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In the Interim...

Berry
Clinical Trials
Bayesian Statistics
Adaptive Trials
FDA
I-Spy 2
Platform Trials
Adaptive Clinical Trials
Interim Analyses
Endovascular Therapy
Epidemiology
Statistics
Drug Development
Alpha
Breast Cancer
Response Adaptive Randomization
Statistical Methods
Remap-Cap
Pharmaceutical Industry
Regression To the Mean
Adaptive Designs

A podcast on statistical science and clinical trials. Explore the intricacies of Bayesian statistics and adaptive clinical trials. Uncover methods that push beyond conventional paradigms, ushering in data-driven insights that enhance trial outcomes while ensuring safety and efficacy. Join us as we dive into complex medical challenges and regulatory landscapes, offering innovative solutions tailore... more

PublishesWeeklyEpisodes77Founded2 years ago
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MathematicsHealth & FitnessMedicineScience

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Latest Episodes

In this episode of "In the Interim…", Dr. Scott Berry examines three recent health-research headlines through a statistician's lens: an Adventist Health Study-2 analysis claiming eggs reduce Alzheimer's risk, an Emory University trial on high-dose vi... more

In this episode of "In the Interim...", Dr. Scott Berry dissects prevailing concepts of “clinically meaningful difference” in clinical trials focusing on progressive diseases. Through detailed examples from pancreatic cancer (Ben Sasse, Revolution Me... more

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In this episode of "In the Interim…", Dr. Don Berry provides a detailed account of co-chairing the 1997 NIH consensus development conference on mammography for women in their 40s. His conversation with Dr. Scott Berry covers the statistical and clini... more

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In this episode of "In the Interim…", Dr. Scott Berry speaks with Dr. Srinivas Murthy, Dr. Thomas Hills, and Dr. Lindsay Berry about the REMAP-CAP trial results on oseltamivir in critically ill influenza patients. The trial used a Bayesian covariate-... more

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Recent Guests

Don Berry
Author of the impact study chronicled in Science Magazine; statistician on CLGB Breast Committee
Duke University (as mentioned); Cancer and Leukemia Group B (CLGB)
Episode: Mammograms: Death Threats, Hillary Clinton and Lead-Time Bias
Srinivas Murthy
Chair of the International Trial Steering Committee for Remap-Cap
University of British Columbia (in infectious disease) and Remap-Cap leadership
Episode: REMAP-CAP Results: Oseltamivir in Critically-Ill Influenza Patients
Tom Hills
Clinical immunologist and infectious disease physician
Te Toka Tume Auckland Hospital; Medical Research Institute of New Zealand
Episode: REMAP-CAP Results: Oseltamivir in Critically-Ill Influenza Patients
Lindsay Berry
Senior statistical scientist at Berry Consults; co-lead of the analysis team for Remap-Cap
Berry Consults
Episode: REMAP-CAP Results: Oseltamivir in Critically-Ill Influenza Patients
Robert Silbergleit
Professor of emergency medicine
University of Michigan
Episode: ICECAP: The Results
Romer Geocadin
Professor of neurology, neurosurgery, anesthesiology, and critical care medicine
Johns Hopkins University
Episode: ICECAP: The Results
Sharon Yeatts
Professor of biostatistics
Medical University of South Carolina
Episode: ICECAP: The Results
Elizabeth Lorenzi
Stroke expert guest, providing clinical context
Episode: Failure of the Proportional Odds is the Result
Tim Berry
Statistician and co-founder of Blend360
Blend360 / Former Merkle executive
Episode: A Visit With Tim Berry

Host

Scott Berry
Host of In the Interim; guides discussion with a focus on trial design, Bayesian methods, and adaptive trials.

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Talking Points

Recent interactions between the hosts and their guests.

Mammograms: Death Threats, Hillary Clinton and Lead-Time Bias
Q: But you're not a medical doctor, are you, Dr. Berry?
Yes, I am a statistician, and I explain the data and its limitations clearly to the committee, emphasizing that being a doctor is not a prerequisite to evaluating evidence and risks in population screening.
A Visit With Tim Berry
Q: What led to the formation of Blend360?
Tim and Patrick Hennessy sought to build a broader analytics-enabled company beyond marketing, ultimately forming Blend360 after deciding to apply analytics across multiple domains and acquiring complementary organizations.
A Visit With Tim Berry
Q: How did Tim's early experiences shape his view of analytics in business?
Tim explains that early work at AT&T and later roles showed him how data could drive concrete business decisions, not just theoretical insight, which set the tone for his career in applied analytics.
Response-Adaptive Randomization in Clinical Trials
Q: So explain to Tammy what response adaptive randomization is.
RAR is a framework where interim analyses adjust allocation probabilities to favor arms performing better, with the aim of treating participants more effectively while still collecting information to compare against a control. The method is nuanced, varies by setting (multi-arm vs two-arm), and requires careful design, regulation-aware modeling, and extensive simulation.
The SNAP Trial with Professors Tong and Davis
Q: What are the three backbone domains and how do they differ by silo?
The backbone domain asks which primary antibiotic to use for each silo (MSSA, MRSA, or PSSA), with MSSA and PSSA comparing penicillins or cephalosporins to flucloxacillin or cephazolin, and MRSA typically comparing vancomycin-based regimens to alternatives.

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Frequently Asked Questions About In the Interim...

What is In the Interim... about and what kind of topics does it cover?

This show centers on statistical science, Bayesian methods, and adaptive clinical trial design for medical research. Across episodes, the conversations weave together practical trial design, regulatory considerations, and real-world case studies (from platform and master protocol trials to adaptive randomization and interim analyses). A recurring thread is how robust statistical thinking, data provenance, and transparent prespecification support faster, safer decision-making in drug development, while balancing ethical considerations and regulatory expectations. The program often features experts in biostatistics, trial methodology, and clinical science, with a penchant for concrete examples, simulations, and debates about when adaptive app... more

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1. Super Data Science: ML & AI Podcast with Jon Krohn
2. The Journal.
3. FT News Briefing
4. Decoder with Nilay Patel
5. JAMA Editors' Summary

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In the Interim... launched 2 years ago and published 77 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on In the Interim...?

Recent guests on In the Interim... include:

1. Don Berry
2. Srinivas Murthy
3. Tom Hills
4. Lindsay Berry
5. Robert Silbergleit
6. Romer Geocadin
7. Sharon Yeatts
8. Elizabeth Lorenzi

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