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Artwork for Freely Filtered, a NephJC Podcast

Freely Filtered, a NephJC Podcast

NephJC Team
Nephrology
Iga Nephropathy
Kidney Disease
Preeclampsia
FDA
Clinical Trials
In-Patient Blood Pressure Management
Hypertension
Kidney Week
Chronic Kidney Disease
Dialysis
Chronic Kidney Disease (CKD)
S-Flit
Acute Kidney Injury
Diabetes
Maternal Health
Vascular Health
PUSH Trial
Hyponatremia
SGLT2 Inhibitors

Twice monthly (aspirational) recap of the NephJC journal club. NephJC reviews the most important manuscripts which are driving nephrology forward and improving our understanding of the kidney.

PublishesTwice monthlyEpisodes101Founded8 years ago
Number of ListenersCategories
MedicineHealth & FitnessScience

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Artwork for Freely Filtered, a NephJC Podcast

Latest Episodes

This is our second time releasing a podcast simultaneous with presentation and publication. Super exciting.This podcast covers a retrospective trial study on pregnancy complications in kidney donors. The FiltrateJoel Topf @kidney_boySwapnil Hiremath ... more

The FiltrateJoel Topf @kidney_boySwapnil Hiremath @hswapnil.medsky.socialAnna Gaddy @annagaddy.bsky.social Natalie Freidin Program director at Medical University of South CarolinaSpecial GuestsBrendon “Brendo” Neuen The first Five-Time guest on Freel... more

Bypass surgery continues to be the laboratory where we test the most innovative ideas on the prevention of AKIThe FiltrateJoel Topf @kidney_boySwapnil Hiremath @hswapnil.medsky.socialVipin VargheseSophia AmbrusoSpecial GuestsRahul Ganatra Deputy Edit... more

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Recent Guests

Amit Garg
Nephrologist and principal investigator of the study
Western University
Episode: FF99 Late Breaking and High Impact Clinical Trials Session at KidneyWk: Pregnancy Outcomes after Kidney Donation
Brendon Neuen
Nephrologist and director of Kidney Trials at Royal North Shore Hospital
The George Institute for Global Health
Episode: FF98 FIND-CKD Finerenone Tackles non-diabetic CKD
Rahul Ganatra
General internist, VA Boston
Veterans Affairs, Boston
Episode: FF97 MERCURI-2, Can a Flozin prevent AKI?
Fernando Fervenza
Clinical nephrologist; lead author on MAGESTI/MaJESTy trial work on membranous nephropathy
Mayo Clinic, Rochester, Minnesota
Episode: FF96 MAJESTY, or Mentor Two
Megan Prochaska
Stone nephrologist, University of Chicago
University of Chicago
Episode: FF95 The PUSH trial. Push it real good!
Vipin Verghese
Nephrologist, Henry Ford Health
Henry Ford Health
Episode: FF95 The PUSH trial. Push it real good!
John Asplin
Nephrologist, associated with Trex and education in stones
Trex/Academic nephrology
Episode: FF95 The PUSH trial. Push it real good!
Carla Nester
Professor of internal medicine and pediatrics; complementologist; expert on C3 glomerulopathy
University of Iowa
Episode: FF94 C3 Glomerulopathy with Carla Nester
Harish Seethapathy
Nephrologist, Mass General Hospital; longstanding interest in hyponatremia
Mass General Hospital / Harvard Medical School
Episode: FF93 Hyponatremia Interventional Trial

Hosts

Joel Topf
Host of Freely Filtered; guides discussion and introduces topics; prominent figure in NephJC community
Swapnil Hiremath
Nephrologist; discusses methods and trial design; regular host/guest

Reviews

4.9 out of 5 stars from 330 ratings
  • Great podcast!

    Addendum 2026: I still think this is the most amazing podcast. Listened to every single episode.

    I would like to suggest:

    GDNT- goal directed nephrology therapy! Maybe this will gain the same traction as GDMT with cardiology! Our patients most definitely deserve all therapies for proteinuric kidney disease!

    Simply THE BEST! As a full time community nephrologist and mom to two active boys, I’ve always felt the lack of a place to go to get up to date information on all things kidney! I listen t... more

    Apple Podcasts
    5
    DocV80
    United States9 months ago
  • No Politics please

    Great podcast being ruined by insertion of politics. Completely unnecessary and unfortunate! Hope the hosts take note.

    Apple Podcasts
    2
    VGa1234$
    United States2 years ago
  • Top Nephro Podcast

    Really enjoy the quality of the talks and the impressive knowledge of the speakers. Breaking down all details of clinical studies and interesting insights from nephrologists . Thank you for delivering a high-quality content in the nephrology field.

    Apple Podcasts
    5
    IMoraX
    Germany3 years ago
  • ⭐️⭐️⭐️⭐️⭐️

    Great topic. But 24-hr turnaround with MACHEON labs and University of Cincinnati. DOn’t wait two weeks. But even if negative 30-40% still can have genetic contribution. What to do with long term treatment seems to depend if mutations are seen in fH,fB,MCP,fI.

    Apple Podcasts
    5
    Rdswinford
    United States4 years ago
  • ⭐️⭐️⭐️⭐️⭐️

    CystatinC now real-time at MHH in Houston. Next project getting it in our panel.

    PseudoAki needs more discussion- ICI in oncology can do etc. it would be nice to know what % increase to expect with tubular blockade.

    Apple Podcasts
    5
    Rdswinford
    United States4 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Audiences repeatedly highlight the value for staying current between Kidney Week cycles.
Many appreciate the accessible but rigorous breakdown of trial methods and endpoints.
Audiences note the engaging, conversational format and strong guest expertise.
Listeners praise the show for up-to-date nephrology trials and practical clinical takeaways.
Some listeners wish for more structured case discussions and fewer digressions.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Talking Points

Recent interactions between the hosts and their guests.

FF99 Late Breaking and High Impact Clinical Trials Session at KidneyWk: Pregnancy Outcomes after Kidney Donation
Q: When you do these kinds of studies, and I applaud you for doing them, do you ever get negative feedback or pushback from people who say that this kind of work might dissuade people from being living donors?
Garg says he has heard that concern, but believes this research rarely deters donation. He sees accurate outcome data as part of clinicians' responsibility, supporting informed decisions and improving donor care while helping sustain living donation.
FF99 Late Breaking and High Impact Clinical Trials Session at KidneyWk: Pregnancy Outcomes after Kidney Donation
Q: Why did this data need to be done?
Earlier studies suggested higher risks of gestational hypertension or preeclampsia after donation, but uncertainty and variation in counseling remained. The new study expanded the earlier cohort and used linked data from three Canadian provinces to assess outcomes with a larger sample.
FF98 FIND-CKD Finerenone Tackles non-diabetic CKD
Q: What led the investigators to use GFR slope as the primary endpoint, and why was the assessment at month 32?
Neuen explains that prior safety data, the expanded indication, and evidence linking GFR slope to clinical outcomes supported the endpoint. Month 32 was chosen to balance gathering slope data with completing the trial more quickly.
FF98 FIND-CKD Finerenone Tackles non-diabetic CKD
Q: Why did FIND-CKD not include a run-in period?
Brendon Neuen says the trial aimed to be more inclusive and reflect real-world care, where patients may take submaximal doses of renin-angiotensin system inhibitors or none at all.
FF96 MAJESTY, or Mentor Two
Q: So, can you explain why Majesty used Obi as the comparator against Tacrolimus and how that choice shaped the trial and its interpretation?
Majesty was designed to compare a potent B-cell–depleting therapy (Obinutuzumab) against a standard immunosuppressive approach (Tacrolimus) in a rigorous, randomized framework to demonstrate superiority in achieving complete remission at 104 weeks. This setup aimed to establish a clear, clinically meaningful difference and to push for FDA consideration, while acknowledging practical constraints like funding and regulatory hurdles that influenced design choices.

Audience Metrics

Listeners, social reach, demographics and more for this podcast.

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Frequently Asked Questions About Freely Filtered, a NephJC Podcast

What is Freely Filtered, a NephJC Podcast about and what kind of topics does it cover?

Freely Filtered delivers in-depth discussions of nephrology trials, trial design, and translational impact, with a strong emphasis on how studies move from the lab to patient care. Episodes frequently center on large, landmark trials, trial methodologies, endpoints, safety signals, and regulatory considerations, often featuring leading nephrologists as guests and seasoned hosts guiding nuanced panel conversations. A standout trait is the mix of rigorous evidence critique with approachable, conversational chemistry among expert clinicians, making complex trial data more accessible to practicing nephrologists and researchers. The show is especially valuable for listeners who want to stay current on nephrology literature, understand trial desi... more

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2. Core IM | Internal Medicine Podcast
3. The Curbsiders Internal Medicine Podcast
4. Annals On Call Podcast
5. The Curious Clinicians

How many episodes of Freely Filtered, a NephJC Podcast are there?

Freely Filtered, a NephJC Podcast launched 8 years ago and published 101 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Freely Filtered, a NephJC Podcast?

Recent guests on Freely Filtered, a NephJC Podcast include:

1. Amit Garg
2. Brendon Neuen
3. Rahul Ganatra
4. Fernando Fervenza
5. Megan Prochaska
6. Vipin Verghese
7. John Asplin
8. Carla Nester

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