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Artwork for AI + a16z

AI + a16z

a16z
Artificial Intelligence
AI Agents
Generative AI
Machine Learning
Cybersecurity
Software Development
Openai
Nvidia
Large Language Models
Artificial General Intelligence
AI Research
Deep Learning
Open Source
Generative Models
Venture Capital
Chatgpt
AGI
AI Applications
AI Infrastructure
AI Coding

Artificial intelligence is changing everything from art to enterprise IT, and a16z is watching all of it with a close eye. This podcast features discussions with leading AI engineers, founders, and experts, as well as our general partners, about where the technology and industry are heading.

PublishesTwice weeklyEpisodes98Founded2 years ago
Number of ListenersCategories
TechnologyEntrepreneurshipBusiness

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Artwork for AI + a16z

Latest Episodes

Recorded live at the a16z Fintech Connect conference in Deer Valley, Alex Rampell speaks with Ben Horowitz, cofounder and general partner at a16z, about how AI has rewritten the fundamental rules of software competition, why crypto infrastructure wil... more

Sophie Buonassisi speaks with Jennifer Li, general partner at a16z, about why infrastructure is becoming one of the most important areas in AI. They discuss how the shift to AI-native systems is reshaping everything from storage and compute to develo... more

Peter Levine speaks with Ash Ashutosh, CEO of Pinecone, about the launch of Nexus and the shift from vector databases to knowledge engines. As agents become the primary users of software, they discuss why traditional retrieval systems break down and ... more

Elena Burger speaks with Malika Aubakirova, partner on the AI infrastructure team at a16z, about why today’s AI systems struggle to learn over time. They discuss the limits of in-context learning, the case for continual learning, and how models may n... more

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Recent Guests

Ben Horowitz
Co-founder and general partner at a16z
a16z
Episode: Ben Horowitz on AI Infrastructure, Economics and The New Laws of Software
Jennifer Li
General Partner at Andreessen Horowitz
Andreessen Horowitz
Episode: AI Infrastructure, Distribution, and the Next Wave of Software
Ash Ashutosh
CEO of Pinecone
Pinecone
Episode: From Vector Databases to Knowledge Engines: The Next Layer of AI
Malika Aubakirova
Partner on the AI infrastructure team at a16z
a16z
Episode: Why We Need Continual Learning
Aaron Levie
CEO of Box
Box
Episode: The Agent Era: Building Software Beyond Chat with Box CEO Aaron Levie
Scott Chacon
CEO of GitButler, former co-founder of GitHub
GitButler / GitHub
Episode: Rethinking Git for the Age of Coding Agents with GitHub Cofounder Scott Chacon
Peter Doyle
CEO of Treeline
Treeline
Episode: How AI Is Reshaping IT Services from the Inside
Patrick Collison
CEO of Stripe
Stripe
Episode: Patrick Collison on Stripe’s Early Choices, Smalltalk, and What Comes After Coding
Vishal Misra
Professor and Vice Dean of Computing and AI at Columbia University
Columbia University
Episode: What's Missing Between LLMs and AGI - Vishal Misra & Martin Casado

Host

Martin Casado
Co-host; General Partner at a16z; focuses on AI infrastructure and venture dynamics

Reviews

4.1 out of 5 stars from 93 ratings
  • The Best Guests

    IMHO the quality of a16z podcasts relies heavily on the guests. Being who they are, a16z gifts us with incredible guests and their wisdom. Thanks so much for being a beacon in the AI mist!

    Apple Podcasts
    5
    Roxtoxroxrox
    United States4 months ago
  • I love how it dives into the core of AI technology.

    Podchaser
    5
    thetravelinggreek
    2 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Shows offer practical, battle-tested insights for builders and investors.
Open-source and engineering-first angles give unique value compared to other AI podcasts.
Guests are consistently high-caliber and deeply informed.
Content stays very relevant to AI infrastructure and VC trends.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Apple Podcasts
#67
United States/Technology
Apple Podcasts
#62
United Kingdom/Technology
Apple Podcasts
#74
Canada/Technology
Apple Podcasts
#63
Italy/Technology
Apple Podcasts
#88
Australia/Technology
Apple Podcasts
#147
Germany/Technology

Talking Points

Recent interactions between the hosts and their guests.

AI Infrastructure, Distribution, and the Next Wave of Software
Q: Jennifer, welcome to GTMnow.
Jennifer thanks the hosts and shares her view on investing in infrastructure for AI, emphasizing a broad definition of infrastructure and the importance of supporting foundational AI models, data pipelines, and developer tools.
Why We Need Continual Learning
Q: Malika, do you want to introduce yourself?
I am a partner on the AI infrastructure team at a16z, excited to discuss continual learning and how we can build systems that learn from experience after deployment.
Rethinking Git for the Age of Coding Agents with GitHub Cofounder Scott Chacon
Q: Why did you pivot from a GUI to emphasize CLI/TUI, and how does that fit agentic workflows?
GUIs are often insufficient for agents because they can't interact with rich, batch-oriented workflows the same way; CLIs and TUIs enable scripting, structured outputs, and agent-friendly data formats, while still allowing a human-friendly experience—it's about optimizing for different user personas and tasks.
Rethinking Git for the Age of Coding Agents with GitHub Cofounder Scott Chacon
Q: What motivates you to rethink Git and its interfaces now, given how foundational Git is to software development?
The motivation is that the current toolset is centuries-old in design and often in conflict with how modern teams and agents operate; with AI-assisted coding, we need interfaces that can surface the right information, support parallel work, and reduce friction in collaboration, not just replicate traditional workflows.
How AI Is Reshaping IT Services from the Inside
Q: What advantages come with inorganic partnerships versus starting from scratch when modernizing MSPs?
Partnerships bring in immediate industry expertise and access to established operators, which helps accelerate adoption and credibility while you simultaneously invest in organic growth to deeply engage end customers.

Audience Metrics

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Frequently Asked Questions About AI + a16z

What is AI + a16z about and what kind of topics does it cover?

A cutting-edge mix of venture-capital perspective, AI infrastructure, and developer-facing tooling, with conversations often centering on how AI changes capital markets, product engineering, and open-source ecosystems. Episodes frequently explore how infrastructure, open models, and scalable platforms shape startup value, funding dynamics, and enterprise adoption, while highlighting the people driving and funding these shifts. Noteworthy strengths include high-caliber guests from leading venture firms and AI startups, plus a clear focus on practical implications for builders, operators, and investors.

Listeners likely benefit from actionable insights on AI infrastructure, funding cycles, and how to position technology bets in rapidly evolv... more

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AI + a16z launched 2 years ago and published 98 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on AI + a16z?

Recent guests on AI + a16z include:

1. Ben Horowitz
2. Jennifer Li
3. Ash Ashutosh
4. Malika Aubakirova
5. Aaron Levie
6. Scott Chacon
7. Peter Doyle
8. Patrick Collison

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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