Rephonic
Artwork for Deep Margin
Head and Neck Cancer
Radiotherapy
Transoral Robotic Surgery
Proton Therapy
Salvage Surgery
Ctdna
Dahanca
Hpv-Positive Head and Neck Cancer
Sinonasal Cancer
ORATOR Trials
Enfortumab Vedotin
Pembrolizumab
Immunotherapy
EGFR
Transoral Robotic Surgery (TORS)
HPV
Sentinel Node Biopsy
Bi-Specifics
Xevinapant
EBV DNA

Cancer coversations from the collar up; a podcast dedicated to head and neck oncology

PublishesWeeklyEpisodes24Founded7 months ago
Number of ListenersCategories
MedicineHealth & Fitness

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Artwork for Deep Margin

Latest Episodes

Another rockstar joins us for a great episode talking through some of the advances in head and neck de-escalation

We're back with Chris Holsinger for part 2 of the TORS adventure

Alan Ho, Medical oncologist at MSKCC talks us through his work around Ozuriftamab Vedotin (Oz-V) and other ADC approaches. Ben criticises Will's combination approaches.

Nadeem Riaz directs the Precision Radiotherapy Initiative and leads a multidisciplinary research lab at the intersection of the DNA damage response and anti-tumor immunity. He talks us through his important paper examining mechanisms of resistance an... more

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Recent Guests

Alan Ho
Chief of Head and Neck Medical Oncology at Memorial Sloan Kettering Cancer Center
Memorial Sloan Kettering Cancer Center
Episode: Episode 21: Alan Ho live (post hoc) from the Multidisciplinary Head and Neck Cancers Symposium
Nadeem Riaz
Associate member at Memorial Sloan-Kettering Cancer Center, physician-scientist
Memorial Sloan-Kettering Cancer Center
Episode: Episode 20: PAPER OF THE MONTH Nadeem Riaz talks us through cellular mechanisms of resistance, cluster f**ks and all the ecosystem.
Yungan Tao
Radiation oncologist at Gustave-Roussy, Paris
Gustave-Roussy
Episode: Episode 19: NIVOPOSTOP - nivolumab post op - a GORTEC triump with Yungan Tao
Jeppe Friborg
Clinical oncologist, head and neck cancer specialist
Dahanca study group
Episode: Episode 18: Our man in Denmark: Jeppe Friborg talks us through DAHANCA/Vores mand i Danmark: Jeppe Friborg taler os gennem DAHANCA
Pierre Blanchard
Radiation oncologist
Gustave Roussy Cancer Center
Episode: Episode 16: PAPER OF THE MONTH ALERT! Immune boost HPV with Mr Meta-Analysis himself Pr Pierre Blanchard
Nabil Saba
Head and neck medical oncologist specializing in sinus/nasal cancers
Head and Neck Medical Oncology
Episode: Episode 17: Nabil Saba talks us through sinonasal cancer
Kate Hutcheson
Leading light of head and neck cancer research and clinician at MD Anderson
MD Anderson Cancer Center
Episode: Episode 15: Don't mention the 'P' word; long term functional outcomes with Professor Kate Hutcheson
Chris Holsinger
Doyen of the head and neck world, Stanford surgeon
Stanford University
Episode: Episode 14 [PART 1] : ding ding round 2 in the red corner it's Chris Holsinger live with the E3311 trial and TORS adventures
David Palma
Professor of radiation oncology, Canada
University/Academic Medical Center (Canada)
Episode: Episode 13: Ding Ding: TORS round 1 - the blue corner we have Professor David Palma talking about RT

Hosts

Ben
Host of Deep Margin; provides interview guidance and clinical framing in episodes
Will
Co-host or interviewer; leads discussion and questions in episodes

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Episode 6: Schilling's Sentinels; Sentinel lymph node biopsy in HNSCC and management of the clinically N0 neck with Clare Schilling
Q: What are the main barriers to wider adoption of Sentinel node biopsy in this field?
Key barriers include pathology workflow demands for thorough serial sectioning, limitations in preoperative depth assessments for metastasis risk, and the need for specialized training and infrastructure to implement a new staging paradigm across centers.
Episode 6: Schilling's Sentinels; Sentinel lymph node biopsy in HNSCC and management of the clinically N0 neck with Clare Schilling
Q: Were these strategies focused on early-stage disease only, or did they include later stages as well?
The foundational data primarily addressed early-stage, N0 neck disease, with the understanding that the biology and pathways of spread in later stages are more complex and require different considerations, though subsequent trials and discussions expanded thinking to broader contexts.
Episode 6: Schilling's Sentinels; Sentinel lymph node biopsy in HNSCC and management of the clinically N0 neck with Clare Schilling
Q: Why is this important, Clare?
Because even small, early tumors have a non-negligible risk of occult metastasis; upfront neck management can reduce relapses and improve long-term outcomes, as shown by pivotal trials and guidelines. It's about balancing disease control with morbidity and tailoring approaches to individual patients.
Episode 5: Xevinapant, X-rays and Xmas is coming with Jonathan Schoenfeld
Q: Given the outcomes, is there any value in pursuing further research with Xevinapant or related agents?
There may be value in exploring biomarker-driven selection, alternative regimens that avoid overlapping toxicities with cisplatin, or combining with immunotherapy in carefully designed studies to preserve the therapeutic index.
Episode 5: Xevinapant, X-rays and Xmas is coming with Jonathan Schoenfeld
Q: What were the key differences between the phase II Gore-Tek study and the phase III Tri-Link study that might explain the divergent results?
Phase III expanded to an international, HPV-negative population and added three extra cycles of Xevinapant after chemoradiation, which may have amplified toxicities and reduced patients' ability to complete the full, intended treatment, undermining potential benefits seen in the earlier trial.

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Frequently Asked Questions About Deep Margin

What is Deep Margin about and what kind of topics does it cover?

This show centers on head and neck oncology, exploring how cutting-edge translational science meets real-world clinical practice. Episodes regularly examine radiotherapy advances, surgical innovations (notably transoral robotic surgery), immunotherapy timing and trial design, biomarker-driven de-escalation, and the practicalities of running multi-center trials. A distinctive thread is the combination of rigorous clinical evidence with practical considerations for patient quality of life, trial accrual, and cross-border trial collaboration, making it a valuable resource for clinicians, researchers, and decision-makers navigating evolving standards of care in head and neck cancer. The format frequently features expert guests who translate com... more

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4. Page 94: The Private Eye Podcast
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Deep Margin launched 7 months ago and published 24 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Deep Margin?

Recent guests on Deep Margin include:

1. Alan Ho
2. Nadeem Riaz
3. Yungan Tao
4. Jeppe Friborg
5. Pierre Blanchard
6. Nabil Saba
7. Kate Hutcheson
8. Chris Holsinger

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