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Artwork for Biotech Bar

以轻松愉快的方式聊聊AI制药

PublishesWeeklyEpisodes6Foundeda year ago
Language
ZH-CN
Categories
Natural SciencesScienceTechnology

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Artwork for Biotech Bar

Latest Episodes

小核酸药物在当前医药行业中非常火热,但在递送技术的创新层面依然存在困境,已上市的小核酸药物仅能针对肝脏靶点。小核酸抗体偶联药物(Antibody-oligonucleotide conjugates,AOC)和小核酸多肽偶联药物(Peptide-oligonucleotide conjugates,POC)利用抗体或多肽将治疗性寡核苷酸递送至特定细胞或组织,将抗体/多肽的组织特异性优势,与小核酸的靶点特异性优势相结合,可一定程度上用于解决目前小核酸药物仅能通过脂质纳米颗粒(LNP)、N-乙酰半乳... more

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6 months ago

"靶向分子+偶联药物”模式(XDC)由靶向分子、连接体 (linker)、效应分子(payload)组成,识别肿瘤细胞后内吞进入溶酶体后释放药物,通过诱导微管抑制、DNA损伤引起细胞凋亡,同时也通过旁观者效应杀死周围肿瘤细胞。 more

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7 months ago

"靶向分子+偶联药物”模式(XDC)对于肿瘤的靶向治疗意义重大,与传统化疗的大面积杀伤特性不同,XDC能够精准识别、攻击肿瘤细胞,可使用更少的药物达到更好治疗效果和更低的毒性。XDC由靶向分子、连接体、细胞毒性药物组成,识别肿瘤细胞后内吞进入溶酶体后释放药物,通过诱导微管抑制、DNA损伤引起细胞凋亡,同时也通过旁观者效应杀死周围肿瘤细胞。XDC的优点主要体现在靶向分子上,它不但帮助药物定位,并且所具备的多种特征也用来维持药物稳定和后续释放,比如和受体结合的亲和性和特异性,稳定性,以及是否可以透膜... more

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7 months ago

抗体偶连药物 (Antibody Drug Conjugate ,ADC)无疑是近几年最火的领域之一,2020年ADC产品全球市场规模约25 亿美元,2027年预计将增至276.5亿美元。很多国内药企纷纷布局ADC药物,也有一些国产ADC成功出海,例如今年映恩生物与BioNTech就两款ADC管线DB-1303、DB-1311达成独家许可和合作协议。ADC现在已经取得很大的成功,但是在开发ADC药物时仍然存在一些难题,包括药代动力学的复杂性和如何降低毒性。同时ADC企业之间似乎也没有非常明显的技... more

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7 months ago

回看过去两三年的融资圈,AI制药绝对是最火的赛道之一。所以在第一季的节目中,我们将聚焦AI制药,跟大家聊一下该领域的各种前沿技术以及投资和创业。 more

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a year ago

回看过去两三年的融资圈,AI制药绝对是最火的赛道之一。所以在第一季的节目中,我们将聚焦AI制药,跟大家聊一下该领域的各种前沿技术以及投资和创业。 more

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a year ago

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#106 Singapore/Technology
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#166 China/Technology

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