
Optimism Vaccine’s panel of experts and idiots explore the dingy crevices between pop culture and forgotten trash in a never-ending quest to celebrate your guilty pleasures in the world of cinema and beyond.
| Publishes | Weekly | Episodes | 300 | Founded | 11 years ago |
|---|---|---|---|---|---|
| Number of Listeners | Categories | Film ReviewsTV & FilmFilm History | |||

THIS WEEK: Torture Dungeon (1969), Fleshpot on 42nd Street (1972) and Blood (1973)
This week we're looking at Milligan's most prolific period and his partnership with William Mishkin, as he abandons any arthouse ambitions for a slew of barely legibl... more
THIS WEEK: Mondo Trasho (1969), Multiple Maniacs (1970) and Pink Flamingos (1972)
We've decided that the best way to break up our Andy Milligan venture is by looking at a far more gleeful trash peddler. It's well past time that we dug into the Manso... more
THIS WEEK: Vapors (1965), Seeds AKA Seeds of Sin (1968) and The Ghastly Ones (1968)
Steve has finally bullied us into covering his matinee idol, Andy Milligan. Does he live up to his reputation as one of the worst filmmakers in the history of the me... more
THIS WEEK: Find the Lady (1976), Volunteers (1985) and Only the Lonely (1991)
Remember these John Candy classics? We sure don't.
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Whether I’m at work or catching a flight this is my favorite podcast to get in-depth, thoughtful movie analysis that I can impressive my friends with at parties. Highly recommend!
Give a listen !
If the words Vinegar Syndrome or psychotronic mean anything to you this is well worth a listen. Doing god’s work fellas.
Just a sweet bunch of fellas talkin Candy Man !
This is a very good podcast. Very good and funny film chatting. It is delightful.
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Apple Podcasts | #216 |
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A sharp, no-nonsense take on cinema and pop culture, blending film critiques with wide-ranging riffs on media, TV, and music. Episodes often pair two to three anchors—hosts and rotating guests—in long-form, provocative banter that combines rigorous analysis, humor, and candid opinions about directors, star personas, and industry trends. Notable threads include how adaptations treat source material, the metatextual jokes about media saturation, and affectionate yet brutal dissections of cult favorites and mainstream releases. A recurring strength is the energy and chemistry among a core trio, plus guest voices that push provocative paths, making it a go-to for listeners who want smart, irreverent culture commentary with a playful edge.
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These podcasts share a similar audience with Optimism Vaccine:
1. The Important Cinema Club
2. Punk Vacation: An Unofficial Vinegar Syndrome Podcast
3. Wild Side: The Official Mondo Macabro Podcast
4. Unsung Horrors
5. The Bay Street Video Podcast
Optimism Vaccine launched 11 years ago and published 300 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.
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Recent guests on Optimism Vaccine include:
1. Jack Eason
2. Tom Jones
3. Jake Tropila
4. Jack Easton
5. Jake Serwin
6. Ian Rhine
7. Esther Rosenfield
8. Aaron Casias
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