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Gene Therapy
Gene & Cell Therapy
Regulatory Landscape
Clinical Trials
Orphan Drug
Cell and Gene Therapy
ASGCT Annual Meeting
FDA CBER
Rare Diseases
Cystic Fibrosis
Covid-19
Immunogenicity
Biologics License Application (BLA)
Cell Therapy
CRISPR
Aptamer Technology
Gene Therapy Development
AAV Gene Therapy
Adeno-Associated Virus
Innovative Trial Designs

The American Society of Gene & Cell Therapy is the premier membership organization for professionals working in cell and gene therapy. On this network, we're sharing exciting stories from our members and the greater scientific community.

PublishesTwice monthlyEpisodes71Founded3 years ago
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ChemistryLife SciencesScience

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Artwork for ASGCT Podcast Network

Latest Episodes

In this episode, Melissa Majerol, Model Lead of the Cell and Gene Therapy Access Model at the Center for Medicare and Medicaid Innovation (CMMI) at CMS, breaks down how the CMMI Access Model program aims to simplify and accelerate patient access to i... more

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Dr. Daniel Stone (Associate Editor-in-Chief, Molecular Therapy Advances) sits down with Dr. Krishanu Saha, Anna Tommasi, and Dr. Dan Cappabianca from the University of Wisconsin-Madison. Join them as they discuss their team’s recent publication, Effi... more

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Molecular Therapy Editor-in-Chief Dr. Joseph Glorioso joins researchers Kathy Steece-Collier (Michigan State University), Jeffrey Kordower (Arizona State University), and Fredric Manfredsson (Barrow Neurological Institute) to discuss their groundbrea... more

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Host Dr. Emily Walsh Martin welcomes Dr. Niki Paulk, CEO and Founder of Siren Biotechnology, for a timely conversation on turning scientific promise into commercial success. Dr. Paulk offers perceptive insights into the complex world of biotech entre... more

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Recent Guests

Melissa Majerol
Model lead for the Cell and Gene Therapy Access Model at the Center for Medicare and Medicaid Innovation
Centers for Medicare and Medicaid Services
Episode: The Issue - Evolving Patient Access to CGTs via Innovation in Medicaid Reimbursement Models with Melissa Majerol
Krish Saha
Professor of Biomedical Engineering, Pediatrics, and Bioethics at the University of Wisconsin-Madison, specialized in ex vivo cell therapy.
University of Wisconsin-Madison
Episode: Cas9-CLIPT-mediated integration of large transgenes with Krishanu Saha, Anna Tommasi, and Dan Cappabianca
Anna Tommasi
Graduate student in the UW Biomedical Engineering Program and a member of the Saha Lab.
University of Wisconsin-Madison
Episode: Cas9-CLIPT-mediated integration of large transgenes with Krishanu Saha, Anna Tommasi, and Dan Cappabianca
Dan Cappabianca
Former Saha Lab member and current postdoc in the SOGI Lab at the University of Wisconsin-Madison.
University of Wisconsin-Madison
Episode: Cas9-CLIPT-mediated integration of large transgenes with Krishanu Saha, Anna Tommasi, and Dan Cappabianca
Niki Paulk
CEO and founder of Siren Biotechnology
Siren Biotechnology
Episode: The Issue - Entrepreneurship, Fundraising, and the Future of Cell & Gene Therapy with Dr. Niki Paulk
Jim Burns
CEO of Ensoma
Ensoma
Episode: The Issue - Unlocking New Therapeutic Potential: Ensoma’s Platform for Rare Disease and Oncology
Dr. Kyriacos Mitrophanous
Chief Innovation Officer at OXB, experienced with lentiviral vectors development for over 25 years
Oxford Biomedica
Episode: Generating CAR T cells in vivo with lentiviral vectors with Drs. Rachael Nimmo and Kyriacos Mitrophanous
Dr. Rachael Nimmo
Formerly Director for the Cell Technology Group at OXB, co-inventor of an innovative CAR T cell technology
Oxford Biomedica
Episode: Generating CAR T cells in vivo with lentiviral vectors with Drs. Rachael Nimmo and Kyriacos Mitrophanous
Kimberly Haugstad
CEO of RareRising and a longtime rare disease advocate
RareRising
Episode: Patients Are the Center with Kimberly Haugstad, MBA

Hosts

Dr. Rory Bricker-Anthony
Scientific Editor of the Molecular Therapy Family of Journals
Lynnea Olivarez
Chair of the Communications Committee

Reviews

4.9 out of 5 stars from 25 ratings
  • Waiting for next episodes…

    Finally a podcast for Gene therapy!! Great job.

    Looking forward to upcoming episodes to learn more about this amazing field.

    Apple Podcasts
    5
    Prasad Trivedi
    United States3 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Listeners praise the quality of content, noting it as a vital resource for learning about gene therapy.
Feedback highlights the engaging discussions with industry experts.
The podcast is recognized for shedding light on complex scientific topics in an accessible way.

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Talking Points

Recent interactions between the hosts and their guests.

The Issue - Evolving Patient Access to CGTs via Innovation in Medicaid Reimbursement Models with Melissa Majerol
Q: What makes sickle cell disease a good condition to focus on for this model?
Sickle cell disease is the most common rare disease in the U.S. and affects different states unequally, with some states anticipating a significant Medicaid impact due to high costs associated with new therapies.
The Issue - Evolving Patient Access to CGTs via Innovation in Medicaid Reimbursement Models with Melissa Majerol
Q: What was the problem you were hoping to solve with the CMMI model for cell and gene therapy?
The goal was to address the high costs of cell and gene therapies, which can exceed $2 million, and to ensure that payers (including Medicaid) would provide access, while addressing manufacturers' struggles to obtain market access necessary for their future investments.
The Issue - Evolving Patient Access to CGTs via Innovation in Medicaid Reimbursement Models with Melissa Majerol
Q: What is Medicare? What is Medicaid? Who does each serve?
Medicare is a federal program primarily for people aged 65 and over, covering about 68 million people. Medicaid is for low-income individuals and covers about 70 million people, with significant variations across states.
Generating CAR T cells in vivo with lentiviral vectors with Drs. Rachael Nimmo and Kyriacos Mitrophanous
Q: How do you see the best way to deliver an in vivo targeting vector?
We envision IV administration into the bloodstream since the vector is specifically targeted to T cells, allowing direct transduction.
Generating CAR T cells in vivo with lentiviral vectors with Drs. Rachael Nimmo and Kyriacos Mitrophanous
Q: Do you have to arm these CAR T, say, with IL-18 or what are your thoughts about that?
We have not yet determined if additional armoring for the CAR T cells will be necessary; the initial clinical data is still being evaluated.

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Frequently Asked Questions About ASGCT Podcast Network

What is ASGCT Podcast Network about and what kind of topics does it cover?

This podcast explores the forefront of gene and cell therapy by featuring insightful discussions with experts in the field. Episodes highlight innovative research, technological advancements, and personal stories from leading scientists, professionals, and advocates focused on various aspects of gene therapy, including challenges, successes, and future potentials. Noteworthy topics include the evolution of therapeutic approaches, patient advocacy, and the importance of community engagement in advancing treatment options for rare diseases.

The unique perspective offered through expert interviews and retrospective analyses makes the content especially appealing to professionals and enthusiasts interested in the sciences, particularly those f... more

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1. Planet Money
2. The Indicator from Planet Money
3. Consider This from NPR
4. Up First from NPR
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ASGCT Podcast Network launched 3 years ago and published 71 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on ASGCT Podcast Network?

Recent guests on ASGCT Podcast Network include:

1. Melissa Majerol
2. Krish Saha
3. Anna Tommasi
4. Dan Cappabianca
5. Niki Paulk
6. Jim Burns
7. Dr. Kyriacos Mitrophanous
8. Dr. Rachael Nimmo

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