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Pharmacology
Cancer
Hypertension
Underwood's Pathology
Public Health
Heart Failure
Diabetes
Graves' Disease
Neoplasia
Human Microbiome
Endocrine System
Gastrointestinal Tract
Dopamine
Opioids
Renin-Angiotensin System
Vision
Dysbiosis
Iodine
Addiction
Ethanol

Clinical Deep Dives is a Medlock Holmes podcast for clinicians and learners who want understanding, not just information. Using classic medical and surgical texts as a guide and the generative power of AI, each episode explores ideas with curiosity and clarity, designed for learning on the move and knowledge that actually sticks. drmanaankarray.substack.com

PublishesDailyEpisodes617Founded6 months ago
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Artwork for Clinical Deep Dives

Latest Episodes

This chapter examines the growing influence of neuroscience in legal and societal understandings of behaviour - particularly in the context of addiction. Neurocentrism refers to the tendency to explain complex human actions primarily, or exclusively,... more

This chapter bridges two historically separate domains: psychoanalytic object relations theory and contemporary neuroscience. It explores how early relationships are not merely psychological experiences, but biologically embedded processes that shape... more

This chapter challenges one of the most deceptively simple questions in psychiatry: what does it mean to be “normal”?

Rather than defining normality as the absence of illness, contemporary perspectives frame mental health as a dynamic process - the ... more

This chapter explores how memory is encoded, stored, and retrieved within the brain - not as a static archive, but as a dynamic and evolving biological process.

Memory begins with encoding, where experience is transformed into neural activity. This ... more

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Mind & Matter
Mind & MatterNick Jikomes

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5.0 out of 5 stars from 2 ratings
  • Genius way to learn

    I’m a third-year medical student in the US. I just found your podcast this week and I think it’s so insightful how you identified the disconnect in modern medical learning. One little recommendation I’d suggest is to put a little more detail about the origin story of this podcast into the podcast description/bio. I think if listeners know right off the bat that it was developed by a physician with your experience it will be even more compelling.

    Apple Podcasts
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    cervicalos
    United States2 months ago

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PSYCH 037: Neuropsychiatric Aspects of Movement Disorders
Q: Question 5: In young patients with acute psychosis who later show wing-beating tremor and Castellan signs, which metabolic disease must be ruled out immediately?
Wilson disease must be ruled out with liver function tests and serum ceruloplasmin because it is treatable and its misdiagnosis can lead to catastrophic neurological damage.
PSYCH 037: Neuropsychiatric Aspects of Movement Disorders
Q: Question 4: What metaphorical term describes cerebellar dysmetria of thought, and what does it imply?
The dysmetria of thought, implying that cerebellar dysfunction disrupts the regulation of cognitive and emotional processes just as motor dysmetria disrupts planned movements.
PSYCH 037: Neuropsychiatric Aspects of Movement Disorders
Q: Question 3: A patient with vivid visual hallucinations and concurrent Parkinsonian symptoms is treated with haloperidol. Why is this contraindicated?
Because this presentation suggests dementia with Lewy bodies, which has extreme neuroleptic sensitivity; typical D2-blocking antipsychotics can trigger severe rigidity and potentially fatal reactions.
PSYCH 037: Neuropsychiatric Aspects of Movement Disorders
Q: Question 2: A Parkinson's patient starts a dopamine agonist like ropinirole and develops compulsive gambling. Which pathway is overstimulated and what is the syndrome?
The mesolimbic reward pathway is overstimulated due to the drug's affinity for D3 receptors, leading to an impulse control disorder (ICD).
PSYCH 037: Neuropsychiatric Aspects of Movement Disorders
Q: Question 1: A 68-year-old man presents with pronounced apathy, emotional incontinence, early backward falls, and vertical gaze palsy. What is the most likely primary pathology and diagnosis?
The most likely primary pathology is a tauopathy, with progressive supranuclear palsy (PSP) as the diagnosis, given the combination of profound apathy, pseudo-bulbar affect, axial falls, and vertical gaze palsy.

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Frequently Asked Questions About Clinical Deep Dives

What is Clinical Deep Dives about and what kind of topics does it cover?

Clinical Deep Dives provides clinician-oriented explorations of medical and surgical ideas, guided by classic texts and informed by AI-assisted perspectives. Episodes frequently map foundational concepts to practical practice, using structured frameworks and case-based discussion to illuminate upstream, midstream, and downstream thinking in patient care. A notable strength is the blend of historical medical literature with contemporary AI-assisted inquiry, making complex topics approachable for learning on the move while maintaining clinical rigor. The show tends to favor frameworks, evidence synthesis, and actionable insights relevant to practicing clinicians, medical educators, and trainees who want depth without sacrificing applicability... more

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Clinical Deep Dives launched 6 months ago and published 617 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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