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In the Interim...

Berry
Clinical Trials
Bayesian Statistics
Adaptive Trials
I-Spy 2
FDA
Alpha
Endovascular Therapy
Platform Trials
Trastuzumab
Pertuzumab
Adaptive Clinical Trials
Drug Development
Regression To the Mean
Interim Analyses
Adaptive Designs
Breast Cancer
Her2-Positive Breast Cancer
Stroke Research
Acute Stroke
STEP Platform Trial

A podcast on statistical science and clinical trials. Explore the intricacies of Bayesian statistics and adaptive clinical trials. Uncover methods that push beyond conventional paradigms, ushering in data-driven insights that enhance trial outcomes while ensuring safety and efficacy. Join us as we dive into complex medical challenges and regulatory landscapes, offering innovative solutions tailore... more

PublishesWeeklyEpisodes32Founded8 months ago
Number of ListenersCategories
MathematicsHealth & FitnessMedicineScience

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Latest Episodes

In this episode of "In the Interim…", Dr. Scott Berry and Dr. Kert Viele analyze how regulatory, editorial, and science community standards often impose additional, inconsistent requirements for novel methods in clinical trial design, rarely applied ... more

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In this episode of "In the Interim…", Dr. Scott Berry examines the mathematical foundations and efficiency claims of the promising zone design for adaptive sample size in clinical trials. Scott unpacks the conditional power thresholds that trigger sa... more

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Episode 30 of “In the Interim…” features Dr. Janet Wittes, Fellow of the American Statistical Association, past president of the Society of Clinical Trials, and founder of Statistics Collaborative, in discussion with Dr. Scott Berry. Dr. Wittes detai... more

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In this episode of "In the Interim…", Dr. Scott Berry chats with Frank Harrell, a professor of Biostatistics at Vanderbilt University and W.J. Dixon Award winner. Harrell describes his transition from frequentist to Bayesian clinical trial design, pr... more

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Recent Guests

Janet Wittes
Statistician with extensive experience in clinical trials and biostatistics.
Statistics Collaborative
Episode: A Visit with Dr. Janet Wittes
Frank Harrell
Professor and founding chair of the Department of Biostatistics at Vanderbilt University.
Vanderbilt University
Episode: Bayesian Clinical Trials with Frank Harrell
Dr. Derek Angus
Distinguished professor and chair of Critical Care Medicine at the University of Pittsburgh.
University of Pittsburgh
Episode: A Visit with Dr. Derek Angus
Michael Proschan
Mathematical statistician at NIH specializing in clinical trials
NIH, NIAID
Episode: A Discussion with Michael Proschan on Response-Adaptive Randomization
Eva Mistry
Associate Professor in the Department of Neurology and Rehabilitation Medicine at the University of Cincinnati
University of Cincinnati
Episode: The STEP Platform with Dr. Eva Mistry and Dr. Jordan Elm
Jordan Elm
Professor of Biostatistics at the Medical University of South Carolina
Medical University of South Carolina
Episode: The STEP Platform with Dr. Eva Mistry and Dr. Jordan Elm
Dr. Kert Viele
Episode: Seamless 2/3 Trial Designs
Dr. Joe Marion
Episode: Seamless 2/3 Trial Designs
Dr. Lindsay Berry
Episode: Seamless 2/3 Trial Designs

Hosts

Scott Berry
Co-host of the podcast with extensive experience in biostatistics and clinical trials.
Don Berry
Co-host of the podcast, focuses on adaptive trial designs and statistical analysis.

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Talking Points

Recent interactions between the hosts and their guests.

The Time Machine
Q: How do you model time in a trial?
You can model time independently or smooth the estimates, depending on the data intervals.
The Time Machine
Q: Why would anybody care about a time machine in clinical trials?
It's about making relative comparisons to the old and new standards of care within platform trials.

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Frequently Asked Questions About In the Interim...

What is In the Interim... about and what kind of topics does it cover?

Exploring the forefront of statistical science and clinical trials, this collection of episodes focuses on innovative methodologies such as Bayesian statistics and adaptive trial designs. Guests include experts who shed light on the complexities of clinical trials, including evolving regulatory landscapes, new treatment paradigms, and the integration of statistical principles across different medical challenges. Highlighting topics like the I-SPY 2 trial for breast cancer and the STEP Platform for stroke management, the discussions are rich in detail and approach clinical research from nuanced perspectives, making it a valuable resource for researchers, statisticians, and healthcare professionals seeking to enhance trial outcomes and effica... more

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1. More or Less: Behind the Stats
2. Freakonomics Radio
3. Americast
4. The Rest Is Politics: US
5. The Daily

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In the Interim... launched 8 months ago and published 32 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on In the Interim...?

Recent guests on In the Interim... include:

1. Janet Wittes
2. Frank Harrell
3. Dr. Derek Angus
4. Michael Proschan
5. Eva Mistry
6. Jordan Elm
7. Dr. Kert Viele
8. Dr. Joe Marion

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