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In the Interim...

Berry
Clinical Trials
Bayesian Statistics
Adaptive Trials
FDA
Platform Trials
Adaptive Clinical Trials
I-Spy 2
Interim Analyses
Epidemiology
Statistics
Alpha
Drug Development
Statistical Methods
Endovascular Therapy
Pharmaceutical Industry
Regression To the Mean
Adaptive Designs
Breast Cancer
Pertuzumab
Trastuzumab

A podcast on statistical science and clinical trials. Explore the intricacies of Bayesian statistics and adaptive clinical trials. Uncover methods that push beyond conventional paradigms, ushering in data-driven insights that enhance trial outcomes while ensuring safety and efficacy. Join us as we dive into complex medical challenges and regulatory landscapes, offering innovative solutions tailore... more

PublishesWeeklyEpisodes62Foundeda year ago
Number of ListenersCategories
Health & FitnessMedicineScienceMathematics

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Latest Episodes

In this episode of "In the Interim…", Dr. Scott Berry details the design, execution, and results of the multi-platform randomized clinical trial (mpRCT) pioneered during the COVID-19 pandemic. He describes how REMAP-CAP, ATTACC, and ACTIV-4a—each dev... more

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In this episode of "In the Interim…", Dr. Scott Berry examines the analytical challenges of comparing performance across eras in both sports and clinical research. Drawing from statistically robust family debates and published research, Scott details... more

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In the 60th episode of “In the Interim…”, Dr. Scott Berry, Dr. Nick Berry, and Dr. Joe Marion discuss how Berry Consultants uses AI in clinical trial design and software development. The conversation addresses current applications, limitations, impli... more

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In this episode of "In the Interim…", Dr. Scott Berry and Dr. Nick Berry investigate how futility in clinical trials and stopping rules in sports illuminate very similar decision problems, albeit with very different consequences. Drawing from basebal... more

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Recent Guests

Victoria Cornelius
Professor of Medical Statistics and Trial Methodology; Director of the Imperial Clinical Unit; Co-Director of the NIHR Research Support Services
Imperial College London
Episode: PANTHER: A Phase 2 International Platform Trial in ARDS
Danny McAuley
Consultant and Professor in Intensive Care Medicine
Queen's University Belfast; NIHR Scientific Director for Research Programs
Episode: PANTHER: A Phase 2 International Platform Trial in ARDS
Anthony Gordon
Professor; head of Division of Anesthetics, Pain Medicine and Intensive Care
Imperial College London; NIHR Health Technology Assessment Program Director
Episode: PANTHER: A Phase 2 International Platform Trial in ARDS
Byron Gajewski
Professor of Biostatistics and Data Science at University of Kansas Medical Center and University of Kansas Cancer Center
University of Kansas Medical Center; University of Kansas Cancer Center
Episode: A Visit with Byron Gajewski: KUMC, Innovative Trial Designs, the HOBIT Trial
Stephen Senn
Award-winning statistician with a long career in academia and industry
University of Glasgow; University College London; Ciba-Geigy (historical)
Episode: A Visit with Stephen Senn: Time, Concurrent Controls, and the Bayesian Guidance
Cora Allen-Savietta
Dr.
Berry Consultants
Episode: Making Sense of Hierarchical Composites
Jessica Overbey
Biostatistician
Berry Consultants
Episode: Making Sense of Hierarchical Composites
Steven Tong
Professor of infectious diseases and clinical trialist; head of adaptive platform trials at Melbourne center
University of Melbourne / Doherty Institute
Episode: The SNAP Trial with Professors Tong and Davis
Josh Davis
Professor of infectious diseases; co-leads the SNAP Trial
University of Newcastle / Hunter Medical Research Institute
Episode: The SNAP Trial with Professors Tong and Davis

Host

Scott Berry
Host focusing on statistical design, platform trials, and Bayesian methods with deep involvement in industry practice.

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The SNAP Trial with Professors Tong and Davis
Q: What are the three backbone domains and how do they differ by silo?
The backbone domain asks which primary antibiotic to use for each silo (MSSA, MRSA, or PSSA), with MSSA and PSSA comparing penicillins or cephalosporins to flucloxacillin or cephazolin, and MRSA typically comparing vancomycin-based regimens to alternatives.
The SNAP Trial with Professors Tong and Davis
Q: What was the genesis of the SNAP Trial?
It grew from observing a high burden of MRSA bloodstream infections in Darwin and prior MRSA work, combining this clinical need with adaptive platform concepts to address multiple questions simultaneously across silos.
The Fallacy of Ordinal Endpoints
Q: How has this discussion evolved with Remap-CAP and other platform trials?
In Remap-CAP, the endpoint includes death and organ support days, and while proportional odds can be appealing, clinicians criticized the imposed weights from the model. This prompted exploration of more clinically informed weighting and ongoing work to publish a framework for deriving weights from patient-centered data.
The Fallacy of Ordinal Endpoints
Q: What is the core argument against a purely proportional odds approach?
The main concern is that proportional odds hides the actual clinical utilities behind weights that are implicit in the data (prevalence). Our critique is that you can and should quantify the weights from utilities or quality-of-life data rather than assume a single, abstract proportional shift.
Bayesian Statistics in Clinical trials: The Past, Present, and Future
Q: Are there ethical concerns in giving a patient treatment with a prior probability that's lower than a different treatment?
Yes, and the clinical trial community tries to maintain treatment equalities by randomizing trials, which can obscure ethical considerations.

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Frequently Asked Questions About In the Interim...

What is In the Interim... about and what kind of topics does it cover?

This program centers on statistical science, Bayesian methods, and adaptive trial designs, with a strong emphasis on practical decision-making in clinical development. Across episodes, listeners are exposed to how interim analyses, hierarchical endpoints, platform trials, and regulatory considerations shape safer, more efficient drug development. The show often features practitioners from Berry Consultants and academia who discuss real-world trial design, regulatory interactions, and the ethics of stopping rules, all while illustrating concepts with concrete case studies. A notable strength is its ability to translate dense statistical theory into actionable guidance for sponsors, regulators, and clinicians, making it a compelling resource ... more

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In the Interim... launched a year ago and published 62 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on In the Interim...?

Recent guests on In the Interim... include:

1. Victoria Cornelius
2. Danny McAuley
3. Anthony Gordon
4. Byron Gajewski
5. Stephen Senn
6. Cora Allen-Savietta
7. Jessica Overbey
8. Steven Tong

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