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Artwork for The Lancet Haematology in conversation with

The Lancet Haematology in conversation with

The Lancet Group
Adverse Event Reporting
Clinical Trials
Patient Reported Outcomes
Hematopoietic Stem Cell Transplantation
Hematological Malignancies
Biologics and Immunotherapies
Tolerability
Novel Therapeutics
Mature T-Cell Lymphomas
Natural Killer Cell Lymphomas
Fetal and Neonatal Autoimmune Thrombocytopenia
Delphi Consensus Study
Ethnicity
Sickle Cell Disease
Venous Thromboembolism
Haematology
Genomic Techniques
Molecular Subtypes
Therapeutic Approaches
Health Inequalities

Lan-Lan Smith, Editor-in-Chief, Emma Cookson, Deputy Editor, and Daniela Marín, Senior Editor at The Lancet Haematology, in conversation with the journal’s authors, explore their latest research and its impact on people’s health, healthcare, and health policy.A monthly audio companion to the journal, this podcast covers a broad range of topics, from racial and ethnic disparities in leukaemia survi... more

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Artwork for The Lancet Haematology in conversation with

Latest Episodes

Most previous patient-reported outcome results for CAR T-cell therapy have come from clinical trials testing these treatments, but information on how patients experience this treatment in real-world settings is scarce.

Dr Fabio Efficace and Dr Alice... more

Dr Carmelo Gurnari joins us to discuss the development of recommendations from the EBMT Practice Harmonisation and Guidelines Committee on diagnosis, prevention, treatment, and donor management of donor cell-derived haematological neoplasms after HCT... more

Dr Penelope Stein joins us to discuss the development of new international guidelines for the diagnosis, management, and treatment of the rare, genetically-linked condition, acute prophyria.

Click here to read the full article: www.thelancet... more

Professor Marc Riedl joins us to discuss two trials testing oral deucrictibant for hereditary angioedema attacks: one testing deucrictibant as on-demand therapy to treat attacks and the other testing deucrictibant for prophylaxis of attacks.

Click h... more

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Recent Guests

Fabio Efficace
A researcher from the Italian group for adult hematologic diseases
Italian group for adult hematologic diseases
Episode: Fabio Efficace and Alice Di Rocco on patient-reported outcomes following CAR T-cell therapy
Alice Di Rocco
Researcher from Sapienza University of Rome
Sapienza University of Rome
Episode: Fabio Efficace and Alice Di Rocco on patient-reported outcomes following CAR T-cell therapy
Carmelo Gurnari
Dr. Carmelo Gurnari, affiliated with University Tor Vergata and Cleveland Clinic
University Tor Vergata; Cleveland Clinic
Episode: Carmelo Gurnari on the development of recommendations from the EBMT Practice Harmonisation and Guidelines Committee
Penny Stein
Author of the guidelines on Management of Acute Porphyria
King's College Hospital
Episode: Penelope Stein on acute prophyria
Marc Riedl
Avid clinician-scientist and author of the trials
University of California, San Diego
Episode: Marc Riedl on hereditary angioedema
Julio Delgado
Jefe de la unidad de oncoinmonoterapia del Hospital Clínic de Barcelona y del EDVAPS
Hospital Clínic de Barcelona; EDVAPS
Episode: Julio Delgado and Valentín Ortiz-Maldonado (Spanish version)
Valentín Ortiz-Maldonado
Especialista Senior de la unidad de oncoinmonoterapia
Hospital Clínic de Barcelona
Episode: Julio Delgado and Valentín Ortiz-Maldonado (Spanish version)
Dylan Graetz
Speaker from St. Jude Children's Research Hospital, contributing author on qualitative methods in haematology
St. Jude Children's Research Hospital
Episode: Erica Kaye and Dylan Graetz discuss expert recommendations for the conduct and appraisal of qualitative research in haematology
Erica Kaye
Speaker from St. Jude Children's Research Hospital, contributing author on qualitative methods in haematology
St. Jude Children's Research Hospital
Episode: Erica Kaye and Dylan Graetz discuss expert recommendations for the conduct and appraisal of qualitative research in haematology

Hosts

Lan-Lan Smith
Host of In Conversation With
Daniela Marín
Editor at The Lancet Haematology; Senior Editor; host of multiple episodes

Reviews

1.0 out of 5 stars from 1 ratings
  • Podcast inexplicably fails to play

    The Lancet Hematology in conversation with podcast consistently fails to play, presenting a completely unhelpful message stating “This episode can’t be played on this device.” This bug is 100% reproducible. I subscribe to >50 podcasts, however, only podcasts published by The Lancet seem to be affected by this issue. Several of my colleagues are similarly affected. After troubleshooting the issue with Apple technical support, I was informed that the bug is due to The Lancet’s server configuration... more

    Apple Podcasts
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    Mac_User_01
    United Statesa year ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

One listener reports a playback issue preventing episode access.
Overall, the show is a trusted source for hematology insights despite occasional technical problems.

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Talking Points

Recent interactions between the hosts and their guests.

Carmelo Gurnari on the development of recommendations from the EBMT Practice Harmonisation and Guidelines Committee
Q: Could you first explain in simple terms what an Allogenic Hematopoietic Stem Cell Transplantation is and how it differs from other types of transplantation?
Allogenic hematopoietic stem cell transplantation replaces the patient's bone marrow with someone else's, transplanting immunologically competent donor cells to reconstitute the patient's immune system, which can also mount graft-versus-leukemia effects to fight residual disease.
Penelope Stein on acute prophyria
Q: So tell us a little bit about autosomal dominant prophoria.
The guest explains that the condition is rare, with three main types, and emphasizes the need for guidelines to help non-specialists manage patients who may present with non-specific symptoms.
Fabio Efficace and Alice Di Rocco on patient-reported outcomes following CAR T-cell therapy
Q: Then my final question is, what do you see as the next steps for research into patient-reported outcomes in the context of CAR T cell therapy?
Need more data from other trials and observational studies, focus on long-term quality of life, standardization of PRO measures, and integration of PRO collection into routine practice.
Fabio Efficace and Alice Di Rocco on patient-reported outcomes following CAR T-cell therapy
Q: And can you describe how you did your study, including who was included and what outcomes were measured and what the main results are as well?
It was a prospective observational study across 13 centers in Italy, measuring symptomatic adverse events 10 days after infusion using the PROCTCA item library, finding high symptom prevalence and underestimation by physicians.
Fabio Efficace and Alice Di Rocco on patient-reported outcomes following CAR T-cell therapy
Q: So, Dr. Efficace and Dr. Di Rocco, thank you very much for joining me today. First, can you start by giving us some background about the importance of reporting patients' experiences during and after CAR T cell therapy and why this study was needed?
CAR T-cell therapy has changed prognosis for DLBCL, and it is important to understand not only efficacy and specific toxicities like CRS and ICANS but also how patients experience the journey, to inform supportive care and patient expectations.

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Frequently Asked Questions About This Podcast

What is This Podcast about and what kind of topics does it cover?

A focused deep-dive into hematology and related health policy, featuring expert clinicians, researchers, and editors who discuss trial design, novel therapies, and real-world access to treatments. Episodes frequently explore CAR-T cell therapy, hematologic malignancies, trial methodology, and the implications of research for patient care, with guests ranging from university clinicians to large cancer centers. Notable strengths include access to leading researchers, timely ASH-related perspectives, and a clear emphasis on translating complex science into clinical or policy context. This makes it valuable for listeners who want evidence-driven insights from active hematology researchers and for sponsors seeking alignment with high-impact medi... more

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this podcast launched 6 years ago and published 59 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on this podcast?

Recent guests on this podcast include:

1. Fabio Efficace
2. Alice Di Rocco
3. Carmelo Gurnari
4. Penny Stein
5. Marc Riedl
6. Julio Delgado
7. Valentín Ortiz-Maldonado
8. Dylan Graetz

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