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Talking Points

TCTMD
Heart Failure
Myocardial Infarction
Clinical Trials
Mitral Regurgitation
Cardiovascular Disease
Atrial Fibrillation
Transcatheter Mitral Valve Replacement
Percutaneous Coronary Intervention
Acute Myocardial Infarction
Beta Blockers
Abyss Trial
Cardiology
FIRE Study
Complete Revascularization
Earth STEMI Trial
Anthracycline-Induced Cardiotoxicity
Cardiovascular Death
PROACT Trial
Storm-Pe
FLOW Trial

A selection of the best interviews conducted by physician leaders and recorded at cardiology conferences around the globe. 06f763f0-76e5-11f0-bb7c-8557ae1d8a8b

PublishesMonthlyEpisodes209Founded10 years ago
Number of ListenersCategory
Science

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Artwork for Talking Points

Latest Episodes

How does discontinuing beta-blockers after MI affect outcomes in patients without HF? Dan Atar and C. Michael Gibson break it down.

In one of the most thought-provoking sessions at New York Valves 2026, Michael Mack and Roxana Mehran moderate a panel discussion looking at the future of TAVI from all angles.

Ruben de Winter and C. Michael Gibson compare clinical outcomes of native vessel versus SVG PCI for patients with prior CABG.

Christian M. Spaulding and C. Michael Gibson look at the 1-year results from the study comparing sirolimus-eluting DCB with DES for de novo coronary lesions.

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Recent Guests

Ruben de Winter
Investigator discussing the PROCTOR trial
Episode: The PROCTOR Trial
Christian Spaulding
Trial investigator presenting the Solution de Novo trial
Episode: The SELUTION DeNovo Trial
Mamas Mamas
Senior Clinical Editor
TCTMD
Episode: The META-AF Trial
Mike Gibson
Senior Clinical Editor, discusses trial with host
TCTMD
Episode: Evolution of Pharmacotherapy in STEMI
Colin Berry
Clinical researcher presenting core CMR study results
Centre for Cardiovascular Research (inferred from context)
Episode: The CorCMR Trial
Katherine Tuttle
Senior Clinical Editor at TCTMD
TCTMD
Episode: The FLOW Trial
Jacob Lønborg
Principal Investigator of the NOTION-3 trial
Episode: The NOTION-3 Trial
Sean Pinney
Professor of Medicine and Chair of Cardiology at Mount Sinai Morningside
Mount Sinai Morningside
Episode: TMVR in the Heart Failure Paradigm
Joanne Lindenfeld
Professor of Medicine and Director of Heart Failure and Transplant at Vanderbilt, and past President of the Heart Failure Society of America
Vanderbilt
Episode: TMVR in the Heart Failure Paradigm

Hosts

Mike Gibson
Co-host of the show; Senior Clinical Editor with frequent trial interpretations and host duties at cardiology conferences.
Mamas Mamas
Senior Clinical Editor with ongoing involvement in trial discussions and editorial commentary.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Apple Podcasts
#97
Taiwan/Science

Talking Points

Recent interactions between the hosts and their guests.

The BETAMI-DANBLOCK Trial
Q: And what did you find?
The primary composite endpoint occurred in 14.2% of patients on beta blockers versus 16.3% in the control group, suggesting a superiority for continuing beta-blocker therapy post-MI, driven largely by fewer recurrent infarctions.
The BETAMI-DANBLOCK Trial
Q: Tell us a little bit about the design, how many patients, and when were the beta-blockers discontinued, and what was the follow-up?
The study used a prospective randomized open-label design with blinded endpoint adjudication. It enrolled over 5,500 patients across Denmark and Norway, with randomization occurring around day two and a median follow-up of about 3.5 years.
The PROCTOR Trial
Q: What surprised you about the one-year results?
Despite expectations from observational data suggesting native vessel PCI might fare better, the randomized results showed higher MACE with native vessel PCI at one year, primarily due to higher non-fatal MI and more frequent revascularization needs in that group.
The PROCTOR Trial
Q: And what did you find regarding specific components of MACE?
There was no significant difference in all-cause mortality between groups, but non-fatal myocardial infarction occurred more often in the native vessel PCI group, largely due to a higher incidence of PCI-related MI, while the SVG group had fewer such events, contributing to the overall lower MACE in that arm.
The PROCTOR Trial
Q: Tell us what you did and what you found.
We randomized 220 patients in total, with nearly equal allocation to native vessel PCI and SVG PCI, and evaluated major adverse cardiovascular events at one year. The primary finding was a substantially lower MACE rate in the SVG PCI group (19%) compared with the native vessel PCI group (34%), driven mainly by lower PCI-related myocardial infarction and fewer repeat revascularizations in the graft group.

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Frequently Asked Questions About Talking Points

What is Talking Points about and what kind of topics does it cover?

The show delivers in-depth discussions of cutting-edge cardiovascular trials and practices, often framed around live conference contexts. Episodes span trial design and interpretation, imaging-guided management, novel pharmacologic and device therapies, and real-world implications for complex coronary and valvular disease, heart failure, and intervention strategies. Guests are typically clinician-researchers or senior editors who bring trial data to life, discuss limitations, and translate findings into practical care or decision-making. A standout pattern is the blend of rigorous data critique with pragmatic considerations for pre-hospital, in-hospital, and post-procedure care, frequently tied to major conferences and evolving guidelines. ... more

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Talking Points launched 10 years ago and published 209 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Talking Points?

Recent guests on Talking Points include:

1. Ruben de Winter
2. Christian Spaulding
3. Mamas Mamas
4. Mike Gibson
5. Colin Berry
6. Katherine Tuttle
7. Jacob Lønborg
8. Sean Pinney

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