The Lead Podcast presented by Heart Rhythm Society

Atrial Fibrillation

Electrophysiology

Ventricular Tachycardia

Catheter Ablation

Heart Failure

Pulmonary Vein Isolation

Heart Rhythm Society

Pulse Field Ablation

Artificial Intelligence

Cardiac Sarcoidosis

Left Bundle Branch Area Pacing

Pulsed Field Ablation

Left Bundle Branch Pacing

Cardiac Electrophysiology

Cardiac Resynchronization Therapy

Machine Learning

Hospital VT Ablation Volume

Post-Procedural Complications

Conduction System Pacing

Biventricular Pacing

The Lead – a weekly journal review podcast that is designed to keep you up to date and informed on the latest publications and hottest topics in electrophysiology. Key takeaways, in-depth interpretations, and informative interviews are all fitted into 15 minute time slots, so that they fit easily into your busy schedule. Click the link below to learn more!

23 ratings

Publishes	Weekly	Episodes	178	Founded	3 years ago
Number of Listeners		Categories	CoursesEducation

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Latest Episodes

The Lead Episode 169: A Discussion of Radiofrequency Ablation Produces Stiffer Atrial Lesions Than Pulse Field Ablation: In vivo and ex vivo magnetic resonance elastography in pigs

In this episode of The Lead, host Deep Chandh Raja, MBBS, MD, PhD, FHRS, is joined by Kars Neven, MD, PhD, and David Chieng, MBBS, CCDS, to discuss the journal article, Radiofrequency Ablation Produces Stiffer Atrial Lesions Than Pulse Field Ablation... more

17 Sep 2026 • 18 min • Most popular

The Lead Episode 168: A Discussion of Weight Loss in Older Patients With Persistent Atrial Fibrillation, The LOSE-AF Randomized Clinical Trial

Description:

In this episode of The Lead, host Jenelle Dziano, PhD candidate, is joined by Roopinder Sandu, MD, MPH, FHRS and Louise Segan, MBBS, MPH, PhD to discuss the journal article, Weight Loss in Older Patients With Persistent Atrial Fibrilla... more

10 Sep 2026 • 19 sec

The Lead Episode 167: A Discussion of The Long-Term Outcomes of Left Bundle-Branch Pacing vs Biventricular Pacing in Heart Failure (The HeartSync-LBBP Randomized Clinical Trial)

In this episode of The Lead, host Deepak Pasupula, MD, MPH, FHRS, is joined by Zaniar Ghazizadeh, MD, and Pugazhendhi Vijayaraman, MD, FHRS, to discuss the journal article, The Long-Term Outcomes of Left Bundle-Branch Pacing vs Biventricular Pacing i... more

3 Sep 2026 • 33 min • Popular

The Lead Episode 166: A Discussion of Relationship Between Time-to-First Atrial Tachyarrhythmia Recurrence and Atrial Fibrillation Burden: Implications for Trial Design

In this episode of The Lead recorded at EHRA, host Christopher Kowalewski, MD, is joined by Tina Baykaner, MD, MPH, and Sanjiv M. Narayan, MD, PhD, FHRS, to discuss the journal article, Relationship Between Time-to-First Atrial Tachyarrhythmia Recurr... more

27 Aug 2026 • 15 min

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Recent Guests

Sanjiv Narayan

Professor from Stanford

Stanford University

Episode: The Lead Episode 166: A Discussion of Relationship Between Time-to-First Atrial Tachyarrhythmia Recurrence and Atrial Fibrillation Burden: Implications for Trial Design

Dr. Jeff Healey

Cardiology Division Director and Yusuf Chir in Cardiology at McMaster University; Senior Scientist at Population Health Research Institute; Electrophysiologist at Hamilton Health Sciences

McMaster University / Hamilton Health Sciences; Population Health Research Institute

Episode: The Lead Episode 165: A Discussion of Left Atrial Appendage Closure or Medical Therapy in Atrial Fibrillation (The CLOSURE-AF Trial)

Dr. Fred Kusumoto

Professor of Medicine, Division of Heart Rhythm Services at Mayo Clinic, Florida; former President of the Heart Rhythm Society

Mayo Clinic, Florida

Episode: The Lead Episode 165: A Discussion of Left Atrial Appendage Closure or Medical Therapy in Atrial Fibrillation (The CLOSURE-AF Trial)

Junaid Zaman

Clinician scientist focused on computational electrophysiology; Keck School of Medicine

Keck School of Medicine, Los Angeles

Episode: The Lead Episode 164: A Discussion of Digital Twin–Guided Ablation for Ventricular Tachycardia

Patrick Boyle

Expert in digital twin technology translating computational heart models to bedside

University of Washington

Episode: The Lead Episode 164: A Discussion of Digital Twin–Guided Ablation for Ventricular Tachycardia

Sana Al-Khatib

Professor from Duke University

Duke University

Episode: The Lead Episode 163: A Discussion of Conduction System vs Biventricular Pacing in Heart Failure, The PhysioSync-HF Randomized Clinical Trial

Wei Hua

Professor from the National Center for the Cutting of Vascular Diseases

National Center for the Cutting of Vascular Diseases, Beijing

Episode: The Lead Episode 163: A Discussion of Conduction System vs Biventricular Pacing in Heart Failure, The PhysioSync-HF Randomized Clinical Trial

Chris Kowalewski

Cardiologist; co-author featured in discussion

Germany

Episode: The Lead Episode 162: A Discussion of Atrial Fibrillation Screening According to Genetic Risk: A Secondary Analysis of the Randomized LOOP Study

Christian Sohns

Professor from Germany

Germany

Episode: The Lead Episode 161: A Discussion of 20 Years: Clinical Outcome After Pulmonary Vein Isolation in Patients With Symptomatic Drug-Refractory Paroxysmal Atrial Fibrillation

Hosts

Tina Baykaner

Cardiologist; expert in digital education and EP topics

Jason Jacobson

Host of The Lead; electrophysiologist

Reviews

5.0 out of 5 stars from 23 ratings

The best way to stay up to date on recent EP Literature
The best way to stay up to date on recent EP Literature.
Apple Podcasts
5
heart burner
United States3 years ago

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Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Content regularly links trial data to real-world patient management decisions.

Experts provide practical trial interpretations valuable for clinical decision-making.

Guests span global institutions, enriching perspectives on practice patterns.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Apple Podcasts	#201	United States/Education/Courses
Apple Podcasts	#111	Canada/Education/Courses
Apple Podcasts	#104	Australia/Education/Courses
Apple Podcasts	#153	Italy/Education/Courses
Apple Podcasts	#179	Germany/Education/Courses
Apple Podcasts	#55	South Korea/Education/Courses

Talking Points

Recent interactions between the hosts and their guests.

The Lead Episode 164: A Discussion of Digital Twin–Guided Ablation for Ventricular Tachycardia

Q: Very nicely said. So Patrick, what do you think about this? What are your comments?

It's a milestone in computational physiology and digital twinning, showing substantial progress and paving the way for scale and multi-center validation while acknowledging the need for careful, responsible use of the digital twin label and clear methodological transparency.

The Lead Episode 164: A Discussion of Digital Twin–Guided Ablation for Ventricular Tachycardia

Q: All right, Junaid, would you like to summarize the paper for us?

The study is a proof-of-concept pilot using digital twins built from MRI-derived fibrosis and electrical modeling to predict VT re-entrant circuits, guiding a pre-specified lesion set that was applied in real VT ablations; eight of ten patients became non-inducible and the majority remained VT-free at over a year, off antiarrhythmics.

The Lead Episode 163: A Discussion of Conduction System vs Biventricular Pacing in Heart Failure, The PhysioSync-HF Randomized Clinical Trial

Q: Could you give me some of the methods and highlight the key results of the study?

The trial randomized 173 patients with reduced ejection fraction and QRS duration to either biventricular pacing or conduction system pacing, predominantly left bundle branch area pacing. The primary composite endpoint included all-cause death, heart failure hospitalization, urgent heart failure visits, and changes in ejection fraction at 12 months. The findings showed that conduction system pacing did not meet non-inferiority and was actually inferior to biventricular pacing on the primary endpoint.

Episode 160: A Discussion of Real-time smartphone alerts during atrial fibrillation episodes with implantable cardiac monitors and wearable devices: SMART-ALERT study

Q: Ken, what do you think about the threshold and the results of this study?

The threshold is a pragmatic compromise and the results show devices are not all created equal; reliability of alerts varies by device, and the study highlights the need for clinicians to understand device performance before acting on alerts.

The Lead Episode 157: A Discussion of Predicting Sudden Cardiac Death in Patients With Sarcoidosis Using a Multimodal Artificial Intelligence Model

Q: Do you expect AI-driven risk models to eventually influence guidelines or require regulatory approvals before widespread use?

Yes, especially if treated as software as a medical device; regulatory considerations will require prospective validation, clear clinical benefit, and demonstrable safety before broad guideline incorporation.

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Frequently Asked Questions About This Podcast

What is This Podcast about and what kind of topics does it cover?

A concise overview of a weekly electrophysiology-focused show that delivers quick, take-away oriented discussions of the latest publications and high-profile topics in heart rhythm. Episodes consistently pair host commentary with expert guests to dissect trial design, real-world applicability, and practice implications across pacing, ablation, anticoagulation, and device therapy. A standout pattern is rigorous interpretation of trial data, with attention to patient selection, endpoints, and long-term impacts on guidelines. The format emphasizes accessible, critical analysis in a short, 15-minute window, often contrasting US and international perspectives. This mix makes it valuable for clinicians, researchers, and industry partners seeking ... more

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Which podcasts are similar to this podcast?

These podcasts share a similar audience with this podcast:

1. This Week in Cardiology
2. Eagle's Eye View: Your Weekly CV Update From ACC.org
3. Cardionerds: A Cardiology Podcast
4. Heart Rhythm TV Pod
5. EHRA Cardio Talk

How many episodes of this podcast are there?

this podcast launched 3 years ago and published 178 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on this podcast?

Recent guests on this podcast include:

1. Sanjiv Narayan
2. Dr. Jeff Healey
3. Dr. Fred Kusumoto
4. Junaid Zaman
5. Patrick Boyle
6. Sana Al-Khatib
7. Wei Hua
8. Chris Kowalewski

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