Gut Podcast

BMJ Group

Gut Microbiota

Gastroenterology

Helicobacter Pylori

Hepatocellular Carcinoma

Immunotherapy

Checkpoint Inhibitor Therapy

Gastric Cancer

Obesity

Gastritis

Gut Microbiome

Pancreatic Cancer

Atopic Dermatitis

Heptocytic Carcinoma Tumor Microenvironment

Tumor Immune Architecture

Antibiotic Resistance

Parkinson's Disease

Pathology

Gut-Brain Axis

Tumor Microenvironment

Liver Cancer

The Gut Podcast is your go-to source for the latest discussions in gastroenterology and hepatology. Each month Dr. Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, dives into key issues in the field by discussing articles with their authors.Gut - gut.bmj.com - is an international journal from BMJ Group and the British Soc... more

34 ratings

Publishes	Monthly	Episodes	133	Founded	17 years ago
Number of Listeners		Categories	MedicineHealth & Fitness

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Guests Host Charts Talking Points

Latest Episodes

Dysbiosis drives PSC-UC-associated colorectal cancer

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Dr Muyiwa Awoniyi, who is an Clinical Staff Transplant Hepatologist and Assistant Professor from... more

10 Sep 2026 • 29 min

Western diet-associated colorectal cancer

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Dr Soeren Ocvirk, from the Research Group WESTGUT, ZIEL - Institute for Food & Health, Technical... more

7 Aug 2026 • 19 min • Most popular

DPP-4 inhibitors and Parkinson’s disease

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Professor Seong Ho Jeong, Assistant professor in the Department of Neurology, Yongin Severance H... more

22 Jul 2026 • 17 min

Defining a gut-peritoneum axis in endometriosis

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Professor Wei Wang from the Department of Gynaecology and Obstetrics, First Affiliated Hospital ... more

3 Jun 2026 • 17 min

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Recent Guests

Muyiwa Awoniyi

Clinical staff transplant hepatologist and assistant professor from Cleveland Clinic

Cleveland Clinic Research Institute

Episode: Dysbiosis drives PSC-UC-associated colorectal cancer

Soeren Ocvirk

Senior author leading the Westgut group; research teams at Technical University of Munich and German Institute of Human Nutrition

Technical University of Munich; German Institute of Human Nutrition

Episode: Western diet-associated colorectal cancer

Seong Ho Jeong

Assistant Professor in Neurology, Yonsei University Health System and Yonsei University College of Medicine; first author of the discussed paper

Yonsei University Health System / Yonsei University College of Medicine

Episode: DPP-4 inhibitors and Parkinson’s disease

Wei Wang

Professor, Department of Gynaecology and Obstetrics, First Affiliated Hospital of Guangzhou Medical University

First Affiliated Hospital of Guangzhou Medical University; Shanghai institutions mentioned in context

Episode: Defining a gut-peritoneum axis in endometriosis

Amanda Muir

Professor, Department of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia and the University of Pennsylvania

Children's Hospital of Philadelphia; University of Pennsylvania

Episode: Eosinophilic oesophagitis: the therapeutic potential of FOXM1 inhibition

Shanshan Wu

Professor, Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University

Beijing Friendship Hospital, Capital Medical University

Episode: Long-term prognosis of lean MASLD: evidence from three population-based prospective cohorts

Yuhan Pang

Professor, Department of Epidemiology & Biostatistics, School of Public Health, Peking University

Peking University

Episode: Long-term prognosis of lean MASLD: evidence from three population-based prospective cohorts

Xiaolong Qi

Professor, Centre of Liver Disease, Zhongda Hospital, Southeast University, Nanjing, China; founder and chair of CHESS Liver Health Consortium

Zhongda Hospital, Southeast University; CHESS

Episode: Managing type 2 diabetes patients with MASLD

Professor Zhi-Yang Shi

Deputy Director of the Department of Cardiology, Renmin Hospital of Wuhan University

Key State Laboratory of New Targets Discovery and Drug Development for Major Diseases, Gannan Medical University

Episode: Targeting MASLD with new nanoparticles

Host

Dr. Philip Smith

Digital and Education Editor of Gut; Honorary Consultant Gastroenterologist at Royal Liverpool University Hospital; host of the podcast.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Apple Podcasts	#246	United Kingdom/Health & Fitness/Medicine
Apple Podcasts	#70	France/Health & Fitness/Medicine
Apple Podcasts	#193	Italy/Health & Fitness/Medicine
Apple Podcasts	#142	Israel/Health & Fitness/Medicine
Apple Podcasts	#167	Japan/Health & Fitness/Medicine
Apple Podcasts	#167	Chile/Health & Fitness/Medicine
Apple Podcasts	#189	India/Health & Fitness/Medicine
Apple Podcasts	#199	Ukraine/Health & Fitness/Medicine
Apple Podcasts	#204	United Arab Emirates/Health & Fitness/Medicine
Apple Podcasts	#208	Denmark/Health & Fitness/Medicine
Apple Podcasts	#219	Austria/Health & Fitness/Medicine
Apple Podcasts	#231	Brazil/Health & Fitness/Medicine
Apple Podcasts	#241	New Zealand/Health & Fitness/Medicine
Apple Podcasts	#244	Netherlands/Health & Fitness/Medicine

Talking Points

Recent interactions between the hosts and their guests.

Dysbiosis drives PSC-UC-associated colorectal cancer

Q: How might this paper impact clinical practice in the near term?

Clinically, the emphasis shifts to proximal colon surveillance, recognizing endoscopic remission may mask histologic activity; there is caution against routine bile acid supplementation and a push toward strategies that restore microbial function with defined consortia, while integrating gut and liver endpoints in trials to avoid missing hepatic signals.

Dysbiosis drives PSC-UC-associated colorectal cancer

Q: What are the new findings highlighted in the paper?

Five main findings emerged: clinically, PSC-UC shows a distinct right- sided dysplasia risk with persistent histologic activity despite modest endoscopic inflammation; a novel MDR2 IL-10 double-knockout mouse model reproduces human disease with right-sided colitis and rapid progression to dysplasia; the microbiota in this model loses 7-alpha dehydroxylation activity and secondary bile acids; germ-free and fecal transfer experiments demonstrate a causal microbiome-driven mechanism; and therapeutically, simply repleting secondary bile acids is not sufficient and may cause liver injury, pointing toward restoring microbial metabolism with careful hepatic considerations.

Dysbiosis drives PSC-UC-associated colorectal cancer

Q: Could you explain the background to your paper and why researching this area is important?

The background centers on a paradox in PSC-UC where cancer risk is high but inflammation markers do not always align with cancer incidence, suggesting factors beyond mucosal inflammation. The team proposed that dysbiosis and microbial metabolism, especially 7-alpha dehydroxylation and secondary bile acids, could explain proximal cancer risk and inform a new causal model linking the microbiome to carcinogenesis.

Western diet-associated colorectal cancer

Q: What new findings does your paper highlight about causality between microbiome function and tumorigenesis?

The study demonstrates causality by showing that specific bacteria that produce secondary bile acids drive tumorigenesis in the colon, that a controlled BACOMI consortium can switch bile acid production in vivo, and that removing the producing strain or mutating it reduces tumor numbers.

Western diet-associated colorectal cancer

Q: Could I ask you to explain the background to your paper on why researching this area is important?

The background is that a Western diet increases dietary fat, elevating bile acid production. Secondary bile acids produced by gut bacteria correlate with colorectal cancer risk, and the study aims to establish a causal link using gnotobiotic mice and defined bacterial consortia.

Audience Metrics

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Frequently Asked Questions About Gut Podcast

What is Gut Podcast about and what kind of topics does it cover?

The program centers on gastroenterology and hepatology, frequently featuring authors and researchers discussing recent studies, clinical implications, and potential translational applications. Topics span gut microbiome research, liver disease (including MASLD and transplant considerations), gastric and Helicobacter pylori-related issues, pancreatology, and innovative therapeutics such as nanoparticles and COX-2 inhibitors. Episodes showcase a mix of mechanistic science, clinical practice implications, and policy/ guideline-relevant discussions, with guests ranging from senior investigators to early-career researchers. A notable strength is the ongoing emphasis on translating research findings into practical diagnostics, risk stratification... more

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Which podcasts are similar to Gut Podcast?

These podcasts share a similar audience with Gut Podcast:

1. FG Podcast
2. American Journal of Gastroenterology Author Podcasts
3. JAMA Clinical Reviews
4. Core IM | Internal Medicine Podcast
5. JAMA Editors' Summary

How many episodes of Gut Podcast are there?

Gut Podcast launched 17 years ago and published 133 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

How do I contact Gut Podcast?

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What guests have appeared on Gut Podcast?

Recent guests on Gut Podcast include:

1. Muyiwa Awoniyi
2. Soeren Ocvirk
3. Seong Ho Jeong
4. Wei Wang
5. Amanda Muir
6. Shanshan Wu
7. Yuhan Pang
8. Xiaolong Qi

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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