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Artwork for ImmunoCAST
Asthma
Food Allergies
Alpha-Gal Syndrome
Allergies
Food Allergy
Specific Ige Testing
Pollen Food Allergy Syndrome
Allergy
Anaphylaxis
Oral Allergy Syndrome
Asthma Peak Week
Allergen Components
Quality Of Life
Allergy Management
Respiratory Allergies
Food Allergens
Tree Nut Allergies
Rhinitis
Cannabis Allergy
Patient Education

From medical guidelines and best practices to educational insights on specific disease states, ImmunoCAST is a podcast dedicated to providing healthcare providers of all specialties clinically relevant, easy-to-digest episodes on allergy related topics.

PublishesTwice monthlyEpisodes59Founded3 years ago
Number of ListenersCategories
Life SciencesHealth & FitnessScienceMedicine

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Artwork for ImmunoCAST

Latest Episodes

A 7% sensitization rate by 3 months of age highlights how early allergic disease can begin, making early recognition critical for long-term patient outcomes. In this episode, internationally recognized allergy researcher and pediatric allergist Dr. A... more

Few scientists have shaped modern allergy medicine as profoundly as Dr. Thomas Platts-Mills. From pioneering research on dust mite allergens and environmental drivers of asthma to helping uncover the IgE-mediated mechanism behind alpha-gal syndrome, ... more

Dr. Ruchi Gupta, board-certified pediatrician and founding director of the Center for Food Allergy and Asthma Research (CFAAR), and PA Gary Falcetano joined forces on a Food Allergy Research and Education (FARE) webinar to discuss nuances and insight... more

Food allergy diagnosis is still too often driven by tests instead of history, leading to unnecessary restriction and missed opportunities for targeted care. In this episode, we invite Dr. Anna Nowak-Wegrzyn, a leading researcher in food allergy and D... more

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Recent Guests

Dr. Anna Asarnoj
Global Allergy Medical Director; researcher in pediatric allergy and immunology
Karolinska Institute; Saks Children and Youth Hospital; Thermo Fisher Scientific
Episode: Early-Life Allergy Risk, Precision Diagnostics, and the Future of Prevention (ft. Dr. Anna Asarnoj)
Dr. Tom Platts-Mills
Influential clinical investigator in allergy and immunology
University of Virginia, Oscar Swineford Professor of Medicine
Episode: Behind the Discovery of Alpha-Gal Syndrome and Other Pioneering Research with Dr. Thomas Platts-Mills
Ruchi Gupta
Distinguished pediatrician and professor; founding director of the Center for Food Allergy and Asthma Research
Northwestern University Feinberg School of Medicine
Episode: Key Takeaways for Managing Food Allergies Across the Lifespan (ft. Ruchi Gupta, MD, MPH)
Anna Nowak-Wegrzyn
Professor of Pediatrics and Director of the Pediatric Allergy and Immunology Division
NYU Grossman School of Medicine
Episode: Food Allergy and EoE: Smarter Diagnosis for Better Care (ft. Anna Nowak-Wegrzyn, MD, PhD)
Dr. Benninger
Otolaryngologist and expert in rhinitis
Cleveland Clinic
Episode: 50th Episode: Top Insights from Our Past Allergy Expert Guests
Dr. Zach Rubin
Popular voice in the allergy community; expert translating complex allergy concepts
Episode: 50th Episode: Top Insights from Our Past Allergy Expert Guests
Tamara Hubbard
Mental health clinician specializing in food allergy-informed mental health
Academy of Food Allergy Counseling
Episode: 50th Episode: Top Insights from Our Past Allergy Expert Guests
Dr. Anne-Marie Shues
Expert on allergen component diagnostics, particularly in pet allergies
Episode: 50th Episode: Top Insights from Our Past Allergy Expert Guests
Dr. Ruchi Gupta
Advocate for improving access to food allergy care in primary settings
Episode: 50th Episode: Top Insights from Our Past Allergy Expert Guests

Hosts

Gary Falcettano
Host of ImmunoCAST
Luke Lemmons
Co-host and writer for healthcare providers

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Talking Points

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Early-Life Allergy Risk, Precision Diagnostics, and the Future of Prevention (ft. Dr. Anna Asarnoj)
Q: What does precision diagnostics mean for primary care providers when managing young children with suspected allergies?
Precision diagnostics can help distinguish true positives from false positives, guiding early introduction decisions and planning, while certain tests (like ovomucoid IgE) offer prognostic insight into whether a child might tolerate baked forms or progress to more persistent allergies.
Early-Life Allergy Risk, Precision Diagnostics, and the Future of Prevention (ft. Dr. Anna Asarnoj)
Q: What were some of the surprising findings you observed within the cohort, particularly regarding component testing and peanut allergy?
Findings showed that Birch sensitization often coincides with peanut sensitization without clinical peanut allergy, leading to concepts like asymptomatic peanut sensitization; specific components (e.g., RAH8, RAH6) helped explain why some children react to peanut while others do not.
Early-Life Allergy Risk, Precision Diagnostics, and the Future of Prevention (ft. Dr. Anna Asarnoj)
Q: So can you tell us a little bit about the BAMSE/BAMPSE cohort and the kind of research you've done with it?
Dr. Asarnoj explains that the cohort tracks about 4,000 children born in Stockholm during 1992-1994, with multiple clinical visits and biomarker assessments to understand early-life allergy development and to identify predictive factors such as component sensitization and longitudinal outcomes.
Behind the Discovery of Alpha-Gal Syndrome and Other Pioneering Research with Dr. Thomas Platts-Mills
Q: What initially spurred your focus on alpha-gal, and how did the investigation unfold?
The discovery started with linking IgE to alpha-gal to delayed meat reactions, followed by mechanistic work showing glycosylation patterns in mammalian proteins and cetuximab, culminating in a broad understanding that alpha-gal sensitization drives a unique delayed anaphylaxis phenotype.
Key Takeaways for Managing Food Allergies Across the Lifespan (ft. Ruchi Gupta, MD, MPH)
Q: Should a test be repeated beyond childhood, and when should re-testing be considered?
Re-testing is important as patients age, since natural tolerance can develop and test results can change; clinicians should consider re-testing every so often to reassess allergy status and determine if a food challenge is appropriate.

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Frequently Asked Questions About ImmunoCAST

What is ImmunoCAST about and what kind of topics does it cover?

A clinically oriented, science-forward series focused on allergy, immunology, and related respiratory conditions. Episodes typically feature leading researchers, clinicians, and educators who unpack diagnostic advances, management strategies, and real-world patient care—from food allergies and eosinophilic esophagitis to allergic rhinitis, venom allergies, and mental health aspects tied to allergy management. The show emphasizes practical guidance for primary care and specialty clinicians, with episodes often discussing diagnostic testing (including component-resolved diagnostics), regional or life-stage considerations, and treatment options such as immunotherapy or biologics. A standout thread is the collaboration between clinicians, resea... more

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Which podcasts are similar to ImmunoCAST?

These podcasts share a similar audience with ImmunoCAST:

1. The Allergist
2. Speaking of Mol Bio

How many episodes of ImmunoCAST are there?

ImmunoCAST launched 3 years ago and published 59 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on ImmunoCAST?

Recent guests on ImmunoCAST include:

1. Dr. Anna Asarnoj
2. Dr. Tom Platts-Mills
3. Ruchi Gupta
4. Anna Nowak-Wegrzyn
5. Dr. Benninger
6. Dr. Zach Rubin
7. Tamara Hubbard
8. Dr. Anne-Marie Shues

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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