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Gene Therapy
Clinical Trials
Cell Therapy
Gene Editing
CRISPR
Cell and Gene Therapy
Adeno-Associated Virus
Rare Diseases
Gene and Cell Therapy
Biotechnology
Crispr-Cas9
Gene & Cell Therapy
Regulatory Landscape
Asgct
Cas9-Clipt
Sickle Cell Disease
ASGCT Annual Meeting
FDA
T-Cells
Patient Advocacy

The American Society of Gene & Cell Therapy is the premier membership organization for professionals working in cell and gene therapy. On this network, we're sharing exciting stories from our members and the greater scientific community.

PublishesDailyEpisodes100Founded4 years ago
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Life SciencesChemistryScience

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Latest Episodes

In this episode of The Issue, CEO of Life Biosciences Jerry McLaughlin joins hosts Sanjay D’Souza, PhD and Jason West, PhD for a discussion on how epigenetic reprogramming could restore function in aging and injured cells. He explains the science beh... more

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This episode, hosted by Daniel Stone, Associate Editor-in-Chief of Molecular Therapy Advances, focuses on the article, Normothermic perfusion of human livers for profiling lentiviral vector pharmacokinetics and transduction. Listen as Robert Carlisle... more

YouTube

In this episode of Scientists, Unedited, host Eirini Vamva, PhD, talks with Bruce Levine, PhD, about his personal life and career in cell therapy. Dr. Levine talks about finding his way into immunology, learning from pivotal mentors, and following th... more

YouTube

Molecular Therapy Oncology has released a new special collection, Advancements in Pediatric Cancer Therapy. Listen in as guest editor Nirali Shah and Editor-in-Chief Timothy Cripe discuss articles in this special collection, which covers the history,... more

YouTube

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Recent Guests

Brannon Nicholls
First author of the paper; DPhil student in Advanced Biosciences and Viral Products Program
University of Oxford
Episode: An Ex Vivo Human Liver Model for Lentiviral Vector Profiling
Robert Carlisle
Professor in Biomedical Engineering; Director of MS in Nanotechnology for Medicine and Health Care
University of Oxford
Episode: An Ex Vivo Human Liver Model for Lentiviral Vector Profiling
Bruce Levine
Professor in Cancer Gene Therapy, University of Pennsylvania
University of Pennsylvania
Episode: From Aspiring Astronaut to CAR-T Pioneer: A Journey of Serendipity with Bruce Levine, PhD
Nirali Shah
Guest editor of the special pediatric cancer immunotherapy collection
Special collection editor for Molecular Therapy Oncology
Episode: Advancements in Pediatric Cancer Therapy with Nirali Shah and Timothy Cripe
Sara Johnson Davis
Recognized leader in patient advocacy and public affairs
Prispa Therapeutics (former), Fulcrum (discussion reference)
Episode: From Innovation to Access: Patient Advocacy as a Strategic Partner with Sara Johnson Davis
Le Cong
PhD, Stanford researcher focusing on AI-driven genome engineering and SSAP-based large gene insertion
Stanford University
Episode: Using AI to Drive Innovation in CGT with Le Cong, PhD
Christin Glorioso
Neuroscientist and physician; guest editor
NeuroAge Therapeutics
Episode: The biological clock of aging and the possibility of lifespan extension with Christin Glorioso and John Bell
John Bell
Researcher from University of Ottawa; guest
University of Ottawa
Episode: The biological clock of aging and the possibility of lifespan extension with Christin Glorioso and John Bell
Anna Maurer
Assistant Professor of Biophysics, University of Michigan; AAV biology researcher
University of Michigan
Episode: Against the Odds: How Dr. Anna Maurer Built a Life in Science

Reviews

4.9 out of 5 stars from 25 ratings
  • Waiting for next episodes…

    Finally a podcast for Gene therapy!! Great job.

    Looking forward to upcoming episodes to learn more about this amazing field.

    Apple Podcasts
    5
    Prasad Trivedi
    United States4 years ago

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Waiting for next episodes...
Finally a podcast for Gene therapy!! Great job. Looking forward to upcoming episodes to learn more about this amazing field.

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Talking Points

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An Ex Vivo Human Liver Model for Lentiviral Vector Profiling
Q: What are the future directions for this platform?
Plans include applying the method to liver sections from cancer patients to model tumor vasculature and immune context, and moving toward whole-blood perfusion to better capture complement and antibody interactions, improving translatability to humans.
An Ex Vivo Human Liver Model for Lentiviral Vector Profiling
Q: What are the main technical challenges encountered during the experiments, and how did you address them?
Challenges included infusion pump failures and bleeding after biopsy; the team replaced older infusion equipment, refined suturing techniques, and implemented more vigilant monitoring to minimize impacts on replicates, although some time points were lost.
An Ex Vivo Human Liver Model for Lentiviral Vector Profiling
Q: Could you summarize the study and what makes the perfusion system a good model for vector pharmacokinetics and tissue transduction?
The study uses discarded human livers connected to a perfusion device to simulate normal physiology, allowing real-time assessment of how a lentiviral vector distributes, transduces hepatocytes, and expresses a reporter gene, while also tracking inflammatory and metabolic markers to gauge safety and function.
From Innovation to Access: Patient Advocacy as a Strategic Partner with Sara Johnson Davis
Q: How has the shift from theoretical to approved therapies changed conversations with patient communities?
The discussion has become more tangible as patients ask what the therapy means for them, including eligibility, access, and long-term risks, while still addressing durability, safety, and burden.
From Innovation to Access: Patient Advocacy as a Strategic Partner with Sara Johnson Davis
Q: What is your advice for scientists and biotech leaders about engaging with patients early in the development process?
Engage with patients earlier than clinicians might expect; involve them in trial design, endpoints, and burden considerations so the drugs developed truly address patient needs, and avoid waiting until a recruitment issue arises.

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Frequently Asked Questions About ASGCT Podcast Network

What is ASGCT Podcast Network about and what kind of topics does it cover?

This network spotlights cell and gene therapy professionals, researchers, clinicians, and advocacy voices, with a strong focus on translational science, delivery platforms, regulatory evolution, and patient access. Conversations span aging biology, rare diseases, genome editing, CNS-directed gene therapy, vector design, manufacturing hurdles, and policy, often pairing scientific deep-dives with practical implications for developers, providers, and funders. A standout trait is the mix of highly technical discussions and founder/advocacy perspective, making it useful for listeners evaluating partnerships, sponsorships, and opportunities to connect with a deeply engaged community working at the cutting edge of life sciences and biotech policy.... more

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Which podcasts are similar to ASGCT Podcast Network?

These podcasts share a similar audience with ASGCT Podcast Network:

1. BioCentury This Week
2. The Readout Loud
3. The Long Run with Luke Timmerman
4. Cell & Gene: The Podcast
5. Biotech Hangout

How many episodes of ASGCT Podcast Network are there?

ASGCT Podcast Network launched 4 years ago and published 100 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on ASGCT Podcast Network?

Recent guests on ASGCT Podcast Network include:

1. Brannon Nicholls
2. Robert Carlisle
3. Bruce Levine
4. Nirali Shah
5. Sara Johnson Davis
6. Le Cong
7. Christin Glorioso
8. John Bell

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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