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Hart2Heart with Dr. Mike Hart

Dr. Mike Hart
Mental Health
Exercise
Nutrition
Circadian Rhythm
Diabetes
Sleep Quality
Psychedelics
THC
Caffeine
Cannabis
Glp-1 Agonists
Obesity
Health Optimization
Testosterone
VO2 Max
Brown Fat
CBD
Hormones
Cardiovascular Disease
Peptides

Hart2Heart is the show where Dr. Mike Hart breaks down evidence-based health, longevity, performance, and modern medicine without the fluff. Each episode explores practical, evidence-based strategies for improving your life, including hormone health, peptides, sleep optimization, nutrition, supplements, exercise, sunlight, psychedelics, and smarter medication use. The goal is simple: help you unde... more

PublishesWeeklyEpisodes221Founded6 years ago
Number of ListenersCategories
MedicineHealth & Fitness

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Artwork for Hart2Heart

Latest Episodes

This episode explores how to use GLP-1 medications like semaglutide/Ozempic and tirzepatide/Mounjaro safely and effectively. Dr. Mike Hart and Dr. Christle Guevarra Do discuss once-weekly dosing, individualized titration, optimal dose selection, food... more

Dr. Mike Hart interviews board-certified urologist Dr. Alex Tatum about peptide access, compounding, and men's health. Tatum argues many peptides are naturally occurring and lacked FDA commercialization incentives, says the FDA's 2023 move banning 19... more

The host explains how he raised his estimated VO2 max in 2026 in his 40s, emphasizing that the biggest driver was structured hard training with progressive overload, not "hacks" like peptides, supplements, sauna, red light, or ketones. After years of... more

Dr. Ksenia Petrushkina joins Dr. Mike Hart for a deep dive into regenerative medicine, peptides, hormones, IV therapies, and longevity. They discuss what conventional medicine and health influencers often get wrong about prevention-focused care, whil... more

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Recent Guests

Dr. Ksenia
Physician specializing in hormones, peptides, regenerative medicine and longevity
Regenerative Clinic, Miami/Aventura, Florida
Episode: #222 Peptides, Hormones, and Longevity: Safety, Skin Aging, NAD+, GLP-1s, and Mitochondrial Health with Dr. Ksenia
Dr. Allen Frances
Psychiatrist and expert guest on AI chatbots and mental health
Former chair of DSM-IV Task Force
Episode: #219 Dr. Allen Frances on AI Chatbots, Mental Health Risks, Privacy, and the Overdiagnosis of Autism
Dr. Sylvain
Food Professor, expert on nutrition and food policy
The Food Professor (podcast/brand)
Episode: #218 Lab-Grown Meat, Grocery Prices, and the Real Drivers of Food Inflation in Canada (with the Food Professor)
Dr. Russell Kennedy
Somatic and Internal Family Systems–oriented physician
Anxiety MD / somatic therapy practice
Episode: #217 Dr. Russell Kennedy on Anxiety as a Body Alarm: Childhood Patterns, Worry, Somatic Healing
Brady Holmer
Elite level runner and endurance performance expert discussed in the episode
Independent athlete and researcher
Episode: #216 VO2 Max, Zone 2 Training, HRV Wearables, Sauna, and Evidence-Based Performance Supplements with Brady Holmer
Tommy Wood
Brain health researcher, author, and speaker
Episode: #215 Brain Health From Morning to Night: Sleep, Exercise, Supplements, Screens, and ADHD Meds
Roger McFillin
Clinical psychologist and author discussed in-depth topics on mind, emotion, and health
Radically Genuine / Substack; clinical psychology
Episode: #213 Emotions, Mind Control, and Mental Health Labels: A Conversation with Dr. Roger McFillin
Dr. Jesse Morse
Cutting edge physician specializing in regenerative medicine and anti-aging
Oztek Pathic Center
Episode: #209 Advanced Healing and Prevention Techniques with Stem Cells and Peptides
Tony Ricci
Athletic performance and mental health coach for athletes
Fightshaped.net
Episode: #201 Building True Mental Toughness with Tony Ricci

Host

Dr. Mike Hart
Host of Hart2Heart

Reviews

4.7 out of 5 stars from 30 ratings
  • Michael Jackson

    Re he!

    Apple Podcasts
    1
    Msgs 40th
    United States2 years ago
  • Smart

    Dr. Hart is sincere and relatable. He chooses thoughtful and provocative guests. Very impressed!

    Apple Podcasts
    5
    otisedwinsmith
    Canada5 years ago
  • For Those Looking To Optimize Their Physical Potential

    Dr. Mike Hart is a brilliant and open minded person. As we all become more aware of group think and the dangers of it it is a relief to have a doctor speak up who is more in favor of plant medicine and healing through overall wellness instead of pharmaceuticals and other short-sighted conventional treatments. Dr. Hart is one of my go to’s when seeking information on human optimization and wellness. Very excited about this podcast.

    Apple Podcasts
    5
    This Isn't Amish Paradise
    United States5 years ago
  • Must listen

    Dr. Mike is on the cutting edge of plant based medicine and taking a whole health approach to optimizing human potential. His social media content is A+ and this podcast is the same. Thank you Dr. Mike!

    Apple Podcasts
    5
    Malbrizio
    United States5 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

High-quality guests and cutting-edge wellness topics.
Sincere and relatable host with thoughtful, provocative guests.
Appreciated for plant-based and whole-health perspectives.
Strong, open-minded host delivering practical health advice.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Talking Points

Recent interactions between the hosts and their guests.

#222 Peptides, Hormones, and Longevity: Safety, Skin Aging, NAD+, GLP-1s, and Mitochondrial Health with Dr. Ksenia
Q: What are the three best ways of slow aging of the skin, and how do topical vs injectable options compare?
Topical GHK-Cu shows evidence-supported results, while injections have mixed results depending on dose and individual factors. Topical formulations are generally more reliable for skin effects, while injections may help some patients, but evidence varies and copper and zinc balance is critical to avoid toxicity. Retin-A remains a widely used topical agent for cell turnover, and combining modalities—topical GHK-Cu, Estriol-containing products, and careful retinoid use—appears practical for many patients.
#222 Peptides, Hormones, and Longevity: Safety, Skin Aging, NAD+, GLP-1s, and Mitochondrial Health with Dr. Ksenia
Q: What do you think mainstream medicine gets wrong about this space, and what do you think health influencers get wrong about this space?
Mainstream medicine tends to remain skeptical about preventative and peptide-based approaches, often requiring FDA approval. In practice, I see patients who improve conditions like blood pressure or cholesterol through weight loss and micronutrient infusions, even if formal trials are lacking. The discrepancy highlights the challenge of translating mechanistic plausibility into broad clinical acceptance, while real-world observations suggest potential benefits worth exploring with careful monitoring.
#218 Lab-Grown Meat, Grocery Prices, and the Real Drivers of Food Inflation in Canada (with the Food Professor)
Q: My first question for you, is lab-grown meat a real solution or is it overhyped?
Lab-grown meat has potential to reduce carbon footprint and enable nutrient customization, but consumer acceptance and cost are major hurdles. It won't be affordable immediately, and clear labeling will be essential for consumer trust and market adoption.
#219 Dr. Allen Frances on AI Chatbots, Mental Health Risks, Privacy, and the Overdiagnosis of Autism
Q: What populations are most at risk when using AI chatbots for mental health?
Frances identifies the very young, the very old, people with severe mental illness, and those who are socially isolated as the most at risk, with the greatest potential for harm if chatbots substitute for appropriate clinical care.
#217 Dr. Russell Kennedy on Anxiety as a Body Alarm: Childhood Patterns, Worry, Somatic Healing
Q: What is the core difference between treating anxiety as a thinking problem versus a feeling problem?
Anxiety is more accurately a feeling problem rooted in the body; addressing the body's alarm through somatic techniques can reduce the drive of anxious thoughts and create a more resilient state.

Audience Metrics

Listeners, social reach, demographics and more for this podcast.

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Frequently Asked Questions About Hart2Heart

What is Hart2Heart about and what kind of topics does it cover?

A results-focused health and wellness show hosted by a cannabis physician who discusses medical cannabis education, preventive medicine, and evidence-based approaches to optimizing physical and cognitive performance. Episodes cover topics from cannabis use and sleep to detox, hydration, cardiovascular health, insulin resistance, and elite athletic training, often featuring doctors and researchers who specialize in regenerative medicine, sports science, and nutrition. The show stands out for its practical, data-driven takes on emerging therapies, personalized health strategies, and real-world recovery and performance insights, with an emphasis on balancing medical nuance with accessible advice for listeners seeking practical lifestyle improv... more

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Which podcasts are similar to Hart2Heart?

These podcasts share a similar audience with Hart2Heart:

1. The Dr. Gabrielle Lyon Show
2. Peptides Explained
3. The Hunter Williams Podcast
4. The Dr. Hyman Show
5. The Peptide Podcast

How many episodes of Hart2Heart are there?

Hart2Heart launched 6 years ago and published 221 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Hart2Heart?

Recent guests on Hart2Heart include:

1. Dr. Ksenia
2. Dr. Allen Frances
3. Dr. Sylvain
4. Dr. Russell Kennedy
5. Brady Holmer
6. Tommy Wood
7. Roger McFillin
8. Dr. Jesse Morse

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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