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Gene Therapy
Gene & Cell Therapy
Regulatory Landscape
Cell and Gene Therapy
Clinical Trials
Orphan Drug
ASGCT Annual Meeting
Rare Diseases
FDA CBER
Cystic Fibrosis
Covid-19
Immunogenicity
Biologics License Application (BLA)
Cell Therapy
CRISPR
Aptamer Technology
Gene Therapy Development
AAV Gene Therapy
Adeno-Associated Virus
Innovative Trial Designs

The American Society of Gene & Cell Therapy is the premier membership organization for professionals working in cell and gene therapy. On this network, we're sharing exciting stories from our members and the greater scientific community.

PublishesTwice monthlyEpisodes65Founded3 years ago
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ScienceLife SciencesChemistry

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Artwork for ASGCT Podcast Network

Latest Episodes

Editor-in-Chief of Molecular Therapy, Dr. Joseph Glorioso, is joined by Rachael Nimmo, PhD, former director of the Cell Technology Group at Oxford Biomedica, and Kyriacos Mitrophanous, PhD, Chief Innovation Officer at Oxford Biomedica, to discuss an ... more

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Join Dr. Paloma Giangrande, Editor-in-Chief of Molecular Therapy Nucleic Acids, as she discusses a recently published MTNA article, Controlling CRISPR-Cas9 genome editing in human cells using a molecular glue degrader, with its authors Drs. Krishanu ... more

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Join Dr. Mohamed Abou-el-Enein, Editor-in-Chief of Molecular Therapy Methods & Clinical Development, as he discusses a recent article published in MTMCD with co-authors Drs. Daniel Stone, Harrison Dulin, and Keith R. Jerome from the Fred Hutchinson C... more

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On this episode of Soundbites of the Annual Meeting, we talked to Kimberly Haugstad, CEO of RareRising and a longtime rare disease advocate who is also the parent of a child with severe hemophilia.

In her conversation with ASGCT's Communications Co... more

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Recent Guests

Dr. Kyriacos Mitrophanous
Chief Innovation Officer at OXB, experienced with lentiviral vectors development for over 25 years
Oxford Biomedica
Episode: Generating CAR T cells in vivo with lentiviral vectors with Drs. Rachael Nimmo and Kyriacos Mitrophanous
Dr. Rachael Nimmo
Formerly Director for the Cell Technology Group at OXB, co-inventor of an innovative CAR T cell technology
Oxford Biomedica
Episode: Generating CAR T cells in vivo with lentiviral vectors with Drs. Rachael Nimmo and Kyriacos Mitrophanous
Kimberly Haugstad
CEO of RareRising and a longtime rare disease advocate
RareRising
Episode: Patients Are the Center with Kimberly Haugstad, MBA
Dr. Rayne Rouce
Pediatric oncologist and physician scientist at Texas Children's Hospital
Texas Children's Hospital
Episode: 25 Years of Molecular Therapy with Drs. Rayne Rouce and Joe Glorioso
Dr. Stephen Kaminsky
Professor of Research in Genetic Medicine at Weill Cornell Medical College and Lead Author on a Phase 1 Clinical Trial of a New Vaccine for Cocaine Addiction
Weill Cornell Medical College
Episode: A Vaccine for Cocaine Addiction with Dr. Stephen Kaminsky
Dr. P.J. Brooks
Deputy Director of the Division of Rare Diseases Research Innovation at the National Center for Advancing Translational Sciences
NIH
Episode: Developing Therapeutic Platforms with Dr. P.J. Brooks
Dr. Kiran Musunuru
The Barry J. Gertz Professor for Translational Research at the University of Pennsylvania's Perelman School of Medicine
University of Pennsylvania, Children's Hospital of Philadelphia
Episode: The Ups and Downs of Conducting Groundbreaking Research with Dr. Kiran Musunuru
Dolan Sondhi
PhD Chemist and Assistant Professor at Weill Cornell Medical College
Weill Cornell Medical College
Episode: The Importance of Long-term Data with Dolan Sondhi, PhD - The Issue
Niki Gallo
Principal Consultant of Regulatory Affairs at Halloran Consulting
Halloran Consulting
Episode: The When, What, How, and Why of FDA Engagement with Niki Gallo - The Issue

Hosts

Dr. Rory Bricker-Anthony
Scientific Editor of the Molecular Therapy Family of Journals
Lynnea Olivarez
Chair of the Communications Committee
Emily Walsh Martin
Host of The Issue

Reviews

4.9 out of 5 stars from 25 ratings
  • Waiting for next episodes…

    Finally a podcast for Gene therapy!! Great job.

    Looking forward to upcoming episodes to learn more about this amazing field.

    Apple Podcasts
    5
    Prasad Trivedi
    United States3 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

The podcast is praised for its focus on relevant and cutting-edge topics in gene therapy, making it a valuable resource for professionals in the field.
Listeners appreciate the depth of knowledge and expertise shared by guests, indicating a high level of satisfaction with the content quality.

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Talking Points

Recent interactions between the hosts and their guests.

Generating CAR T cells in vivo with lentiviral vectors with Drs. Rachael Nimmo and Kyriacos Mitrophanous
Q: How do you see the best way to deliver an in vivo targeting vector?
We envision IV administration into the bloodstream since the vector is specifically targeted to T cells, allowing direct transduction.
Generating CAR T cells in vivo with lentiviral vectors with Drs. Rachael Nimmo and Kyriacos Mitrophanous
Q: Do you have to arm these CAR T, say, with IL-18 or what are your thoughts about that?
We have not yet determined if additional armoring for the CAR T cells will be necessary; the initial clinical data is still being evaluated.
Generating CAR T cells in vivo with lentiviral vectors with Drs. Rachael Nimmo and Kyriacos Mitrophanous
Q: Do you think that this strategy will be useful for treating autoimmune diseases?
Yes, there is potential for in vivo CAR T therapy to treat autoimmune diseases; initial trials have shown promising results in eradicating autoreactive B cells.
Generating CAR T cells in vivo with lentiviral vectors with Drs. Rachael Nimmo and Kyriacos Mitrophanous
Q: How do you avoid off-target transduction, like in the liver, for example?
The NIPA targeting approach helps avoid off-target transduction effectively, ensuring specific targeting to the T cells and minimizing unwanted effects.
A Molecular Glue Degrader to Control CRISPR with Drs. Krishanu Saha and Namita Khajanchi
Q: What do you believe are the prospects for adapting this technology?
We see this as a proof of concept study but believe it can be applied to many different types of diseases and indications, especially with effective delivery.

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Frequently Asked Questions About ASGCT Podcast Network

What is ASGCT Podcast Network about and what kind of topics does it cover?

Focusing on the advancements and challenges in gene and cell therapy, the episodes regularly feature experts discussing groundbreaking research, innovative therapies, and the implications for patient care. Themes range from the role of patient advocacy in therapy development to the challenges presented by regulatory landscapes in the biotech sector. Notably, there is a strong emphasis on community engagement and collaborative approaches to improve access to stem cell and gene therapies, making it a vital resource for professionals interested in the latest scientific developments in this evolving field. The podcast offers deep insights into both the successes and hurdles faced in gene and cell therapy, providing listeners with a well-rounded... more

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Which podcasts are similar to ASGCT Podcast Network?

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1. BioCentury This Week
2. Cell & Gene: The Podcast
3. The Readout Loud
4. Biotech Hangout
5. The Long Run with Luke Timmerman

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ASGCT Podcast Network launched 3 years ago and published 65 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on ASGCT Podcast Network?

Recent guests on ASGCT Podcast Network include:

1. Dr. Kyriacos Mitrophanous
2. Dr. Rachael Nimmo
3. Kimberly Haugstad
4. Dr. Rayne Rouce
5. Dr. Stephen Kaminsky
6. Dr. P.J. Brooks
7. Dr. Kiran Musunuru
8. Dolan Sondhi

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