Rephonic
Artwork for Entrepreneur Rx
Artificial Intelligence
MU Medical
Nanodropper
Originstory
Deeplook
Simbiosys
Lenoss Medical
Glaucoma
Ophthalmology
Surf Therapeutics
Healthcare
Radiology
Breast Cancer
Regulatory FDA
Reimbursement
Series B
Entrepreneurship
Oculomics
Eye Drops

What does it take to build something that matters? Hosted by John Shufeldt, Entrepreneur Rx features conversations with founders, investors, executives, and innovators who are building the future. From entrepreneurship and venture capital to technology, healthcare, defense, and leadership, each episode explores the stories, challenges, and lessons behind creating impactful companies and driving me... more

PublishesWeeklyEpisodes92Founded5 years ago
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EntrepreneurshipBusiness

Listen to this Podcast

Artwork for Entrepreneur Rx

Latest Episodes

What if AI could help clinicians move beyond detection and make breast cancer treatment more precise and personalized?

In this episode of Entrepreneur Rx, host John Shufeldt sits down with Stacey Stevens, CEO of SimBioSys, to discuss her career in ... more

What does it take to build healthcare technology that can make vital signs easier to capture, track, and use?

In this episode of Entrepreneur Rx, host John Shufeldt sits down with Mitch Foster, founder and CEO of Mindset Medical, to discuss his car... more

What does it take to turn decades of healthcare experience into technology that could help improve cancer detection and patient care?

In this episode of Entrepreneur Rx, host John Shufeldt sits down with Marissa Fayer, CEO of DeepLook Medical, to di... more

How do you prove that the person speaking to you is actually human?

In this episode of Entrepreneur Rx, host John Shufeldt sits down with Visar Berisha, founder and CEO of OriginStory, to explore one of the most urgent problems emerging in the age o... more

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Recent Guests

Stacey Stevens
CEO of SimBioSys
SimBioSys
Episode: Stacey Stevens: Building Precision Medicine for Breast Cancer Treatment
Mitch Foster
Founder/Entrepreneur and Mindset Medical co-founder
Mindset Medical / Former Executive at Synthes and Globus Medical
Episode: Mitch Foster: Turning the Smartphone into a Medical Device
Marissa Fayer
CEO of DeepLook, expert in imaging software for radiology
DeepLook
Episode: Marissa Fayer: Advancing AI, Medical Imaging, and the Future of Women’s Health
Visar Berisha
Founder of OriginStory; radar/voice-AI researcher; ASU professor and PhD holder
OriginStory
Episode: Visar Berisha: Proving What’s Real in the Age of Deepfakes
Nishant Doctor
Founder of Surf Therapeutics
Surf Therapeutics
Episode: Nishant Doctor: Reimagining Autoimmune Treatment Through Ultrasound Neuromodulation
Dom Messerli
Founder of Lenoss Medical, spine implants innovator
Lenoss Medical
Episode: Dom Messerli: Reinventing Spine Surgery with Lenoss Medical
Allisa Song
CEO of MU Medical
MU Medical
Episode: Allisa Song: From Medical Student to CEO of MU Medical

Host

John Shufeldt
Host of Entrepreneur Rx; guides interviews with founders, investors, executives, and innovators in healthcare, technology, and entrepreneurship.

Reviews

5.0 out of 5 stars from 8 ratings
  • One to add to your rotation!

    John strikes a great balance between actionable advice and compelling stories from the business world. It's like having a coffee chat with seasoned professionals, giving you insights you didn't even know you needed.

    From Bona and Team Capsho

    Apple Podcasts
    5
    Bona and Team Capsho
    United States3 years ago
  • This is my new favorite podcast!

    Very inspirational & Interesting

    Apple Podcasts
    5
    Kc mo mo
    United States5 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Very inspirational and interesting—great for motivation and practical takeaways.
Feels like a practical masterclass for building healthcare tech companies.
Great balance of actionable advice and compelling stories from leaders in business.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Talking Points

Recent interactions between the hosts and their guests.

Mitch Foster: Turning the Smartphone into a Medical Device
Q: What advice would you give to aspiring entrepreneurs?
Go for it without delay, embrace scenario planning and prepare for time without a paycheck, accept that startups require sacrifice, and learn to pivot while maintaining a glass-half-full mindset and a willingness to learn from failures.
Stacey Stevens: Building Precision Medicine for Breast Cancer Treatment
Q: What advice would you give to young healthcare entrepreneurs?
The advice emphasizes tackling hard, regulated problems with a resilient mindset, building trust with physicians and payers, and communicating a crisp, evidence-backed value proposition to scale in a market with many AI players.
Stacey Stevens: Building Precision Medicine for Breast Cancer Treatment
Q: How did the transition from AI in detection to precision medicine unfold at SimBioSys?
Stacey describes moving from detection-oriented AI to end-to-end precision medicine, including surgical planning tools, measuring tumor volumes for conservation decisions, and expanding into tissue- and image-based risk assessments to guide treatment.
Stacey Stevens: Building Precision Medicine for Breast Cancer Treatment
Q: What years were you at Philips, and how did that shape your later work?
She explains a long tenure at Philips in the 90s through 2006, which laid the groundwork for leading ICAD and later ventures by showing how to scale global healthcare programs and navigate regulatory and market transitions.
Dom Messerli: Reinventing Spine Surgery with Lenoss Medical
Q: What are the near-term milestones for 2026?
Targets include performing 1,000 procedures in a year, starting a post-market clinical study (Perl 1), achieving over $2 million in sales, and closing a Series B to fund sales and operations growth toward profitability.

Audience Metrics

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Listeners per Episode
Gender Skew
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Professions
Age Range
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Frequently Asked Questions About Entrepreneur Rx

What is Entrepreneur Rx about and what kind of topics does it cover?

Conversations center on building meaningful tech-enabled ventures, especially in healthcare, medical devices, and AI-driven health solutions. Episodes spotlight founder journeys, fundraising, regulatory and reimbursement hurdles, partnerships, and go-to-market strategies, with real-world deployments and clinical impact shaping the narratives. The show is likely to appeal to aspiring founders, operators, and investors who want practical lessons from hands-on experiences across healthcare technology, venture funding, and leadership. A notable strength is a blunt, actionable lens on navigating tough trade-offs, team building under pressure, and delivering patient-centered innovation at scale.

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How many listeners does Entrepreneur Rx get?

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To see how many followers or subscribers Entrepreneur Rx has on Spotify and other platforms such as Castbox and Podcast Addict, simply upgrade your account. You'll also find viewership figures for their YouTube channel if they have one.

Which podcasts are similar to Entrepreneur Rx?

These podcasts share a similar audience with Entrepreneur Rx:

1. The Game with Alex Hormozi
2. Pivot
3. The Daily

How many episodes of Entrepreneur Rx are there?

Entrepreneur Rx launched 5 years ago and published 92 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

How do I contact Entrepreneur Rx?

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Where can I see ratings and reviews for Entrepreneur Rx?

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What guests have appeared on Entrepreneur Rx?

Recent guests on Entrepreneur Rx include:

1. Stacey Stevens
2. Mitch Foster
3. Marissa Fayer
4. Visar Berisha
5. Nishant Doctor
6. Dom Messerli
7. Allisa Song

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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