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Artwork for BioTalk Unzipped

BioTalk Unzipped

Gregory Austin
Drug Development
Clinical Trials
Pharmaceutical Industry
Rare Diseases
AI In Drug Discovery
Medical Device Recalls
FDA
Covid-19 Pandemic
Artificial Intelligence
Cancer Treatment
Healthcare Data Science
AI In Healthcare
Drug Discovery
Ligand-Directed Degradation
Life Sciences
Biotechnology
Immunotherapy
Cancer
Biologics
Mentorship

BioTalk Unzipped, hosted by Gregory Austin and Dr. Chad Briscoe, unzips the stories behind medical progress through candid, intelligent, and often entertaining conversations with leaders across biotechnology, pharmaceuticals, medical technology, clinical research, bioanalysis, and drug development. Each episode explores the science, strategy, setbacks, breakthroughs, and human stories shaping the ... more

PublishesMonthlyEpisodes43Founded3 years ago
Number of ListenersCategories
Health & FitnessScienceLife SciencesMedicine

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Artwork for BioTalk Unzipped

Latest Episodes

Oncology drug development is becoming more complex, and bioanalysis can no longer be treated as simple drug measurement.

Sponsored by Leucentra, leucentra.com/

Inspired by science, empowered by IT. Leucentra helps life science and healthcar... more

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Can artificial intelligence help make cancer therapies safer, more targeted, and more effective?

In this episode of BioTalk Unzipped, Gregory Austin sits down with Dr. Daniel Reker, Assistant Professor at Duke University, for a wide-ranging conversa... more

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Why haven’t we cured cancer yet? A Genentech scientist explains the real reason.

In this episode of BioTalk Unzipped, Gregory Austin and Dr. Chad Briscoe sit down with Dr. Bob Liu, Senior Principal Scientist at Genentech Roche, to unpack one of the ... more

YouTube

Recorded October 31, 2025

In this episode of BioTalk Unzipped, Gregory Austin and Dr. Chad Briscoe sit down with Dr. Kate Neville, immunologist turned seasoned biotech patent attorney at Marshall, Gerstein & Borun, to unpack one of the most misunder... more

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Recent Guests

Daniel Reker
Assistant Professor at Duke University; intersects AI, chemistry and nanomedicine
Duke University
Episode: Active Machine Learning for Drug Discovery & Nanomedicine with Dr. Daniel Reker
Bob Liu
Senior principal scientist at Genentech Roche in bioanalytical sciences
Genentech Roche
Episode: Why Haven’t We Cured Cancer Yet? | Dr. Bob Liu Explains
Kate Neville
Partner at Marshall, Gerstein & Borun; IP attorney with immunology background
Marshall, Gerstein & Borun
Episode: The Intersection of Biotech, Patent Law, and AI with Dr. Kate Neville, IP Attorney
Chris Hopkins
Experienced geneticist, biochemist, and entrepreneur
Glafabra
Episode: Long-acting Cell-Based Gene Therapy, Fabry Disease and Beyond with Glafabra CEO, Dr. Chris Hopkins
Binodh DeSilva
Senior Vice President, Bioanalysis at Ultragenyx
Ultragenyx Pharmaceutical
Episode: Fail Fast, Learn Faster: Drug Development in Rare Disease with Dr. Binodh DeSilva
Pin-Kuang Lai
Professor at Stevens Institute of Technology
Stevens Institute of Technology
Episode: Unlocking Antibody Development with AI with Dr. Pin-Kuang Lai
Robert Thorne
Denali Fellow at Denali Therapeutics
Denali Therapeutics
Episode: The Science and Hope of Brain Cancer with Dr. Robert Thorne, Denali Therapeutics
Russell Weiner
AAPS President (American Association of Pharmaceutical Scientists)
AAPS
Episode: Inside AAPS NBC with AAPS President Dr. Russ Weiner
Dr. Alfred Botchway
CEO of Attentive Science and a distinguished figure in biomedical science with over 25 years of experience.
Attentive Science
Episode: Navigating Challenges in Drug Discovery with Dr. Alfred Botchway

Hosts

Gregory Austin
Host of Bio Talk Unzipped
Dr. Chad Briscoe
Co-host and interviewer

Reviews

5.0 out of 5 stars from 13 ratings
  • Smart, Real, Egaging

    Most science podcasts feel dry. This one’s different. Smart guests, real talk, and conversations that actually keep you hooked.

    Apple Podcasts
    5
    mikepedersen
    United Statesa year ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Content balances technical depth with accessibility for non-specialists.
High-caliber guests and crisp, practical science talk.
Sponsors feel naturally integrated and relevant to a life-sciences audience.
Conversations are engaging, with real-world context and insights.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Talking Points

Recent interactions between the hosts and their guests.

Fail Fast, Learn Faster: Drug Development in Rare Disease with Dr. Binodh DeSilva
Q: As a past president of AAPS and someone who's passionate about bridging science and business, what advice would you give scientists who are trying to leap into broader leadership roles?
Be curious and understand your adjacencies—know what other teams are doing and how your data translates into decisions across the drug development process.
Unlocking Antibody Development with AI with Dr. Pin-Kuang Lai
Q: What collaborations exist with industry, and how have they shaped the work?
There are ongoing collaborations with AstraZeneca where sequences and experimental data are used to train and test the model, with students participating as interns, illustrating a strong industry-academia link that informs real-world development.
Unlocking Antibody Development with AI with Dr. Pin-Kuang Lai
Q: How is the model validated to avoid overfitting and ensure reliability?
They use independent datasets and multiple validation approaches to ensure the model generalizes beyond the training data, treating the system as a closed, trainable model rather than a publicly accessible one until published.
Unlocking Antibody Development with AI with Dr. Pin-Kuang Lai
Q: What makes predicting high-concentration viscosity challenging, and how does AI help?
Viscosity affects subcutaneous delivery because only limited volumes can be injected; AI helps by integrating sequence and structure features to predict which antibodies will have high viscosity early, guiding selection and formulation efforts.
Navigating Challenges in Drug Discovery with Dr. Alfred Botchway
Q: What are your strategic goals for Attentive looking into the future?
We are expanding globally to regions like Australia and Abu Dhabi to enhance non-clinical research.

Audience Metrics

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Frequently Asked Questions About BioTalk Unzipped

What is BioTalk Unzipped about and what kind of topics does it cover?

Biotech and pharma professionals tune in for insightful conversations with leaders across biotechnology, pharmaceuticals, bioanalysis, and drug development. Episodes center on AI-driven drug discovery, regulators and policy, novel therapies (including cell-based and antibody approaches), and practical realities of bringing innovations to patients. A recurring strength is translating complex science into accessible, real-world narratives, often anchored by high-profile researchers and industry insiders. Notable touches include candid discussions about safety, ethics, funding realities, and the regulatory landscape, making it useful for listeners seeking actionable insights, partner opportunities, or sponsorship alignment with science-forward... more

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1. The Daily

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BioTalk Unzipped launched 3 years ago and published 43 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on BioTalk Unzipped?

Recent guests on BioTalk Unzipped include:

1. Daniel Reker
2. Bob Liu
3. Kate Neville
4. Chris Hopkins
5. Binodh DeSilva
6. Pin-Kuang Lai
7. Robert Thorne
8. Russell Weiner

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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