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In the Interim...

Berry
Clinical Trials
Bayesian Statistics
Adaptive Trials
FDA
Platform Trials
I-Spy 2
Adaptive Clinical Trials
Interim Analyses
Endovascular Therapy
Epidemiology
Statistics
Drug Development
Alpha
Breast Cancer
Response Adaptive Randomization
Statistical Methods
Remap-Cap
Pharmaceutical Industry
Regression To the Mean
Adaptive Designs

A podcast on statistical science and clinical trials. Explore the intricacies of Bayesian statistics and adaptive clinical trials. Uncover methods that push beyond conventional paradigms, ushering in data-driven insights that enhance trial outcomes while ensuring safety and efficacy. Join us as we dive into complex medical challenges and regulatory landscapes, offering innovative solutions tailore... more

PublishesWeeklyEpisodes82Founded2 years ago
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MathematicsHealth & FitnessMedicineScience

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In this episode of "In the Interim…", Scott Berry is joined by Jenny Devenport and Kaspar Rufibach of Merck Group, co-authors of the EFSPI Statistical Methodology Leaders paper "Statistical Methodology Groups in the Pharmaceutical Industry," and May ... more

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In this episode of "In the Interim…", Dr. Scott Berry shares the framework he presented at a CSRC regulatory science hackathon on digital twins and synthetic controls in cardiovascular clinical trials. He separates three kinds of models that are ofte... more

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In this episode of "In the Interim…", Dr. Scott Berry recounts a presentation he gave to the Speak Foundation, a patient organization focused on limb-girdle muscular dystrophy and makes the case for master protocols directly to the stakeholder trials... more

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In this episode of "In the Interim…", Dr. Scott Berry talks with Dr. Alun Bedding, a professional certified coach and statistician who spent decades in pharmaceutical statistics, including as global head of statistical methods, collaboration, and out... more

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Recent Guests

Alun Bedding
Director at the Alun Bedding Coaching and Consulting Group; professional certified coach and statistician
Alun Bedding Coaching and Consulting Group
Episode: Science Coaching With Alun Bedding
Roger Lewis
Senior Medical Scientist at Berry Consultants; Professor of Emergency Medicine at UCLA
Berry Consultants / UCLA
Episode: The CHIPS Trial: Bayesian Adaptive Trial in JAMA
Anna McGlothlin
Senior Statistical Scientist at Berry Consultants; Director focusing on adaptive/complex trials
Berry Consultants
Episode: The CHIPS Trial: Bayesian Adaptive Trial in JAMA
Nick Berry
Senior Statistical Scientist at Berry Consultants; focuses on FAC software and modeling
Berry Consultants
Episode: The CHIPS Trial: Bayesian Adaptive Trial in JAMA
Don Berry
Author of the impact study chronicled in Science Magazine; statistician on CLGB Breast Committee
Duke University (as mentioned); Cancer and Leukemia Group B (CLGB)
Episode: Mammograms: Death Threats, Hillary Clinton and Lead-Time Bias
Srinivas Murthy
Chair of the International Trial Steering Committee for Remap-Cap
University of British Columbia (in infectious disease) and Remap-Cap leadership
Episode: REMAP-CAP Results: Oseltamivir in Critically-Ill Influenza Patients
Tom Hills
Clinical immunologist and infectious disease physician
Te Toka Tume Auckland Hospital; Medical Research Institute of New Zealand
Episode: REMAP-CAP Results: Oseltamivir in Critically-Ill Influenza Patients
Lindsay Berry
Senior statistical scientist at Berry Consults; co-lead of the analysis team for Remap-Cap
Berry Consults
Episode: REMAP-CAP Results: Oseltamivir in Critically-Ill Influenza Patients
Will Meurer
Professor of emergency medicine and neurology; Berry Consultants medical and statistical scientist; IDE sponsor for Icecap
University of Michigan; Berry Consultants
Episode: ICECAP: The Results

Host

Scott Berry
Statistician specializing in clinical trial design and Bayesian methods

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Talking Points

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Mammograms: Death Threats, Hillary Clinton and Lead-Time Bias
Q: But you're not a medical doctor, are you, Dr. Berry?
Yes, I am a statistician, and I explain the data and its limitations clearly to the committee, emphasizing that being a doctor is not a prerequisite to evaluating evidence and risks in population screening.
A Visit With Tim Berry
Q: What led to the formation of Blend360?
Tim and Patrick Hennessy sought to build a broader analytics-enabled company beyond marketing, ultimately forming Blend360 after deciding to apply analytics across multiple domains and acquiring complementary organizations.
A Visit With Tim Berry
Q: How did Tim's early experiences shape his view of analytics in business?
Tim explains that early work at AT&T and later roles showed him how data could drive concrete business decisions, not just theoretical insight, which set the tone for his career in applied analytics.
Response-Adaptive Randomization in Clinical Trials
Q: So explain to Tammy what response adaptive randomization is.
RAR is a framework where interim analyses adjust allocation probabilities to favor arms performing better, with the aim of treating participants more effectively while still collecting information to compare against a control. The method is nuanced, varies by setting (multi-arm vs two-arm), and requires careful design, regulation-aware modeling, and extensive simulation.
The SNAP Trial with Professors Tong and Davis
Q: What are the three backbone domains and how do they differ by silo?
The backbone domain asks which primary antibiotic to use for each silo (MSSA, MRSA, or PSSA), with MSSA and PSSA comparing penicillins or cephalosporins to flucloxacillin or cephazolin, and MRSA typically comparing vancomycin-based regimens to alternatives.

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Frequently Asked Questions About In the Interim...

What is In the Interim... about and what kind of topics does it cover?

Conversations and solo explanations about Bayesian statistics, adaptive trial design, and the decisions that shape clinical research. Statistician Scott Berry guides discussions of trial methods, interpreting results, regulatory considerations, and patient outcomes, often using published studies and real trial experiences to make complex statistical questions more practical. Episodes range from technical explorations of interim analyses, futility rules, and virtual controls to broader discussions of research integrity, screening policy, and leadership in pharmaceutical statistics.

Guests include clinical investigators, biostatisticians, physicians, and industry professionals who bring direct experience designing, conducting, or interpretin... more

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1. NEJM AI Grand Rounds
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In the Interim... launched 2 years ago and published 82 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on In the Interim...?

Recent guests on In the Interim... include:

1. Alun Bedding
2. Roger Lewis
3. Anna McGlothlin
4. Nick Berry
5. Don Berry
6. Srinivas Murthy
7. Tom Hills
8. Lindsay Berry

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