Biotech Bar
钰沐菡_漫谈医药以轻松愉快的方式聊聊AI制药
| Publishes | Twice monthly | Episodes | 7 | Founded | 3 years ago |
|---|---|---|---|---|---|
| Language |  ZH-CN | Categories | Natural SciencesTechnologyScience | ||
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Latest Episodes
哈喽大家好，我是钰沐菡，欢迎回来。我们的播客在段更了一段时间之后， 终于要重新跟大家见面了。接下来的几期，我们会聚焦小分子药物领域，跟大家聊一下最近很火的减肥药，靶向GLP1受体的小分子激动剂，靶向降解药物，分子胶和PROTAC等小分子药物领域的进展。
本期节目，我们来聊一聊最近很火的药物靶点GLP1R (glucagon-like peptide-1 receptor)，具体来聊一聊GLP1R激动剂开发的历史，小分子激动剂最近的进展，结构生物学以及近些年冷冻电镜技术得快速发展对于GLP1受体以... more
小核酸药物在当前医药行业中非常火热，但在递送技术的创新层面依然存在困境，已上市的小核酸药物仅能针对肝脏靶点。小核酸抗体偶联药物（Antibody-oligonucleotide conjugates，AOC）和小核酸多肽偶联药物（Peptide-oligonucleotide conjugates，POC）利用抗体或多肽将治疗性寡核苷酸递送至特定细胞或组织，将抗体/多肽的组织特异性优势，与小核酸的靶点特异性优势相结合，可一定程度上用于解决目前小核酸药物仅能通过脂质纳米颗粒（LNP）、N-乙酰半乳... more
"靶向分子+偶联药物”模式（XDC）由靶向分子、连接体 (linker)、效应分子（payload）组成，识别肿瘤细胞后内吞进入溶酶体后释放药物，通过诱导微管抑制、DNA损伤引起细胞凋亡，同时也通过旁观者效应杀死周围肿瘤细胞。
抗体偶连药物 （ADC）中使用的payload一般是细胞毒性化合物。目前最常用的payload主要针对DNA或微管蛋白，针对DNA的有：卡利霉素、双卡霉素、PBD、SN-38和DXd，针对微管蛋白的有 Auristatins（MMAE、MMAF） 和美登素衍生物（DM2，... more
"靶向分子+偶联药物”模式（XDC）对于肿瘤的靶向治疗意义重大，与传统化疗的大面积杀伤特性不同，XDC能够精准识别、攻击肿瘤细胞，可使用更少的药物达到更好治疗效果和更低的毒性。XDC由靶向分子、连接体、细胞毒性药物组成，识别肿瘤细胞后内吞进入溶酶体后释放药物，通过诱导微管抑制、DNA损伤引起细胞凋亡，同时也通过旁观者效应杀死周围肿瘤细胞。XDC的优点主要体现在靶向分子上，它不但帮助药物定位，并且所具备的多种特征也用来维持药物稳定和后续释放，比如和受体结合的亲和性和特异性，稳定性，以及是否可以透膜... more
Chart Rankings
How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.
Apple Podcasts | #109 | China/Technology |
Audience Metrics
Listeners, social reach, demographics and more for this podcast.
| Gender Skew | Location | Interests | |||
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| Professions | Age Range | Household Income | |||
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Biotech Bar launched 3 years ago and published 7 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.
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