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JAMA Ophthalmology Author Interviews

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Interviews with authors of articles from JAMA Ophthalmology. JAMA Ophthalmology, published continuously since 1869, is an international, peer-reviewed ophthalmology and visual science journal. Covering research, science, & clinical practice in ophthalmology and vision science.

PublishesMonthlyEpisodes130Founded9 years ago
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Artwork for JAMA Ophthalmology Author Interviews

Latest Episodes

Interview with Iqbal Ike K. Ahmed, MD, and Jawad Muayad, MD, authors of Nicotinamide Supplementation and Primary Open-Angle Glaucoma in Patients With Ocular Hypertension. Hosted by Neil Bressler, MD. Related Content:

• Nicotinamide Supplementation... more

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Interview with Rishi P. Singh, MD, author The Retina Clinic as a Window Into Systemic Vascular Health. Hosted by Neil Bressler, MD. Related Content:

• The Retina Clinic as a Window Into Systemic Vascular Health

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Interview with Allison I. Summers, OD, MCR, author of Web-Based Amblyopia Decision Support Tool. Hosted by Neil Bressler, MD. Related Content:

• Web-Based Amblyopia Decision Support Tool

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Interview with Tiarnán D. L. Keenan, BM BCh, PhD, author of Modest and Variable Correlations Between Geographic Atrophy Enlargement Rates in Fellow Eyes in the AREDS2 Study. Hosted by Neil Bressler, MD. Related Content:

• Modest and Variable Corre... more

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Recent Guests

Iq Ahmed
Corresponding author; John A. Moran Eye Center, University of Utah
University of Utah
Episode: Nicotinamide and Primary Open-Angle Glaucoma in Ocular Hypertension
Jawad Muayad
First author; Bernice and Harvey Jones Eye Institute, University of Arkansas for Medical Sciences
University of Arkansas for Medical Sciences
Episode: Nicotinamide and Primary Open-Angle Glaucoma in Ocular Hypertension
Rishi Singh
Author of invited commentary; Chair of the Department of Ophthalmology at Massachusetts Eye and Ear Infirmary and Harvard Medical School
Massachusetts Eye and Ear Infirmary / Harvard Medical School
Episode: The Retina Clinic as a Window Into Systemic Vascular Health
Allison Summers
Associate professor of ophthalmology; first author of the Special Communication describing the tool
Oregon Health & Science University (OHSU)
Episode: Web-Based Amblyopia Decision Support Tool
Tiarnán Keenan
Corresponding author of the study
National Eye Institute, NIH
Episode: Geographic Atrophy Enlargement Rates in the AREDS2 Study
Alvin Liu
First author of the meta-analysis on prevalence and disparities of retinal conditions
Johns Hopkins University School of Medicine
Episode: Prevalence and Health Care Disparities of Retinal Conditions
Paula Anne Newman-Casey
Corresponding author of the randomized clinical trial on the CSEE program
University of Michigan
Episode: Support, Educate, Empower Program and Medication Adherence
Kara Cavuoto
Professor of Clinical Ophthalmology at the Bascom Palmer Eye Institute
University of Miami Miller School of Medicine
Episode: Language Accessibility at Select Academic Ophthalmology Centers
Tien Wong
Professor and dean at Tsinghua Medicine at Tsinghua University in Beijing, China
Tsinghua University
Episode: Aflibercept Dose in Polypoidal Choroidal Vasculopathy

Host

Neil Bressler
Host of JAMA Ophthalmology Author Interviews

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Talking Points

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Nicotinamide and Primary Open-Angle Glaucoma in Ocular Hypertension
Q: What safety considerations should clinicians keep in mind, and how do they address potential risks?
Liver injury risk emerges at higher doses (around 3 g/day) in global trials; thus, lower doses are generally safer, and any future trials must carefully monitor liver-related adverse events and establish safe, effective dosing regimens.
Nicotinamide and Primary Open-Angle Glaucoma in Ocular Hypertension
Q: What are the next steps before this could influence clinical practice?
The researchers advocate for a properly designed randomized controlled trial to determine dosing, safety, and efficacy, along with understanding interactions with genetics and real-world safety signals.
Nicotinamide and Primary Open-Angle Glaucoma in Ocular Hypertension
Q: What is the absolute risk reduction, and how does that translate into numbers for clinical decision-making?
Among those who started nicotinamide, about 3% converted to glaucoma compared with about 10% in those who did not, yielding roughly a 6% absolute risk reduction and roughly 1 in 18 individuals potentially spared from conversion in this dataset.
Nicotinamide and Primary Open-Angle Glaucoma in Ocular Hypertension
Q: What did the real-world data show about nicotinamide use and conversion to glaucoma, and how robust are those findings?
The analysis found a roughly two-thirds reduction in POAG diagnosis risk and reductions in related therapies, with results persisting across multiple sensitivity analyses, though the authors note possible healthy user bias and the need for randomized trials to confirm causation.
Nicotinamide and Primary Open-Angle Glaucoma in Ocular Hypertension
Q: Could nicotinamide supplementation be a neuroprotective strategy for glaucoma beyond lowering intraocular pressure, and what was the preclinical rationale?
The authors described glaucoma as a metabolic neurodegenerative disease where NAD+ levels decline with age, making retinal ganglion cells vulnerable. Nicotinamide, a direct NAD+ precursor, could replenish NAD+ and support mitochondrial function, potentially offering neuroprotection independent of IOP reduction.

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Frequently Asked Questions About JAMA Ophthalmology Author Interviews

What is JAMA Ophthalmology Author Interviews about and what kind of topics does it cover?

This show features in-depth conversations with leading ophthalmology researchers, clinicians, and educators who author pivotal studies and trials. Episodes commonly center on clinical findings, trial designs, and emerging technologies in eye health—ranging from amblyopia decision support and geographic atrophy analyses to language accessibility in ophthalmology care and AI-driven tools. The format often delves into study methodology, data interpretation, regulatory considerations, and practical implications for patient care, with guests usually explaining their work for a scientifically literate audience. A notable pattern is the inclusion of a mix of physician-scientists, university researchers, and clinical trial leaders across medicine a... more

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Which podcasts are similar to JAMA Ophthalmology Author Interviews?

These podcasts share a similar audience with JAMA Ophthalmology Author Interviews:

1. Ophthalmology Journal
2. Experts InSight
3. The Retina Channel Podcast
4. RETINA Journal Podcasts
5. New Retina Radio by Eyetube

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JAMA Ophthalmology Author Interviews launched 9 years ago and published 130 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on JAMA Ophthalmology Author Interviews?

Recent guests on JAMA Ophthalmology Author Interviews include:

1. Iq Ahmed
2. Jawad Muayad
3. Rishi Singh
4. Allison Summers
5. Tiarnán Keenan
6. Alvin Liu
7. Paula Anne Newman-Casey
8. Kara Cavuoto

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