baker, professor at Wake Forest University School of Medicine, shares insights from the groundbreaking U.S. POINTER trial—the largest study of its kind exploring how lifestyle chang... more

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Recent Guests

Beau Ances
Neurologist; expert on gut-brain axis and Alzheimer's disease
Washington University in St. Louis
Episode: The Gut-Brain Connection: How the Microbiome May Influence Alzheimer’s Risk | Dr. Beau Ances
Dr. Michael Detke
Leader in the Spring Trial program for a protease inhibitor targeting P gingivalis
Lighthouse Pharmaceuticals
Episode: Alzheimer’s and Gum Disease: Exploring the Role of Oral Bacteria in Brain Health | Dr. Michael Detke
Dr. Jeffrey Cummings
Alzheimer's researcher at the University of Nevada Las Vegas
University of Nevada Las Vegas
Episode: Inside the Alzheimer’s Drug Pipeline: What New Clinical Trials Mean for the Future | Dr. Jeffrey Cummings
Dr. Laura Baker
Professor of gerontology and geriatric medicine
Wake Forest University School of Medicine
Episode: Lifestyle & Brain Health: U.S. POINTER Study | Dr. Laura D. Baker
Sharon Cohen
Neurologist, memory director of the Toronto Memory Program
Toronto Memory Program
Episode: Detecting Alzheimer’s: How to Recognize Early Signs | Dr. Sharon Cohen
Armen Moughamian
A cognitive neurologist and medical director at the Ray Dolby Brain Health Center
California Pacific Medical Center and Sutter Health
Episode: Leqembi & Kisunla: New Alzheimer's Treatments Explained | Dr. Armen J. Moughamian

Host

Nancy Keech
Host of Let's Talk Alzheimer's

Chart Rankings

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Talking Points

Recent interactions between the hosts and their guests.

Inside the Alzheimer’s Drug Pipeline: What New Clinical Trials Mean for the Future | Dr. Jeffrey Cummings
Q: What is the outlook for tau-targeting therapies and how might they fit with anti-amyloid drugs?
Tau-targeting approaches, including newer delivery methods, are coming into play and are likely to be used in combination with anti-amyloid therapies to address the broader pathology of Alzheimer's disease.
Inside the Alzheimer’s Drug Pipeline: What New Clinical Trials Mean for the Future | Dr. Jeffrey Cummings
Q: Are amyloid-targeting therapies still relevant given mixed symptom outcomes, and what are the safety considerations?
Amyloid drugs still slow disease progression on average and remain a core pillar of therapy; ongoing improvements aim to reduce adverse events like ARIA while preserving efficacy.
Inside the Alzheimer’s Drug Pipeline: What New Clinical Trials Mean for the Future | Dr. Jeffrey Cummings
Q: How many drugs are currently in the pipeline and how many trials are active?
There are 158 drugs in 192 active trials, with about 20 new drugs introduced this year, signaling a significant acceleration in the field.
Detecting Alzheimer’s: How to Recognize Early Signs | Dr. Sharon Cohen
Q: From the listeners, how can family members approach a loved one who seems to be forgetting things without causing defensiveness?
Lead with concern, not accusation, frame it as a shared concern for safety and well-being, and propose a medical evaluation while offering support and understanding.
Lifestyle & Brain Health: U.S. POINTER Study | Dr. Laura D. Baker
Q: How was the US Pointer study designed and how many participants were involved?
The study enrolled about 2,000 participants across five regions, randomized to either a self-guided program or a more structured, highly accountable plan. Both groups focused on four lifestyle pillars, with the structured group meeting more frequently and receiving closer accountability, which yielded greater cognitive benefits over two years.

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Frequently Asked Questions About Let's Talk Alzheimer's

What is Let's Talk Alzheimer's about and what kind of topics does it cover?

This show centers on the latest in Alzheimer's research, diagnostics, trials, and emerging treatments, with frequent discussions of biomarkers, amyloid and tau-targeting therapies, and real-world considerations for patients, families, and caregivers. Episodes also explore lifestyle interventions, early signs, and practical pathways to diagnosis and access to care, including implications of new medications and delivery technologies. The format often pairs clinical experts with a seasoned host to translate complex science into actionable insights for clinicians, researchers, caregivers, and informed consumers. A standout trait is the emphasis on timely, evidence-based updates across pharmacologic and non-pharmacologic approaches, plus clear d... more

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Which podcasts are similar to Let's Talk Alzheimer's?

These podcasts share a similar audience with Let's Talk Alzheimer's:

1. Speaking of Alzheimer's
2. Up First from NPR
3. The Journal.
4. The Daily
5. The Peter Attia Drive

How many episodes of Let's Talk Alzheimer's are there?

Let's Talk Alzheimer's launched 3 months ago and published 6 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Let's Talk Alzheimer's?

Recent guests on Let's Talk Alzheimer's include:

1. Beau Ances
2. Dr. Michael Detke
3. Dr. Jeffrey Cummings
4. Dr. Laura Baker
5. Sharon Cohen
6. Armen Moughamian

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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