HemaSphere Podcast

HemaSphere Journal

Immune Effector Cell-Associated Hematotoxicity

Acute Leukemias Of Ambiguous Lineage

Blinatumomab

TP53

Acute Myeloid Leukemia

Tascuinimod

NUP98 Rearranged AML

Car-T Therapy

RNA Sequencing

ECAL

Clinical Implementation Of Rna-Seq

Acute Lymphoblastic Leukemia

MRD

Dresden, Germany

Myelodysplastic Syndromes

Bone Marrow Microenvironment

Myeloproliferative Neoplasms

Metabolism

Metabolomics

Spatial Metabolomics

HemaSphere is the official online, open access journal of the European Hematology Association (EHA). HemaSphere publishes exciting basic, translational, and clinical research in hematology. We are pleased to introduce our new podcast series where our host and guest speakers exchange ideas about select HemaSphere publications. Spend some time with us and enjoy casual and insightful discussions abou... more

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Publishes	Infrequently	Episodes	28	Founded	3 years ago
Number of Listeners		Categories	Natural SciencesHealth & FitnessScienceMedicine

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Latest Episodes

Why Inflammatory Signaling Holds the Key to Durable MDS Therapies - Dr Manja Wobus, Dr Katja Sockel

In this episode, host Dr Charles de Bock delves into groundbreaking preclinical research exploring the potential of tasquinimod to restore blood cell production and modify the bone marrow microenvironment in MDS with Dr Manja Wobus and Dr Katja Socke... more

17 Jun 2026 • 38 min

YouTube

p53 in Cancer: Dual Threat - Dr Isabelle Plo, Dr Barbara Monte-Mór

Discover the latest insights into the multifaceted role of p53 in normal hematopoiesis and its critical involvement in myeloproliferative neoplasms (MPNs). This episode features Dr. Isabelle Plo and Dr. Barbara Monte-Mór sharing their expertise on TP... more

7 May 2026 • 36 min

YouTube

Blinatumomab in De Novo AYA ALL - Dr Matthew Greenwood

In this episode, host HemaSphere Scientific Editor Dr Charley de Bock speaks with Associate Professor Dr Matthew Greenwood about the SUBLIME (ALL09) trial, which explores replacing consolidation chemotherapy with blinatumomab in adolescents and young... more

9 Feb 2026 • 46 min

YouTube

Inequalities in sickle cell therapies - Dr Stephen Hibbs, Dr Paul Telfer, Mary-Shaniqua - Patient Advocate

In this extended episode of the HemaSphere podcast, based on a must-read Perspective "Can health inequalities in sickle cell disease be addressed through novel therapies?", our host Scientific Editor Charles de Bock discusses sickle cell disease with... more

2 Dec 2025 • 55 min

YouTube

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Recent Guests

Manja Wobus

Professor and head of the Stem Cell Research Lab

University of Dresden

Episode: Why Inflammatory Signaling Holds the Key to Durable MDS Therapies - Dr Manja Wobus, Dr Katja Sockel

Katya Sockel

Senior physician and head of the MDS/MPN program

University of Dresden

Episode: Why Inflammatory Signaling Holds the Key to Durable MDS Therapies - Dr Manja Wobus, Dr Katja Sockel

Isabelle Plo

Researcher, INSERM Gustave-Roussy University

INSERM, Gustave-Roussy, Paris/Saclay, France

Episode: p53 in Cancer: Dual Threat - Dr Isabelle Plo, Dr Barbara Monte-Mór

Barbara Monte-Mór

Researcher, Instituto Nacional de Cancer

Instituto Nacional de Cancer, Rio de Janeiro, Brazil

Episode: p53 in Cancer: Dual Threat - Dr Isabelle Plo, Dr Barbara Monte-Mór

Matthew Greenwood

Associate Professor, University of Sydney; Staff Specialist, Royal North Shore Hospital

University of Sydney; Royal North Shore Hospital

Episode: Blinatumomab in De Novo AYA ALL - Dr Matthew Greenwood

Mary Shaniqua

Advocacy Leader and person with lived experience of sickle cell disease

Patient advocate

Episode: Inequalities in sickle cell therapies - Dr Stephen Hibbs, Dr Paul Telfer, Mary-Shaniqua - Patient Advocate

Stephen Hebs

Hematologist, Research Fellow at Queen Mary University of London; Scientific Editor at HemaSphere

Queen Mary University of London; HemaSphere

Episode: Inequalities in sickle cell therapies - Dr Stephen Hibbs, Dr Paul Telfer, Mary-Shaniqua - Patient Advocate

Paul Telfer

Blood Specialist; Clinical Lead for Hemoglobinopathy Services, Barts Health

Barts Health

Episode: Inequalities in sickle cell therapies - Dr Stephen Hibbs, Dr Paul Telfer, Mary-Shaniqua - Patient Advocate

Anikó Sijs-Szabó

Clinical hematologist; co-author of the study on transcriptional profiling for ALAL classification

Leiden University Medical Center; Erasmus Medical Center, Rotterdam

Episode: Defining Lineage in Ambiguous Leukemia: A Transcriptomic View - Dr. Anikó Sijs-Szabó & Roger Mulet Lázaro, PhD

Host

Charles de Bock

Host of the HemaSphere Podcast

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Apple Podcasts

#198

United Kingdom/Health & Fitness/Medicine

Talking Points

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Why Inflammatory Signaling Holds the Key to Durable MDS Therapies - Dr Manja Wobus, Dr Katja Sockel

Q: What are the next steps for translating these findings into the clinic?

The team is preparing a phase I/II proof-of-concept trial in low-risk MDS to assess safety and hematologic impact, while exploring biomarkers that identify patients with an active inflammatory S100A9 axis who may benefit from therapy.

Why Inflammatory Signaling Holds the Key to Durable MDS Therapies - Dr Manja Wobus, Dr Katja Sockel

Q: Why did you choose Tascuinimod as the drug to test in MDS, and how does it mechanistically work?

Tascuinimod inhibits S100A9-driven signaling by binding to S100A9 and dampening downstream pathways, including NF-kB and inflammasome activation, with additional pleiotropic effects on other inflammatory networks; its prior clinical experience and tolerability in other cancers supported repurposing for MDS.

Why Inflammatory Signaling Holds the Key to Durable MDS Therapies - Dr Manja Wobus, Dr Katja Sockel

Q: Can you introduce what S100A9 is and why you focused on this molecule in MDS?

S100A9 is a damage-associated molecular pattern protein produced mainly by myeloid cells; it drives inflammatory signaling in the bone marrow, contributing to the inflammatory environment that supports disease progression in MDS, making it a compelling target for early intervention.

Part 1 - Metabolism in hematology - Ep 3.4

Q: How has the Seahorse analyzer shaped current research in metabolism?

The Seahorse platform enables dynamic, real-time monitoring of cellular metabolism, allowing researchers to assess glycolysis and fatty acid oxidation and to tailor experiments to specific questions, while now supporting 3D models and smaller cell numbers.

Part 1 - Metabolism in hematology - Ep 3.4

Q: What makes metabolism research exciting right now given all the new technologies?

The guests explain that advances in mass spectrometry, flow-based and real-time metabolic assays like Seahorse, and better data analysis allow us to observe subtle yet impactful metabolic changes in immune and hematopoietic cells, enabling deeper mechanistic insights and translation to disease biology.

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Frequently Asked Questions About HemaSphere Podcast

What is HemaSphere Podcast about and what kind of topics does it cover?

Thoughtful discussions focused on hematology research, translational medicine, and clinical practice, with episodes often centered on cutting-edge studies, therapeutic strategies, and translational pipelines. Guests include renowned clinicians, scientists, and patient advocates, who break down complex papers, trial designs, and novel therapies for a professional audience. The format tends to blend basic science with clinical implications, highlighting biomarkers, trial plans, and real-world impact. A notable strength is connecting diverse experts across institutions and geographies to illuminate how hematology research translates into patient care. Potential listeners who want deep dives into current hematology topics, study methodologies, ... more

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HemaSphere Podcast launched 3 years ago and published 28 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on HemaSphere Podcast?

Recent guests on HemaSphere Podcast include:

1. Manja Wobus
2. Katya Sockel
3. Isabelle Plo
4. Barbara Monte-Mór
5. Matthew Greenwood
6. Mary Shaniqua
7. Stephen Hebs
8. Paul Telfer

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