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The Pauling Principle

PAULING.AI
Longevity
Aging
Menopause
DNA Damage
Molecular Dynamics
Cardiovascular Disease
Cyclodextrin
Animal Research Automation
Boltzgen
Boltz-2
Aging Biology
Naked Mole Rat
UK Biobank
Germinal
Grenade
RNA Design
Gene Therapy
CRISPR
Antibody Design
Artificial Intelligence

AI and drug discovery to extend healthy human lifespan. Sponsored by www.pauling.ai

PublishesMonthlyEpisodes29Foundeda year ago
Number of ListenersCategories
ScienceLife Sciences

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Latest Episodes

In this episode I sit down with Karmen Čondić-Jurkić, co-founder and Executive Director of the Open Molecular Software Foundation, the organization behind OpenFE, Open Force Field, OpenFold, and OpenADMET.

We talk about what it takes to build scient... more

I sat down with Christopher Bradley, CEO and Co-Founder of Matter Bio, a company working at the intersection of longevity science and oncology. Christopher co-founded Matter Bio alongside Harvard geneticist George Church with a central thesis: that t... more

Most doctors treat you after you get sick. Professor Andrea Maier is trying to make sure you never get there. In this episode, I sit down with one of the world's leading longevity scientists, a biogerontologist who holds professorships across three c... more

In this episode of The Pauling Principle I sit with Marco Quarta, Founder and current CSO of Rubedo and we discuss cellular senescence, one of the most prominent causes of aging, and a variety of potential therapies. As well as Rubedo recent positive... more

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Recent Guests

Chris Bradley
Founder/Co-founder of Matter Bio
Matter Bio
Episode: The Pauling Principle - Episode 28
Andrea Maier
Professor of longevity and genetic medicine, discussed as a guest on the show
National University of Singapore, Chi Longevity (as referenced)
Episode: The Pauling Principle Episode 27 - Longevity Medicine with Andrea Maier
Hugo Verli
Professor and expert in molecular simulations
Episode: The Pauling Principle Episode 26 - How do you simulate a molecule that won't sit still?
Chaitanya Joshi
ML researcher focused on RNA design and Grenade model
Grenade project (RNA design platform)
Episode: The Pauling Principle Episode 25 - How to design RNA (and the origin of life)
Aubrey de Grey
Longevity researcher, LEV Foundation founder
LEV Foundation
Episode: The Pauling Principle Episode 24 - Longevity with Aubrey de Grey
Santiago Mille
Researcher involved in Germinal and antibody design
ARC Institute/HeLab collaboration
Episode: The Pauling Principle Episode 23 - Germinal and Antibody Design
Maria Marinova
Longevity expert with years of work in the field
Thelion Initiative (fractions mentioned)
Episode: The Pauling Principle Episode 21 - Reversing Reproductive Aging: Science, Not Science Fiction
Matt Kaeberlein
Longevity researcher and CEO of OptiSpan; founder of the Dog Aging Project
OptiSpan; Dog Aging Institute (Dog Aging Project)
Episode: The Pauling Principle Episode 20 - Scientific Discovery + Longevity with Matt Kaeberlein
Gabriele Corso
Guest discussing Boltzgen and foundational models for molecules
MIT (lab of Regina Barzilay and Tommy Yacuba)
Episode: The Pauling Principle Episode 22 - Bolz-2, Boltzgen and foundational models for molecules

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Apple Podcasts
#20
Chile/Science/Life Sciences
Apple Podcasts
#26
Colombia/Science/Life Sciences
Apple Podcasts
#210
Chile/Science
Apple Podcasts
#214
Colombia/Science

Talking Points

Recent interactions between the hosts and their guests.

The Pauling Principle Episode 19 - Taking photos of cells with Shantanu Singh of the Broad Institute
Q: Do foundation models really outperform traditional features in imaging biology?
In some cases they perform as well as handcrafted features but often do not outperform well-tuned traditional methods yet. The key is to maintain strong baselines, carefully benchmark progress, and recognize that complexity does not automatically translate to better performance.
The Pauling Principle Episode 19 - Taking photos of cells with Shantanu Singh of the Broad Institute
Q: How has the field addressed the challenge of translating rich single-cell data into practical insights?
We start with robust experimental design, using positive and negative controls, and then analyze whether simple baselines (like averaging cell features) suffice or if more complex representations are truly needed. We continually test against strong baselines and emphasize reproducibility, including batch correction and careful evaluation frameworks.
The Pauling Principle Episode 19 - Taking photos of cells with Shantanu Singh of the Broad Institute
Q: What exactly is the Cell Painting Assay and why is it central to your work?
Cell Painting is a multiplexed fluorescence imaging approach that labels multiple organelles and structures in cells, producing high-dimensional data where thousands of measurements can be extracted per cell. It provides a broad signature of cell state that can be used for downstream tasks like clustering, mechanism-of-action prediction, and screening for compounds that modulate specific phenotypes.
The Pauling Principle Episode 19 - Taking photos of cells with Shantanu Singh of the Broad Institute
Q: What drew you to the Broad Institute and this line of imaging-focused biology?
I came from a computer science background and shifted into biology to apply machine learning to problems like identifying cell states from images. The Broad's scale and its tradition of high-throughput imaging made it possible to pursue this at a level that could generate real, actionable data for drug discovery and understanding disease.
The Pauling Principle Episode 20 - Scientific Discovery + Longevity with Matt Kaeberlein
Q: What led you to transition from academic aging biology to leading a company focused on proactive healthcare?
The guest describes wanting a fulfilling shift from bureaucratic academia to a role where scientific work directly translates into real-world health benefits, leading to the founding of a company after exploring multiple biotech opportunities and meeting partners with shared interests in applying aging biology to improve lives.

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Frequently Asked Questions About The Pauling Principle

What is The Pauling Principle about and what kind of topics does it cover?

This series centers on cutting-edge biotech, aging biology, and AI-enabled drug discovery, with frequent deep dives into longevity research, gene therapy, and computational modeling. Episodes often feature scientists, founders, and engineers discussing how first-principles biology, genome editing, AI workflows, and novel delivery platforms could extend healthy lifespans and accelerate translational science. A notable throughline is the emphasis on rigorous evidence, practical pathways to clinical impact, and the strategic challenges of funding, regulation, and commercialization. Listeners likely include biotech researchers, startup professionals, and investors seeking actionable insights on emerging technologies and translational timelines;... more

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The Pauling Principle launched a year ago and published 29 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on The Pauling Principle?

Recent guests on The Pauling Principle include:

1. Chris Bradley
2. Andrea Maier
3. Hugo Verli
4. Chaitanya Joshi
5. Aubrey de Grey
6. Santiago Mille
7. Maria Marinova
8. Matt Kaeberlein

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