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Public Health
Infectious Disease
Oncology
Cancer
Snake Bites
Envenomation
Davidson's Medicine
Antimicrobial Resistance
Colonization
Immunotherapy
TNM Classification
Chronic Pain
Scorpion Stings
Antivenom
Baily & Love
Day Case Surgery
Pain Relief
Anesthesia
Epidemiology
Microbial Flora

Clinical Deep Dives is a Medlock Holmes podcast for clinicians and learners who want understanding, not just information. Using classic medical and surgical texts as a guide, each episode explores ideas with curiosity and clarity — designed for learning on the move and knowledge that actually sticks. drmanaankarray.substack.com

PublishesDailyEpisodes201Founded18 days ago
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MedicineEducationCoursesHealth & Fitness

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Latest Episodes

While voluntary movement and conscious sensation occupy our awareness, the autonomic nervous system (ANS) works continuously in the background—regulating heart rate, blood pressure, digestion, temperature, and metabolic balance without pause.

In thi... more

Movement is often thought of as a conscious act, yet much of what keeps us upright, balanced, and safe occurs without deliberate thought. Reflexes act first; voluntary control refines later.

In this episode, Medlock Holmes investigates how posture a... more

Hearing and balance share a common origin: mechanical energy translated into neural meaning. Air vibrations become sound; head movement becomes orientation; acceleration becomes awareness of motion.

In this episode, Medlock Holmes explores how the a... more

Vision feels immediate and authoritative, yet what we experience as “seeing” is not a direct recording of reality. It is a carefully reconstructed narrative, assembled from photons, probabilities, and prior expectations.

In this episode, Medlock Hol... more

Smell and taste are often treated as minor senses, yet they are among the most ancient, direct, and emotionally powerful sensory systems in human physiology. Unlike vision or hearing, they rely on chemical recognition—molecules binding to receptors—a... more

Touch, pain, and temperature feel immediate and personal, yet each sensation is the result of layered physiological translation. Mechanical force becomes electrical activity. Thermal change becomes coded frequency. Tissue threat becomes urgency.

In ... more

Not all messages in the nervous system say the same thing, even when they travel along the same path. What determines whether a signal excites, inhibits, sharpens, softens, or reshapes behaviour is not electricity alone—but chemistry.

In this episod... more

Electrical signals travel swiftly, but they do not leap blindly from cell to cell. Between neurons, muscles, and glands lie junctions—carefully regulated spaces where signals are translated, filtered, delayed, amplified, or restrained.

In this episo... more

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Host

Dr. Mana Ankarry
Host of Clinical Deep Dives, engaging in in-depth discussions about clinical topics.

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Talking Points

Recent interactions between the hosts and their guests.

Biochem 22: Biosynthesis of Amino Acids, Nucleotides, and Related Molecules
Q: If our bodies are so smart, why can we manufacture some amino acids from scratch?
It relates to evolutionary trade-offs. Some amino acids are complex to create, and if they're readily available in the diet, the body might lose the ability to synthesize them.
Davidson 4. Clinical Immunology
Q: What crucial outcome, vital for maintaining self-tolerance, occurs if a naive T cell successfully binds to a peptide HLA complex but fails to interact with its co-stimulatory molecules?
The T cell would likely become functionally unresponsive, or anergic, which is a mechanism of peripheral tolerance.
Davidson 4. Clinical Immunology
Q: What is the precise metabolic reason that the defect in NADPH oxidase specifically makes CGD patients susceptible to catalyzed positive organisms?
The answer lies in hydrogen peroxide. NADPH oxidase normally creates massive amounts of hydrogen peroxide for killing. If it's defective, the phagocyte relies on trace amounts of hydrogen peroxide made elsewhere, which catalyzed positive organisms can break down, leaving the phagocyte with zero oxidative capacity against that specific invader.
Davidson 2. Clinical Therapeutics
Q: Check in Q2, the saturation test. You have two patients. One is taking amoxicillin, which is first order, the other is taking phenytoin, zero order. If you increase the dose for both by 20%, what happens?
Amoxicillin concentration increases predictably by 20%, while the phenytoin patient risks uncontrolled progressive accumulation and toxicity.
Davidson 2. Clinical Therapeutics
Q: Check-in Q1, the Nuance Test. If you're comparing two drugs, and drug A is ten times more potent than drug B, is drug A automatically the better choice?
Not necessarily. The choice depends on their maximal efficacy and therapeutic index.

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Frequently Asked Questions About Clinical Deep Dives

What is Clinical Deep Dives about and what kind of topics does it cover?

This podcast engages medical professionals and learners by providing deep explorations of clinical topics, often referencing classic medical and surgical texts. Each episode is designed to enhance understanding rather than just deliver information, addressing key anatomical complexities and clinical implications relevant to various specialties. A unique aspect is the integration of case studies and narratives that emphasize practical insights, making the content relatable and memorable for listeners engaged in the healthcare field. Topics range widely from specific anatomical structures to the intricacies of surgical procedures, fostering a curious and clear approach to medical education.

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How many episodes of Clinical Deep Dives are there?

Clinical Deep Dives launched 18 days ago and published 201 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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