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Artwork for AI + a16z

AI + a16z

a16z
Artificial Intelligence
AI Agents
Generative AI
Machine Learning
Cybersecurity
Software Development
Openai
NVIDIA
Large Language Models
Artificial General Intelligence
AI Research
Deep Learning
Open Source
Generative Models
Venture Capital
Chatgpt
AGI
AI Applications
AI Infrastructure
Pylon

Artificial intelligence is changing everything from art to enterprise IT, and a16z is watching all of it with a close eye. This podcast features discussions with leading AI engineers, founders, and experts, as well as our general partners, about where the technology and industry are heading.

PublishesTwice weeklyEpisodes101Founded2 years ago
Number of ListenersCategories
EntrepreneurshipBusinessTechnology

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Artwork for AI + a16z

Latest Episodes

Matt Bornstein speaks with Mirendil cofounders Behnam Neyshabur and Harsh Mehta about their vision for building self-accelerating AI.

After leading research efforts at Google and Anthropic, the founders started Mirendil around a simple question: wha... more

Yoko Li and Justine Moore speak with Ideogram founder and CEO Mohammad Norouzi about image generation models, design workflows, and the evolving relationship between AI and creative work.

The conversation covers Ideogram's decision to release an ope... more

Sarah Wang speaks with Exa cofounder and CEO Will Bryk about building search infrastructure for the AI era.

The conversation covers Exa’s origins, why traditional search engines were not designed for AI agents, and how search changes when the user i... more

Martin Casado speaks with George Fraser, cofounder and CEO of Fivetran, about the future of data infrastructure in the age of AI.

The conversation covers Fivetran’s merger with dbt, the changing role of data platforms, and why Fraser believes many c... more

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Recent Guests

Behnam Neyshabur
Co-founder of Mirendil, former research scientist at Anthropic
Mirendil
Episode: Building Self-Accelerating AI with Mirendil
Harsh Mehta
Co-founder of Mirendil, former research scientist at Anthropic
Mirendil
Episode: Building Self-Accelerating AI with Mirendil
Will Bryk
CEO and co-founder of Exa
Exa
Episode: Building Search for AI Agents with Exa CEO Will Bryk
Ben Horowitz
Co-founder and general partner at a16z
a16z
Episode: Ben Horowitz on AI Infrastructure, Economics and The New Laws of Software
Jennifer Li
General Partner at Andreessen Horowitz
Andreessen Horowitz
Episode: AI Infrastructure, Distribution, and the Next Wave of Software
Ash Ashutosh
CEO of Pinecone
Pinecone
Episode: From Vector Databases to Knowledge Engines: The Next Layer of AI
Malika Aubakirova
Partner on the AI infrastructure team at a16z
a16z
Episode: Why We Need Continual Learning
Aaron Levie
CEO of Box
Box
Episode: The Agent Era: Building Software Beyond Chat with Box CEO Aaron Levie
Scott Chacon
CEO of GitButler, former co-founder of GitHub
GitButler / GitHub
Episode: Rethinking Git for the Age of Coding Agents with GitHub Cofounder Scott Chacon

Host

Martin Casado
Host/Co-host; a16z general partner; involved in multiple episodes

Reviews

4.0 out of 5 stars from 95 ratings
  • The Best Guests

    IMHO the quality of a16z podcasts relies heavily on the guests. Being who they are, a16z gifts us with incredible guests and their wisdom. Thanks so much for being a beacon in the AI mist!

    Apple Podcasts
    5
    Roxtoxroxrox
    United States5 months ago
  • I love how it dives into the core of AI technology.

    Podchaser
    5
    thetravelinggreek
    2 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

The guests consistently deliver insightful, high-signal discussions.
Production quality and topic relevance are standout strengths.
Listeners praise practical takeaways for enterprise AI and tooling.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Apple Podcasts
#82
United States/Technology
Apple Podcasts
#75
United Kingdom/Technology
Apple Podcasts
#88
Italy/Technology
Apple Podcasts
#108
Australia/Technology
Apple Podcasts
#31
Argentina/Technology
Apple Podcasts
#31
New Zealand/Technology

Talking Points

Recent interactions between the hosts and their guests.

Building Self-Accelerating AI with Mirendil
Q: How do you balance safety and openness given the potential for dual-use applications?
There needs to be guardrails and selective access to ensure safety (e.g., bio-safety) while still allowing beneficial applications; the team argues for a nuanced approach that focuses on positive-sum outcomes and responsible deployment.
Building Self-Accelerating AI with Mirendil
Q: What are the main incentives and business model considerations when building a company around such technology?
The incentive structure must align with sharing powerful capabilities and enabling customers to own their AI infra, otherwise companies risk depersonalizing or hoarding technology; the goal is to accelerate science while maintaining safety and broad access.
Building Self-Accelerating AI with Mirendil
Q: Can you explain what self-accelerating AI really means and how it might be realized in practice?
Self-accelerating AI refers to systems that can perform AI research and engineering at high throughput, iterating rapidly to improve themselves and their capabilities, moving beyond single-model improvements to a broader ecosystem of models and agents that collectively advance science.
Building Search for AI Agents with Exa CEO Will Bryk
Q: What inspired you to start Exa and pursue a better-than-Google search for agents?
Bryk describes a life mission around high-quality knowledge, the realization that Transformers made deeper search feasible, and a desire to empower agents with comprehensive, context-rich results beyond traditional search. He emphasizes a philosophy of building for deep understanding rather than surface-level answers.
AI Infrastructure, Distribution, and the Next Wave of Software
Q: Jennifer, welcome to GTMnow.
Jennifer thanks the hosts and shares her view on investing in infrastructure for AI, emphasizing a broad definition of infrastructure and the importance of supporting foundational AI models, data pipelines, and developer tools.

Audience Metrics

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Frequently Asked Questions About AI + a16z

What is AI + a16z about and what kind of topics does it cover?

The show centers on AI infrastructure, enterprise AI, and the business and policy implications of rapid software acceleration. Conversations weave together technical deep-dives on AI systems, agent-enabled software, and scalable infrastructure with VC and market dynamics shaping funding, go-to-market strategies, and platform evolution. Notable throughlines include practical engineering lessons for deploying AI in enterprises, governance and security challenges, and the shifting economics of AI compute and software as a service. The format often features candid guest perspectives from founders, engineers, and industry leaders, alongside thoughtful host commentary on how AI is altering categories from developer tooling to IT services and vent... more

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AI + a16z launched 2 years ago and published 101 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on AI + a16z?

Recent guests on AI + a16z include:

1. Behnam Neyshabur
2. Harsh Mehta
3. Will Bryk
4. Ben Horowitz
5. Jennifer Li
6. Ash Ashutosh
7. Malika Aubakirova
8. Aaron Levie

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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