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CLOT Conversations

Thrombosis Canada
Venous Thromboembolism
Thrombosis
Apixaban
Cancer-Associated Thrombosis
Anticoagulation
DVT
Pulmonary Embolism
D-Dimer
Rivaroxaban
Mechanical Heart Valves
Patient Care
Cancer
Cerebral Venous Thrombosis
Anticoagulation Management
Canada
COPD
COBRA Study
Transcatheter Aortic Valve Replacement
Periprocedural Management
Cancer Research

Unlock the latest breakthroughs in thrombosis diagnosis and management with CLOT Conversations - the must-listen podcast for healthcare professionals. Join hosts Dr Jameel Abdulrehman, a Hematologist with specialization in Thrombosis and Hemostasis at the University Health Network in Toronto, and David Airdrie, the Executive Director of Thrombosis Canada, as they delve into new research and explor... more

PublishesMonthlyEpisodes56Founded4 years ago
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MedicineLife SciencesScienceHealth & Fitness

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Latest Episodes

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Hormone therapy is used across a wide range of clinical settings—from contraception and menopause management to pregnancy care and gender-affirming therapy. But how do these treatments influence thrombosis risk, and how should clini... more

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Post-thrombotic syndrome (PTS) affects up to half of patients following deep vein thrombosis and can significantly impair quality of life. Yet treatment options have historically been limited.

In this episode of CLOT Conversations,... more

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Perioperative anticoagulation management is a common and complex clinical challenge. In this episode of CLOT Conversations, Drs. James Douketis and Joseph Shaw discuss new ISTH guidance on surgical and procedural bleed risk stratifi... more

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Which DOAC bleeds less in acute VTE?

In this episode, we explore the COBRRA trial comparing apixaban vs rivaroxaban and what it means for clinical practice.

The COBRRA trial provides the first direct, randomized comparison of apix... more

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Recent Guests

Susan Kahn
Clinical epidemiologist and internist; renowned venous thromboembolism expert
Jewish General Hospital, McGill University
Episode: C-TRACT Trial: Endovascular Therapy for Post-Thrombotic Syndrome with Dr. Susan Kahn
Lana Castellucci
Hematologist and clinical scientist; lead author of COBRA trial
University of Ottawa / Ottawa Hospital Research Institute
Episode: Which DOAC Bleeds Less? COBRRA Trial Insights for VTE Care with Dr Lana Castellucci
Dr. Deborah Siegal
Clinician and scientist hematologist specializing in thrombosis medicine
Ottawa Hospital; University of Ottawa; Ottawa Hospital Research Institute
Episode: ARTESiA: Apixaban vs Aspirin Bleeding Risk with Dr D Siegal
Dr. Tzu-Fei Wang
Hematologist and associate professor, Division of Hematology, University of Ottawa and Ottawa Hospital; ISTH Education Committee member
University of Ottawa / Ottawa Hospital / ISTH
Episode: WAVe Study: Cancer, Obesity, Anticoagulation with Dr Tzu-Fei Wang and Dr Gregoire Le Gal
Dr. Gregoire Le Gal
Professor of Medicine, lead of thrombosis program, University of Ottawa; senior scientist at Ottawa Hospital Research Institute
University of Ottawa / Ottawa Hospital Research Institute
Episode: WAVe Study: Cancer, Obesity, Anticoagulation with Dr Tzu-Fei Wang and Dr Gregoire Le Gal
Dr. Jeff Weitz
Professor of Medicine and Biochemistry; Executive Director of the Thrombosis and Atherosclerosis Research Institute; expert in thrombosis and hemostasis
McMaster University
Episode: ROXI-VTE Trials Explained: Dr. Jeff Weitz on Next-Generation Thrombosis Prevention
Dr. Grégoire Le Gal
Professor of Medicine, Thrombosis Program lead
University of Ottawa / Ottawa Hospital / Ottawa Hospital Research Institute
Episode: Diagnosing the “Second Clot”: Lessons from PREDICTORS with Dr Vicky Mai and Dr Grégoire Le Gal
Jennifer Vancelli
Nurse practitioner at the Hospital for Sick Children, adjunct lecturer at the University of Toronto.
Hospital for Sick Children, University of Toronto
Episode: Low Health Literacy in Pediatric Thrombosis: Clinical Risks and Realities - L. Avila and J. Vincelli
Dr. Laura Avila
Clinician scientist at the Child Health Evaluative Sciences Program at the Hospital for Sick Children in Toronto
Hospital for Sick Children
Episode: Children and PE: Outcomes You Need to Know - L. Avila and J. Vincelli

Hosts

David Airdrie
Executive Director of Thrombosis Canada; Host
Dr. Jameel Abdulrehman
Co-host, Hematologist specializing in thrombosis and hemostasis
Dr. Maha Osman
Co-host

Reviews

5.0 out of 5 stars from 11 ratings
  • Incredible poise

    Honestly, I’m not even in the medical field but I found the hosts voices really calming. It’s like ASMR to me, helps me sleep. 🩸

    Apple Podcasts
    5
    fluffnook
    Canada2 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Experts with strong credentials; content feels rigorous and practical
Calming host voices, great for sleep and focus
High-quality clinical insights that help translate research to practice

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Talking Points

Recent interactions between the hosts and their guests.

WAVe Study: Cancer, Obesity, Anticoagulation with Dr Tzu-Fei Wang and Dr Gregoire Le Gal
Q: What were the key safety outcomes in terms of bleeding and thrombotic events?
The study found a major bleeding rate of 5 percent with 3 out of 91 patients, and a six-month recurrent VTE rate around 7.3%, suggesting bleeding risk is higher in this population but still within a feasible range when dosing is tailored to body weight and monitored.
WAVe Study: Cancer, Obesity, Anticoagulation with Dr Tzu-Fei Wang and Dr Gregoire Le Gal
Q: So to begin, can you tell us what the motivation is to conduct this study?
The motivation was to challenge the conventional dosing cap from product monographs for dalteparin in obese patients with cancer-associated thrombosis and determine whether weight-based dosing beyond 90 kilograms could be safely implemented in real-world practice, given rising obesity and the need for effective thromboprophylaxis in this high-risk group.
Diagnosing the “Second Clot”: Lessons from PREDICTORS with Dr Vicky Mai and Dr Grégoire Le Gal
Q: What are clinical decision rules and which ones were used in the study?
Clinical decision rules are scoring systems that combine symptoms and risk factors to estimate the probability of disease and guide testing. The study used well-validated rules for DVT and PE, including the Well's score for DVT and the revised Geneva score for PE, among others.
Which DOAC Bleeds Less? COBRRA Trial Insights for VTE Care with Dr Lana Castellucci
Q: What are the practical implications for clinicians and patients?
Apixaban should be considered a first-line option for most patients with acute VTE, though drug-drug interactions, patient preference for dosing frequency, and individual characteristics should guide final choices.
Which DOAC Bleeds Less? COBRRA Trial Insights for VTE Care with Dr Lana Castellucci
Q: Were there differences in recurrent VTE or mortality?
Secondary outcomes showed similar recurrent VTE rates and no fatal recurrent VTEs; all-cause mortality was also similar between groups.

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Frequently Asked Questions About CLOT Conversations

What is CLOT Conversations about and what kind of topics does it cover?

Clinically oriented discussions focused on thrombosis, anticoagulation, and venous thromboembolism. Episodes frequently compare anticoagulants (notably DOACs) in acute VTE, explore cancer-associated thrombosis and obesity-related dosing, discuss diagnostic rules and pediatric thrombosis, and translate trial results into practical care strategies for frontline clinicians. Guests are leading hematologists, researchers, and clinicians who share study design insights, real-world dosing considerations, and implications for guidelines and patient management. The show stands out for high-caliber expert guests, a practical, evidence-driven approach, and a willingness to challenge established practices with emerging data. Potential listeners include... more

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Which podcasts are similar to CLOT Conversations?

These podcasts share a similar audience with CLOT Conversations:

1. Two Onc Docs
2. Core IM | Internal Medicine Podcast
3. The Clinical Problem Solvers
4. The Curbsiders Internal Medicine Podcast
5. This Week in Cardiology

How many episodes of CLOT Conversations are there?

CLOT Conversations launched 4 years ago and published 56 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on CLOT Conversations?

Recent guests on CLOT Conversations include:

1. Susan Kahn
2. Lana Castellucci
3. Dr. Deborah Siegal
4. Dr. Tzu-Fei Wang
5. Dr. Gregoire Le Gal
6. Dr. Jeff Weitz
7. Dr. Grégoire Le Gal
8. Jennifer Vancelli

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