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Artwork for Journal of the American Society of Nephrology

Journal of the American Society of Nephrology (JASN)

American Society of Nephrology
Chronic Kidney Disease
Nephrology
Kidney Disease
SGLT2 Inhibitors
Iga Nephropathy
Acute Kidney Injury
Patient Care
Autosomal Dominant Polycystic Kidney Disease
Kidney Transplantation
Dialysis
Albuminuria
Diabetes
CKD Screening Guidelines
Proteinuria
Clinical Trials
Individualized Risk Prediction
Kidney Stones
JASN
Obesity
Cardiovascular Disease

JASN, the flagship journal of the ASN, publishes basic and clinical science original research articles relevant to the broad discipline of nephrology. The JASN Podcast features discussions with authors of recently published articles. Moderated by the JASN Editor-in-Chief and Deputy Editors, each JASN Podcast episode discusses the latest findings featured in the pages of the journal. Additionally, ... more

PublishesTwice monthlyEpisodes96Founded6 years ago
Number of ListenersCategories
MedicineHealth & FitnessScience

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Artwork for Journal of the American Society of Nephrology

Latest Episodes

Dr. Oyindamola Christiana Adebayo discusses the results of her study, "Expression of Apolipoprotein L1 Risk Variants at the Plasma Membrane and Haplotype-Dependent Cytotoxicity," on behalf of her coauthors, with JASN Deputy Editor David H. Ellison.

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ASN Kidney Translation explores advances in Cardiovascular-Kidney-Metabolic syndrome, including building a cardio-nephrology service (Kidney360), cardiorenal benefits of SGLT2 inhibitors & GLP-1 receptor agonists (JASN), & PREVENT risk prediction (CJ... more

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Dr. Fan-Chi Chang discusses findings from her study, "Cell-Specific Roles of Angiopoietin-2 in CKD," with JASN Deputy Editor Alan S.L. Yu.

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Drs. Benjamin Catanese and Daniel Edmonston discuss their study, "Cardiovascular Outcomes among New Users of GLP-1 Receptor Agonists Compared with DPP-4 Inhibitors and Sulfonylureas in Kidney Failure," with JASN Deputy Editor Manjula Kurella Tamura.

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Recent Guests

Christiana Adebayo
First author of the paper; postdoctoral researcher
Laboratory for Pediatric Nephrology, University of Leuven
Episode: APOL1 at the Plasma Membrane and Cytotoxicity
Karen Dowolsky
Assistant Professor at the University of Washington
University of Washington, Kidney Heart Service
Episode: ASN Kidney Translation Series: Cardiovascular-Kidney-Metabolic (CKM) Syndrome Advances
Nisha Bansal
Professor, Director of the Kidney Heart Service
University of Washington
Episode: ASN Kidney Translation Series: Cardiovascular-Kidney-Metabolic (CKM) Syndrome Advances
Sydney Hartzell
Assistant Professor, General Nephrologist and Scientist
University of Utah
Episode: ASN Kidney Translation Series: Cardiovascular-Kidney-Metabolic (CKM) Syndrome Advances
Sreeni Vadhu
Professor of Internal Medicine, Co-director of Cardioscler metabolism center
University of Utah
Episode: ASN Kidney Translation Series: Cardiovascular-Kidney-Metabolic (CKM) Syndrome Advances
Fan-Chi Chang
Nephrologist and Physician Scientist at National Taiwan University Hospital
Episode: Temporal, Cell-Specific Angiopoietin-2 in CKD
Benjamin Catanese
Medical Doctor and nephrologist, Duke University
Duke University
Episode: Cardiovascular Effects of GLP-1 RA in Kidney Failure
Daniel Edmonston
Assistant Professor of Medicine, Duke University; Clinical Investigator
Duke University
Episode: Cardiovascular Effects of GLP-1 RA in Kidney Failure
Navdeep Tangri
Physician scientist, ASN AI workgroup member
University of Manitoba
Episode: ASN Kidney Translation Series: Artificial Intelligence in Nephrology

Hosts

David Ellison
Host of JASN Podcast; Professor of Medicine and Chemical Physiology/Biochemistry; Deputy Editor at JASN
Matthew Sparks
Host of ASN Kidney Translation Podcast; Communications Editor; nephrology communications
Manjula Kurella Tamura
Host of the JASN Podcast; Deputy Editor of Clinical Science at JASN

Reviews

4.0 out of 5 stars from 15 ratings
  • Great Content…

    But the audio quality needs work. The speakers have different volume levels and sound distant.

    Apple Podcasts
    4
    JDRMD
    United States3 years ago
  • Two stars

    I think they can improve the podcast experience. The host doesn't have the best voice for a podcast. Remember that you already have a good image, and you have to be consistent with who you are.

    Apple Podcasts
    3
    Sarracana
    Colombia4 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

The host voice can be polarizing for some listeners.
Audio quality is variable across episodes, with inconsistent volume levels.
Guests are generally strong subject-matter experts, delivering depth when audio quality is good.
Listener feedback suggests clearer guest briefings could improve conversations.

Chart Rankings

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Talking Points

Recent interactions between the hosts and their guests.

APOL1 at the Plasma Membrane and Cytotoxicity
Q: What unanswered questions did you aim to address with the cell culture model?
The study aimed to clarify the source of calcium driving cytotoxicity, whether extracellular or ER-derived, and to determine if the channel is a non-selective cation permease, which has implications for drug screening and understanding tissue-specific effects.
APOL1 at the Plasma Membrane and Cytotoxicity
Q: What are the key takeaways and future directions?
Variants traffic to the plasma membrane via actin-dependent transport with distinct dynamics; APOL1 functions as a plasma membrane non-selective cation channel contributing to cytotoxicity; therapies could target the plasma membrane to block APOL1, with emphasis on understanding trafficking and haplotype-specific effects for personalized approaches.
APOL1 at the Plasma Membrane and Cytotoxicity
Q: Why use HEK cells first and then validate in podocytes?
HEK cells provide a convenient, transfectable model to study basic mechanisms quickly, but they don't fully recapitulate kidney podocyte biology, so results are validated in podocyte lines and patient-derived cells to ensure relevance to disease.
APOL1 at the Plasma Membrane and Cytotoxicity
Q: Could you discuss what APOL1 normally does and the proposed mechanisms for toxicity of the variants?
APOL1 is involved in immunity as part of HDL and protection against certain parasites; the G1/G2 variants likely cause gain-of-function effects that increase cytotoxicity via changes in calcium handling, mitochondrial function, and inflammatory signaling, with pathogenicity influenced by haplotype background.
Subclinical Primary Aldosteronism and eGFR Decline
Q: What is the main finding about subclinical aldosterone excess and kidney function?
Higher ARR and renal-independent aldosterone production were associated with faster GFR decline, independent of traditional hypertension or measured aldosterone alone, suggesting the regulatory context of aldosterone is more important than its absolute level.

Audience Metrics

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Frequently Asked Questions About This Podcast

What is This Podcast about and what kind of topics does it cover?

The program features in-depth conversations with nephrology researchers, clinicians, and translational scientists who discuss recent studies across the kidney disease spectrum. Episodes frequently center on CKD progression, nephrology therapies, transplant and dialysis innovations, and methods for improving patient care—from genetic influences on dialysis outcomes to conservative management and advanced biomarkers. A standout trait is the strong emphasis on translating published research into practical implications for clinicians, patients, and health systems, often linking study design, measurement challenges, and policy considerations to real-world care. The format tends to blend rigorous methods discussions with actionable takeaways, and... more

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Which podcasts are similar to this podcast?

These podcasts share a similar audience with this podcast:

1. Clinical Journal of the American Society of Nephrology (CJASN)
2. ASN Podcast
3. Kidney360
4. Freely Filtered, a NephJC Podcast
5. JAMA Clinical Reviews

How many episodes of this podcast are there?

this podcast launched 6 years ago and published 96 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on this podcast?

Recent guests on this podcast include:

1. Christiana Adebayo
2. Karen Dowolsky
3. Nisha Bansal
4. Sydney Hartzell
5. Sreeni Vadhu
6. Fan-Chi Chang
7. Benjamin Catanese
8. Daniel Edmonston

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