谭勇品读医药风云
E药经理人读书谭勇品读医药风云
| Publishes | Daily | Episodes | 1442 | Founded | 2 years ago |
|---|---|---|---|---|---|
| Language |  ZH-CN | Number of Listeners | Categories | Society & CultureNewsPhilosophyBusiness News |
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Latest Episodes
一款罕见病明星药物引发的监管拉锯，正在将安进推向风暴眼。近日，FDA药物评价与研究中心（CDER）提议撤销安进重磅药物阿伐可泮的上市批准，这已经是FDA与安进围绕阿伐可泮展开的第三轮“正面对峙”。回顾双方长达五个月的博弈过程，可谓一波三折、充满戏剧性：2026年初，FDA已经要求安进自愿撤市，遭到安进强硬拒绝。而后2026年3月，FDA进一步发布安全通报，将该药物的死亡数据曝光，确认该药物造成76例药物性肝损伤病例，其中8例死亡，但安进仍坚守其立场。事件的关键在于，阿伐可泮究竟出现了什么问题，安... more
这一路走来，可清晰窥见上海莱士创新转型的核心特征。
一是从“仿制”到“首创”，验证“AI+单抗”核心技术平台能力。徐俊透露，在SR604的研发过程中，AI分子模拟技术起到了关键作用。研发团队利用AI技术，将抗体与抗原APC的相互作用解析精度推进到“埃米级别”，在海量的可能性中模拟、筛选并优化出了具有最高亲和力的抗体序列。AI的介入，使得“点石成金”成为可能，将一个其他团队未能成功的靶点推进到临床后期。
一是在传统血液制品“挖出新金矿”。在徐俊看来，创新并非只有“从0到1”的颠覆，上海莱士还在通过... more
如果说现有再平衡疗法是在“刹车系统”上做文章，那把安全做到极致也难免失灵。上海莱士自主研发的创新药SR604的颠覆性在于，它跳出了这套系统，在更精妙的维度上完成了“再平衡”。
首先，SR604的作用机制是全球首创，从根源上破解“血栓与止血”的矛盾。通常来讲，APC作为人体抗凝系统中的重要一环，当血管发生损伤时，蛋白C才会被激活为APC，避免凝血反应过度放大。
但血友病患者本就凝血因子匮乏、凝血功能低下，若抗凝系统持续强力运作，会进一步压制本就薄弱的止血能力。SR604正是通过特异性结合并精准调控... more
全球血友病治疗赛道，正站在一个关键的十字路口。
在全球约80万血友病患者的需求面前，传统凝血因子替代治疗沉疴难愈，新兴的非因子疗法百花齐放，却始终绕不开致命的“血栓”阴影和FDA的“黑框警告”。
市场喧嚣与期待交织。在近日举办的2026年世界血友病联盟（WFH）全球大会上，上海莱士副董事长、总经理徐俊博士分享了自主研发的创新药SR604临床试验进展，其I/Ⅱ期关键数据远超预期效果。作为全球首个靶向活化蛋白C（APC）的血友病单抗产品，这款中国原研新药带来了“零血栓、每两月一针、广谱覆盖”的差异... more
Reviews
- 一点小建议
主播内容很好，但普通话程度不易听懂。建议使用AI阅读或找个普通话标准的人播音
Apple Podcasts3米粒不吃米
United States9 months ago
Chart Rankings
How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.
Apple Podcasts | #51 | China/Society & Culture/Philosophy |
Apple Podcasts | #133 |  Hong Kong/Society & Culture/Philosophy |
Audience Metrics
Listeners, social reach, demographics and more for this podcast.
| Listeners per Episode | Gender Skew | Location | |||
|---|---|---|---|---|---|
| Interests | Professions | Age Range | |||
| Household Income | Social Media Reach | ||||
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谭勇品读医药风云 launched 2 years ago and published 1442 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.
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