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Clinical Deep Dives is a Medlock Holmes podcast for clinicians and learners who want understanding, not just information. Using classic medical and surgical texts as a guide and the generative power of AI, each episode explores ideas with curiosity and clarity, designed for learning on the move and knowledge that actually sticks. drmanaankarray.substack.com

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Latest Episodes

Seizures are among the most dramatic manifestations of brain dysfunction - but not all seizures arise from the same mechanisms. This chapter explores the neuropsychiatric dimensions of epilepsy alongside psychogenic nonepileptic seizures (PNES), wher... more

Brain tumours do not merely occupy space - they alter function. This chapter explores how focal growths within the brain can produce profound changes in cognition, behaviour, and personality, often before neurological signs become obvious.

In this e... more

The brain depends on a constant, finely regulated blood supply. When this flow is disrupted - whether abruptly, as in stroke, or gradually, as in vascular disease - the consequences extend far beyond motor deficits. This chapter explores how cerebrov... more

This chapter is not about a disorder, but about a way of seeing. The neuropsychiatric approach reframes the patient encounter as an integration of neurology and psychiatry - recognising that behaviour, cognition, and emotion are expressions of brain ... more

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5.0 out of 5 stars from 2 ratings
  • Genius way to learn

    I’m a third-year medical student in the US. I just found your podcast this week and I think it’s so insightful how you identified the disconnect in modern medical learning. One little recommendation I’d suggest is to put a little more detail about the origin story of this podcast into the podcast description/bio. I think if listeners know right off the bat that it was developed by a physician with your experience it will be even more compelling.

    Apple Podcasts
    5
    cervicalos
    United States2 months ago

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PSYCH 021: Pharmacogenetics
Q: Question 5: What do we call a drug that inhibits its own metabolism as its concentration reaches steady state?
Autofunocopying (autophenocopying), where the drug inhibits the enzyme that clears it, altering pharmacokinetics over time.
PSYCH 021: Pharmacogenetics
Q: Question 4: What adverse event does FDA testing for HLA-B*1502 or HLA-A*3101 aim to prevent when prescribing carbamazepine?
Severe immune-mediated skin reactions, specifically Stevens-Johnson syndrome or toxic epidermal necrolysis.
PSYCH 021: Pharmacogenetics
Q: Question 3: An extensive metabolizer on a CYP2D6 substrate is given a CYP2D6 inhibitor; what pharmacokinetic phenomenon occurs?
Phenocopying, where the inhibitor converts a genetically normal enzyme into a functional poor metabolizer, causing drug buildup and toxicity.
PSYCH 021: Pharmacogenetics
Q: Question 2: Which enzyme and allele explain immediate facial flushing and nausea after small amounts of alcohol in East Asian descent, acting as a deterrent to alcohol dependence?
Alcohol dehydrogenase (ADH1B2) allele, which causes rapid acetaldehyde accumulation and immediate toxic reactions.
PSYCH 021: Pharmacogenetics
Q: Question 1: Which CYP2D6 phenotype best explains life-threatening respiratory depression after a standard dose of codeine in a post-operative patient?
Ultra-rapid metabolizer (UM) phenotype, due to duplicated CYP2D6 genes, leading to rapid conversion of codeine to toxic morphine.

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Frequently Asked Questions About Clinical Deep Dives

What is Clinical Deep Dives about and what kind of topics does it cover?

Clinical Deep Dives provides clinician-oriented explorations of medical and surgical ideas, guided by classic texts and informed by AI-assisted perspectives. Episodes frequently map foundational concepts to practical practice, using structured frameworks and case-based discussion to illuminate upstream, midstream, and downstream thinking in patient care. A notable strength is the blend of historical medical literature with contemporary AI-assisted inquiry, making complex topics approachable for learning on the move while maintaining clinical rigor. The show tends to favor frameworks, evidence synthesis, and actionable insights relevant to practicing clinicians, medical educators, and trainees who want depth without sacrificing applicability... more

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1. Dr. Matt and Dr. Mike's Medical Podcast
2. Mind & Matter

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Clinical Deep Dives launched 5 months ago and published 599 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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