Kidney Compass: Navigating Clinical Trials

Iga Nephropathy

Chronic Kidney Disease

SGLT2 Inhibitors

Proteinuria

Sibeprenlimab

Empagliflozin

Finerenone

Albuminuria

Nudge-Ckd

Smart-C

Iron Deficiency In Kidney Disease

Telitassusept

Alport Syndrome

Obinutuzumab

Sparsentan

Digital Infrastructure

Origin 3

Atacicept

Atherosclerotic Cardiovascular Disease

Scholarly/clinical Trials In Nephrology

Hosted by Brendon Neuen, MBBS, PhD, and Shikha Wadhwani, MD, MS, Kidney Compass: Navigating Clinical Trials is a regular podcast exploring and breaking down the latest updates and nuances of clinical trials in nephrology. By listening to Kidney Compass, you'll get the guidance you need to navigate the changing landscape of clinical trials across the spectrum of kidney disease.

21 ratings

Publishes	Daily	Episodes	22	Founded	2 years ago
Categories	MedicineHealth & Fitness

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Guests Hosts Reviews Charts Talking Points

Latest Episodes

Rituximab Cuts Relapse Risk in MCD, FSGS in TURING Trial

At the European Renal Association (ERA) Congress in Glasgow, Scotland, results from the TURING trial offered long-awaited evidence that rituximab can meaningfully reduce relapse rates in adults with minimal change disease (MCD) and focal segmental gl... more

17 Aug 2026 • 17 min

VISIONARY 2-Year eGFR Data in IgA Nephropathy

Hosts Brendon Neuen, MBBS, PhD, and Shikha Wadhwani, MD, MS, welcome Dana Rizk, MD, professor of medicine in the Division of Nephrology at the University of Alabama at Birmingham. Rizk walks through the 24-month eGFR and safety findings from the phas... more

14 Aug 2026 • 37 min

REMODEL Trial Provides Mechanistic Rationale for Semaglutide in CKD

At the World Congress of Nephrology 2026 in Yokohama, Japan, growing attention is being paid not just to whether therapies improve outcomes in chronic kidney disease, but how they work at a mechanistic level.

In this episode of Kidney Compass, host... more

14 Apr 2026 • 14 min

IV Iron and Functional Outcomes in Kidney Transplant Recipients

Iron deficiency is increasingly recognized as a clinically meaningful yet underexplored contributor to morbidity in kidney disease, extending beyond its traditional association with anemia. In populations such as kidney transplant recipients, where g... more

14 Apr 2026 • 17 min

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Clinical Journal of the American Society of Nephrology (CJASN)American Society of Nephrology

Recent Guests

David Cherney

Leader in diabetes complications research

University of Toronto (informal affiliation in conversation)

Episode: REMODEL Trial Provides Mechanistic Rationale for Semaglutide in CKD

Martin de Borst

Professor, UMCG Groningen, Netherlands

UMCG Groningen

Episode: IV Iron and Functional Outcomes in Kidney Transplant Recipients

Hong Zhang

Professor from Peking University First Hospital, IGF nephropathy researcher

Peking University First Hospital

Episode: Phase 3 Data on Telitacicept in IgA Nephropathy at ASN Kidney Week 2025

Jicheng Liu

Professor from China, IGF nephropathy researcher

Unspecified Chinese institution

Episode: Phase 3 Data on Telitacicept in IgA Nephropathy at ASN Kidney Week 2025

Sophia Zoungas

Professor of Medicine at Monash University

Monash University

Episode: Understanding Renal Outcomes in SURPASS-CVOT, With Sophia Zoungas, MBBS, PhD

Danny Gale

St. Peter's Chair of Nephrology at University College London; Director of the RaDaR Registry

University College London, RaDaR Registry

Episode: Setanaxib, Alport Syndrome, and RaDaR Updates at Kidney Week 2025, With Danny Gale, MB BChir, PhD

Brad Rovin

Division chief of nephrology and lupus nephritis expert

The Ohio State University Wexner Medical Center

Episode: Obinutuzumab, REGENCY, & Updates in Lupus Nephritis, With Brad Rovin, MD

Richard Lafayette, MD

Professor of Medicine at Stanford University

Stanford University

Episode: Kidney Compass: Atacicept and ORIGIN 3 at Kidney Week 2025, with Richard Lafayette, MD

Tor Biering-Sørensen

Professor from the University of Copenhagen

University of Copenhagen

Episode: NUDGE-CKD and the Power of Pragmatic Trials

Hosts

Brendon Neuen

Host focused on nephrology trials and trial interpretation

Shikha Wadhwani

Co-host and nephrology clinician with trial-focused insights

Reviews

5.0 out of 5 stars from 21 ratings

Insightful podcast
Thank you for this amazing podcast. It’s been really helpful to keep up with upcoming treatments for iga nephropathy patients
Apple Podcasts
5
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Australiaa year ago

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Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Polished host + expert guests provide clear trial takeaways.

Great for understanding how new therapies fit into practice.

Comprehensive breakdown of endpoints and real-world impact.

Strong on trial design and safety considerations.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Apple Podcasts	#142	Singapore/Health & Fitness/Medicine
Apple Podcasts	#185	Ireland/Health & Fitness/Medicine
Apple Podcasts	#209	Netherlands/Health & Fitness/Medicine
Apple Podcasts	#226	Norway/Health & Fitness/Medicine
Apple Podcasts	#231	New Zealand/Health & Fitness/Medicine
Apple Podcasts	#234	Sweden/Health & Fitness/Medicine

Talking Points

Recent interactions between the hosts and their guests.

NUDGE-CKD and the Power of Pragmatic Trials

Q: What was the design and rationale of the Nudge-Ckd trial in Denmark?

It was a nationwide randomized, two-by-two editorial implementation trial that nudged both patients and general practitioners with simple letters to increase uptake of guideline-directed therapies for CKD; it leveraged Danish registries and e-book notifications to identify and contact participants.

REMODEL Trial Provides Mechanistic Rationale for Semaglutide in CKD

Q: What are the implications of Remodel for non-diabetic kidney disease and the broader CKD population?

The mechanistic observations—endothelial and inflammatory pathway modulation and intra-renal fat reduction—could be relevant to non-diabetic CKD, indicating a potential broader applicability beyond diabetes, though evidence remains limited and warrants dedicated trials in non-diabetic populations.

REMODEL Trial Provides Mechanistic Rationale for Semaglutide in CKD

Q: Do the benefits of semaglutide in Remodel depend on whether patients are also taking an SGLT-2 inhibitor, or are they additive?

The findings suggest that the benefits are largely additive and largely independent of baseline SGLT-2 inhibitor use, implying that GLP-1 receptor agonists add complementary protective mechanisms when used with SGLT-2 inhibitors.

REMODEL Trial Provides Mechanistic Rationale for Semaglutide in CKD

Q: For listeners who haven't heard about Remodel yet, what was the primary aim of the trial and what were the key findings?

Remodel was designed to answer why semaglutide benefits the kidney, focusing on MRI-based oxygenation outcomes and a suite of mechanistic and clinical secondary outcomes. It found no improvement in intra-renal oxygenation but did show reductions in peri-renal fat, hilar fat, and markers of kidney fibrosis, along with a notable drop in albuminuria; biopsy data suggested favorable effects on endothelial cells and inflammation.

Phase 3 Data on Telitacicept in IgA Nephropathy at ASN Kidney Week 2025

Q: How many patients were randomized and what were the baseline characteristics?

Over 500 screened, about 380 randomized in a one-to-one fashion to teletassiept or placebo, with projections focusing on heavy proteinuria and EGFR risk profiles.

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Frequently Asked Questions About This Podcast

What is This Podcast about and what kind of topics does it cover?

A professional-level deep dive into nephrology clinical trials, focusing on trial design, data interpretation, and emerging therapies across kidney diseases. Episodes frequently explore trial results (from GLP-1–based approaches to IgA nephropathy and lupus nephritis), mechanisms, safety signals, and practical takeaways for clinical practice. Guests are leading researchers and clinicians who dissect study design, endpoints, biomarkers, and real-world applicability, often considering how new data should influence guidelines and patient messaging. The show stands out for its rigorous, evidence-focused discussions that pair sophisticated nephrology science with implications for patient outcomes, trial planning, and therapeutic sequencing.

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These podcasts share a similar audience with this podcast:

1. Clinical Journal of the American Society of Nephrology (CJASN)

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this podcast launched 2 years ago and published 22 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on this podcast?

Recent guests on this podcast include:

1. David Cherney
2. Martin de Borst
3. Hong Zhang
4. Jicheng Liu
5. Sophia Zoungas
6. Danny Gale
7. Brad Rovin
8. Richard Lafayette, MD

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