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Artwork for Clinical Pharmacology Podcast

Clinical Pharmacology Podcast with Nathan Teuscher

Nathan Teuscher
Pharmacokinetics
Clinical Pharmacology
Drug Development
FDA
Communication Skills
Computer System Validation
Project Optimus
Artificial Intelligence
Pharmacodynamics
Technical Presentations
Hepatic Impairment
Oncology
PKPD Modeling
Regulatory Guidance Documents
Non-Compartmental Analysis
Indirect Response Models
Pharmacometrics
Dose Proportionality
Pharmaceutical Discipline
Data Presentation

I discuss clinical pharmacology and pharmacometrics topics from the perspective of drug development scientists. I share my expertise and knowledge about designing and conducting clinical pharmacology studies and discuss how to analyze the data using the most effective approaches. I draw from my experience of over 20 years working in drug development organizations and consultancies.

PublishesMonthlyEpisodes57Founded3 years ago
Number of ListenersCategories
Life SciencesScience

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Artwork for Clinical Pharmacology Podcast

Latest Episodes

In this episode I discuss bioequivalence testing and how it was developed to support generic drug approvals, but is now a mainstream tool for all of drug development. I discuss the basics of what bioequivalence means, how the studies are designed, an... more

In this episode we’re going to define Volume of Distribution, look at the different types of Volume of Distribution parameters, talk about how we actually calculate it, examine what drives its value, and—most importantly—discuss why it matters for th... more

This episode is an interview with Michael Stackhouse, the Chief Innovation Officer at Atorus Research. We discussed a variety of topics such as modern data science tools, why regulatory agencies want to get rid of SAS transport files in favor of Data... more

This episode is an interview with Dr. Wouter Vaes, the Chief Science Officer of Peregrion. We discuss how accelerator mass spectrometry is being used in early clinical development for drug metabolism and pharmacokinetics. We discuss using this techno... more

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Recent Guests

Mike Stackhouse
Chief Innovation Officer at Atorus Research
Atorus Research
Episode: Talking about data science with Mike Stackhouse (Ep. 55)
Wouter Vaes
Chief Scientific Officer of Peregrine, with a PhD in toxicology
Peregrine
Episode: Using Accelerator Mass Spectrometry in Clinical Pharmacology
Dr. Aruna Dhontabhaktuni
Founder and CEO of RegKey and PharmaPro Consulting, expert in clinical pharmacology and regulatory strategy
RegKey
Episode: Using AI tools for regulatory intelligence (Ep. 53)
Ahmed Elmokadem
Senior Scientist at Metrum Research Group with expertise in modeling and simulation for drug development.
Metrum Research Group
Episode: QSP Modeling with Ahmed Elmokadem (Ep. 51)
Julie Bullock
Key opinion leader on the FDA's Project Optimus initiative with over 20 years of drug development experience, former FDA oncology clinical pharmacology reviewer.
Episode: Project Optimus (Ep. 21)
Michael Piperno
Communication expert, trainer and coach with 28 years of experience helping professionals communicate clearly.
Founder of a brand communications agency
Episode: Communication for scientists (Ep. 19)

Host

Nathan Teuscher
Host of the Clinical Pharmacology Podcast, with extensive experience in drug development and analytics.

Reviews

5.0 out of 5 stars from 103 ratings
  • Hidden gem

    Clear and concise summaries on scads of topics. The host is a highly polished and seasoned presenter. I highly recommend for those interested in primers or refreshers of drug development related areas.

    Apple Podcasts
    5
    tdawgUM
    United States2 years ago
  • Interesting and Informative

    Excellent information from an experienced clinical pharmacologist with a talent for breaking things down so they are easy to understand.

    Apple Podcasts
    5
    MontageMonday
    United States3 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Polished host with ability to break down complex topics.
Clear, concise primers on drug development and PK/PD.
Informative with easy-to-understand explanations of regulatory-friendly practices.
Great for primers and refreshers in drug development.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Talking Points

Recent interactions between the hosts and their guests.

Talking about data science with Mike Stackhouse (Ep. 55)
Q: For people who are uninformed, tell people what dataset JSON is, and maybe briefly describe it so that they can visualize it.
Dataset JSON is a schema on top of JSON that standardizes how CDISC data sets are written and shared, including metadata upfront and data after, enabling more efficient, verifiable data transfer and web-based viewing; it aims for backwards compatibility with the legacy SAS transport format while improving machine readability and data manageability.
Talking about data science with Mike Stackhouse (Ep. 55)
Q: That's really cool. So tell me, I've read this term and I know we've talked before and you talk about modern data science tools. So what is a modern tool versus maybe a current tool that people know is SAS or R for data science?
Mike explains that modern tools are those enabled by cloud architectures, scalable infrastructure, and multi-language capabilities, allowing faster automation and reproducibility, while still using familiar languages like SAS and R where appropriate; the emphasis is on not binding to a single tool, and on using a mix of languages and platforms to achieve scalable, auditable analyses.
Using Accelerator Mass Spectrometry in Clinical Pharmacology
Q: How can microtracer approaches benefit oncology drug development?
Microtracer studies can provide essential pharmacokinetic data earlier in the development process, potentially allowing for better planning of additional studies and faster drug development timelines.
Using Accelerator Mass Spectrometry in Clinical Pharmacology
Q: Can you explain the differences between AMS and liquid scintillation counting regarding sample handling and how the doses differ?
AMS allows for significantly lower radioactive doses with higher sensitivity, making sample handling easier and reducing ethical concerns compared to liquid scintillation counting, which requires larger doses and more extensive safety precautions.
QSP Modeling with Ahmed Elmokadem (Ep. 51)
Q: What value does QSP really add to clinical pharmacology support for drug development?
QSP connects biology to pharmacology, offering insight into mechanisms and foresight through simulations, supporting informed decisions.

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Frequently Asked Questions About Clinical Pharmacology Podcast

What is Clinical Pharmacology Podcast about and what kind of topics does it cover?

A practical, expert-led deep-dive into clinical pharmacology, pharmacometrics, and drug development. Episodes cover pharmacokinetics basics (volume of distribution, NCA, model selection) and advanced topics like MID, QSP, regulatory intelligence, and AI-enabled workflows. Across conversations, the host emphasizes actionable modeling decisions, regulatory considerations, data standards, and real-world case examples, making it valuable for scientists, sponsors, and teams building PK/PD strategies.

Noteworthy strengths include accessible explanations of complex concepts, frequent guest insights from industry practitioners, and a clear focus on how modeling and data science drive decision making in development and submissions. The show appears... more

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Which podcasts are similar to Clinical Pharmacology Podcast?

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1. The Readout Loud
2. Up First from NPR
3. Drug Story
4. Freakonomics Radio
5. The Daily

How many episodes of Clinical Pharmacology Podcast are there?

Clinical Pharmacology Podcast launched 3 years ago and published 57 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Clinical Pharmacology Podcast?

Recent guests on Clinical Pharmacology Podcast include:

1. Mike Stackhouse
2. Wouter Vaes
3. Dr. Aruna Dhontabhaktuni
4. Ahmed Elmokadem
5. Julie Bullock
6. Michael Piperno

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