Gut Podcast

BMJ Group

Gut Microbiota

Gastroenterology

Helicobacter Pylori

Hepatocellular Carcinoma

Immunotherapy

Checkpoint Inhibitor Therapy

Gastric Cancer

Obesity

Gastritis

Pancreatic Cancer

Atopic Dermatitis

Heptocytic Carcinoma Tumor Microenvironment

Tumor Immune Architecture

Antibiotic Resistance

Parkinson's Disease

Tumor Microenvironment

Pathology

Gut-Brain Axis

Breastfeeding

Infant Health

The Gut Podcast is your go-to source for the latest discussions in gastroenterology and hepatology. Each month Dr. Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, dives into key issues in the field by discussing articles with their authors.Gut - gut.bmj.com - is an international journal from BMJ Group and the British Soc... more

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Publishes	Monthly	Episodes	131	Founded	17 years ago
Number of Listeners		Categories	Health & FitnessMedicine

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Guests Hosts Charts Talking Points

Latest Episodes

DPP-4 inhibitors and Parkinson’s disease

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Professor Seong Ho Jeong, Assistant professor in the Department of Neurology, Yongin Severance H... more

22 Jul 2026 • 17 min

Defining a gut-peritoneum axis in endometriosis

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Professor Wei Wang from the Department of Gynaecology and Obstetrics, First Affiliated Hospital ... more

3 Jun 2026 • 17 min • Most popular

Eosinophilic oesophagitis: the therapeutic potential of FOXM1 inhibition

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Professor Amanda Muir from the Department of Gastroenterology, Hepatology, and Nutrition, The Ch... more

6 May 2026 • 14 min • Popular

Long-term prognosis of lean MASLD: evidence from three population-based prospective cohorts

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Professor Shanshan Wu from the Department of Gastroenterology, Beijing Friendship Hospital, Capi... more

16 Apr 2026 • 17 min

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Recent Guests

Seong Ho Jeong

Assistant Professor in Neurology, Yonsei University Health System and Yonsei University College of Medicine; first author of the discussed paper

Yonsei University Health System / Yonsei University College of Medicine

Episode: DPP-4 inhibitors and Parkinson’s disease

Wei Wang

Professor, Department of Gynaecology and Obstetrics, First Affiliated Hospital of Guangzhou Medical University

First Affiliated Hospital of Guangzhou Medical University; Shanghai institutions mentioned in context

Episode: Defining a gut-peritoneum axis in endometriosis

Amanda Muir

Professor, Department of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia and the University of Pennsylvania

Children's Hospital of Philadelphia; University of Pennsylvania

Episode: Eosinophilic oesophagitis: the therapeutic potential of FOXM1 inhibition

Shanshan Wu

Professor, Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University

Beijing Friendship Hospital, Capital Medical University

Episode: Long-term prognosis of lean MASLD: evidence from three population-based prospective cohorts

Yuhan Pang

Professor, Department of Epidemiology & Biostatistics, School of Public Health, Peking University

Peking University

Episode: Long-term prognosis of lean MASLD: evidence from three population-based prospective cohorts

Xiaolong Qi

Professor, Centre of Liver Disease, Zhongda Hospital, Southeast University, Nanjing, China; founder and chair of CHESS Liver Health Consortium

Zhongda Hospital, Southeast University; CHESS

Episode: Managing type 2 diabetes patients with MASLD

Professor Zhi-Yang Shi

Deputy Director of the Department of Cardiology, Renmin Hospital of Wuhan University

Key State Laboratory of New Targets Discovery and Drug Development for Major Diseases, Gannan Medical University

Episode: Targeting MASLD with new nanoparticles

Professor Jun Li

Senior author on the paper and expert from Zhejiang University

Zhejiang University School of Medicine

Episode: Performance of the China-CLIF framework in acute-on-chronic liver failure

Dr. Fernando Lucas-Ruiz

First author on the study regarding liver transplant outcomes

Biomedical Research Institute of Murcia

Episode: Predicting short-term liver transplant outcomes with graft microbial DNA signature

Hosts

Dr. Philip Smith

Digital and Education Editor of Gut; Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital; Host of the series invoking expert guests on gastroenterology and hepatology topics.

Philip Smith

Digital and Education Editor of Gut; Gastroenterologist and educator.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Apple Podcasts	#163	Australia/Health & Fitness/Medicine
Apple Podcasts	#111	Finland/Health & Fitness/Medicine
Apple Podcasts	#163	Taiwan/Health & Fitness/Medicine
Apple Podcasts	#169	Japan/Health & Fitness/Medicine
Apple Podcasts	#191	Ireland/Health & Fitness/Medicine
Apple Podcasts	#208	Mexico/Health & Fitness/Medicine
Apple Podcasts	#240	Chile/Health & Fitness/Medicine

Talking Points

Recent interactions between the hosts and their guests.

DPP-4 inhibitors and Parkinson’s disease

Q: What are the key next steps the researchers see moving forward?

Priorities include identifying the exact molecular substrate driving the gut-mediated effect, testing across the DPP-4 inhibitor class, and designing trials that enroll patients most likely to benefit based on gut-origin markers and prodromal signs.

DPP-4 inhibitors and Parkinson’s disease

Q: How might this paper translate into clinical practice in the foreseeable future?

While not a treatment recommendation yet, the findings support clinical trials of DPP-4 inhibitors in Parkinson's disease, emphasize patient stratification (body-first subtype with gut-origin), and suggest early intervention could be key for efficacy.

DPP-4 inhibitors and Parkinson’s disease

Q: So, what are the new findings your paper has highlighted?

The study demonstrates that a gut-targeted DPP-4 inhibitor reduces gut inflammation and alpha-synuclein spread along the gut-brain axis, preserves dopaminergic neurons, and that these effects are independent from GLP-1 signaling and do not require brain penetration.

DPP-4 inhibitors and Parkinson’s disease

Q: Firstly, could I ask you to explain the background to your paper, on why researching this area is so important?

The guest explains that GLP-1 drugs generated interest in Parkinson's disease, leading to exploring DPP-4 inhibitors which raise endogenous GLP-1, but ultimately the benefit appeared to be tied to the gut rather than a brain mechanism; this set up the gut-first hypothesis and the need to test inflammation and alpha-synuclein spread via the gut-brain axis.

Defining a gut-peritoneum axis in endometriosis

Q: What are the key future research priorities suggested by the authors?

Priorities include confirming the role of specific microbes like P. aeruginosa, dissecting the guard-peritoneum axis, identifying bacterial metabolites that disrupt tight junctions, and testing barrier-restoring or probiotic-based strategies in more rigorous models.

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Frequently Asked Questions About Gut Podcast

What is Gut Podcast about and what kind of topics does it cover?

The discussions center on cutting-edge gastroenterology and hepatology research, with episodes spanning liver disease (MASLD/lean MASLD, transplant outcomes, fibrosis risk, non-invasive screening), pharmacology and therapeutics (COX-2 inhibitors, targeted nanoparticles), and mucosal biology (epithelial repair in eosinophilic esophagitis). Guests are typically leading clinicians and researchers presenting new findings, discussing clinical implications, and outlining future research directions. Across episodes, the show often highlights practical implications for risk stratification, diagnosis, and treatment pathways, including how biomarkers, imaging thresholds, and novel therapies could influence real-world patient care. The format tends to... more

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Which podcasts are similar to Gut Podcast?

These podcasts share a similar audience with Gut Podcast:

1. American Journal of Gastroenterology Author Podcasts
2. JAMA Clinical Reviews
3. Core IM | Internal Medicine Podcast
4. NEJM This Week
5. BSG From Top to Bottom

How many episodes of Gut Podcast are there?

Gut Podcast launched 17 years ago and published 131 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

How do I contact Gut Podcast?

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What guests have appeared on Gut Podcast?

Recent guests on Gut Podcast include:

1. Seong Ho Jeong
2. Wei Wang
3. Amanda Muir
4. Shanshan Wu
5. Yuhan Pang
6. Xiaolong Qi
7. Professor Zhi-Yang Shi
8. Professor Jun Li

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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