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In the Interim...

Berry
Clinical Trials
Bayesian Statistics
Adaptive Trials
FDA
Platform Trials
I-Spy 2
Adaptive Clinical Trials
Interim Analyses
Endovascular Therapy
Epidemiology
Statistics
Pharmaceutical Industry
Drug Development
Alpha
Breast Cancer
Response Adaptive Randomization
Statistical Methods
Remap-Cap
Regression To the Mean
Adaptive Designs

A podcast on statistical science and clinical trials. Explore the intricacies of Bayesian statistics and adaptive clinical trials. Uncover methods that push beyond conventional paradigms, ushering in data-driven insights that enhance trial outcomes while ensuring safety and efficacy. Join us as we dive into complex medical challenges and regulatory landscapes, offering innovative solutions tailore... more

PublishesWeeklyEpisodes84Founded2 years ago
Number of ListenersCategories
MathematicsHealth & FitnessMedicineScience

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Latest Episodes

In this mailbag episode of "In the Interim…", Dr. Scott Berry answers two listener questions and weighs in on the pace of innovation in clinical trial science. Asked what infrastructure a learning healthcare system would require, Scott defines one th... more

In this episode of "In the Interim…", Dr. Scott Berry and Dr. Kert Viele, Director of Research at Berry Consultants, review the European Medicines Agency's draft reflection paper on methodological aspects in confirmatory platform trials. They walk th... more

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In this episode of "In the Interim…", Scott Berry is joined by Jenny Devenport and Kaspar Rufibach of Merck Group, co-authors of the EFSPI Statistical Methodology Leaders paper "Statistical Methodology Groups in the Pharmaceutical Industry," and May ... more

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In this episode of "In the Interim…", Dr. Scott Berry shares the framework he presented at a CSRC regulatory science hackathon on digital twins and synthetic controls in cardiovascular clinical trials. He separates three kinds of models that are ofte... more

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Recent Guests

Jenny Devenport
Senior Director of Patient Focused Real-World Evidence at Merck Healthcare
Merck Group
Episode: Statistical Methodology Groups in the Pharmaceutical Industry
Kaspar Rufibach
Senior Director and Head of Advanced Biostatistical Sciences at Merck Group
Merck Group
Episode: Statistical Methodology Groups in the Pharmaceutical Industry
May Mo
Associate Vice President of Biostatistics and Head of Design and Innovation at Amgen
Amgen
Episode: Statistical Methodology Groups in the Pharmaceutical Industry
Alun Bedding
Director at the Alun Bedding Coaching and Consulting Group; professional certified coach and statistician
Alun Bedding Coaching and Consulting Group
Episode: Science Coaching With Alun Bedding
Roger Lewis
Senior Medical Scientist at Berry Consultants; Professor of Emergency Medicine at UCLA
Berry Consultants / UCLA
Episode: The CHIPS Trial: Bayesian Adaptive Trial in JAMA
Anna McGlothlin
Senior Statistical Scientist at Berry Consultants; Director focusing on adaptive/complex trials
Berry Consultants
Episode: The CHIPS Trial: Bayesian Adaptive Trial in JAMA
Nick Berry
Senior Statistical Scientist at Berry Consultants; focuses on FAC software and modeling
Berry Consultants
Episode: The CHIPS Trial: Bayesian Adaptive Trial in JAMA
Don Berry
Author of the impact study chronicled in Science Magazine; statistician on CLGB Breast Committee
Duke University (as mentioned); Cancer and Leukemia Group B (CLGB)
Episode: Mammograms: Death Threats, Hillary Clinton and Lead-Time Bias
Srinivas Murthy
Chair of the International Trial Steering Committee for Remap-Cap
University of British Columbia (in infectious disease) and Remap-Cap leadership
Episode: REMAP-CAP Results: Oseltamivir in Critically-Ill Influenza Patients

Host

Scott Berry
Statistician specializing in clinical trial design and Bayesian methods

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Statistical Methodology Groups in the Pharmaceutical Industry
Q: Are there negatives of having a methodology group at a pharmaceutical company?
The guests acknowledge the risk of dividing project statisticians from methodologists, but describe collaboration, movement between roles, and continued involvement in product work as ways to avoid a divide. They see specialists as helping with deeper methodological work while project statisticians contribute essential business context.
Statistical Methodology Groups in the Pharmaceutical Industry
Q: What is a Statistical Methodology Group?
Jenny Devenport describes it as a strategic investment that supports the conception, evaluation, implementation, and application of appropriate statistical methods. Kaspar Rufibach adds that such groups help scale inventions through publication, industry collaboration, regulatory dialogue, and validated software.
Mammograms: Death Threats, Hillary Clinton and Lead-Time Bias
Q: But you're not a medical doctor, are you, Dr. Berry?
Yes, I am a statistician, and I explain the data and its limitations clearly to the committee, emphasizing that being a doctor is not a prerequisite to evaluating evidence and risks in population screening.
A Visit With Tim Berry
Q: What led to the formation of Blend360?
Tim and Patrick Hennessy sought to build a broader analytics-enabled company beyond marketing, ultimately forming Blend360 after deciding to apply analytics across multiple domains and acquiring complementary organizations.
A Visit With Tim Berry
Q: How did Tim's early experiences shape his view of analytics in business?
Tim explains that early work at AT&T and later roles showed him how data could drive concrete business decisions, not just theoretical insight, which set the tone for his career in applied analytics.

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Frequently Asked Questions About In the Interim...

What is In the Interim... about and what kind of topics does it cover?

Conversations and solo explanations about Bayesian statistics, adaptive trial design, and the decisions that shape clinical research. Statistician Scott Berry guides discussions of trial methods, interpreting results, regulatory considerations, and patient outcomes, often using published studies and real trial experiences to make complex statistical questions more practical. Episodes range from technical explorations of interim analyses, futility rules, and virtual controls to broader discussions of research integrity, screening policy, and leadership in pharmaceutical statistics.

Guests include clinical investigators, biostatisticians, physicians, and industry professionals who bring direct experience designing, conducting, or interpretin... more

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3. Planet Money
4. Freakonomics Radio
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In the Interim... launched 2 years ago and published 84 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on In the Interim...?

Recent guests on In the Interim... include:

1. Jenny Devenport
2. Kaspar Rufibach
3. May Mo
4. Alun Bedding
5. Roger Lewis
6. Anna McGlothlin
7. Nick Berry
8. Don Berry

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